ISRN Hematology最新文献_第2页

Clinicohematological study of thrombocytosis in children. 儿童血小板增多症临床血液学研究。

ISRN Hematology Pub Date : 2014-01-29 eCollection Date: 2014-01-01 DOI: 10.1155/2014/389257

Nathiya Subramaniam, Suneel Mundkur, Pushpa Kini, Nalini Bhaskaranand, Shrikiran Aroor

{"title":"Clinicohematological study of thrombocytosis in children.","authors":"Nathiya Subramaniam, Suneel Mundkur, Pushpa Kini, Nalini Bhaskaranand, Shrikiran Aroor","doi":"10.1155/2014/389257","DOIUrl":"https://doi.org/10.1155/2014/389257","url":null,"abstract":"Introduction. Primary thrombocytosis is very rare in children; reactive thrombocytosis is frequently observed in children with infections, anemia, and many other causes. Aims and Objectives. To identify the etiology of thrombocytosis in children and to analyze platelet indices (MPV, PDW, and PCT) in children with thrombocytosis. Study Design. A prospective observational study. Material and Methods. A total of 1000 patients with thrombocytosis (platelet > 400 × 10(9)/L) were studied over a period of 2 years. Platelet distribution width (PDW), mean platelet volume (MPV), and plateletcrit (PCT) were noted. Results. Of 1000 patients, 99.8% had secondary thrombocytosis and only two children had primary thrombocytosis (chronic myeloid leukemia and acute myelogenous leukemia, M7). The majority of the children belonged to the age group of 1month to 2 years (39.7%) and male to female ratio was 1.6 : 1. Infection with anemia (48.3%) was the most common cause of secondary thrombocytosis followed by iron deficiency alone (17.2%) and infection alone (16.2%). Respiratory infection (28.3%) was the predominant infectious cause observed. Thrombocytosis was commonly associated with IDA among all causes of anemia and severity of thrombocytosis increased with severity of anemia (P = 0.021). With increasing platelet count, there was a decrease in MPV (<0.001). Platelet count and mean PDW among children with infection and anemia were significantly higher than those among children with infection alone and anemia alone. None were observed to have thromboembolic manifestations. Conclusions. Primary thrombocytosis is extremely rare in children than secondary thrombocytosis. Infections in association with anemia are most commonly associated with reactive thrombocytosis and severity of thrombocytosis increases with severity of anemia. ","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2014 ","pages":"389257"},"PeriodicalIF":0.0,"publicationDate":"2014-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/389257","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32489675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Two cases and review of the literature: primary percutaneous angiography and antiplatelet management in patients with immune thrombocytopenic purpura. 免疫性血小板减少性紫癜的经皮血管造影及抗血小板治疗两例及文献复习。

ISRN Hematology Pub Date : 2013-12-29 DOI: 10.1155/2013/174659

Estelle Torbey, Harout Yacoub, Donald McCord, James Lafferty

引用次数: 17

Addition of multimodal therapy to standard management of steady state sickle cell disease. 在稳定状态镰状细胞病的标准管理中增加多模式治疗。

ISRN Hematology Pub Date : 2013-12-09 eCollection Date: 2013-01-01 DOI: 10.1155/2013/236374

Iheanyi Okpala, Osita Ezenwosu, Anthony Ikefuna, Augustine Duru, Barth Chukwu, Anazoeze Madu, Theresa Nwagha, Sunday Ocheni, Obike Ibegbulam, Ifeoma Emodi, Uche Anike, Charles Nonyelu, Chukwudi Anigbo, Kingsley Agu, Ifeoma Ajuba, Awele Chukwura, Ogechukwu Ugwu, Uche Ololo

{"title":"Addition of multimodal therapy to standard management of steady state sickle cell disease.","authors":"Iheanyi Okpala, Osita Ezenwosu, Anthony Ikefuna, Augustine Duru, Barth Chukwu, Anazoeze Madu, Theresa Nwagha, Sunday Ocheni, Obike Ibegbulam, Ifeoma Emodi, Uche Anike, Charles Nonyelu, Chukwudi Anigbo, Kingsley Agu, Ifeoma Ajuba, Awele Chukwura, Ogechukwu Ugwu, Uche Ololo","doi":"10.1155/2013/236374","DOIUrl":"https://doi.org/10.1155/2013/236374","url":null,"abstract":"Most people on folic acid to boost erythropoiesis and prophylactic antimicrobials, the standard management of steady state sickle cell disease (SCD), have unacceptable numbers of crises. The objective of this study was to evaluate the effects of adding multimodal therapy with potassium thiocyanate and omega-3 fatty acids to the standard management of steady state SCD. Pre- and post-treatment numbers of crises and other disease indices were compared in 16 HbSS individuals on folic acid and paludrine after 12 months of adding eicosapentaenoic acid 15 mg/kg/day, docosahexaenoic acid 10 mg/kg/day, and potassium thiocyanate 1-2 mL/day, each milliliter of which contained 250 mg of thiocyanate and 100 micrograms of iodine to prevent hypothyroidism: a possible side-effect due to competitive inhibition of the transport of iodide into the thyroid gland by thiocyanate. Median number of crises reduced from 3/yr to 1/yr (P < 0.0001). There was no evidence of impaired thyroid function. Plasma level of tri-iodothyronine improved (P < 0.0001). Steady state full blood count and bilirubin level did not change significantly. The findings suggest that addition of potassium thiocyanate and eicosapentaenoic and docosahexaenoic acids to standard management of steady state SCD reduces the number of crises. This observation needs to be evaluated in larger studies. ","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"236374"},"PeriodicalIF":0.0,"publicationDate":"2013-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/236374","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31997671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Assessment of regulatory T cells in childhood immune thrombocytopenic purpura. 儿童免疫性血小板减少性紫癜调节性T细胞的评估。

ISRN Hematology Pub Date : 2013-11-05 eCollection Date: 2013-01-01 DOI: 10.1155/2013/143687

Karina L M Mazzucco, Lauro M Junior, Natália E Lemos, Andréa Wieck, Annelise Pezzi, Alvaro M Laureano, Bruna Amorin, Vanessa Valim, Lucia Silla, Liane E Daudt, Paulo J C Marostica

{"title":"Assessment of regulatory T cells in childhood immune thrombocytopenic purpura.","authors":"Karina L M Mazzucco, Lauro M Junior, Natália E Lemos, Andréa Wieck, Annelise Pezzi, Alvaro M Laureano, Bruna Amorin, Vanessa Valim, Lucia Silla, Liane E Daudt, Paulo J C Marostica","doi":"10.1155/2013/143687","DOIUrl":"https://doi.org/10.1155/2013/143687","url":null,"abstract":"This study had the objective to assess the frequency of Tregs in children newly diagnosed with ITP and ascertain whether an association exists between Tregs and platelet counts, by means of a comparison with healthy controls. This case-control study included 19 patients newly diagnosed with ITP-whose blood samples were collected at four points in time: before any therapy and 1, 3, and 6 months after diagnosis-and 19 healthy controls. Tregs (CD4(+) CD25(+)Foxp3 T cells) were evaluated by flow cytometry. There was a statistically significant difference in platelet count between the case and control groups. There were no significant differences in Treg counts between cases and controls at any point during the course of the study and no difference in Treg counts between the chronic and nonchronic groups and no significant correlation between Tregs and platelet counts in the case and control groups. The findings of this study did not show any statistically significant correlation between Tregs and number of platelets in the case and control groups. Treg cells did not play a role in the regulation of autoimmunity in children with ITP. ","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"143687"},"PeriodicalIF":0.0,"publicationDate":"2013-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/143687","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31919642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Survival and Prognostic Factors for AIDS and Non-AIDS Patients with Non-Hodgkin's Lymphoma in Bahia, Brazil: A Retrospective Cohort Study. 巴西巴伊亚艾滋病和非艾滋病非霍奇金淋巴瘤患者的生存和预后因素:一项回顾性队列研究。

ISRN Hematology Pub Date : 2013-10-29 eCollection Date: 2013-01-01 DOI: 10.1155/2013/904201

Estela Luz, Marinho Marques, Ivana Luz, Cristiani Stelitano, Eduardo Netto, Iguaracyra Araújo, Carlos Brites

{"title":"Survival and Prognostic Factors for AIDS and Non-AIDS Patients with Non-Hodgkin's Lymphoma in Bahia, Brazil: A Retrospective Cohort Study.","authors":"Estela Luz, Marinho Marques, Ivana Luz, Cristiani Stelitano, Eduardo Netto, Iguaracyra Araújo, Carlos Brites","doi":"10.1155/2013/904201","DOIUrl":"https://doi.org/10.1155/2013/904201","url":null,"abstract":"Despite the benefits of HAART, HIV-infected patients are increasingly affected by different malignancies. We compared a 5-year-period survival time and prognostic factors for HIV-1-infected individuals diagnosed with non-Hodgkin lymphomas (NHL) in a nested case-control study, with non-HIV-infected individuals in Salvador, Brazil. Survival time and prognostic factors were compared to HIV-negative patients. 31 cases (versus 63 controls) had a significantly more advanced NHL at diagnosis and lower mean CD4 count (26 cells/mm(3)) than controls. Mean overall survival (OS) was 35.8 versus 75.4 months, for cases and controls, respectively (P < 0.001), while mean event-free survival time (EFS) was 34.5 months for cases, versus 68.8 for controls (P = 0.002). Higher IPI, increased LDH levels, bone marrow infiltration, lower absolute lymphocyte counts (<1,000 cells/mm(3)), and type B symptoms were associated with a shorter survival time for cases. Although patients without poorer prognostic factors at baseline had an OS comparable to controls, the mean CD4 cell count for cases was similar for patients with favorable and nonfavorable response to therapy. Our findings suggest that HIV-1 infection is significantly associated with a shorter survival time for patients with NHL, independently of other predictive factors and of disease stage. ","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"904201"},"PeriodicalIF":0.0,"publicationDate":"2013-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/904201","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31912525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Interaction of Normal and Sickle Hemoglobins for Sodium Dodecylsulphate and Hydrogen Peroxide at pH 5.0 and 7.2. 十二烷基硫酸钠和过氧化氢在pH 5.0和7.2下正常血红蛋白和镰状血红蛋白的相互作用。

ISRN Hematology Pub Date : 2013-10-10 eCollection Date: 2013-01-01 DOI: 10.1155/2013/629640

Fortunatus C Ezebuo, Sabinus Oscar O Eze, Colin B Lukong, Ferdinand C Chilaka

{"title":"Interaction of Normal and Sickle Hemoglobins for Sodium Dodecylsulphate and Hydrogen Peroxide at pH 5.0 and 7.2.","authors":"Fortunatus C Ezebuo, Sabinus Oscar O Eze, Colin B Lukong, Ferdinand C Chilaka","doi":"10.1155/2013/629640","DOIUrl":"https://doi.org/10.1155/2013/629640","url":null,"abstract":"Clinical manifestations of malaria primarily result from proliferation of the parasite within the hosts' erythrocytes. The malaria parasite digests hemoglobin within its digestive vacuole through a sequential metabolic process involving multiple proteases. The activities of these proteases could lead to the production of ROS which could lead to the death of the parasites due to the destruction of their membrane. The action of SDS on hemoglobins can be likened to the way malarial proteases destabilizes host hemoglobin. Hence, the study was designed to determine the binding parameters of SDS and H2O2 for normal, sickle trait carrier and sickle hemoglobins at pH 5.0 and 7.2 using UV-VIS Titration Spectrophotometry. Hb-SDS interactions were significantly different at pH 5.0 but were not at pH 7.2. Also, Hb-H2O2 interactions were statistically different at pH 5.0 and 7.2. The interactions suggest that HbA and HbS are easily destabilized than HbAS and that HbAS has more affinity for H2O2. These suggest a production of more ferryl intermediates or hydroxyl radicals. All these interactions may hinder the development of the malaria parasite at the intraerythrocytic stage and could likely account for a significant proportion of the mechanism that favours the resistance to malaria by individuals with HbAS. ","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"629640"},"PeriodicalIF":0.0,"publicationDate":"2013-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/629640","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31858479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The modern primitives: applying new technological approaches to explore the biology of the earliest red blood cells. 现代原始人：应用新技术方法探索最早的红细胞生物学。

ISRN Hematology Pub Date : 2013-10-03 DOI: 10.1155/2013/568928

Stuart T Fraser

引用次数: 0

Portal hypertension and myeloproliferative neoplasms: a relationship revealed. 门脉高压与骨髓增生性肿瘤的关系

ISRN Hematology Pub Date : 2013-09-16 eCollection Date: 2013-01-01 DOI: 10.1155/2013/673781

Ahmet Burak Toros, Serkan Gokcay, Guven Cetin, Muhlis Cem Ar, Yesim Karagoz, Besir Kesici

{"title":"Portal hypertension and myeloproliferative neoplasms: a relationship revealed.","authors":"Ahmet Burak Toros, Serkan Gokcay, Guven Cetin, Muhlis Cem Ar, Yesim Karagoz, Besir Kesici","doi":"10.1155/2013/673781","DOIUrl":"https://doi.org/10.1155/2013/673781","url":null,"abstract":"Background/Objectives. Patients with myeloproliferative neoplasms have a well-established increased risk of thrombosis. Many trials report identification of an underlying myeloproliferative neoplasm by investigation of the patients developing portal hypertensive esophagus and/or fundus variceal hemorrhage in the absence of any known etiology. This trial was designed to investigate the association between myeloproliferative neoplasms and portal hypertension and to detect the frequency of portal hypertension development in this subset of patients. Methodology. Twenty-nine patients previously diagnosed with polycythemia vera, essential thrombocytopenia, and primary myelofibrosis, who were under followup at the hematology outpatient clinic of our hospital, were included in the trial. Results. In our trial, we detected portal hypertension in 13.8% of the patients (n = 4), as a finding that was similar to those obtained in other studies performed to date. Conclusions. Considering the fact that diagnosis of myeloproliferative neoplasms usually takes a long time, treatment should be started (while, on the other hand, assessing the investigational and therapeutical choices for the complications) right after the bone marrow biopsy or cytogenetic studies required for establishing the final diagnosis have been performed. ","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":" ","pages":"673781"},"PeriodicalIF":0.0,"publicationDate":"2013-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/673781","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40265106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Waldenström macroglobulinemia: clinical and immunological aspects, natural history, cell of origin, and emerging mouse models. Waldenström巨球蛋白血症:临床和免疫学方面，自然史，细胞起源，和新兴的小鼠模型。

ISRN Hematology Pub Date : 2013-09-09 DOI: 10.1155/2013/815325

Siegfried Janz

{"title":"Waldenström macroglobulinemia: clinical and immunological aspects, natural history, cell of origin, and emerging mouse models.","authors":"Siegfried Janz","doi":"10.1155/2013/815325","DOIUrl":"https://doi.org/10.1155/2013/815325","url":null,"abstract":"Waldenström macroglobulinemia (WM) is a rare and currently incurable neoplasm of IgM-expressing B-lymphocytes that is characterized by the occurrence of a monoclonal IgM (mIgM) paraprotein in blood serum and the infiltration of the hematopoietic bone marrow with malignant lymphoplasmacytic cells. The symptoms of patients with WM can be attributed to the extent and tissue sites of tumor cell infiltration and the magnitude and immunological specificity of the paraprotein. WM presents fascinating clues on neoplastic B-cell development, including the recent discovery of a specific gain-of-function mutation in the MYD88 adapter protein. This not only provides an intriguing link to new findings that natural effector IgM(+)IgD(+) memory B-cells are dependent on MYD88 signaling, but also supports the hypothesis that WM derives from primitive, innate-like B-cells, such as marginal zone and B1 B-cells. Following a brief review of the clinical aspects and natural history of WM, this review discusses the thorny issue of WM's cell of origin in greater depth. Also included are emerging, genetically engineered mouse models of human WM that may enhance our understanding of the biologic and genetic underpinnings of the disease and facilitate the design and testing of new approaches to treat and prevent WM more effectively. ","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"815325"},"PeriodicalIF":0.0,"publicationDate":"2013-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/815325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31791014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

HBsAg Positive Patient Characteristics in Hospital and Blood Donation Camps. 医院及献血营HBsAg阳性患者特征分析

ISRN Hematology Pub Date : 2013-09-04 eCollection Date: 2013-01-01 DOI: 10.1155/2013/675191

Deepti Sachan, Joy Varghese, Jensingh Joseph, Vijaya Srinivasan, Venkataraman Jayanthi, Mohamed Rela

{"title":"HBsAg Positive Patient Characteristics in Hospital and Blood Donation Camps.","authors":"Deepti Sachan, Joy Varghese, Jensingh Joseph, Vijaya Srinivasan, Venkataraman Jayanthi, Mohamed Rela","doi":"10.1155/2013/675191","DOIUrl":"https://doi.org/10.1155/2013/675191","url":null,"abstract":"Background. Prevention of the residual risk of transfusion transmitted hepatitis B virus infection (HBV) is mostly dependant on serological screening of blood donors for HBsAg and antibody to hepatitis B core antigen (anti-HBc Ab). This study aimed to study the prevalence of HBsAg and anti-HBc Ab and to compare the profile of blood donors attending a blood donation camp and people attending a hospital based camp. Methods. In the blood donor camp, all the blood units were screened for HBV, (HBsAg and anti-HBc), and in the hospital based camp, screening was done for HBsAg alone. Baseline demographic characteristics were noted. Results. The number of blood bank donors was 363 (47.5%) and hospital camp attendees was 402 (52.5%). Prevalence of HBsAg positivity was similar in both the groups at 1.7% and 1.9%, respectively. Anti-HBc Ab positivity (Total) was 6% among the blood donors; Overall prevalence of HBV infection in this group was 3.2%. Conclusion. Policy for checking the collected blood unit by 3 tests for anti-HBc, anti-HBsAb, and HBsAg should be reconsidered to possibly achieve the zero risk goal of transfusion transmitted HBV infection. Blood obtained from a vaccinated donor may give an added protection to the recipient. ","PeriodicalId":14727,"journal":{"name":"ISRN Hematology","volume":"2013 ","pages":"675191"},"PeriodicalIF":0.0,"publicationDate":"2013-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/675191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31772999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7