{"title":"Dual-Functional β-Ga2O3 Nanostuctures: Morphology-Driven Advances in Photocatalysis and Cold Cathode Emission","authors":"Brahami Das, Nirmalya Sankar Das, Souvik Bhattacharjee, Suvra Pal, Kalyan Kumar Chattapadhyay","doi":"10.1002/slct.202506124","DOIUrl":"https://doi.org/10.1002/slct.202506124","url":null,"abstract":"<div>\u0000 \u0000 <p>Dimensional shrinkage and morphology modulation of nanostructured β-Ga<sub>2</sub>O<sub>3</sub> play a crucial role in regulating its photocatalytic and cold-emission performances. In this work, β-Ga<sub>2</sub>O<sub>3</sub> nanostructures were synthesized via calcination of gallium oxyhydroxide, prepared through a simple chemical route. Morphological control was achieved using polyvinylpyrrolidone (PVP) as a shape-directing agent, which suppresses particle agglomeration and promotes controlled growth along specific crystallographic facets. In addition to conventional structural and morphological characterizations, the photocatalytic performance of Ga<sub>2</sub>O<sub>3</sub> systems was evaluated by time-resolved UV–Vis absorption spectroscopy during degradation of eosin B (EB) dye under UV irradiation. The porous β-Ga<sub>2</sub>O<sub>3</sub> nanoflakes exhibited a significantly larger effective surface area and enhanced UV–Vis light absorption compared to irregularly shaped, agglomerated Ga<sub>2</sub>O<sub>3</sub>. Consequently, the nanoflake-based β-Ga<sub>2</sub>O<sub>3</sub> achieved a photodegradation efficiency of ∼99% within 30 min of UV-exposure, markedly superior to that of the agglomerated Ga<sub>2</sub>O<sub>3</sub> counterpart (∼30%). Furthermore, the β-Ga<sub>2</sub>O<sub>3</sub> nanoflakes demonstrated enhanced cold emission characteristics, attributed to their high aspect ratio, porous morphology, and increased density of emission sites. Overall, this study presents a facile, low-cost, and environmentally benign strategy for tailoring the morphology of Ga-based oxide nanostructures, enabling superior photocatalytic activity for wastewater remediation and improved cold-cathode emission performance compared to commercially available gallium oxide.</p>\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2026-03-09DOI: 10.1002/slct.202507030
Kiran Gadivaddar, Jagdish R. Tonannavar, Jayashree Tonannavar
{"title":"Study of O─H···O Bonded Cyclic Trimer of (S)–(–)–1–Methyl–2–pyrrolidinemethanol by a Combined Spectroscopic and Computational Approach","authors":"Kiran Gadivaddar, Jagdish R. Tonannavar, Jayashree Tonannavar","doi":"10.1002/slct.202507030","DOIUrl":"https://doi.org/10.1002/slct.202507030","url":null,"abstract":"<div>\u0000 \u0000 <p>The O─H···O bonded cyclic trimer model for (S)–(–)–1–Methyl–2–pyrrolidinemethanol (MPM) has been proposed. Based on the experimental IR spectral features, a combined DFT and MD modeling techniques has been applied to obtain the most stable O─H···O bonded cyclic trimer. There are two measured electronic absorption bands at 292 and 329 nm in the UV–Vis region attributed to a self–induced aggregation with J–type alignment of the electronic transition dipole moments with head–to–tail interactions between the monomer species in the cyclic trimer in agreement with the MD simulations in solvent media. The cyclic trimer in chloroform predicted two bands at 242 and 249 nm and corresponds to the broad band at 292 nm. In the observed concentration–dependent ECD spectra, a band at 238 nm shifts to 245 nm with enhanced intensity by a factor of 3. These results establish the cyclic trimer as a basic supramolecular motif where cooperative O─H···O bonding and electron delocalization providing the stability for the trimer structure.</p>\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"GC-MS Profiling and Anti-Influenza Potential of Phyllanthus emblica (Indian Gooseberry) Extract: In Vitro and In Silico Approaches","authors":"Sanjit Boora, Sapna Wadhwa, Nitin Kumar, Kumari Soniya, Anish Khan, Varsha Potdar, Samander Kaushik","doi":"10.1002/slct.202505774","DOIUrl":"https://doi.org/10.1002/slct.202505774","url":null,"abstract":"<div>\u0000 \u0000 <p>Influenza A virus remains a persistent global health challenge requiring novel therapeutic interventions. This study evaluated the antiviral efficacy of aqueous, ethanolic, and methanolic extracts of <i>Phyllanthus emblica</i> against the H1N1pdm09 virus and identified active compounds (GCMS) through molecular docking analysis. Cytotoxicity was determined using MTT assays, and more than 95% viability was found at concentrations of 62.50 µg/mL for the aqueous extract, 125 µg/mL for the ethanolic & methanolic extract. In contrast, antiviral activity was assessed through RT-qPCR quantification of viral genomic load via cycle threshold (Ct) values across pre-treatment, co-treatment, and post-treatment protocols. Antioxidant activity was evaluated using DPPH assays, and molecular docking examined binding affinities against key viral proteins. The aqueous extract demonstrated negligible antiviral activity, while ethanolic and methanolic extracts showed substantial efficacy, particularly under co-treatment conditions. Ethanolic extract achieved the highest viral inhibition with Ct values of 27.09 (<i>p</i><0.0001), while methanolic extract showed Ct values of 25.25 (<i>p</i><0.0001) in co-treatment compared to virus control (Ct). Antioxidant analysis revealed superior activity in the methanolic extract (IC<sub>50</sub> = 1.044 ± 02 µg/mL) compared to the ethanolic extract (IC<sub>50</sub> = 5.769 ± 02 µg/mL). These biological activities are attributed to the rich presence of phenolic and triterpenoids identified in the extracts. Molecular docking identified γ-sitosterol as the most potent compound with potential binding affinities, including M2 protein (−10.98), neuraminidase (−7.68), RdRp (−9.52), and hemagglutinin (−9.94 kcal/mol). <i>P. emblica</i> extracts demonstrate significant anti-influenza activity through multi-target mechanisms, positioning this natural source as a valuable candidate for sustainable antiviral drug development, and γ-sitosterol is identified as a strong M2 inhibitor.</p>\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2026-03-09DOI: 10.1002/slct.202506821
Ali Bilgic
{"title":"Comparative Study of Magnetic and Non-magnetic Pillar[5]Arene-Functionalized Sporopollenin Microcapsules for Efficient Methylene Blue Removal From Aqueous Solution","authors":"Ali Bilgic","doi":"10.1002/slct.202506821","DOIUrl":"https://doi.org/10.1002/slct.202506821","url":null,"abstract":"<div>\u0000 \u0000 <p>This study reports the synthesis and comparative adsorption performance of pillararene-functionalized sporopollenin microcapsules (<b><i>Sp-P[5]-PCA</i></b>) and their magnetic derivatives (<b><i>MSp-P[5]-PCA</i></b>) for methylene blue (MB) removal from aqueous solutions. The prepared microcapsules were systematically characterized using FTIR, SEM, XRD, EDX, and TGA to elucidate their structural, morphological, and physicochemical properties. The results confirmed that magnetic modification coupled with surface functionalization significantly modified the surface characteristics and crystallinity of the pristine sporopollenin matrix. The effects of solution pH and adsorbent dosage on MB adsorption were investigated, revealing an optimal adsorbent dose of 0.0015 g for both materials. MB removal efficiency increased with increasing pH and reached a maximum in the pH range of 8–9. Kinetic studies demonstrated that adsorption followed the pseudo-second-order model for both microcapsules. Isotherm analysis showed a good fit with the linear Langmuir model, yielding high maximum adsorption capacities of 208.33 mg g<sup>−1</sup> <b><i>for Sp-P[5]-PCA</i></b> and 270.16 mg g<sup>−1</sup> for <b><i>MSp-P[5]-PCA</i></b> at 298 K. Thermodynamic parameters indicated a feasible and exothermic adsorption process favored at lower temperatures. The adsorption mechanism involves π–π interactions, hydrogen bonding, and host–guest encapsulation. Notably, magnetic microcapsules retained 69.15% efficiency after ten reuse cycles, demonstrating their sustainability and potential for wastewater remediation.</p>\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2026-03-09DOI: 10.1002/slct.202506321
Betül Taşdelen, Sevil Erdoğan
{"title":"Preparation and Characterization of Sodium Alginate Radiation Grafted Poly(N-isopropylacrylamide)/Poly(itaconic acid) Microspheres for Bone Tissue Engineering Applications","authors":"Betül Taşdelen, Sevil Erdoğan","doi":"10.1002/slct.202506321","DOIUrl":"https://doi.org/10.1002/slct.202506321","url":null,"abstract":"<div>\u0000 \u0000 <p>Novel pH- and temperature-responsive semi-interpenetrating network (s-IPN) microspheres were developed via a three-step approach, involving radiation grafting of sodium alginate (SA) onto a poly(N-isopropylacrylamide) (PNIPAAm) /poly(itaconic acid) (PIA) microsphere matrix. In the first step, PNIPAAm microspheres were prepared using the inverse suspension polymerization technique. In the second step, a selected fraction of PNIPAAm microspheres (180–250 µm size range) was used to prepare PNIPAAm/PIA graft copolymers via the radiation-induced modification technique. Subsequently, PNIPAAm/PIA microspheres were immersed in an SA solution, followed by gamma radiation-induced polymerization at a dose of 25 kGy. The prepared s-IPN microspheres were characterized using scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) analyses. The swelling kinetics of the novel s-IPN microspheres were best described by the Peppas model. The <i>n</i> > 0.5 value in the Peppas model indicates that the mechanism is non-Fickian transport. The swelling behavior, pH-sensitivity, swelling kinetics, and hydrolytic degradation properties of the new s-IPN microspheres were improved by the incorporation of SA and itaconic acid (IA) into the gel structure.</p>\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147665906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2026-03-09DOI: 10.1002/slct.202503947
Amrutha Asokan, Ambili K.S, Usha K. Aravind, C. T. Aravindakumar
{"title":"NH2-MIL-101(Al) and Its Kaolin Composite for the Adsorptive Removal of NSAIDs From Water","authors":"Amrutha Asokan, Ambili K.S, Usha K. Aravind, C. T. Aravindakumar","doi":"10.1002/slct.202503947","DOIUrl":"https://doi.org/10.1002/slct.202503947","url":null,"abstract":"<div>\u0000 \u0000 <p>The extensive use of nonsteroidal anti-inflammatory drugs (NSAIDs) has led to their uncontrolled release into aquatic environments, posing increasing risks to human health and ecosystems. Metal–organic frameworks (MOFs) have emerged as promising adsorbents for the removal of such emerging contaminants from water. In this study, the adsorption performance of NH<sub>2</sub>-MIL-101(Al) was systematically investigated for the removal of five NSAIDs—diclofenac, mefenamic acid, naproxen, ibuprofen, and bufexamac—from aqueous solutions. The effects of key operational parameters, including initial concentration, solution pH, temperature, adsorbent dosage, and contact time, were optimized. Maximum removal efficiencies of approximately 100%, 92.65%, and 62.58% were obtained for mefenamic acid, diclofenac, and naproxen, respectively, at pH 6, while ibuprofen and bufexamac exhibited optimal adsorption at pH 5 and pH 8. A kaolin-supported NH<sub>2</sub>-MIL-101(Al) composite was synthesized and characterized using FT-IR, XRD, UV–visible spectroscopy, thermal analysis, and FE-SEM, confirming successful incorporation, uniform dispersion within the kaolin matrix, and good thermal stability up to 450°C. The composite achieved nearly complete removal of mefenamic acid (10 ppm, 50 mL) within 10 min, demonstrating significantly higher adsorption efficiency than pristine kaolin. These findings highlight the strong potential of NH<sub>2</sub>-MIL-101(Al)-based composites for efficient water purification.</p>\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Discovery of Piplartine as a Potent Multitargeting Anti-HIV and Anti-TB Lead Molecule: Network Pharmacology, In silico, and In vitro Studies to Analyze Its Role in HIV/TB Co-infection","authors":"Ankur Gupta, Pratiksha Khanal, Anusha Chettri, Ashwini More, Shraddha Y. Gaikwad, Manish Bansal, Nisheeth Agarwal, Anupam Mukherjee","doi":"10.1002/slct.202506762","DOIUrl":"https://doi.org/10.1002/slct.202506762","url":null,"abstract":"<div>\u0000 \u0000 <p>Piplartine (PL) modulates key cancer-related signalling pathways. Though these pathways also influence immune responses during human immunodeficiency virus (HIV) and <i>Mycobacterium tuberculosis</i> (Mtb) infection, PL's effects on these infections remain unexplored. This study aims to investigate PL's therapeutic potential against HIV, Mtb, and co-infection using network pharmacology, in silico, and in vitro approaches. Gene targets associated with HIV, Mtb, and PL were retrieved from public databases, and a protein-protein interaction (PPI) network was constructed to identify 16 hub genes among 53 common targets. Gene Ontology and KEGG pathway enrichment analyses highlighted TP53, STAT3, HSP90AA1, IL1B, and CASP3 as key regulators. in silico studies revealed PL's strong affinity for host, HIV, and Mtb targets. Isolated PL exhibited potent anti-HIV activity with an EC<sub>50</sub> of 0.735 µg/mL in TZM-bl cells, indicating strong efficacy at sub-cytotoxic levels (CC<sub>50</sub> 5.24 µg/mL). It inhibited HIV-1 replication in strains HIV-1<sub>VB028</sub> and HIV-1<sub>UG070</sub>. PL inhibited RTase and Protease activity by 75% and 58.6%, respectively, and lowered p24 antigen levels by ∼84% at day 5 postinfection. Viral load dropped to 66,180 copies/mL by day 11, compared to >1,000,000 copies/mL in controls. Additionally, PL showed antimicrobial activity against Mtb H37Rv with an MIC of 37.5 µg/mL, highlighting its potential as a promising lead candidate against HIV/Mtb co-infections.</p>\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2026-03-09DOI: 10.1002/slct.202507268
Manav Parmar, Ishita Modasiya, Paresh K. Patel, Bhumi Shah, Bonny Y. Patel
{"title":"From Antibacterial Limitations to Enzymatic Modulation: Exploring α-Amylase Inhibition and Repurposing of 6-APA Derivatives Through Enzymatic and In Silico Profiling","authors":"Manav Parmar, Ishita Modasiya, Paresh K. Patel, Bhumi Shah, Bonny Y. Patel","doi":"10.1002/slct.202507268","DOIUrl":"https://doi.org/10.1002/slct.202507268","url":null,"abstract":"<div>\u0000 \u0000 <p>A novel series of <i>β</i>-lactam analogues derived from 6-aminopenicillanic acid (6-APA) was synthesized and evaluated for their antidiabetic potential through in vitro α-amylase inhibition, molecular docking, and ADMET studies. Structure–activity analysis revealed that electronic effects and substituent orientation significantly influence activity. Compound <b>4a</b> (benzaldehyde derivative) showed the highest α-amylase inhibition (83.71 ± 0.98%), comparable to acarbose (86.61 ± 0.65%), followed by <b>4d</b> (<i>para</i>-nitro, 82.90 ± 0.19%). Molecular docking studies further demonstrated that <b>4e</b>, <b>4f</b>, and <b>4a</b> exhibited superior binding affinities, with total docking scores of 8.21, 7.93, and 7.81, respectively, surpassing that of acarbose (7.87). ADMET analysis confirmed favorable pharmacokinetic profiles, identifying <b>4h</b> and <b>4i</b> as the safest analogues with LD<sub>50</sub> values of 15,000 mg/kg and 2880 mg/kg, respectively. Although the series showed moderate antibacterial activity, all compounds displayed high drug-likeness scores, with <b>4a</b> achieving the maximum (0.86). These findings highlight 6-APA as a privileged scaffold for designing safe and effective nontraditional antidiabetic agents.</p>\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2026-03-09DOI: 10.1002/slct.202504328
Fahad Mohammad Alminderej, Lotfi Mohamed Aroua
{"title":"Synthesis, Structure–Activity Relationships, and Pharmacological Profile of Bioactive Urea-Based Therapeutics","authors":"Fahad Mohammad Alminderej, Lotfi Mohamed Aroua","doi":"10.1002/slct.202504328","DOIUrl":"https://doi.org/10.1002/slct.202504328","url":null,"abstract":"<div>\u0000 \u0000 <p>This review summarizes the synthesis and biological activities of urea derivatives in medical chemistry. This work is dedicated to the 200th anniversary of the discovery of urea as a useful starting material for organic and medicinal chemistry. The review is focused on the role of urea as a versatile scaffold in organic and medicinal chemistry; predominant emphasis is given to the chemistry of bioactive compounds and especially to the synthesis of drugs of various pharmacologically relevant categories. Urea and its analogues are one of the core skeletons discovered in medicinal chemistry and are well-known for their extensive use in various clinically active therapeutic agents. Its unusual structural and electronic properties, including its capacity as a planar hydrogen bond donor–acceptor functionality, allow its potent and specific interaction with a range of biological targets. This has placed the urea scaffold as a privileged structure for drug development. This exhaustive review assimilates all the research made on urea derivatives and is put across in two distinct ways, that is, synthesis and various bioactivities of urea derivatives. In the first part of the review, the synthetic approaches adopted for the assembly of urea-motifs containing molecules is critically discussed. It describes both traditional mechanisms using phosgene and isocyanates as well as more contemporary and safer methods with significantly increased safety profiles and efficiency. The latter section is dedicated to an exhaustive analysis of the extended pharmacological profile of these compounds. We emphasize the importance of the urea derivatives as useful molecules with a great potential as drugs in many areas such as oncology (inhibitors of kinases), infectious diseases (antiviral, antibacterials, and antifungal), and central nervous system disorders (anticonvulsant). Their utilization as enzyme deactivates, antagonist to receptors, and blockers of ion channels is also addressed, with examples from both approved drugs and prospective clinical trial substances. This review intends to be an important resource for medicinal chemists by systematically summarizing the synthetic methods and the structure–activity relationship (SAR) of bioactive urea derivatives. It highlights the utility and continued significance of the urea pharmacophore and the hope that such studies will lead to new and better therapeutic agents.</p>\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2026-03-09DOI: 10.1002/slct.202506693
Ekaterina A. Maksimova, Vadim A. Shiryaev, Yuri N. Klimochkin
{"title":"Photoinitiated Reactions of Homoadamantane-4,5-Dione","authors":"Ekaterina A. Maksimova, Vadim A. Shiryaev, Yuri N. Klimochkin","doi":"10.1002/slct.202506693","DOIUrl":"https://doi.org/10.1002/slct.202506693","url":null,"abstract":"<div>\u0000 \u0000 <p>New derivatives containing a homoadamantane framework have been obtained by photochemical reactions of homoadamantane-4,5-dione with various reagents. It has been found that products of photoaddition to the carbonyl group are formed in most of the reactions. When using benzaldehyde, dimethylformamide, isobutyric aldehyde, and salicylic aldehyde, additional formation of ester derivatives was observed. When using dioxane as a reagent, the formation of a mixture of diastereomers was detected. In the case of norbornene, the product of the Paterno-Buchi reaction and a side compound of norbornene dichloromethylation were formed. The presented methods make it possible to obtain these substances in a fairly convenient and chemically accessible way. The obtained compounds present a prospect for further transformations</p>\u0000 </div>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"11 10","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}