ISRN Hematology最新文献_第7页

Notch Signaling in T-Cell Development and T-ALL. T细胞发育和T-ALL中的Notch信号转导

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-01-23 DOI: 10.5402/2011/921706

Xiaoyu Li, Harald von Boehmer

引用次数: 0

Clonal hypereosinophilic syndrome: two cases report in black men from sub-saharan Africa and literature reviews. 克隆性高嗜酸性粒细胞综合征:撒哈拉以南非洲黑人2例报告及文献综述。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-03-22 DOI: 10.5402/2011/974609

Kodjovi Messie, Ahoefa Vovor, Irenee Messanh Kueviakoe, Levi Kankoe Sallah, Kossi Agbetiafa, Akuete Yvon Segbena

{"title":"Clonal hypereosinophilic syndrome: two cases report in black men from sub-saharan Africa and literature reviews.","authors":"Kodjovi Messie, Ahoefa Vovor, Irenee Messanh Kueviakoe, Levi Kankoe Sallah, Kossi Agbetiafa, Akuete Yvon Segbena","doi":"10.5402/2011/974609","DOIUrl":"https://doi.org/10.5402/2011/974609","url":null,"abstract":"The first case is about a man of 60 years old suffering of hypereosinophilic syndrome (HES) developed since 1998. He presented chronic cough, insomnia, and negative parasitical test. We observed hypereosinophilia and fibroblastic hyperplasia at the bone marrow biopsy. Initially, hydroxyurea and α-interferon treatment failed. We proposed to him imatinib mesylate in May 2003. The FIP1L1-PDGFRA gene was detected. The second case is about a man of 34 years old seen in March 2002. First investigation concluded to CML. Progressively, eosinophil cells increased, and complications occurred as oedema syndrome, dyspnoea, and parietal chronic endocarditic fibrosis associated with pericarditis. In addition, a bowel obstruction happened and was cured by surgery. Bcr-abl fusion was negative, and FIP1L1-PDGFRA gene was detected after and imatinib mesylate was given. Actually, endocarditic fibrosis decreased. The two patients are in haematological and cytogenetic remission. We concluded that clonal HES is present in Africa, and imatinib mesylate is effective.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2011 ","pages":"974609"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/974609","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30298213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Changing patterns in the clinical pathological features of hodgkin lymphoma: a report from debrecen, hungary. 霍奇金淋巴瘤临床病理特征的变化模式:来自匈牙利德布勒森的报告。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-12-01 DOI: 10.5402/2011/810708

Zsófia Miltényi, Zsófia Simon, Edit Páyer, László Váróczy, Lajos Gergely, Adám Jóna, Arpád Illés

{"title":"Changing patterns in the clinical pathological features of hodgkin lymphoma: a report from debrecen, hungary.","authors":"Zsófia Miltényi, Zsófia Simon, Edit Páyer, László Váróczy, Lajos Gergely, Adám Jóna, Arpád Illés","doi":"10.5402/2011/810708","DOIUrl":"https://doi.org/10.5402/2011/810708","url":null,"abstract":"Introduction. Hodgkin lymphoma shows a well-known geographic pattern, but temporal changes have been found recently as well. Patients and Methods. 439 Hodgkin lymphoma patients' clinicopathological and treatment data were processed in calendar periods of approximately ten years. The patients were treated at our department from 1980 until the end of 2008. Results. The first period (1980-89) contained 177 patients, the second (1990-99) 147, and the third (2000-08) 115 Hodgkin lymphoma patients. The mean age of the patients was 40.1, 35.9, and 36.8 years in order. The male/female ratio: 1.42, 1.45, 1.05 in order. Contrary-wise a unimodal age group pattern could have been seen with an incidence peak between 30 and 39 in the past decades. The incidence of classical mixed cellularity histological subtype is decreasing (43.7%, 58.23%, 42.6%, P = 0.0098 (it is only significant in the second period)); classical nodular sclerosis shows an increasing tendency (25%, 27.32%, 34.78%, P = 0.1734). The first incidence peak is predominantly created by classical nodular sclerosis, meanwhile the second peak by classical mixed cellularity. The number of early-stage patients (59.12%) is beyond the advanced stage (40%) in the last decade. Meanwhile, the number of second-stage patients was increasing (25.8%, 26.35%, 49.56% P < 0.0001) and of patients in third stage was decreasing (53.4 %, 50.67%, 20% P < 0.0001). The 5- and 10-year overall survival data were progressing: 59.7 %, 77.4 %, and 90.5 % and 44.1 %, 70.6 % and 90.5 % (expected survival) in the last decade. Conclusions. Changes can be explained by the altered nature of Hodgkin lymphoma, the changes in socioeconomic status and the development of diagnostic and therapy methods.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2011 ","pages":"810708"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30347327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Extranodal MALT Lymphoma of the Right Triceps Muscle following Influenza Vaccine Injection: A Rare Case with an Interesting Presentation. 流感疫苗注射后右三头肌结外MALT淋巴瘤:一例罕见且有趣的表现。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-06-09 DOI: 10.5402/2011/617293

S M Edwards-Bennett, D Straus, E A Athanasian, J Yahalom

引用次数: 11

Structural and Functional Characterization of a New Double Variant Haemoglobin (HbG-Philadelphia/Duarte α(2)β(2)). 一种新的双变异血红蛋白(HbG-Philadelphia/Duarte α(2)β(2))的结构和功能表征。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2010-11-29 DOI: 10.5402/2011/735314

Antonella Fais, Mariano Casu, Paolo Ruggerone, Matteo Ceccarelli, Simona Porcu, Benedetta Era, Roberto Anedda, Maria Carla Sollaino, Renzo Galanello, Marcella Corda

{"title":"Structural and Functional Characterization of a New Double Variant Haemoglobin (HbG-Philadelphia/Duarte α(2)β(2)).","authors":"Antonella Fais, Mariano Casu, Paolo Ruggerone, Matteo Ceccarelli, Simona Porcu, Benedetta Era, Roberto Anedda, Maria Carla Sollaino, Renzo Galanello, Marcella Corda","doi":"10.5402/2011/735314","DOIUrl":"https://doi.org/10.5402/2011/735314","url":null,"abstract":"WE REPORT THE FIRST CASE OF COSEGREGATION OF TWO HAEMOGLOBINS (HBS): HbG-Philadelphia [α68(E17)Asn → Lys] and HbDuarte [β62(E6)Ala → Pro]. The proband is a young patient heterozygous also for β°-thalassaemia. We detected exclusively two haemoglobin variants: HbDuarte and HbG-Philadelphia/Duarte. Functional study of the new double variant HbG-Philadelphia/Duarte exhibited an increase in oxygen affinity, with a slight decrease of cooperativity and Bohr effect. This functional behaviour is attributed to β62Ala → Pro instead of α68Asn → Lys substitution. Indeed, HbG-Philadelphia isolated in our laboratory from blood cells donor carrier for this variant is not affected by any functional modification, whereas purified Hb Duarte showed functional properties very similar to the double variant. NMR and MD simulation studies confirmed that the presence of Pro instead of Ala at the β62 position produces displacement of the E helix and modifications of the tertiary structure. The substitution α68(E17)Asn → Lys does not cause significant structural and dynamical modifications of the protein. A possible structure-based rational of substitution effects is suggested.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2011 ","pages":"735314"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/735314","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30253061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hematological reference values for healthy adults in togo. 多哥健康成人血液学参考值

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2010-11-07 DOI: 10.5402/2011/736062

Irenee Messanh Kueviakoe, Akuete Yvon Segbena, Helene Jouault, Ahoefa Vovor, Michele Imbert

引用次数: 54

Relapse of Acute Myeloid Leukemia with t(16;21)(p11;q22) Mimicking Autoimmune Pancreatitis after Second Allogeneic Bone Marrow Transplantation. 第二次异体骨髓移植后t(16;21)(p11;q22)模拟自身免疫性胰腺炎的急性髓系白血病复发。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-01-10 DOI: 10.5402/2011/285487

Yuhei Kamada, Kazumi Suzukawa, Kenichi Taoka, Yasushi Okoshi, Yuichi Hasegawa, Shigeru Chiba

引用次数: 8

Effects of iron supplementation on erythropoietic response in patients with cancer-associated anemia treated by means of erythropoietic stimulating agents. 补铁对使用促红细胞生成药治疗癌症相关性贫血患者的促红细胞生成反应的影响。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-10-13 DOI: 10.5402/2011/108397

Torbjörn Karlsson

引用次数: 0

The role of albumin in human toxicology of cobalt: contribution from a clinical case. 白蛋白在人体钴毒理学中的作用:来自一个临床病例的贡献。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2010-10-31 DOI: 10.5402/2011/690620

Simona Catalani, Roberto Leone, Maria Cristina Rizzetti, Alessandro Padovani, Pietro Apostoli

引用次数: 28

Splenic complications of sickle cell anemia and the role of splenectomy. 镰状细胞性贫血的脾并发症及脾切除术的作用。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2010-10-31 DOI: 10.5402/2011/864257

Ahmed H Al-Salem

引用次数: 77