ChemistrySelect最新文献_第8页

Emerging Chemical Upcycling and Repurposing Strategies for Waste Pharmaceuticals 新兴的化学品升级回收和废物药物再利用策略

IF 2.3 4区化学

ChemistrySelect Pub Date : 2026-09-16 DOI: 10.1002/slct.74555

Letícia Ribeiro Magalhães, Lourena Mafra Veríssimo, Euzébio Guimarães Barbosa, Alessandro Kappel Jordão

{"title":"Emerging Chemical Upcycling and Repurposing Strategies for Waste Pharmaceuticals","authors":"Letícia Ribeiro Magalhães, Lourena Mafra Veríssimo, Euzébio Guimarães Barbosa, Alessandro Kappel Jordão","doi":"10.1002/slct.74555","DOIUrl":"https://doi.org/10.1002/slct.74555","url":null,"abstract":"With the aging of population, improvements in health standards, and developments in the pharmaceutical industry, access to medication has become widespread, leading to accumulation of expired or unused drugs in households and, consequently a significant generation of pharmaceutical waste. When improperly disposed of, this pharmaceutical waste can contaminate soil and water, compromising the health of ecosystems. Many strategies to reduce pharmaceutical pollution have been suggested in the past, such as collecting and properly disposing of waste drugs through incineration, extending medicine expiration dates, providing a greater variety of package sizes to prevent leftovers, and better regulation of stocking and dispensing practices. However, what could be done with waste drugs besides reverse logistics and proper disposal programs? By answering this question, this review aims to provide an overview of drug repurposing strategies that can contribute to the valorization of pharmaceutical waste and integration into the circular economy. Through the literature survey, waste drugs were shown to be a valuable resource in diverse areas such as corrosion inhibition, electrochemistry, organic synthesis, fluorescence, nanotechnology, materials science, agriculture, flow improvement, surface science, and photocatalysis. This field of research is still relatively unexplored and yet promising, considering the current worldwide need for eco-friendly industrial alternatives.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 36","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.74555","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148974862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Waste PET-Derived Porous Carbon for Adsorption-Coupled Nonradical Fenton-Like Degradation of Organic Dyes 废pet衍生多孔碳吸附耦合非自由基类芬顿降解有机染料的研究

IF 2.3 4区化学

ChemistrySelect Pub Date : 2026-09-16 DOI: 10.1002/slct.74405

Shuyao Wang, Yue Liu, Wei Zhang

{"title":"Waste PET-Derived Porous Carbon for Adsorption-Coupled Nonradical Fenton-Like Degradation of Organic Dyes","authors":"Shuyao Wang, Yue Liu, Wei Zhang","doi":"10.1002/slct.74405","DOIUrl":"https://doi.org/10.1002/slct.74405","url":null,"abstract":"<div>\u0000 \u0000 Waste polyethylene terephthalate (PET) was upcycled into a bifunctional porous carbon (PET-C-1) through base-catalyzed hydrolysis followed by one-step pyrolysis. The hydrolysis-derived potassium terephthalate precursor suppressed aromatic carbon loss and promoted in situ pore development, yielding PET-C-1 with a BET surface area of 1149 m2 g−1, a pore volume of 1.11 cm3 g−1, and partially graphitized framework. The carbonization process also generated H2- and CO-containing gas products, suggesting the possibility of additional product valorization. The PET-C-1 exhibits rapid adsorption of organic dye malachite green (MG) and acts as a metal-free catalyst for H2O2 activation and oxidative degradation of MG. Complete removal of 50 ppm MG from water was achieved within 8 min. Mechanistic studies suggest that the PET-C-1/H2O2 system proceeds mainly through a surface-mediated nonradical electron-transfer pathway rather than a conventional ·OH-dominated Fenton process. This work demonstrates a feasible route for converting waste PET into functional carbon catalysts and highlights the potential of plastic-derived carbons for adsorption-coupled oxidative water treatment.\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 36","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148974961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burmannic Acid With Normal Cell Safety Exhibits ROS-Mediated X-Ray-Sensitizing Effects on Oral Cancer Cells 具有正常细胞安全性的牛蒡酸对口腔癌细胞显示ros介导的x射线增敏作用

IF 2.3 4区化学

ChemistrySelect Pub Date : 2026-09-16 DOI: 10.1002/slct.74568

Kun-Han Yang, Chung-Yi Chen, Ching-Yu Yen, Hsin-I Lu, Jen-Yang Tang, Tsu-Ming Chien, Fang-Rong Chang, Jiiang-Huei Jeng, Ming-Yii Huang, Hsueh-Wei Chang

{"title":"Burmannic Acid With Normal Cell Safety Exhibits ROS-Mediated X-Ray-Sensitizing Effects on Oral Cancer Cells","authors":"Kun-Han Yang, Chung-Yi Chen, Ching-Yu Yen, Hsin-I Lu, Jen-Yang Tang, Tsu-Ming Chien, Fang-Rong Chang, Jiiang-Huei Jeng, Ming-Yii Huang, Hsueh-Wei Chang","doi":"10.1002/slct.74568","DOIUrl":"https://doi.org/10.1002/slct.74568","url":null,"abstract":"Burmannic acid (BURA), a novel Indonesian cinnamon-derived apocarotenoid, showed antiproliferative effects on oral cancer cells without combined application. The purpose of this study is to assess the potential radiosensitizing ability of BURA in oral cancer cells. ATP assay and flow cytometry were conducted to evaluate the radiosensitizing effects on antiproliferation and anti-oral cancer mechanisms, with comparisons to normal cells. Combined treatment (x-ray/BURA), exhibiting normal (S–G) cell safety, shows antiproliferative activity against oral cancer cells, which is alleviated by a ROS inhibitor, N-acetylcysteine (NAC). Mechanistically, x-ray/BURA in oral cancer cells upregulated or activated higher subG1 occurrence, apoptosis (annexin V/caspase-3), intrinsic/extrinsic caspase-8/9, cell/mitochondrial ROS, diminishment of mitochondrial membrane potential/glutathione, and oxidative DNA damage than x-ray, BURA, and that of normal cells. Moreover, NAC partially attenuated these mechanisms. In conclusion, x-ray/BURA appears to be at least partly ROS-dependent modulation of radiosensitization and antiproliferative effects in oral cancer cells, with limited adverse impact on normal cells.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 36","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.74568","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148974963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Copper(II) Acetate as a Dual-Function Reagent: A Useful Acetyl Source for the In Situ N-Acetylation of Anilines 醋酸铜作为双功能试剂：苯胺原位n -乙酰化的有效乙酰源

IF 2.3 4区化学

ChemistrySelect Pub Date : 2026-09-16 DOI: 10.1002/slct.74569

Savita Gat, E. V. Venkat Shivaji Ramarao, Rana Chatterjee, Sujeet Gaware, Rambabu Dandela

引用次数: 0

Magnetron-Sputtered Niobium-Coated Biochar for Reusable Adsorption of Ivermectin and Diclofenac From Water 磁控溅射铌包覆生物炭可重复吸附水中的伊维菌素和双氯芬酸

IF 2.3 4区化学

ChemistrySelect Pub Date : 2026-09-16 DOI: 10.1002/slct.74565

Adelício Lucas Alberto, Sabrina Frantz Lütke, Yasmin Vieira, Cesar Aguzzoli, Salah Knani, Marcos Leandro Silva Oliveira, Luis Felipe Oliveira Silva, Guilherme Luiz Dotto

{"title":"Magnetron-Sputtered Niobium-Coated Biochar for Reusable Adsorption of Ivermectin and Diclofenac From Water","authors":"Adelício Lucas Alberto, Sabrina Frantz Lütke, Yasmin Vieira, Cesar Aguzzoli, Salah Knani, Marcos Leandro Silva Oliveira, Luis Felipe Oliveira Silva, Guilherme Luiz Dotto","doi":"10.1002/slct.74565","DOIUrl":"https://doi.org/10.1002/slct.74565","url":null,"abstract":"Biochar was surface-modified using the Magnetron Sputtering technique, coating it with thin films of niobium to improve its selectivity and reusability for the removal of ivermectin (IVM) and diclofenac (DCF) from water. Batch experiments were conducted to investigate the effects of pH and temperature, adsorption kinetics and equilibrium, thermodynamic behavior, thermal regeneration, and interference from inorganic salts. The material exhibited a specific surface area of 369 m2 g−1 and a pore volume of 0.183 cm3 g−1, while Nb deposition shifted the PZC from 6.50 to 7.40. Equilibrium data were best described by the Sips model, with maximum adsorption capacities of 171.8 mg g−1 for IVM at 328 K and 96.2 mg g−1 for DCF at 298 K. IVM adsorption kinetics were best described by the Elovich model, whereas the pseudo-first-order model provided the best fit for DCF. Adsorption was endothermic for IVM and exothermic for DCF, demonstrating compound-dependent interactions with the modified surface. The highest removal yields were 61.67% and 89.19%. The adsorbent maintained its removal performance for 11 adsorption–regeneration cycles, and the tested salts decreased removal selectivity by no more than 15%.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 36","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.74565","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148974863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Synthesis of a Potent, Cell Active Purine-Based Amidoxime Against the Dengue Virus 一种有效的细胞活性嘌呤基偕胺肟抗登革病毒的设计与合成

IF 2.3 4区化学

ChemistrySelect Pub Date : 2026-09-16 DOI: 10.1002/slct.74553

Dimitrios Kiousis, Despoina Giannioti, Georgia Kalyva, Vasiliki Zogali, Maharah Binte Abdul Mahid, Kitti Wing Ki Chan, Minos-Timotheos Matsoukas, Subhash G. Vasudevan, Gerasimos Rassias

{"title":"Design and Synthesis of a Potent, Cell Active Purine-Based Amidoxime Against the Dengue Virus","authors":"Dimitrios Kiousis, Despoina Giannioti, Georgia Kalyva, Vasiliki Zogali, Maharah Binte Abdul Mahid, Kitti Wing Ki Chan, Minos-Timotheos Matsoukas, Subhash G. Vasudevan, Gerasimos Rassias","doi":"10.1002/slct.74553","DOIUrl":"https://doi.org/10.1002/slct.74553","url":null,"abstract":"According to WHO, the dengue virus (DENV) is a global health threat and major risk for a pandemic with an estimated 2.5 billion people in more than 100 tropical and subtropical countries at risk of infection. Despite this significant burden, no antiviral drugs are currently approved, thus prompting extensive research efforts pursuing dengue antivirals. Following from our previous work on allosteric inhibitors of the dengue protease, we synthesized novel inhibitors with improved potency and drug-like characteristics while maintaining the pharmacophore domains of two arylamidoxines and a bromobenzyl substituent. Iterative scaffold hopping and morphing, exemplified purine derivative 4 (SP-835G) with DENV2 EC50 0.1 µM, CC50>100 µM and clogP 3.61. Docking studies support that the corresponding active diamidine SP-835A shares the same allosteric binding at the dengue protease as our previous hit diamidine SP-471. The synthesis of the purine core was optimized to perform at gram scale without need for chromatography including Suzuki–Miyaura cross coupling, Buchwald–Hartwig Ν-arylation and nucleophilic aromatic substitution reactions.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 36","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.74553","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148974864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variation of Tetrahedrons and Cations Regulates LIDTs in 3D-DL Structure MIR-NLO Crystals 四面体和阳离子的变化调节了3D-DL结构MIR-NLO晶体中的lidt

IF 2.3 4区化学

ChemistrySelect Pub Date : 2026-09-16 DOI: 10.1002/slct.74544

Chaoyi Zhu

{"title":"Variation of Tetrahedrons and Cations Regulates LIDTs in 3D-DL Structure MIR-NLO Crystals","authors":"Chaoyi Zhu","doi":"10.1002/slct.74544","DOIUrl":"https://doi.org/10.1002/slct.74544","url":null,"abstract":"<div>\u0000 \u0000 The incomplete understanding of the relationship between structural changes and laser-induced damage thresholds (LIDTs) in mid-infrared nonlinear-optical (MIR-NLO) crystals considerably restricts the design and synthesis of MIR-NLO crystals with high LIDTs. This review summarizes the structures of 87 types of three-dimensional diamond-like (3D-DL) structure MIR-NLO crystals and their LIDTs. Specifically, their LIDTs were measured under specific pump laser conditions (approximately 1.06 µm). These 3D-DL structure MIR-NLO crystals were first categorized into three major categories according to their optical band gaps: 1.17 eV ≤ Eg ≤ 2.33 eV, 2.34 eV ≤ Eg ≤ 3.50 eV, 3.51 eV ≤ Eg ≤ 4.66 eV. Within each major category, they were subsequently discussed in the order of structural types (β-ZnS structure, defect β-ZnS structure, A-ions-substituted β-ZnS structure, α-ZnS structure, defect α-ZnS structure, and A-ions-substituted α-ZnS structure). The final statistical results reveal that the types of tetrahedrons and cations, their arrangement patterns, and dimensional reduction effects across different structures all play a decisive role in the magnitude of LIDT improvement.\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 36","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148974958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Metal Oxide-Supported Low-Iridium Catalysts for Acidic Water Oxidation 金属氧化物负载的酸性水氧化低铱催化剂研究进展

IF 2.3 4区化学

ChemistrySelect Pub Date : 2026-09-16 DOI: 10.1002/slct.74535

Wenjing Li, Baoshuai Du, Zhicheng Yan, Shengcheng Shu, Guoxin Ma, Bingrong Guo, Siwei Li

{"title":"Recent Advances in Metal Oxide-Supported Low-Iridium Catalysts for Acidic Water Oxidation","authors":"Wenjing Li, Baoshuai Du, Zhicheng Yan, Shengcheng Shu, Guoxin Ma, Bingrong Guo, Siwei Li","doi":"10.1002/slct.74535","DOIUrl":"https://doi.org/10.1002/slct.74535","url":null,"abstract":"<div>\u0000 \u0000 Proton exchange membrane water electrolysis (PEMWE) is a promising route to sustainable hydrogen production, but large-scale deployment is limited by sluggish anodic oxygen evolution reaction (OER) kinetics and scarce iridium (Ir). Metal oxide supports can lower Ir demand by improving its dispersion and utilization and by regulating the coordination and electronic structure of active sites. This review classifies representative supports into two nonexclusive families: redox-responsive, electronically adaptive oxides and structurally robust, electronically tunable oxides. Their functions are compared through lattice anchoring and confinement, interfacial charge transfer and redox buffering, vacancy-mediated oxygen migration and spillover, and regulation of adsorbate evolution mechanism (AEM), lattice oxygen mechanism (LOM), oxide pathway mechanism (OPM), and related pathways. Particular emphasis is placed on strong metal oxide–support interactions and the coupled effects of Ir─O─M bonding, charge redistribution, coordination distortion, and spatial confinement. Benefits are assessed alongside trade-offs in conductivity, site accessibility, vacancy dynamics, and support degradation. Catalyst Ir content, half-cell loading, and MEA anode loading are distinguished, with half-cell and device-level performance evaluated separately. This framework links fundamental interfacial chemistry with catalyst-level metrics and realistic device requirements for practical PEMWE implementation. Finally, priorities are identified for operando characterization, dissolution analysis, standardized benchmarking, descriptor-guided support design, and durable low-Ir MEAs.\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 36","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148974959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Dipeptide–Tryptamine Conjugates: Evaluating Antioxidant, Cytotoxic Properties and Molecular Docking Studies 二肽-色胺缀合物的合成：评价抗氧化、细胞毒性和分子对接研究

IF 2.3 4区化学

ChemistrySelect Pub Date : 2026-09-16 DOI: 10.1002/slct.74550

Şenay Akkar, Samet Öz, F. Zehra Küçükbay, Güldeniz Şekerci, Houssem Boulebd, Suat Tekin, Hasan Küçükbay

引用次数: 0

Acetate-Promoted Catecholase Activity of a Manganese–Schiff Base Complex: A Spectroscopic Elucidation 一种锰-席夫碱配合物的醋酸盐促进的儿茶酚酶活性：光谱分析

IF 2.3 4区化学

ChemistrySelect Pub Date : 2026-09-16 DOI: 10.1002/slct.74523

Surama Meher, Pratap Kumar Deheri, Sohini Sarkar

{"title":"Acetate-Promoted Catecholase Activity of a Manganese–Schiff Base Complex: A Spectroscopic Elucidation","authors":"Surama Meher, Pratap Kumar Deheri, Sohini Sarkar","doi":"10.1002/slct.74523","DOIUrl":"https://doi.org/10.1002/slct.74523","url":null,"abstract":"<div>\u0000 \u0000 Synthesis, characterizations, and catecholase activity of a manganese complex (1) have been reported. The complex was derived from a Schiff base, H2L (a condensed product of 3-chlorosalicylaldehyde and ethylenediamine), using manganese(II) acetate and was found as a bio-functional model of catechol oxidase. Different spectroscopic techniques, like, high-resolution mass spectrometry (HRMS), electronic spectroscopy, IR spectroscopy, x-ray photoelectron spectroscopy (XPS), and electron paramagnetic resonance (EPR) spectroscopy have been utilized for characterization purpose. The complex may be a mononuclear species with one Mn3+ and a coordinated acetate moiety. However, the results of elemental analysis and HRMS indicate the possible formation of a trinuclear species. 1 has been found as a bio-mimic of catechol oxidase in acetonitrile. The turnover number was observed as 613.12 h−1. 1H-NMR spectral result indicates that almost complete conversion of 3,5- di tert butyl catechol (3,5-DTBC) to 3,5-di tert butyl quinone (3,5-DTBQ) is possible in five minutes. Based on EPR and ESI-MS studies with the substrate-1 mixtures, a tentative metal-centric (probably stemming from Mn3+) mechanism has been interpreted. The acetate (playing both as an auxiliary ligand and a base) is probably responsible for the quick oxidation process in comparison to the other Mn complexes, prepared from the same ligand.\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 36","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148974962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0