ISRN Hematology最新文献_第4页

The Platelet Function Analyzer (PFA-100) as a Screening Tool in Neurosurgery. 血小板功能分析仪(PFA-100)在神经外科筛查中的应用。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-08-08 DOI: 10.5402/2012/839242

Ralf Karger, Karoline Reuter, Jochen Rohlfs, Christopher Nimsky, Ulrich Sure, Volker Kretschmer

{"title":"The Platelet Function Analyzer (PFA-100) as a Screening Tool in Neurosurgery.","authors":"Ralf Karger, Karoline Reuter, Jochen Rohlfs, Christopher Nimsky, Ulrich Sure, Volker Kretschmer","doi":"10.5402/2012/839242","DOIUrl":"https://doi.org/10.5402/2012/839242","url":null,"abstract":"We investigated whether the inclusion of the PFA-100 in the preoperative screening of neurosurgical patients might reduce perioperative bleeding complications. Patients with intracranial space-occupying lesions who were scheduled for neurosurgery underwent routine preoperative PFA-100 testing. In case of an abnormal PFA test, patients received prophylactic treatment with desmopressin. 93 consecutive patients were compared to 102 consecutive patients with comparable characteristics operated before introduction of the PFA-100 testing. 2 patients (2.2%) in the PFA group and 2 patients (2.0%) in the non-PFA group experienced clinically relevant intracranial bleeding confirmed by computed tomography (OR 1.05, 95% CI 0.39-2.82; P = 1.0). Transfusions were not significantly different between the two groups. 13 (14.0%) patients in the PFA group and 5 (4.9%) patients in the non-PFA group received desmopressin (OR 3.2, 95% CI 1.1-9.2; P = 0.045). Preoperative screening with the PFA-100 did result in a significant increase in the administration of desmopressin, which could not reduce perioperative bleeding complications or transfusions.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"839242"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/839242","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30863730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Mechanism of protein-z-mediated inhibition of coagulation factor xa by z-protein-dependent inhibitor: a molecular dynamic approach. 蛋白-z介导的凝血因子xa受z蛋白依赖抑制剂抑制的机制:分子动力学方法。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-03-20 DOI: 10.5402/2012/762728

Mohammad Reza Dayer, Omid Ghayour, Mohammad Saaid Dayer

{"title":"Mechanism of protein-z-mediated inhibition of coagulation factor xa by z-protein-dependent inhibitor: a molecular dynamic approach.","authors":"Mohammad Reza Dayer, Omid Ghayour, Mohammad Saaid Dayer","doi":"10.5402/2012/762728","DOIUrl":"https://doi.org/10.5402/2012/762728","url":null,"abstract":"Protein Z is a plasma protein functioning as a carrier for ZPI. Protein Z also accelerates inhibitory effect of ZPI on factor Xa by 1000-fold. Inhibition of coagulation cascade via FXa by ZPI and other serpins is very important safety factor for normal homeostasis protecting human life against unwanted thrombosis. In the present work using native structure of PZ, ZPI, FXa and in a dynamic simulation, using NAMD software, the ternary complex was studied in an up to 10 nanoseconds protocol. Rely on trajectory analyses, we postulated that PZ binds ZPI by using its SP-like domain and through noncovalent forces. PZ then transfers ZPI through-out the blood, and by using its GLA domain and a bivalent cation of calcium, PZ binds to phospholipid bilayers (e.g., platelet) where the FXa is preallocated. In case of PZ-ZPI binding to plasma membrane, a series of complementary interactions take place between FXa, and PZ-ZPI complex including interactions between RCL loop of ZPI and catalytic site of FXa and some take place between long arm of PZ (composed of GLA, EGF1, and EGF2 domains) and GLA domain of FXa. In our claim these complementary interactions lead PZ to bind correctly to prelocated FXa.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":" ","pages":"762728"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/762728","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40186040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Hematological Manifestations of SLE at Initial Presentation: Is It Underestimated? SLE首发时的血液学表现是否被低估?

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-07-09 DOI: 10.5402/2012/961872

P K Sasidharan, M Bindya, K G Sajeeth Kumar

{"title":"Hematological Manifestations of SLE at Initial Presentation: Is It Underestimated?","authors":"P K Sasidharan, M Bindya, K G Sajeeth Kumar","doi":"10.5402/2012/961872","DOIUrl":"https://doi.org/10.5402/2012/961872","url":null,"abstract":"SLE can present with hematological manifestations alone or along with features of other system involvement. With a low index of clinical suspicion or inadequate follow up the diagnosis may be delayed or missed at the time of presentation, in those with hematological abnormalities as the initial manifestation. An observational study was conducted among patients of SLE, in a tertiary referral centre of North Kerala, with the purpose of estimating the proportion of patients with hematological manifestations as the initial presentation of the disease and to study their nature. It was observed that 82% of the patients had hematological manifestations at presentation. It is the most common presenting manifestation of SLE in people of North Kerala. Autoimmune hypothyroidism was one of the common coexisting abnormalities in these patients, which is not included in the American College of Rheumatology (ACR) criteria for diagnosis. Arthritis was uncommon among those who presented with hematological manifestations. A significant number of patients do not satisfy the ACR criteria at the time of diagnosis but do so on follow up. The ACR criteria are weak to diagnose such patients and therefore need revision. We therefore propose an alternative to ACR criteria as \"Kozhikode criteria for SLE\".","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"961872"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/961872","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30788500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 27

Thrombotic microangiopathies. 血栓性微血管病。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-07-25 DOI: 10.5402/2012/310596

Mohamed Radhi, Shannon L Carpenter

引用次数: 0

RhC Phenotyping, Adsorption/Elution Test, and SSP-PCR: The Combined Test for D-Elute Phenotype Screening in Thai RhD-Negative Blood Donors. RhC表型、吸附/洗脱试验和SSP-PCR:泰国RhC阴性献血者d -洗脱表型筛选的联合试验

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-11-14 DOI: 10.5402/2012/358316

Songsak Srijinda, Chamaiporn Suwanasophon, Unchalee Visawapoka, Malinee Pongsavee

{"title":"RhC Phenotyping, Adsorption/Elution Test, and SSP-PCR: The Combined Test for D-Elute Phenotype Screening in Thai RhD-Negative Blood Donors.","authors":"Songsak Srijinda, Chamaiporn Suwanasophon, Unchalee Visawapoka, Malinee Pongsavee","doi":"10.5402/2012/358316","DOIUrl":"https://doi.org/10.5402/2012/358316","url":null,"abstract":"The Rhesus (Rh) blood group is the most polymorphic human blood group and it is clinically significant in transfusion medicine. Especially, D antigen is the most important and highly immunogenic antigen. Due to anti-D, it is the cause of the hemolytic disease of the newborn and transfusion reaction. About 0.1%-0.5% of Asian people are RhD-negative, whereas in the Thai population, the RhD-negative blood type only occurs in 0.3%. Approximately 10%-30% of RhD-negative in Eastern Asian people actually were D-elute (DEL) phenotype, the very weak D antigen that cannot be detected by indirect antiglobulin test (IAT). There are many reports about anti-D immunization in RhD-negative recipients through the transfusion of red blood cells from individuals with DEL phenotype. D-elute phenotype screening in Thai RhD-negative blood donors was studied to distinguish true RhD-negative from DEL phenotype. A total of 254 Thai serologically RhD-negative blood donors were tested for RhCE phenotypes and anti-D adsorption/elution test. In addition, RhC(+) samples were tested for RHD 1227A allele by SSP-PCR technique. The RhD-negative phenotype samples consisted of 131 ccee, 4 ccEe, 1 ccEE, 101 Ccee, 16 CCee, and 1 CcEe. The 42 Ccee and 8 CCee phenotype samples were typed as DEL phenotype and 96% of DEL samples were positive for RHD 1227A allele. The incidence of RhC(+) was 46.4%, and 48 of the 118 RhC(+) samples were positive for both anti-D adsorption/elution test and SSP-PCR technique for RHD 1227A allele. The sensitivity and specificity were 96% and 100%, respectively, for RHD 1227A detection as compared with the adsorption/elution test. In conclusion, RhC(+) phenotype can combine with anti-D adsorption/elution test and RHD 1227A allele SSP-PCR technique for distinguishing true RhD-negative from DEL phenotype.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"358316"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/358316","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31096908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Comparative effects of three iron chelation therapies on the quality of life of greek patients with homozygous transfusion-dependent Beta-thalassemia. 三种铁螯合疗法对希腊纯合子输血依赖性β -地中海贫血患者生活质量的比较影响。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-12-17 DOI: 10.5402/2012/139862

Vasilis Goulas, Alexandra Kourakli-Symeonidis, Charalambos Camoutsis

{"title":"Comparative effects of three iron chelation therapies on the quality of life of greek patients with homozygous transfusion-dependent Beta-thalassemia.","authors":"Vasilis Goulas, Alexandra Kourakli-Symeonidis, Charalambos Camoutsis","doi":"10.5402/2012/139862","DOIUrl":"https://doi.org/10.5402/2012/139862","url":null,"abstract":"This prospective study assessed the quality of life of patients with homozygous transfusion-dependent beta-thalassemia in Greece receiving three different iron chelation treatments. Patients enrolled were receiving one of the following chelation therapies: deferoxamine (n = 21), deferasirox (n = 75), or deferoxamine in combination with deferiprone (n = 39). The three groups were compared in terms of their quality of life, satisfaction and adherence to treatment, control of their health, and self-esteem through the completion of five questionnaires. A higher percentage of patients receiving deferoxamine felt that their treatment negatively influenced their body and skin appearance and limited their ability to work, attend school, and perform daily tasks (P = 0.0066). The adherence to treatment rate and self-esteem were the lowest in the deferoxamine group (P < 0.05). The deferoxamine group also had the lowest physical component summary score in the SF-36 questionnaire (P = 0.014). This study suggests that the quality of life of beta-thalassemia patients receiving chelation therapy is dependent on the type of iron chelation treatment they receive. The study provides insight into important factors associated with the quality of life of these patients, which are essential for developing a more suitable clinical support team and counseling in order to maximize the treatment benefits for these patients in daily clinical practice.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"139862"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/139862","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31158975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

Sexual dimorphism in hematocrit response following red blood cell transfusion of critically ill surgical patients. 外科危重病人输血后红细胞压积反应中的性别二态性。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-03-22 DOI: 10.5402/2012/298345

Fredric M Pieracci, Carlton C Barnett, Nicole Townsend, Ernest E Moore, Jeffery Johnson, Walter Biffl, Denis D Bensard, Clay C Burlew, Andrew Gerber, Christopher C Silliman

{"title":"Sexual dimorphism in hematocrit response following red blood cell transfusion of critically ill surgical patients.","authors":"Fredric M Pieracci, Carlton C Barnett, Nicole Townsend, Ernest E Moore, Jeffery Johnson, Walter Biffl, Denis D Bensard, Clay C Burlew, Andrew Gerber, Christopher C Silliman","doi":"10.5402/2012/298345","DOIUrl":"https://doi.org/10.5402/2012/298345","url":null,"abstract":"The change in hematocrit (ΔHct) following packed red blood cell (pRBCs) transfusion is a clinically relevant measurement of transfusion efficacy that is influenced by post-transfusion hemolysis. Sexual dimorphism has been observed in critical illness and may be related to gender-specific differences in immune response. We investigated the relationship between both donor and recipient gender and ΔHct in an analysis of all pRBCs transfusions in our surgical intensive care unit (2006-2009). The relationship between both donor and recipient gender and ΔHct (% points) was assessed using both univariate and multivariable analysis. A total of 575 units of pRBCs were given to 342 patients; 289 (49.9%) donors were male. By univariate analysis, ΔHct was significantly greater for female as compared to male recipients (3.81% versus 2.82%, resp., P < 0.01). No association was observed between donor gender and ΔHct, which was 3.02% following receipt of female blood versus 3.23% following receipt of male blood (P = 0.21). By multivariable analysis, recipient gender remained associated significantly with ΔHct (P < 0.01). In conclusion, recipient gender is independently associated with ΔHct following pRBCs transfusion. This association does not appear related to either demographic or anthropomorphic factors, raising the possibility of gender-related differences in recipient immune response to transfusion.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":" ","pages":"298345"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5402/2012/298345","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40186039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Evaluation of the first commercial hepcidin ELISA for the differential diagnosis of anemia of chronic disease and iron deficiency anemia in hospitalized geriatric patients. 首个商用hepcidin ELISA鉴别诊断住院老年患者慢性病贫血和缺铁性贫血的评价

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-02-29 DOI: 10.5402/2012/567491

Inge Geerts, Pieter Vermeersch, Etienne Joosten

引用次数: 35

Regulation of immune responses by histone deacetylase inhibitors. 组蛋白去乙酰化酶抑制剂对免疫反应的调节。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-03-18 DOI: 10.5402/2012/690901

Paul V Licciardi, Tom C Karagiannis

引用次数: 49

Evaluation of transfusion pyrexia: a review of differential diagnosis and management. 输血性热病的评估：鉴别诊断和处理方法综述。

ISRN Hematology Pub Date : 2012-01-01 Epub Date: 2012-10-15 DOI: 10.5402/2012/524040

Oladimeji P Arewa

{"title":"Evaluation of transfusion pyrexia: a review of differential diagnosis and management.","authors":"Oladimeji P Arewa","doi":"10.5402/2012/524040","DOIUrl":"10.5402/2012/524040","url":null,"abstract":"Background/purpose. Transfusion pyrexia (fever) is an important clinical sign/symptom occurring either as an isolated event or as part of a constellation of signs and symptoms in relation to blood transfusion. It is an important cause of morbidity and may be an important sign of life-threatening complications of blood transfusion. Pyrexia is often a reason for the discontinuation of a blood transfusion episode, and adequate evaluation remains a challenge for clinicians. The decision to stop a blood transfusion episode on account of fever is often a difficult one. This paper reviews the differential diagnosis of transfusion pyrexia (TP), the pathogenesis as well as current management measures. Study selection and data source. Literature sources include medical texts, journals, dissertations, and internet-based electronic materials Results and conclusion. Adequate evaluation of pyrexia accompanying blood transfusion remains a challenge for clinicians. An algorithm to assist the clinician in the evaluation of fever occurring in a blood transfusion recipient is developed and presented. Continuous medical education is necessary for clinicians towards improved patient care in transfusion medicine.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2012 ","pages":"524040"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3478717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31022335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0