ISRN Hematology最新文献_第3页

Detailed analysis of diffuse large B cell lymphoma patients: a single-center, retrospective study. 弥漫性大B细胞淋巴瘤患者的详细分析:单中心回顾性研究。

ISRN Hematology Pub Date : 2013-07-30 eCollection Date: 2013-01-01 DOI: 10.1155/2013/908191

Murat Ozbalak, M Cem Ar, Nukhet Tuzuner, Ayse Salihoglu, A Emre Eskazan, Seniz Ongoren Aydin, Zafer Baslar, Teoman Soysal, Yildiz Aydin, Anil Barak Dolgun, Onder Ergonul, Burhan Ferhanoglu

{"title":"Detailed analysis of diffuse large B cell lymphoma patients: a single-center, retrospective study.","authors":"Murat Ozbalak, M Cem Ar, Nukhet Tuzuner, Ayse Salihoglu, A Emre Eskazan, Seniz Ongoren Aydin, Zafer Baslar, Teoman Soysal, Yildiz Aydin, Anil Barak Dolgun, Onder Ergonul, Burhan Ferhanoglu","doi":"10.1155/2013/908191","DOIUrl":"https://doi.org/10.1155/2013/908191","url":null,"abstract":"The aim of this single-center, retrospective study was to investigate the impact of rituximab, reconsider the validity of International Prognostic Index (IPI), and evaluate the prognostic role of the cell of origin (CoO) in a relatively young cohort. Three hundred twelve diffuse large B cell lymphoma patients (median age: 52) were included. Rituximab significantly improved the 3- and 5-year progression free survival (PFS) (70% versus 65% and 41% versus 36%, resp.; P < 0.001) but led only to a slight, insignificant increase in 3- and 5-year overall survival (OS) (71% versus 77.3% and %67 versus 74.5%, resp.; P = 0.264). In the young, low risk patient subgroup (aaIPI = 0&1; n = 129), rituximab improved 3- and 5-year PFS and OS rates (P < 0.001 and P = 0.048, resp.). The efficacy of rituximab in young high risk patients was comparable to the literature. CoO data were available in 190 patients. The OS at 3 years was 79% for GC and 64% for non-GC subgroups (P = 0.014). To the best of our knowledge, this is the first study which investigated the impact of R-CHOP in the context of CoO and IPI in a relatively young cohort. CoO was not an independent risk factor for prognosis in the multivariate analysis although patients with GC showed a significant survival advantage in the univariate analysis. CoO was also found to be a significant determinant of response in refractory/relapsed patients. Our results confirm the efficacy of rituximab in low and high risk, young patients outside of a randomized clinical trial setting. ","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"908191"},"PeriodicalIF":0.0,"publicationDate":"2013-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/908191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31689603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Frequency and Outcome of Graft versus Host Disease after Stem Cell Transplantation: A Six-Year Experience from a Tertiary Care Center in Pakistan. 干细胞移植后移植物抗宿主病的频率和结果:巴基斯坦三级医疗中心6年的经验

ISRN Hematology Pub Date : 2013-06-27 Print Date: 2013-01-01 DOI: 10.1155/2013/232519

Natasha Ali, Salman Naseem Adil, Mohammad Usman Shaikh, Nehal Masood

{"title":"Frequency and Outcome of Graft versus Host Disease after Stem Cell Transplantation: A Six-Year Experience from a Tertiary Care Center in Pakistan.","authors":"Natasha Ali, Salman Naseem Adil, Mohammad Usman Shaikh, Nehal Masood","doi":"10.1155/2013/232519","DOIUrl":"https://doi.org/10.1155/2013/232519","url":null,"abstract":"Objective. The objective of this study was to evaluate the frequency and outcome of graft versus host disease after stem cell transplantation for various haematological disorders in Pakistan. Materials and Methods. Pretransplant workup of the patient and donor was performed. Mobilization was done with G-CSF 300 μ g twice daily for five day. Standard GvHD prophylaxis was done with methotrexate 15 mg/m(2) on day +1 followed by 10 mg/m(2) on days +3 and +6 and cyclosporine. Grading was done according to the Glucksberg classification. Results. A total of 153 transplants were done from April 2004 to December 2011. Out of these were allogeneic transplants. There were females and males. The overall frequency of any degree of graft versus host disease was 34%. Acute GvHD was present in patients while had chronic GvHD. Grade II GvHD was present in patients while grade III and IV GvHD was seen in patients each. Acute myeloid leukemia and chronic myeloid leukemia were most commonly associated with GvHD. The mortality in acute and chronic GvHD was 8.8% and 12% respectively. Conclusion. The frequency of graft versus host disease in this study was 34% which is lower compared to international literature. The decreased incidence can be attributed to reduced diversity of histocompatibility antigens in our population. ","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"232519"},"PeriodicalIF":0.0,"publicationDate":"2013-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/232519","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31650539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Detection of minimal residual disease by flow cytometry for patients with multiple myeloma submitted to autologous hematopoietic stem cell transplantation. 自体造血干细胞移植后多发性骨髓瘤患者微量残留病变的流式细胞术检测

ISRN Hematology Pub Date : 2013-06-20 Print Date: 2013-01-01 DOI: 10.1155/2013/847672

Suzane Dal Bó, Annelise Pezzi, Bruna Amorin, Vanessa Valim, Rosane Isabel Bittencourt, Lucia Silla

{"title":"Detection of minimal residual disease by flow cytometry for patients with multiple myeloma submitted to autologous hematopoietic stem cell transplantation.","authors":"Suzane Dal Bó, Annelise Pezzi, Bruna Amorin, Vanessa Valim, Rosane Isabel Bittencourt, Lucia Silla","doi":"10.1155/2013/847672","DOIUrl":"https://doi.org/10.1155/2013/847672","url":null,"abstract":"The treatment strategy in multiple myeloma (MM) is to get complete remission followed by high-dose chemotherapy and autologous Hematopoietic Stem Cell Transplantation (HSCT). Neoplastic Plasma Cells (NPCs) are CD45(-/dim), CD38(+high), CD138(+), CD19(-), and CD56(+high) in most cases. The description of this immunophenotype is of major importance as it leads to the correct identification of minimal residual disease (MRD). Samples from 44 Patients were analyzed prospectively in this study. We analyzed if the presence of MRD at three months after HSCT was predictive of relapse or death. There were 40 evaluable patients of whom 16/40 patients had MRD at three moths after HSCT and there were none in cytological relapse. The mean overall survival (OS) was 34 months and disease-free survival (RFS) was 28 months after HSCT. There was no significant difference in the log rank analysis comparing OS and the presence of MRD (P = 0,611) and RFS (P = 0,3106). Here, we demonstrate that three color flow cytometry (FCM) is more sensitive for MDR evaluation than cytological analyzes. However, based in our data we can not affirm that MRD is a good predictor of MM relapse or death. In conclusion, our results could be attributed to a short followup, small sample size, and over most to the inability of a three-color FCM to detect the NPC population. ","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"847672"},"PeriodicalIF":0.0,"publicationDate":"2013-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/847672","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31588602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Bacteriological safety of blood collected for transfusion at university of gondar hospital blood bank, northwest ethiopia. 埃塞俄比亚西北部贡达尔大学医院血库采集的输血用血液的细菌学安全性。

ISRN Hematology Pub Date : 2013-06-20 Print Date: 2013-01-01 DOI: 10.1155/2013/308204

Hailegebriel Wondimu, Zelalem Addis, Feleke Moges, Yitayal Shiferaw

{"title":"Bacteriological safety of blood collected for transfusion at university of gondar hospital blood bank, northwest ethiopia.","authors":"Hailegebriel Wondimu, Zelalem Addis, Feleke Moges, Yitayal Shiferaw","doi":"10.1155/2013/308204","DOIUrl":"https://doi.org/10.1155/2013/308204","url":null,"abstract":"Background. Transfusion associated bacterial infection has remained more frequent with a sever risk of morbidity and mortality. This study assessed the bacteriological safety of blood collected for transfusion. Method. A cross-sectional study was conducted at University of Gondar hospital blood bank from December 2011 to June 2012. Bacterial isolation, identification, and antimicrobial susceptibility tests were done as per the standard procedure. Chi-square test and P value were used to assess associations between risk factors and the bacterial isolation rate. Results. Twenty-one (15.33%) blood units were found contaminated with bacteria, and 95.24% contamination was due to external sources. The commonly isolated bacteria were Staphylococcus aureus, Coagulase negative Staphylococci, Escherichia coli, Klebsiella species, Streptococci species, Enterobacter species, and Citrobacter species. All of the bacteria isolated were 100% sensitive to Gentamicin, Chloramphenicol, Amoxicillin, and Doxycycline. Multiple antimicrobial resistances were observed in 66.7% of the isolates. Not using glove by phlebotomist, touching disinfected phlebotomy site and double puncture at the same hand or both hands of a donor were found to be risk factors for bacterial contamination. Conclusion. Bacterial contamination of blood to be transfused is a common problem in the hospital. So attention should be given to activities performed at the blood bank for safe transfusion practices. ","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"308204"},"PeriodicalIF":0.0,"publicationDate":"2013-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/308204","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31588601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Expression level of IL-6 secreted by bone marrow stromal cells in mice with aplastic anemia. 骨髓基质细胞分泌IL-6在再生障碍性贫血小鼠中的表达水平。

ISRN Hematology Pub Date : 2013-06-18 Print Date: 2013-01-01 DOI: 10.1155/2013/986219

Yong Feng Chen, Zhong Min Wu, Cong Xie, Shi Bai, Li Dong Zhao

{"title":"Expression level of IL-6 secreted by bone marrow stromal cells in mice with aplastic anemia.","authors":"Yong Feng Chen, Zhong Min Wu, Cong Xie, Shi Bai, Li Dong Zhao","doi":"10.1155/2013/986219","DOIUrl":"https://doi.org/10.1155/2013/986219","url":null,"abstract":"Parasecretion of the hematopoietic cytokines is considered as one of the mechanisms account for bone marrow hematopoiesis disorder. In this study, the level of IL-6 secreted by bone marrow stromal cells from a mouse model of aplastic anemia was analyzed. The aplastic anemia mouse model was established with cyclophosphamide in combination with chloramphenicol and (60)Co γ radiation. The impairment of bone marrow hematopoiesis induced by irradiation and chemotherapeutic drugs was subsequently characterized by peripheral blood cell count, pathomorphological changes, and apoptosis rate. Furthermore, the in vitro proliferation of bone marrow stromal cells (BMSC) and the IL-6 secretion levels of BMSC were analyzed. In our model of aplastic anemia, the number of peripheral blood cells and bone marrow cells (BMC) were notably decreased, and the apoptosis rate of BMC increased. Furthermore, the proliferation of BMSC was obviously impeded while the IL-6 secretion levels of BMSC significantly increased. The findings of our study suggested that the IL-6 secretion level may be enhanced to some extent by the induction of aplastic anemia caused by irradiation and chemotherapeutic drugs and that the abnormal level of IL-6 might probably interfere with the stability of the bone marrow hematopoietic microenvironment. ","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"986219"},"PeriodicalIF":0.0,"publicationDate":"2013-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/986219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31580685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 21

Hematological and Genetic Predictors of Daytime Hemoglobin Saturation in Tanzanian Children with and without Sickle Cell Anemia. 坦桑尼亚有或无镰状细胞性贫血儿童日间血红蛋白饱和度的血液学和遗传学预测因子。

ISRN Hematology Pub Date : 2013-04-03 Print Date: 2013-01-01 DOI: 10.1155/2013/472909

Sharon E Cox, Julie Makani, Charles R Newton, Andrew M Prentice, Fenella J Kirkham

{"title":"Hematological and Genetic Predictors of Daytime Hemoglobin Saturation in Tanzanian Children with and without Sickle Cell Anemia.","authors":"Sharon E Cox, Julie Makani, Charles R Newton, Andrew M Prentice, Fenella J Kirkham","doi":"10.1155/2013/472909","DOIUrl":"https://doi.org/10.1155/2013/472909","url":null,"abstract":"Low hemoglobin oxygen saturation (SpO2) is common in Sickle Cell Anemia (SCA) and associated with complications including stroke, although determinants remain unknown. We investigated potential hematological, genetic, and nutritional predictors of daytime SpO2 in Tanzanian children with SCA and compared them with non-SCA controls. Steady-state resting pulse oximetry, full blood count, transferrin saturation, and clinical chemistry were measured. Median daytime SpO2 was 97% (IQ range 94-99%) in SCA (N = 458), lower (P < 0.0001) than non-SCA (median 99%, IQ range 98-100%; N = 394). Within SCA, associations with SpO2 were observed for hematological variables, transferrin saturation, body-mass-index z-score, hemoglobin F (HbF%), genotypes, and hemolytic markers; mean cell hemoglobin (MCH) explained most variability (P < 0.001, Adj r (2) = 0.09). In non-SCA only age correlated with SpO2. α-thalassemia 3.7 deletion highly correlated with decreased MCH (Pearson correlation coefficient -0.60, P < 0.0001). In multivariable models, lower SpO2 correlated with higher MCH (β-coefficient -0.32, P < 0.001) or with decreased copies of α-thalassemia 3.7 deletion (β-coefficient 1.1, P < 0.001), and independently in both models with lower HbF% (β-coefficient 0.15, P < 0.001) and Glucose-6-Phosphate Dehydrogenase genotype (β-coefficient -1.12, P = 0.012). This study provides evidence to support the hypothesis that effects on red cell rheology are important in determining SpO2 in children with SCA. Potential mechanisms and implications are discussed.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"472909"},"PeriodicalIF":0.0,"publicationDate":"2013-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/472909","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31537550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Assessment of hepatic and pancreatic iron overload in pediatric Beta-thalassemic major patients by t2* weighted gradient echo magnetic resonance imaging. t2*加权梯度回声磁共振成像评估儿童β -地中海贫血重症患者肝脏和胰腺铁负荷。

ISRN Hematology Pub Date : 2013-03-28 Print Date: 2013-01-01 DOI: 10.1155/2013/496985

Doaa Mohammed Youssef, Faten Fawzy Mohammad, Ayman Ahmed Fathy, Maha Aly Abdelbasset

{"title":"Assessment of hepatic and pancreatic iron overload in pediatric Beta-thalassemic major patients by t2* weighted gradient echo magnetic resonance imaging.","authors":"Doaa Mohammed Youssef, Faten Fawzy Mohammad, Ayman Ahmed Fathy, Maha Aly Abdelbasset","doi":"10.1155/2013/496985","DOIUrl":"https://doi.org/10.1155/2013/496985","url":null,"abstract":"Background. MRI has emerged for the noninvasive assessment of iron overload in various tissues. The aim of this paper is to evaluate hepatic and pancreatic iron overload by T2(∗) weighted gradient echo MRI in young beta-thalassemia major patients and to correlate it with glucose disturbance and postsplenectomy status. Subjects and Methods. 50 thalassemic patients, in addition to 15 healthy controls. All patients underwent clinical assessment and laboratory investigations. Out of 50 thalassemic patients, 37 patients were splenectomized. MRI was performed for all subjects. Results. All patients showed significant reduction in the signal intensity of the liver and the pancreas on T2(∗)GRD compared to controls, thalassemic patients who had abnormal glucose tolerance; diabetic and impaired glucose tolerance patients displayed a higher degree of pancreatic and hepatic siderosis and more T2(∗) drop in their signal intensity than those with normal blood sugar level. Splenectomized thalassemic patients had significantly lower signal intensity of the liver and pancreas compared to nonsplenectomized patients. Conclusion. T2(∗) gradient echo MRI is noninvasive highly sensitive method in assessing hepatic and pancreatic iron overload in thalassemic patients, more evident in patients with abnormal glucose tolerance, and is accelerated in thalassemic splenectomized patients.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"496985"},"PeriodicalIF":0.0,"publicationDate":"2013-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/496985","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31376562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Hemoglobin A2 Lowered by Iron Deficiency and α -Thalassemia: Should Screening Recommendation for β -Thalassemia Change? 缺铁和α -地中海贫血导致血红蛋白A2降低:β -地中海贫血的筛查建议是否应该改变?

ISRN Hematology Pub Date : 2013-01-01 Epub Date: 2013-03-12 DOI: 10.1155/2013/858294

Srdjan Denic, Mukesh M Agarwal, Bayan Al Dabbagh, Awad El Essa, Mohamed Takala, Saad Showqi, Javed Yassin

{"title":"Hemoglobin A2 Lowered by Iron Deficiency and α -Thalassemia: Should Screening Recommendation for β -Thalassemia Change?","authors":"Srdjan Denic, Mukesh M Agarwal, Bayan Al Dabbagh, Awad El Essa, Mohamed Takala, Saad Showqi, Javed Yassin","doi":"10.1155/2013/858294","DOIUrl":"https://doi.org/10.1155/2013/858294","url":null,"abstract":"Screening for β -thalassemia trait (BTT) relies on measuring hemoglobin (Hb) A2. Since multiple factors can affect HbA2 levels, the screening can become unreliable. In 1356 healthy Arabs enrolled into a federally funded premarital BTT screening program, the effects of iron deficiency (ID), α (+)-thalassemia trait, gender, smoking, and tribalism on HbA2 were studied. The complete blood count and hemoglobin fractions were determined on the entire cohort; serum ferritin (<15 μ g/L) in 391 subjects was used to determine ID. BTT was present in 29 (2.1%) subjects (HbA2 > 3.5%). Among 77(20.3%) subjects with ID, the mean HbA2 (2.30 ± 0.23%) was 0.2% lower than in subjects without iron deficiency (2.50 ± 0.24%, P < 0.0001). In 65 (38%)/172 subjects with phenotypic α (+)-thalassemia trait, the mean HbA2 (2.43 ± 0.24%) was 0.13% lower than in subjects without α (+)-thalassemia trait, P < 0.0001. The mean HbA2 did not differ between males and females, smokers and nonsmokers, and between the tribes. Thus, 35 (2.6%) subjects with HbA2 between 3.2 and 3.5% were at a risk of false negative diagnosis of BTT. Since iron deficiency and α (+)-thalassemia are both common and both lower HbA2, modifications in screening recommendations for BTT are proposed.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"858294"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/858294","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31351280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 39

MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies. 淋巴恶性肿瘤中的微RNA和糖皮质激素诱导的细胞凋亡

ISRN Hematology Pub Date : 2013-01-01 Epub Date: 2013-01-29 DOI: 10.1155/2013/348212

Ronit Vogt Sionov

引用次数: 0

CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and Disease. CD47:一种调节造血细胞健康和疾病多种功能的细胞表面糖蛋白。

ISRN Hematology Pub Date : 2013-01-01 Epub Date: 2013-01-21 DOI: 10.1155/2013/614619

Per-Arne Oldenborg

{"title":"CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health and Disease.","authors":"Per-Arne Oldenborg","doi":"10.1155/2013/614619","DOIUrl":"https://doi.org/10.1155/2013/614619","url":null,"abstract":"Interactions between cells and their surroundings are important for proper function and homeostasis in a multicellular organism. These interactions can either be established between the cells and molecules in their extracellular milieu, but also involve interactions between cells. In all these situations, proteins in the plasma membranes are critically involved to relay information obtained from the exterior of the cell. The cell surface glycoprotein CD47 (integrin-associated protein (IAP)) was first identified as an important regulator of integrin function, but later also was shown to function in ways that do not necessarily involve integrins. Ligation of CD47 can induce intracellular signaling resulting in cell activation or cell death depending on the exact context. By binding to another cell surface glycoprotein, signal regulatory protein alpha (SIRPα), CD47 can regulate the function of cells in the monocyte/macrophage lineage. In this spotlight paper, several functions of CD47 will be reviewed, although some functions may be more briefly mentioned. Focus will be on the ways CD47 regulates hematopoietic cells and functions such as CD47 signaling, induction of apoptosis, and regulation of phagocytosis or cell-cell fusion.","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"614619"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/614619","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31324088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 189