ChemistrySelect最新文献

Comprehensive Impact of Eaton's Reagent in Organic Synthesis: An Overview 伊顿试剂在有机合成中的综合影响：综述

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-07-21 DOI: 10.1002/slct.202502756

Satheeshkumar Rajendran, Nitin Bharat Charbe, Nikhil D. Amnerkar, Arul Murugesan, Saurabh C. Khadse, Sushesh Srivatsa Palakurthi, Sai Raghuveer Chava, Kolandaivel Prabha, Roberto Acevedo

{"title":"Comprehensive Impact of Eaton's Reagent in Organic Synthesis: An Overview","authors":"Satheeshkumar Rajendran, Nitin Bharat Charbe, Nikhil D. Amnerkar, Arul Murugesan, Saurabh C. Khadse, Sushesh Srivatsa Palakurthi, Sai Raghuveer Chava, Kolandaivel Prabha, Roberto Acevedo","doi":"10.1002/slct.202502756","DOIUrl":"https://doi.org/10.1002/slct.202502756","url":null,"abstract":"Eaton's reagent is a unique mixture of phosphorus pentoxide and methanesulfonic acid and has emerged as a versatile and potent catalyst in modern synthetic chemistry. This review provides a comprehensive overview of Eaton's reagent, detailing its preparation, mechanistic pathways, and diverse applications in organic synthesis. Since its introduction, Eaton's reagent has become invaluable, promoting a wide range of transformations, including Friedel–Crafts reactions, cyclodehydration, Beckmann rearrangement, aminolysis, and multi-component reactions. The reagent's distinct advantages over traditional catalysts, such as higher reactivity, milder reaction conditions, and improved yields, make it particularly effective for synthesizing heterocyclic compounds, pharmaceuticals, natural products, polymers, and advanced materials. Eaton's reagent has also been shown to facilitate solvent-free and eco-friendly synthetic methodologies, aligning with the increasing demand for sustainable chemical processes. This review consolidates recent advancements and applications of Eaton's reagent, underscoring its critical role in advancing synthetic methodologies and providing a foundation for future research to explore innovative reactions, mechanisms, and broader applications in organic synthesis.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ionic Liquid Functionalized Tragacanth Gum Hydrogel for Methyl Orange: Radiation Synthesis, Structure–Properties, and Selective Adsorption 甲基橙用离子液体功能化黄歌胶水凝胶：辐射合成、结构、性能及选择性吸附

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-07-21 DOI: 10.1002/slct.202501771

Xin Yang, Jifu Du, Zhen Dong, Long Zhao

{"title":"Ionic Liquid Functionalized Tragacanth Gum Hydrogel for Methyl Orange: Radiation Synthesis, Structure–Properties, and Selective Adsorption","authors":"Xin Yang, Jifu Du, Zhen Dong, Long Zhao","doi":"10.1002/slct.202501771","DOIUrl":"https://doi.org/10.1002/slct.202501771","url":null,"abstract":"The selective adsorption of purely targeted dye from mixed dye solutions draws significant attention for potential recovery and reuse. In this work, a series of alkyl substituted ionic liquids (1-alkyl -3-vinyl- imidazolium bromide [CnVIm]Br, n = 4, 6, 8, 10, and 12) modified tragacanth gum (TG-CnBr) was synthesized by radiation technique. The prepared TG based hydrogel was used to separate the molecules of methyl orange (MO) from the mixed anionic dyes. The correlation between the length of alkyl chain and the adsorption performance was investigated. TG-C12Br demonstrated the highest adsorption performance to MO among all the tested anionic dyes. The selectivity coefficient for MO versus indigo carmine (IC) and acid fuchsin (AF) are 5.856 and 107.5, respectively. The optimal conditions for the adsorption of MO were pH of 6.0, adsorbent dose of 0.6 mg/L, and contact time of 420 min. The maximum adsorption capacity of MO on TG-C12Br at 25, 35 and 50 °C are 389.11, 400.00, and 414.94 mg/g, respectively. The MO removal was enhanced under high salinity condition. The adsorption of MO probably through hydrophobic adsorption, hydrogen bond, electrostatic attraction, and π−π interactions. Therefore, TG-C12Br prepared by radiation technique exhibited a promising application prospect for selective adsorption of MO dye.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Synthesis of Nanoengineered Pt-Doped Au Nanoparticles Using Punica granatum Leaf Extract for Enhanced Cytotoxicity Against SH-SY5Y Neuroblastoma Cells 利用石榴叶提取物绿色合成纳米工程pt掺杂金纳米颗粒增强对SH-SY5Y神经母细胞瘤细胞的细胞毒性

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-07-21 DOI: 10.1002/slct.202502073

Dr. Somnath Devidas Bhinge, Shagufta Juber Pathan, Sejal Sanjay Kamble, Pallavi Namdev Patil, Kiran Datttray Sable, Mangesh Anil Bhutkar, Shubhangi Patil, Vinay Bagal, Anil Savali

{"title":"Green Synthesis of Nanoengineered Pt-Doped Au Nanoparticles Using Punica granatum Leaf Extract for Enhanced Cytotoxicity Against SH-SY5Y Neuroblastoma Cells","authors":"Dr. Somnath Devidas Bhinge, Shagufta Juber Pathan, Sejal Sanjay Kamble, Pallavi Namdev Patil, Kiran Datttray Sable, Mangesh Anil Bhutkar, Shubhangi Patil, Vinay Bagal, Anil Savali","doi":"10.1002/slct.202502073","DOIUrl":"https://doi.org/10.1002/slct.202502073","url":null,"abstract":"The study aimed to develop an eco-friendly method for synthesizing bimetallic gold-platinum nanoparticles using Punica granatum ethanolic extract (PuGr-Pt-Au-BiNPs) and to evaluate their therapeutic potential. A green synthesis approach was employed to fabricate these multimetallic nanoparticles, which were subsequently characterized using spectroscopic, microscopic, calorimetric, and zeta potential analyses. The nanoparticles exhibited an irregular morphology with an average size of 18.13 ± 5.6109 nm and a zeta potential of −27.8 mV, indicating good colloidal stability. In cytotoxicity studies, PuGr-Pt-Au-BiNPs exhibited significantly higher inhibitory activity (65.74 ± 1.2200%) compared to the crude extract (48.25 ± 0.6202%) and showed an IC₅₀ value of 52.14 µg mL −1 against SH-SY5Y neuroblastoma cells. Notably, the nanoparticles exhibited minimal toxicity against normal L-929 fibroblast cells, even at higher concentrations, confirming their biocompatibility. These favorable outcomes can be attributed to the nanoparticles nanoscale dimensions, low polydispersity, and enhanced surface reactivity, which collectively facilitate improved interaction with biological systems. These findings underscore the therapeutic potential of green-synthesized PuGr-Pt-Au-BiNPs as selective, biocompatible agents with potent anticancer activity against neuroblastoma, supporting their applicability in future biomedical and pharmaceutical interventions.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Al-Based Porphyrin Metal-Organic Framework for the Reduction of Carbon Dioxide to Formic Acid 铝基卟啉金属-有机骨架将二氧化碳还原为甲酸

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-07-21 DOI: 10.1002/slct.202500408

Muhammad Junaid, Taghrid S. Alomar, Muhammad Nadeem, Najla AlMasoud, Amal A. Al-wallan, Zeinhom M. El-Bahy, Hafiz Muhammad Asif

{"title":"Al-Based Porphyrin Metal-Organic Framework for the Reduction of Carbon Dioxide to Formic Acid","authors":"Muhammad Junaid, Taghrid S. Alomar, Muhammad Nadeem, Najla AlMasoud, Amal A. Al-wallan, Zeinhom M. El-Bahy, Hafiz Muhammad Asif","doi":"10.1002/slct.202500408","DOIUrl":"https://doi.org/10.1002/slct.202500408","url":null,"abstract":"In this study, a porphyrin-based photocatalyst, TCPP@AlMOF, was synthesized and thoroughly characterized for its ability to capture and convert CO₂ under xenon lamp illumination. The synthesized framework was confirmed through a combination of spectroscopic and structural analyses, including ¹H NMR, PXRD, BET, BJH, TGA-DSC, FTIR, and SEM. BET surface area measurements showed a decrease from 272.5 m2/g (before CO2 reduction experiment) to 234.1 m2/g (after CO2 reduction experiment), indicating effective interaction of CO₂ with the porous framework. The maximum CO₂ adsorption capacity was found to be 0.168 mmol/g, with a desorption efficiency of 4.44%, while regenerated TCPP@AlMOF retained partial adsorption capability, demonstrating its recyclability. FTIR and GC-MS studies confirmed the conversion of CO₂ into formic acid, with no significant byproducts detected. Electrochemical studies using LSV and chronoamperometry established the diffusion-controlled nature of the reduction process and the stability of the catalyst under operating conditions. Compared to other known photocatalytic systems, TCPP@AlMOF offers a visible light active, metal-free platform with efficient CO2 reduction capability under mild conditions. This work highlights the potential of porphyrin-functionalized MOFs for sustainable CO2 conversion.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Effect of Aspartate on Chrysophyllum africanum Adsorption on Steel in Saline Media: Experimental and Theoretical Insights 天冬氨酸对非洲菊花在盐水介质中吸附钢的协同作用：实验和理论见解

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-07-21 DOI: 10.1002/slct.202500729

C. L. Ohia, D. I. Njoku, M. A. Chidiebere, B. I. Onyeachu, E. E. Oguzie, Prisca Chiamaka Onuoha

{"title":"Synergistic Effect of Aspartate on Chrysophyllum africanum Adsorption on Steel in Saline Media: Experimental and Theoretical Insights","authors":"C. L. Ohia, D. I. Njoku, M. A. Chidiebere, B. I. Onyeachu, E. E. Oguzie, Prisca Chiamaka Onuoha","doi":"10.1002/slct.202500729","DOIUrl":"https://doi.org/10.1002/slct.202500729","url":null,"abstract":"This study explores the corrosion inhibition potential of Chrysophyllum africanum (CA) biomass extract on mild steel in a 3.5% NaCl solution and how its performance is enhanced by blending with aspartic acid (AA). While both CA and AA exhibit low inhibition efficiencies individually of about 40% and 35%, respectively in neutral environments, their blending significantly improves protection, achieving up to 89.1% inhibition efficiency. GC-MS and FTIR were employed to characterize the CA's active components. The corrosion inhibition was assessed using gravimetric, electrochemical, and surface imaging techniques. A proposed mechanism highlights that the dissociation of AA in aqueous solution and its proton-donating ability promote electrostatic adsorption in neutral media, which is otherwise limited. Computational studies using DFT and MDS simulations support this synergy, revealing increased adsorption energies when CA is blended with AA. The synergistic interaction, quantified with an index of 0.339, demonstrates a cooperative effect between the two agents. These findings suggest that blending CA with AA offers a promising, eco-friendly corrosion inhibitor for mild steel in saline environments.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Characterization of Pectin/HEMA/ZrO2 Composite Via Gamma Irradiation: Antimicrobial and Anti-Inflammatory Activities 果胶/HEMA/ZrO2复合材料的制备及γ辐射表征：抗菌和抗炎活性

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-07-21 DOI: 10.1002/slct.202502158

Tarek Mansour Mohamed, Asmaa sayed Ali, Ghada A. Mahmoud

{"title":"Preparation and Characterization of Pectin/HEMA/ZrO2 Composite Via Gamma Irradiation: Antimicrobial and Anti-Inflammatory Activities","authors":"Tarek Mansour Mohamed, Asmaa sayed Ali, Ghada A. Mahmoud","doi":"10.1002/slct.202502158","DOIUrl":"https://doi.org/10.1002/slct.202502158","url":null,"abstract":"This study explores the gamma radiation-assisted synthesis of a novel biodegradable polymeric composite composed of pectin (PC), poly 2-hydroxyethyl methacrylate (HEMA), and polypropylene glycol (PPG) as a cross-linker reinforced with zirconium dioxide (ZrO₂) nanoparticles, PC/PHEMA/ ZrO₂. Gamma radiation induces polymerization and crosslinking while promoting the decomposition of zirconium oxychloride (ZrOCl₂) to form ZrO₂ nanoparticles in situ. The optimized formulation (PC: HEMA: PPG: ZrO₂ = 2:20:2:1 wt%) was obtained at a 10 kGy irradiation dose. The hydrogel exhibited a moderate swelling capacity, with rapid initial water uptake and equilibrium at ∼81. The second-order swelling kinetic model provided a better fit to the experimental data than the first-order kinetic one. X-ray diffraction (XRD) analysis confirmed the hydrogel's amorphous nature, showing no changes upon ZrO₂ incorporation. Scanning electron microscopy (SEM) revealed that the addition of PPG enhanced structural uniformity, while ZrO₂ increased surface roughness, which may improve antimicrobial properties. Biocompatibility tests showed high cell viability (IC50 = 224.16 ± 2.52 µg/mL in oral epithelial cells), indicating its potential for biomedical applications. Antimicrobial evaluation confirmed the composite's effectiveness against pathogenic microorganisms, and anti-inflammatory assays demonstrated significant activity (IC50 = 9.43 µg/mL). PC/PHEMA/ZrO₂ holds promise for biomedical applications due to its biocompatibility, antimicrobial efficiency, and anti-inflammatory properties.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design, Synthesis, and Structure–Activity Relationship (SAR) Studies of Novel Disubstituted Benzimidazole Derivatives as Potential Anti-HIV and Antimicrobial Agents 新型二取代苯并咪唑衍生物的设计、合成及构效关系研究

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-07-21 DOI: 10.1002/slct.202500615

Dr. Tushar Ranjan Mohapatra, Dr. Swastika Ganguly, Rahul Ghosh, Dr. Kiattawee Choowngkomon

{"title":"Design, Synthesis, and Structure–Activity Relationship (SAR) Studies of Novel Disubstituted Benzimidazole Derivatives as Potential Anti-HIV and Antimicrobial Agents","authors":"Dr. Tushar Ranjan Mohapatra, Dr. Swastika Ganguly, Rahul Ghosh, Dr. Kiattawee Choowngkomon","doi":"10.1002/slct.202500615","DOIUrl":"https://doi.org/10.1002/slct.202500615","url":null,"abstract":"Human immunodeficiency virus (HIV), the causative agent of acquired immunodeficiency syndrome (AIDS), significantly weakens the immune system, increasing susceptibility to opportunistic infections such as tuberculosis, bacterial, and fungal diseases. In this study, a series of 17 novel benzimidazole-based derivatives were designed and synthesized via a reflux method using potassium carbonate as a catalyst. Structural confirmation of the synthesized molecules was achieved through advanced spectroscopic techniques, including proton and carbon nuclear magnetic resonance (1H-NMR and 13C-NMR), mass spectrometry, and elemental analysis. The compounds were evaluated for their potential antiviral (anti-HIV), anti-mycobacterial, antibacterial, and antifungal activities. One of the synthesized benzimidazole derivatives demonstrated remarkable HIV inhibition, achieving approximately 88% relative inhibition. Another analog exhibited strong anti-mycobacterial activity against Mycobacterium smegmatis with a minimum inhibitory concentration (MIC) of 0.195 µg/mL, and also showed potent antibacterial effects against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa, with MIC values ranging from 3.125 µg/mL to 6.25 µg/mL. Additionally, a different benzimidazole derivative displayed significant antifungal activity, with MIC values of 6.25 µg/mL against Candida albicans and 3.125 µg/mL against Aspergillus niger. To gain insights into the molecular interactions and pharmacokinetic profiles, molecular docking studies and in silico ADME (Absorption, Distribution, Metabolism, and Excretion) predictions were conducted on the most active compounds. The results underscore the potential of benzimidazole-based scaffolds as promising multifunctional agents targeting HIV and co-infecting microbial pathogens.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144672795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Zeolite-Catalyzed Stereoselective Synthesis of Glycosylated 4-Thiazolidinones with Selective Anticancer Activity Against Rhabdomyosarcoma 沸石催化立体选择性合成具有选择性抗横纹肌肉瘤活性的糖基化4-噻唑烷酮

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-07-21 DOI: 10.1002/slct.202500717

Fernando J. Lorenzo, Agustina Gonzalez, Ana Paula Irazoqui, Ignacio O. Costilla, Claudia G. Buitrago, Darío C. Gerbino, Sandra D. Mandolesi, Romina A. Ocampo

引用次数: 0

Innovative Strategies for Oxygen Evolution Reaction Using Layered Double Hydroxide-Based Electrocatalysts 层状双氧水基电催化剂析氧反应的创新策略

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-07-21 DOI: 10.1002/slct.202502680

Zifeng Li, Honglin Gao, Li Che, Aiyi Dong

引用次数: 0

An Improved, Concise, and Scalable Approach for the Total Synthesis of Salvianolic Acid F 一种改进的、简洁的、可扩展的丹酚酸F全合成方法

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-07-21 DOI: 10.1002/slct.202503300

Huanjun Xu, Caicui Li, Yao Cheng, Xiaodan Wang, Xue Wang, Wei Sun, Lijuan Wang, Yiying Li, Wubo Wan, Jinhui Wang

引用次数: 0