ISRN Hematology最新文献_第8页

Clinical challenges of primary diffuse large B-cell lymphoma of the dura: case report and literature review. 硬脑膜原发性弥漫性大b细胞淋巴瘤的临床挑战:病例报告及文献复习。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-04-27 DOI: 10.5402/2011/945212

Rabih Said, Sanaa Rizk, Qun Dai

引用次数: 17

Iron depletion: an ameliorating factor for sickle cell disease? 缺铁:镰状细胞病的改善因素?

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-07-05 DOI: 10.5402/2011/473152

P C Giordano, W Huisman, C L Harteveld

引用次数: 10

A Systematic Review and Meta-Analysis of Front-line Anthracycline-Based Chemotherapy Regimens for Peripheral T-Cell Lymphoma. 基于蒽环类药物的外周T细胞淋巴瘤前线化疗方案的系统回顾和元分析》（A Systematic Review and Meta-Analysis of Front-line Anthracycline-Based Chemotherapy Regimens for Peripheral T-Cell Lymphoma）。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-06-16 DOI: 10.5402/2011/623924

Abeer N Abouyabis, Pareen J Shenoy, Rajni Sinha, Christopher R Flowers, Mary Jo Lechowicz

引用次数: 0

Management of warfarin anticoagulation in patients with fractured neck of femur. 华法林抗凝在股骨颈骨折患者中的应用。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-02-24 DOI: 10.5402/2011/294628

Feras Ashouri, Wissam Al-Jundi, Akash Patel, Jitendra Mangwani

{"title":"Management of warfarin anticoagulation in patients with fractured neck of femur.","authors":"Feras Ashouri, Wissam Al-Jundi, Akash Patel, Jitendra Mangwani","doi":"10.5402/2011/294628","DOIUrl":"https://doi.org/10.5402/2011/294628","url":null,"abstract":"Background. Most orthopaedic units do not have a policy for reversal of anticoagulation in patients with hip fractures. The aim of this study was to examine the current practice in a district general hospital and determine difference in the time to surgery, if any, with cessation of warfarin versus cessation and treatment with vitamin K. Methods. A retrospective review of the case notes between January 2005 and December 2008 identified 1797 patients with fracture neck of femur. Fifty seven (3.2%) patients were on warfarin at the time of admission. Patients were divided into 2 groups (A and B). Group A patients (16/57; 28%) were treated with cessation of warfarin only and group B patients (41; 72%) received pharmacological therapy in addition to stopping warfarin. Time to surgery between the two groups was compared. Results. The mean INR on admission was 2.9 (range 1.7-6.5) and prior to surgery 1.4 (range 1.0-2.1). Thirty eight patients received vitamin K only and 3 patients received fresh frozen plasma and vitamin K. The average time to surgery was 4.4 days in group A and 2.4 days in group B. The difference was statistically significant (P < .01). Conclusion. Reversal of high INR is important to avoid significant delay in surgery. There is a need for a national policy for reversing warfarin anticoagulation in patients with hip fractures requiring surgery. Vitamin K is safe and effective for anticoagulation reversal in hip fracture patients.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2011 ","pages":"294628"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/294628","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30253055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Late effect of the cervical irradiation on periodontal status and cariogen flora in hodgkin lymphoma patients. 宫颈放射治疗对霍奇金淋巴瘤患者牙周状况及牙原菌群的影响。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-03-06 DOI: 10.5402/2011/823926

Zsófia Simon, Ildikó Tar, Katalin Gáll, Borbála Ivancsó, Judit Szabó, Arpád Illés

{"title":"Late effect of the cervical irradiation on periodontal status and cariogen flora in hodgkin lymphoma patients.","authors":"Zsófia Simon, Ildikó Tar, Katalin Gáll, Borbála Ivancsó, Judit Szabó, Arpád Illés","doi":"10.5402/2011/823926","DOIUrl":"https://doi.org/10.5402/2011/823926","url":null,"abstract":"Cervical radiotherapy may leads to elevated caries risk in Hodgkin-lymphoma (HL) patients. Our aim was to estimate the late effect of cervical irradiation on periodontal status in HL patients. Patients filled out query-form, their clinical data were collected, periodontal status was examined, decayed-missing-filled-teeth and periodontal-indexes were calculated. We examined 68 patients who received, 64 patients who did not received cervical radiotherapy and 51 control person. 23.5% of cervical irradiated, 18.15% of not irradiated patients and 17.64% of controls had subjective xerostomia, but it was not objective by sialometry. Mean decayed-missing-filled-teeth-index was 22.53 among irradiated, 21.54 among not irradiated patients while it was 17.23 in control group. Periodontal index was 2.47, 2.42, and 2.14 in different groups. Difference between decayed-missing-filled-teeth indexes of irradiated patients and controls was significant. We have to emphasize the importance of prevention and closer dental observation of HL patients.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2011 ","pages":"823926"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/823926","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30254004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

POEMS Syndrome Presentation with an Abscess within the Plasmacytoma-A Rare Case Report. POEMS综合征伴浆细胞瘤内脓肿一例罕见病例报告。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-03-30 DOI: 10.5402/2011/173164

Rishi Agarwal, Muneer H Abidi, Bala Grandhi

{"title":"POEMS Syndrome Presentation with an Abscess within the Plasmacytoma-A Rare Case Report.","authors":"Rishi Agarwal, Muneer H Abidi, Bala Grandhi","doi":"10.5402/2011/173164","DOIUrl":"https://doi.org/10.5402/2011/173164","url":null,"abstract":"POEMS Syndrome is a rare cause of demyelinating and axonal mixed neuropathy. Plasmacytomas are usually seen in POEMS syndrome and can be osseous or extramedullary. Plasmacytomas presenting as an abscess has not been noted earlier. Our patient presented with localized hyperpigmented patch on the back and later developed progressive weakness in upper and lower limbs. Initially serum and urine protein electrophoresis were normal. The patient was thought to have Chronic Inflammatory Demyelinating Polyneuropathy and was treated accordingly without any improvement. Repeat serum protein electrophoresis showed monoclonal gammopathy. MRI of the back revealed an abscess in the paravertebral soft tissues reaching up to the skin. Needle biopsy was consistent with plasmacytoma. Later, he developed a purulent fungating lesion in the lower midback. Antibiotics were started and local resection was done followed by radiation. Pathology of the resected mass showed plasmacytoma extensively involving subcutaneous soft tissue and bone. The patient improved with the treatment. Cystic plasmacytomas and abscess within the plasmacytoma has not been reported earlier. Whether abscess formation is part of the disease spectrum due to infiltration of overlying tissue or is secondary to localized immunosuppression is unknown. Local treatment of a single plasmacytoma is useful in ameliorating systemic symptoms.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2011 ","pages":"173164"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/173164","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30255719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Coexistence of plasma cell dyscrasia with prefibrotic stage of primary myelofibrosis: a case report. 原发髓纤维化伴浆细胞增生1例。

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-05-19 DOI: 10.5402/2011/404057

George Tsirakis, Peggy Kanellou, Maria Kaparou, Andrew Passam, Amalia Zampoulaki, Kostas Stylianou, Michael G Alexandrakis

{"title":"Coexistence of plasma cell dyscrasia with prefibrotic stage of primary myelofibrosis: a case report.","authors":"George Tsirakis, Peggy Kanellou, Maria Kaparou, Andrew Passam, Amalia Zampoulaki, Kostas Stylianou, Michael G Alexandrakis","doi":"10.5402/2011/404057","DOIUrl":"https://doi.org/10.5402/2011/404057","url":null,"abstract":"Introduction. Coexistence of myeloproliferative neoplasms with lymphoproliferative syndromes has been described in the past, whereas plasma cell dyscrasias seem to be the most common cases. Case Presentation. We present a case of a 59-year-old Caucasian female of Greek origin who presented with thrombocytosis. Clinical and laboratory investigation disclosed the presence of a smoldering myeloma with coexisting histological and molecular characteristics of primary myelofibrosis. The patient had the acquired point mutation V617F in the JAK2 gene but not the bcr-abl rearrangement and was treated for myelofibrosis with subsequent improvement of all haematological parameters without evidence of myelomatic evolution. Conclusion. We present the first case in the literature of a smoldering myeloma coexisting with primary myelofibrosis. The underlying pathogenetic mechanism could be either related to the presence of a pluripotent neoplastic stem cell capable to differentiate into both lymphoid and myeloid cells or be related to two separate nosologic entities.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2011 ","pages":"404057"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/404057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30253056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hepatitis C virus-related lymphomagenesis in a mouse model. 小鼠模型中丙型肝炎病毒相关淋巴瘤的发生

ISRN Hematology Pub Date : 2011-01-01 Epub Date: 2011-07-26 DOI: 10.5402/2011/167501

Kyoko Tsukiyama-Kohara, Satoshi Sekiguchi, Yuri Kasama, Nagla Elwy Salem, Keigo Machida, Michinori Kohara

{"title":"Hepatitis C virus-related lymphomagenesis in a mouse model.","authors":"Kyoko Tsukiyama-Kohara, Satoshi Sekiguchi, Yuri Kasama, Nagla Elwy Salem, Keigo Machida, Michinori Kohara","doi":"10.5402/2011/167501","DOIUrl":"https://doi.org/10.5402/2011/167501","url":null,"abstract":"B cell non-Hodgkin lymphoma is a typical extrahepatic manifestation frequently associated with hepatitis C virus (HCV) infection. The mechanism by which HCV infection leads to lymphoproliferative disorder remains unclear. Our group established HCV transgenic mice that expressed the full HCV genome in B cells (RzCD19Cre mice). We observed a 25.0% incidence of diffuse large B cell non-Hodgkin lymphomas (22.2% in male and 29.6% in female mice) within 600 days of birth. Interestingly, RzCD19Cre mice with substantially elevated serum-soluble interleukin-2 receptor α-subunit (sIL-2Rα) levels (>1000 pg/mL) developed B cell lymphomas. Another mouse model of lymphoproliferative disorder was established by persistent expression of HCV structural proteins through disruption of interferon regulatory factor-1 (irf-1(_/_)/CN2 mice). Irf-1(_/_)/CN2 mice showed extremely high incidences of lymphomas and lymphoproliferative disorders. Moreover, these mice showed increased levels of interleukin (IL)-2, IL-10, and Bcl-2 as well as increased Bcl-2 expression, which promoted oncogenic transformation of lymphocytes.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2011 ","pages":"167501"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2011/167501","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30255718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18