ISRN Hematology最新文献_第6页

18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Management of Aggressive Non-Hodgkin's B-Cell Lymphoma. 18-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描治疗侵袭性非霍奇金b细胞淋巴瘤。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-03-11 DOI: 10.5402/2012/456706

M J Shelly, S McDermott, O J O'Connor, M A Blake

引用次数: 4

Anemia in heart failure patients. 心力衰竭患者的贫血。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-03-25 DOI: 10.5402/2012/246915

Michael G Alexandrakis, George Tsirakis

引用次数: 38

DIC Score: Statistical Relationship with PT, APTT, and Simplified Scoring Systems with Combinations of PT and APTT. DIC评分:与PT、APTT的统计关系，以及PT和APTT结合的简化评分系统。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-03-05 DOI: 10.5402/2012/579420

Vani Chandrashekar

引用次数: 12

The Effects of Continuous Blood Purification for SIRS/MODS Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 持续血液净化对SIRS/MODS患者的影响:随机对照试验的系统回顾和荟萃分析

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-09-26 DOI: 10.5402/2012/986795

Tian Hongliang, Zeng Rong, Wang Xiaojing, Sun Rao, Li Lun, Tian Jinhui, Cao Nong, Yang Kehu

{"title":"The Effects of Continuous Blood Purification for SIRS/MODS Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Tian Hongliang, Zeng Rong, Wang Xiaojing, Sun Rao, Li Lun, Tian Jinhui, Cao Nong, Yang Kehu","doi":"10.5402/2012/986795","DOIUrl":"https://doi.org/10.5402/2012/986795","url":null,"abstract":"Background. Continuous veno-venous hemofiltration (CVVH) has aroused great concern in recent years because its effect on clearing inflammatory mediators and its mechanism of clinical effects in the treatment of critical illness has also become a research direction. Objective. To evaluate the efficacy of continuous blood purification for systemic inflammatory response syndrome (SIRS)/multiple organ dysfunction syndrome (MODS) patients. Methods. A systematic review of the literature was undertaken to assess randomized controlled trials on CVVH. Results. 11 RCTs involving a total of 414 patients were included. Compared with the control group, CVVH for SIRS/MODS patients has several advantages including better effects on clearing the plasma inflammatory mediators IL-6 [SMD(3d) = -0.45, 95%CI, (-0.83, -0.07), SMD(7d) = -1.07, 95%CI, (-1.52, -0.62)], on plasma TNF-alfa [SMD(3d) = -0.87, 95%CI, (-1.69, -0.04), SMD(7d) = -1.42, 95%CI, (-2.49, -0.35)], lower white blood cell (WBC) count [MD = 2.61, 95%CI, (1.49, 3.73)], shorter hospital stays [MD = -7.21 days, 95%CI, (-10.68, -3.74)] and better stability of hemodynamics. However, there is no significant difference in the mortality rate [MODS:RR = 0.62, 95%CI, (0.38, 1.01), SIRS:RR = 0.75, 95%CI, (0.57, 1.08)]. Conclusions. The study showed that CVVH was able to eliminate inflammatory mediators (TNF-alfa, IL-6) in plasma effectively, lower WBC count and shorter hospital stays than conventional therapeutic measures.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"986795"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/986795","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30971542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Angiogenesis in Non-Hodgkin's Lymphoma: An Intercategory Comparison of Microvessel Density. 非霍奇金淋巴瘤的血管生成:微血管密度的分类间比较。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-03-27 DOI: 10.5402/2012/943089

Deepti Aggarwal, Gunjan Srivastava, Ruchika Gupta, Leela Pant, Gopal Krishan, Sompal Singh

{"title":"Angiogenesis in Non-Hodgkin's Lymphoma: An Intercategory Comparison of Microvessel Density.","authors":"Deepti Aggarwal, Gunjan Srivastava, Ruchika Gupta, Leela Pant, Gopal Krishan, Sompal Singh","doi":"10.5402/2012/943089","DOIUrl":"https://doi.org/10.5402/2012/943089","url":null,"abstract":"Background. This study was aimed at comparing angiogenesis, seen as microvessel density (MVD) in subtypes of non-Hodgkin's lymphoma (NHL). Methods. In this study, 64 cases of NHL diagnosed over a three-year period were included along with 15 lymph node biopsies of reactive hyperplasia. NHLs were classified using REAL classification, and immunohistochemistry was performed for CD34 in all cases. CD34-stained sections were evaluated for \"hot spots,\" where MVD was assessed and expressed as per mm(2). Appropriate statistical methods were applied. Results. There were 6 cases of well-differentiated lymphocytic lymphoma (SLL), 21 diffuse large B-cell lymphoma (DLBCL), 15 follicular lymphoma, 10 lymphoblastic lymphoma, 7 MALToma, and 5 peripheral T-cell lymphoma (PTCL). Mean MVD was highest in reactive hyperplasia (191.92 ± 12.16 per mm(2)) compared to all NHLs. Among NHLs, PTCL demonstrated the highest MVD (183.42 ± 8.24) followed by DLBCL (149.91 ± 13.68). A significant difference was found in MVD between reactive and individual lymphoma groups. SLL had significantly lower MVD than other lymphoma subtypes. Conclusion. Angiogenesis, assessed by MVD, showed significant differences among subtypes of NHL, especially the indolent types like SLL. The higher MVD in aggressive lymphomas like PTCL and DLBCL can potentially be utilized in targeted therapy with antiangiogenic drugs.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":" ","pages":"943089"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/943089","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40185988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 19

A method for the in vivo measurement of zebrafish tissue neutrophil lifespan. 在体内测量斑马鱼组织中性粒细胞寿命的方法。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-07-16 DOI: 10.5402/2012/915868

Giles Dixon, Philip M Elks, Catherine A Loynes, Moira K B Whyte, Stephen A Renshaw

{"title":"A method for the in vivo measurement of zebrafish tissue neutrophil lifespan.","authors":"Giles Dixon, Philip M Elks, Catherine A Loynes, Moira K B Whyte, Stephen A Renshaw","doi":"10.5402/2012/915868","DOIUrl":"10.5402/2012/915868","url":null,"abstract":"Neutrophil function is thought to be regulated, in large part, by limitation of lifespan by apoptosis. A number of studies suggest that circulating neutrophils have a half-life of approximately 6 hours, although contradictory evidence exists. Measuring tissue neutrophil lifespan, however, is more problematic. It is thought that tissue neutrophils survive longer, perhaps with a half-life in the order of 3-5 days, but this has never been directly measured. Zebrafish are an emerging model organism, with several advantages for the study of vertebrate immunity. In zebrafish, neutrophils constitutively assume tissue locations allowing their direct study in vivo. Using a transgenic approach, neutrophils were labelled with a photoconvertible pigment, Kaede. Photoconversion parameters were optimised and the stability of the Kaede confirmed. Individual neutrophils were photoconverted by scanning a confocal 405 nm laser specifically over each cell and their survival monitored for 48 hours, revealing an in vivo half-life for zebrafish tissue neutrophils of around 120 hours (117.7 hrs, 95% CI 95.67-157.8). Laser energy did not extend neutrophil lifespan, and we conclude that this represents a lower bound for the lifespan of a resting tissue neutrophil in the developing zebrafish larva. This is the first direct measurement of the lifespan of an in vivo tissue neutrophil.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"915868"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30798958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pattern of β-Thalassemia and Other Haemoglobinopathies: A Cross-Sectional Study in Bangladesh. β-地中海贫血和其他血红蛋白病的模式:在孟加拉国的横断面研究。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-06-14 DOI: 10.5402/2012/659191

M Mesbah Uddin, Sharif Akteruzzaman, Taibur Rahman, A K M Mahbub Hasan, Hossain Uddin Shekhar

引用次数: 28

Clinical and electrocardiographic evaluation of sickle-cell anaemia patients with pulmonary hypertension. 镰状细胞性贫血合并肺动脉高压的临床及心电图评价。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-03-25 DOI: 10.5402/2012/768718

N I Oguanobi, E C Ejim, B C Anisiuba, B J C Onwubere, S O Ike, O G Ibegbulam, O Agwu

{"title":"Clinical and electrocardiographic evaluation of sickle-cell anaemia patients with pulmonary hypertension.","authors":"N I Oguanobi, E C Ejim, B C Anisiuba, B J C Onwubere, S O Ike, O G Ibegbulam, O Agwu","doi":"10.5402/2012/768718","DOIUrl":"https://doi.org/10.5402/2012/768718","url":null,"abstract":"Pulmonary hypertension is an emerging complication of sickle cell anaemia with associated increased risk of mortality. In order to evaluate the clinical and electrocardiographic findings in adult sickle-cell patients with pulmonary hypertension, a cross sectional study was conducted on sixty two sickle cell anaemia patients and sixty two age and sex matched normal controls. Elevated pulmonary artery pressures (PAP), defined by PAP ≥ 30 mm Hg on echocardiography, was demonstrated in 41.9% of patients with sickle cell anaemia and in 3.2% of the controls; χ(2) = 26.571, P < 0.001. Right ventricular hypertrophy, increased P-wave duration, QTc interval, and QTc dispersion were significantly associated with pulmonary hypertension. Significant correlation was found between mean PAP and (1) Frequency of crisis (Spearman correlation = 0.320; P = 0.011), (2) body mass index (Pearson's correlation = -0.297; P = 0.019), and (3) QTc interval (Pearson's correlation 0.261; P = 0.040). Pulmonary hypertension in adult sickle anaemia patients is associated with electrocardiographic evidence of right ventricular hypertrophy, and correlates significantly with frequency of vaso-occlusive crisis, and QTc interval. The observations by this study tend to suggest that these parameters could be useful for early detection and prevention of pulmonary hypertension in patients with sickle cell anaemia.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":" ","pages":"768718"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/768718","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40185987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Venous thromboembolism: classification, risk factors, diagnosis, and management. 静脉血栓栓塞:分类、危险因素、诊断和管理。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-10-17 DOI: 10.5402/2011/124610

Fatemeh Moheimani, Denise E Jackson

{"title":"Venous thromboembolism: classification, risk factors, diagnosis, and management.","authors":"Fatemeh Moheimani, Denise E Jackson","doi":"10.5402/2011/124610","DOIUrl":"https://doi.org/10.5402/2011/124610","url":null,"abstract":"Venous thromboembolism (VTE) is categorised as deep venous thrombosis (DVT) and pulmonary embolism (PE). VTE is associated with high morbidity and causes a huge financial burden on patients, hospitals, and governments. Both acquired and hereditary risks factors contribute to VTE. To diagnose VTE, noninvasive cost-effective diagnostic algorithms including clinical probability assessment and D-dimer measurement may be employed followup by compression ultrasonography for suspected DVT patients and multidetector computed tomography angiography for suspected PE patients. There are pharmacological and mechanical interventions to manage and prevent VTE. The pharmacological approaches mainly target pathways in coagulation cascade nonspecifically: conventional anticoagulants or specifically: new generation of anticoagulants. Excess bleeding is one of the major risk factors for pharmacological interventions. Hence, nonpharmacological or mechanical approaches such as inferior vena cava filters, graduated compression stockings, and intermittent pneumatic compression devices in combination with pharmacological interventions or alone may be a good approach to manage VTE.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2011 ","pages":"124610"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/124610","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30255717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 91

Hemoglobin disorders in South India. 南印度的血红蛋白紊乱。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-06-28 DOI: 10.5402/2011/748939

Vani Chandrashekar, Mamta Soni

{"title":"Hemoglobin disorders in South India.","authors":"Vani Chandrashekar, Mamta Soni","doi":"10.5402/2011/748939","DOIUrl":"https://doi.org/10.5402/2011/748939","url":null,"abstract":"Cation exchange-high performance liquid chromatography (CE-HPLC) is increasingly being used as a first line of investigation for hemoglobinopathies and thalassemias. Together with a complete blood count, the CE-HPLC is effective in categorizing hemoglobinopathies as traits, homozygous disorders and compound heterozygous disorders. We carried out a one year study in Apollo Hospitals, Chennai (Tamil Nadu, South India) during which 543 abnormal chromatogram patterns were seen. The commonest disorder we encountered was β-thalassemia trait (37.9%), followed by HbE trait (23.2%), homozygous HbE disease (18.9%), HbS trait (5.3%), HbE β-thalassemia (4.6%), HbS β-thalassemia (2.5%), β-thalassemia major (2.3%), HbH (1.6%), homozygous HbS (1.4%), HbD trait (0.7%). The average value of HbA2 in β-thalassemia minor was 5.4%. β-thalassemia major had an average HbF of 88% and in HbH the mean A2 was 1.4%. Among the HbE disorders the HbA2 + HbE was 30.1% in the heterozygous state, 90.8% in the homozygous state and 54.8% in HbE β-thalassemia. In the sickle cell disorders, HbS varied from 30.9% in the trait to 79.9% in the homozygous state to 65.6% in HbS β-thalassemia.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2011 ","pages":"748939"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/748939","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30253063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 53