ChemistrySelect最新文献

{"title":"Direct Conversion of Aryl/Alkyl Methyl Halides Into Aldehydes Using Commercially Available Ru(II) Complexes","authors":"Preeti Devi,&nbsp;Sonia Rani,&nbsp;Senthilkumar Muthaiah","doi":"10.1002/slct.202500870","DOIUrl":"https://doi.org/10.1002/slct.202500870","url":null,"abstract":"<p>The conversion of methyl halides into aldehydes often involves the nucleophilic substitution reaction of methyl halides with hydroxide to form alcohols, followed by the conversion of alcohols into aldehydes using a stoichiometric amount of oxidizing agents. The above transformation is also achieved by the Sommelet reaction that avoids the formation of an alcohol intermediate and employs the eco-friendly hexamethylenetetramine as the reagent. The Sommelet reaction works in the presence of a large amount of Brønsted acid, which hampers the sustainability of the reaction. Herein, our group reported three different catalyst systems developed from commercially available Ru complexes namely, [Ru(<i>p</i>-cymene)Cl₂]₂, [Ru(benzene)Cl₂]₂, and [Ru(1,5-cod)Cl₂]_n for the efficient conversion of aryl/alkyl methyl halides into corresponding aldehydes in very good to excellent yields while using hexamethylenetetramine as the reagent. All three developed catalyst systems were efficient for the facile conversion of aryl and alkyl methyl halides into aromatic and aliphatic aldehydes. The synthetic methodology was also extended for the synthesis of dialdehydes as well for the gram-scale synthesis of both napthaldehyde and succinaldehyde.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incorporation of Tubular Carbon Nitride and Bi2O3 Flower for Efficient Photodegradation of BPA","authors":"Lan Li,&nbsp;Guojun Yuan,&nbsp;Xiao-Fei Wang,&nbsp;Chen-Hao Bao,&nbsp;Xusheng Wang,&nbsp;Chengchao Jin,&nbsp;Zhi Chen,&nbsp;Ruixia Gao","doi":"10.1002/slct.202502299","DOIUrl":"https://doi.org/10.1002/slct.202502299","url":null,"abstract":"<p>Photocatalysis presents an effective approach for the removal of organic pollutants such as bisphenol A (BPA). In this study, CN-Bi₂O₃ heterojunction composites were synthesized to enhance photocatalytic degradation efficiency. The combination of bismuth oxide (Bi₂O₃) with carbon nitride (CN) broadens light absorption and promotes effective charge separation, as confirmed by spectroscopic and electrochemical analyses. Among the composites, CN-Bi₂O₃-0.5 exhibited the highest performance, achieving a BPA removal efficiency of 76.0% within 30 min, far exceeding that of pure CN (1.1%) and Bi₂O₃ (3.2%). Scavenger and trapping experiments revealed that photogenerated holes (h⁺) and superoxide radicals (∙O₂⁻) played dominant roles in the degradation process. The composite also demonstrated good stability and reusability across multiple cycles. These findings highlight the potential of CN-Bi₂O₃ composites as efficient and robust photocatalysts for environmental remediation applications.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Properties of Visible Radical Photoinitiators Based on Semi-Indigo","authors":"Mi Wang,&nbsp;Guanhao Ma,&nbsp;Shining Li,&nbsp;Jinqing Qu","doi":"10.1002/slct.202501484","DOIUrl":"https://doi.org/10.1002/slct.202501484","url":null,"abstract":"<p>Nowadays, with the development of light-emitting diode (LED), developing photoinitiators compatible with LED has emerged as a critical area of research. The maximum absorption peak of existing photoinitiators is between 200–400 nm, which is not compatible with LED light sources. In this study, four LED hydrogen-abstraction free radical photoinitiators (PIs) were synthesized by introducing aldehyde groups directly into semi-indigo by a one-step method at room temperature. Compared to the absorption peak of benzophenone (BP) at 257 nm, the maximum absorption wavelengths of PI-1, PI-2, PI-3, and PI-4 exhibited a redshift to 507 nm, 523 nm, 496 nm, and 494 nm, respectively. These PIs demonstrated a significant redshift, with their absorption extending beyond 600 nm. Meanwhile, under the irradiation of LED@ 520 nm (5 mW/cm²), the double bond conversion rate of PI-3 and PI-4 exceeds 98%. On the other hand, the migration stability of the curing system was evaluated employing an immersion extraction technique. The mobility values recorded for PI-1, PI-2, PI-3, and PI-4 were 0.74%, 0.71%, 1.30%, and 0.76%, respectively, which were substantially lower in comparison to that of BP at 22.5%. Moreover, PIs have excellent cell compatibility and can be used in 3D printing. These findings highlight that PI1–PI4 possesses long-wavelength absorption, low migration, and is synthesized via a straightforward process.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Taurine-Containing Poly(vinyl alcohol)/Chitosan Electrospun Mat: Characterization and Biological Activity on Neuroblastoma Cells as Promising Neural Tissue Scaffold","authors":"Betül Mutlu Özçınar,&nbsp;Cem Bülent Üstündağ,&nbsp;Rabia Çakır","doi":"10.1002/slct.202501728","DOIUrl":"https://doi.org/10.1002/slct.202501728","url":null,"abstract":"<p>Neural tissue engineering aims to repair or regenerate damaged nerve tissue, particularly following injury or neurodegenerative diseases. Nanofiber scaffolds produced from various biopolymers via electrospinning can serve as multifunctional bioactive scaffolds that can stimulate nerve regeneration, while providing a supportive environment for neuronal growth and differentiation. In this study, 2-aminoethanesulfonic acid, taurine, and a free amino acid with antioxidant properties in many cell types and tissues, were successfully incorporated at different ratios (1%–20%wt) into poly vinylalcohol/Chitosan (PVA/Cht/Trn) electrospun mats and characterized from various aspects. Microstructural analysis of the electrospun mats showed that the increase in the amount of taurine caused significant changes in fibre diameter. The chemical analyze was confirmed by observing taurine-specific peaks on the electrospun mats. In addition, the incorporation of taurine improved the mechanical properties of the electrospun mats and increased the DPPH radical scavenging activity. To evaluate the potential of the produced electrospun mats as scaffolds, their cytotoxic activities were investigated on human neuroblastoma cell line (SH-SY5Y). Taurine-loaded nanofibrous mats are cytocompatible for SH-SY5Y cells. Additionally, it was observed that the nanofibrous mat containing 1% taurine was effective on cell proliferation. Results show that PVA/Cht/Trn electrospun mats can be a cytocompatible tissue scaffold for nerve tissue engineering applications.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dihydropyrimidinone Based Chromones as New α-Glucosidase Inhibitors","authors":"Kumara Swamy Taviti,&nbsp;T. B. Patrudu,&nbsp;Vishnuvardhana Kishore Polisetti,&nbsp;Venkatesh Bhumireddy Chinnachennaiahgari,&nbsp;Satyanarayana Yatam,&nbsp;Naresh Kumar Katari,&nbsp;Rambabu Gundla","doi":"10.1002/slct.202405463","DOIUrl":"https://doi.org/10.1002/slct.202405463","url":null,"abstract":"<p>This study assesses newly synthesized chromones with a 3,4-dihydropyrimidin-2(1H)-one core at C-3, combined with triazole derivatives for their antidiabetic potential. Compounds <b>5a</b> and <b>5b</b> showed strong inhibition of α-glucosidase, with IC₅₀ values of 58.99 ± 4.15 nmol and 49.18 ± 2.18 nmol. Docking studies indicated effective binding within the active site of α-glucosidase (−10.7 kcal/mol for 5a and −10.9 kcal/mol for 5b). Computational assessments suggested both compounds have favorable profiles for drug-likeness, ADME, and toxicity, highlighting their potential as therapeutic agents for diabetes.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202405463","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unusual, Methylated Impurity in Diethyl Sulphate: Identification, Structure Elucidation, and Linkage with N-Methyl Impurity of An Active Pharmaceutical Ingredient","authors":"Nagesh A. Bhale,&nbsp;Ganesh Birajdar,&nbsp;Suraj Agade,&nbsp;Rahul Khemchandani,&nbsp;Chandra Shekhar,&nbsp;Meeravali Shaik,&nbsp;Dr. Gananadhamu Samanthula,&nbsp;Dr. Amol G. Dikundwar","doi":"10.1002/slct.202404945","DOIUrl":"https://doi.org/10.1002/slct.202404945","url":null,"abstract":"<p>Diethyl sulphate (DES) is one of the most economical and commonly used reagents for N-ethylation in bulk manufacturing of active pharmaceutical ingredients (API) and specialty chemicals. In synthesis of an API, involving an N-ethylation step on a hetero-aromatic ring, along with the desired N-ethylated product, formation of an N-methyl impurity is a commonly encountered challenge. A potential source for methyl group is often linked with the ethylating agents and/or solvents used in the reaction. In case, where DES is used as an ethylating agent, the formation of undesired N-methyl impurity is generally ascribed to the presence of dimethyl sulphate, a well-known impurity in DES. In this article, we present a case study wherein another lesser-known impurity namely, ethyl methyl sulphate (EMS) was revealed to be responsible for the generation of N-methyl impurity in an API. Systematic evaluation of different batches of DES with varying amounts of this largely unknown impurity was performed using gas chromatography-mass spectrometry technique and its structure was established as ethyl methyl sulphate. The level of corresponding N-methyl impurity in various API batches which was found to be in the range 0.02-0.17% correlated well with that of this mixed alkylated impurity in different DES batches used in the synthesis. An in silico toxicity prediction study suggested the mutagenic and carcinogenic nature of ethyl methyl sulphate further highlighting the importance of its identification and control. It is shown that trace amount of methanol in the bulk ethanol contributes to the formation of ethyl methyl sulphate which ultimately effects the formation of N-methyl derivative of the API. It is demonstrated that the level of ethyl methyl sulphate in DES could be reduced by a quenching reaction, by treating it with a phenol or an amine as well as by simple normal phase column chromatography.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photoredox-Catalyzed α-Arylation of Bromotrifluoroacetone with Electron-Rich (Hetero)Arenes","authors":"Satoshi Mizuta,&nbsp;Tomoko Yamaguchi,&nbsp;Masaharu Iwasaki,&nbsp;Takeshi Ishikawa","doi":"10.1002/slct.202502626","DOIUrl":"https://doi.org/10.1002/slct.202502626","url":null,"abstract":"<p>Photoredox-catalyzed radical addition of bromotrifluoroacetone and (hetero)arenes to carbonyl compounds has been established under mild conditions. The proposed method enables the synthesis of valuable α-aryl trifluoromethyl ketone compounds, including biologically relevant arene derivatives, with good yields and regioselectivities. This method eliminates competitive bromination using Zn(OAc)₂ as an additive.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202502626","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design and Syntheses of Amphicharged Bolaamphiphilic Molecules from L-Lysine and L-Glutamic Acid","authors":"Neelakshi Neelakshi,&nbsp;Ankita Singh,&nbsp;Dr Ramesh Ramapanicker","doi":"10.1002/slct.202500922","DOIUrl":"https://doi.org/10.1002/slct.202500922","url":null,"abstract":"<p>A new class of amphicharged bolaamphiphilic molecules is reported here, which contain cationic and anionic head groups derived from lysine and glutamic acids, respectively. The molecules are categorized into three sets based on the number and nature of charges on the head groups and on the length of the hydrophobic chain connecting the head groups. Set 1 contains three molecules, each having two amino groups on one end and two carboxylic acids on the other, but with different alkyl chains connecting the two head groups. In set 2, one of the head groups has two amino groups, while the other has 4 carboxylic acid groups and the chain length of the connector is either 6 or 12 carbon atoms. In set 3, the charges on the head groups are reversed by placing 4 amino groups on one of the head groups and two carboxylic acids on the other. It is found that the CMC of these compounds decreased with an increase in the length of the aliphatic chain connecting the head groups and with an increase in the number of cationic and anionic units in the head groups.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(Bpin)2-Catalyzed Cycloaddition Reaction of Epoxides and Carbon Dioxide with a Broad Range of Functional Groups","authors":"Weili Li,&nbsp;Xinghua Ma","doi":"10.1002/slct.202501786","DOIUrl":"https://doi.org/10.1002/slct.202501786","url":null,"abstract":"<p>Carbon dioxide (CO₂) fixation and utilization is a critical area of research for scientists, particularly in light of the escalating greenhouse effect. Among the various strategies being explored, the transformation of CO₂ into high-value compounds is particularly advantageous. In this study, we report one general approach for synthesizing the cyclic carbonates from epoxides and carbon dioxide using Lewis acid catalysis, bis(pinacolato)diboron ((Bpin)₂), which is one commercial available, stable, and cost-effective reagent. The cycloaddition reactions were conducted under mild conditions and demonstrated high yields while accommodating a wide range of broad functional groups. This methodology offers an economical and practical route for the synthesis of cyclic carbonates.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient Co-Production Of 5-Hydroxymethyl Furfural and Furfural from Biomass Utilizing Zr-Loaded Zsm-5 Zeolite Catalyst","authors":"Phan Huy Hoang,&nbsp;Thai Dinh Cuong,&nbsp;Le Quang Dien","doi":"10.1002/slct.202500991","DOIUrl":"https://doi.org/10.1002/slct.202500991","url":null,"abstract":"<p>In this study, Zr-loaded ZSM-5 zeolite catalysts were prepared by incorporating zirconium species into a mesoporous ZSM-5 framework. The research aimed to fine-tune the zeolite modification process to enhance its catalytic activity. The resulting mesoporous Zr/ZSM-5 catalyst was applied for the conversion of biomass-derived sugars into furfural and 5-hydroxymethylfurfural (HMF). Sugar hydrolysate obtained from enzymatic corn stalk hydrolysis served as the feedstock. Key reaction parameters—including catalyst dosage, temperature, reaction time, and Zr ion content—were systematically investigated to optimize conversion efficiency. Under optimal conditions, the catalyst achieved furfural and HMF yields of 90.3 ± 0.5% and 49.8 ± 0.5%, respectively. The as-synthesized Zr/ZSM-5 solid acid catalyst demonstrated excellent performance, indicating its strong potential for sustainable and economically viable biorefining of lignocellulosic biomass.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}