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Enhancing Dry Reforming of Methane with Calcium-Substituted LaNiO₃ Perovskite Catalysts for Syngas Production and Carbon Resistance
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-23 DOI: 10.1002/slct.202403401
Chao-Wei Huang, Po-Chou Chen, Yu-Tang Lin, To-Yu Wang, Duo-Syuan Lin, Ying-Shuo Cheng, Dong-En Wu, Kanit Manatura, Wei-Yu Chen, Kun-Yi Andrew Lin, Andrew C. Chien
{"title":"Enhancing Dry Reforming of Methane with Calcium-Substituted LaNiO₃ Perovskite Catalysts for Syngas Production and Carbon Resistance","authors":"Chao-Wei Huang,&nbsp;Po-Chou Chen,&nbsp;Yu-Tang Lin,&nbsp;To-Yu Wang,&nbsp;Duo-Syuan Lin,&nbsp;Ying-Shuo Cheng,&nbsp;Dong-En Wu,&nbsp;Kanit Manatura,&nbsp;Wei-Yu Chen,&nbsp;Kun-Yi Andrew Lin,&nbsp;Andrew C. Chien","doi":"10.1002/slct.202403401","DOIUrl":"https://doi.org/10.1002/slct.202403401","url":null,"abstract":"<p>Perovskite La<sub>1-x</sub>Ca<sub>x</sub>NiO<sub>3</sub> catalysts doped with varying molar ratios of Ca (x = 0.1, 0.2, 0.3) were investigated to enhance the efficiency of dry reforming of methane (DRM). The experiments were conducted under operational conditions with a CO<sub>2</sub>/CH<sub>4</sub> feed ratio 1:1 at atmospheric pressure and various reaction temperatures ranging from 550 to 800 °C. At 800 °C, the LaNiO<sub>3</sub> catalyst achieved a CH<sub>4</sub> conversion rate of 63.3% and a syngas H<sub>2</sub>/CO ratio of 0.56. In contrast, the La<sub>1-x</sub>Ca<sub>x</sub>NiO<sub>3</sub> catalyst, with partial substitution of Ca where x = 0.3, demonstrated markedly enhanced CH<sub>4</sub> conversion rates of 98.05%, coupled with syngas production showcasing an H<sub>2</sub>/CO ratio of 0.98. This underscores the superior catalytic activity of the Ca-substituted perovskite LaNiO<sub>3</sub> catalysts, which not only achieved a comparable CH<sub>4</sub> conversion rate at 800 °C but also allowed for the adjustment of the syngas H<sub>2</sub>/CO ratio closer to 1.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in the Synthesis of 3-Cyanoindoles: A Literature Review
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-23 DOI: 10.1002/slct.202405473
Gaurav Badoni, Chandra Bhan Singh, Sakshi Benjwal, Dr. Surendra Puri
{"title":"Recent Advances in the Synthesis of 3-Cyanoindoles: A Literature Review","authors":"Gaurav Badoni,&nbsp;Chandra Bhan Singh,&nbsp;Sakshi Benjwal,&nbsp;Dr. Surendra Puri","doi":"10.1002/slct.202405473","DOIUrl":"https://doi.org/10.1002/slct.202405473","url":null,"abstract":"<p>Indole-based molecules represent a class of organic compounds that have attracted significant attention due to their remarkable chemical properties. Among these, 3-cyano indole is a highly valuable precursor in organic synthesis. Incorporating a cyano group into the indole ring opens new pathways for synthesizing a diverse range of functionalized indole derivatives. Furthermore, the 3-cyano indoles core also exists in many biologically interesting compounds, attracting and inspiring scientists and researchers to develop novel methodologies with unique functional group diversification around the 3-cyano indole to actively pursue the discovery of innovative methods capable of making a significant impact in the preparation of therapeutic agents for drug discoveries and development.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Overview on Recent Progress of Microsphere-Hydrogel Combination Systems as Scaffolds for Tissue Engineering
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-23 DOI: 10.1002/slct.202405745
Qianfen Qi, Rongcai Liang, Baoqi Ding, Jiaxin Liu, Limei Xie, Meihua Deng, Chao Lin, Zhizhao Yuan, Xiuzhi Wang, Sijin Duan, Chunguang Ren
{"title":"An Overview on Recent Progress of Microsphere-Hydrogel Combination Systems as Scaffolds for Tissue Engineering","authors":"Qianfen Qi,&nbsp;Rongcai Liang,&nbsp;Baoqi Ding,&nbsp;Jiaxin Liu,&nbsp;Limei Xie,&nbsp;Meihua Deng,&nbsp;Chao Lin,&nbsp;Zhizhao Yuan,&nbsp;Xiuzhi Wang,&nbsp;Sijin Duan,&nbsp;Chunguang Ren","doi":"10.1002/slct.202405745","DOIUrl":"https://doi.org/10.1002/slct.202405745","url":null,"abstract":"<p>Tissue engineering aiming to develop and manufacture bioactive tissue or organ substitutes has been extensively studied. As an ideal scaffold material, the microsphere-hydrogel combination system (MHCS), which combines the excellent functionalities of hydrogels and the unique structural advantages of microspheres, has been widely used in the development of biological substitutes for tissue engineering. With adjustable mechanical properties, the MHCS can simulate extracellular matrix-like microstructure and microenvironment conducive to cell growth. These properties endow the MHCS with unique advantages in tissue repair, leading to significant progress in the regeneration of bone, skin, blood vessels, nerves, and other tissues. In this paper, we reviewed the latest progress in MHCS construction based on natural polymers, synthetic polymers, inorganic materials, and their composites. We also classified the raw materials that were utilized for the construction of microspheres and hydrogels and discussed the properties and applications of MHCS. Finally, the challenges and perspectives of MHCS were emphasized and pointed out the direction of future development, such as conducted advanced processing technologies and multidisciplinary cooperation to solve the limitations of uneven microsphere distribution and mismatched degradation rates, thus providing a reference for the design and fabrication of MHCS in the field of tissue engineering.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unveiling the Synthesis, Characterization, and Multifunctional Applications of Ca₅(PO₄)₃F@Ca₅P₈ Nanocomposites From Phosphate Waste for Antioxidant Activity and Evans Bleu Decomposition
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-23 DOI: 10.1002/slct.202406193
Amina Tabet, Abderrhmane Bouafia, Khansaa Al-Essa, Ibtissam Laib, Salah Eddine Laouini, Fahad Alharthi, Abdullah Al Souwaileh, Mokni-Tlili Sonia, Tomasz Trzepieciński
{"title":"Unveiling the Synthesis, Characterization, and Multifunctional Applications of Ca₅(PO₄)₃F@Ca₅P₈ Nanocomposites From Phosphate Waste for Antioxidant Activity and Evans Bleu Decomposition","authors":"Amina Tabet,&nbsp;Abderrhmane Bouafia,&nbsp;Khansaa Al-Essa,&nbsp;Ibtissam Laib,&nbsp;Salah Eddine Laouini,&nbsp;Fahad Alharthi,&nbsp;Abdullah Al Souwaileh,&nbsp;Mokni-Tlili Sonia,&nbsp;Tomasz Trzepieciński","doi":"10.1002/slct.202406193","DOIUrl":"https://doi.org/10.1002/slct.202406193","url":null,"abstract":"<p>This study explores the innovative synthesis and versatile applications of Ca₅(PO₄)₃F@Ca₅P₈ nanocomposites (NCs), crafted from phosphate waste sourced from Djebel Onk, Algeria, advancing sustainable material use and environmental remediation. FTIR analysis unveiled distinct functional groups, including C─H, P─H, P─O, and F─Ca, underscoring the material's chemical richness, while XRD revealed a crystalline architecture blending hexagonal (Ca₅(PO₄)₃F) and monoclinic (Ca₅P₈) phases, with a precise crystallite size of 22.45 ± 1.18 nm. SEM and EDS showcased uniform spherical particles averaging 24 nm, brimming with Ca, P, O, and F elements. Optical properties dazzled with peak absorption at 391 nm, direct and indirect bandgaps of 1.62 and 2.98 eV, and an Urbach energy of 0.435 eV, signaling exceptional UV–visible absorption capabilities. Beyond its structural elegance, the nanocomposite exhibited remarkable antioxidant prowess, neutralizing nearly 100% of hydrogen peroxide, and delivered striking photocatalytic performance, degrading 99.2% of Evans Blue dye in just 140 min (rate constant 0.01334 min<sup>−1</sup>). Antibacterial assays further highlighted its potency, effectively combating <i>S. aureus</i>, <i>C. albicans</i>, and other microbes. These compelling results position Ca₅(PO₄)₃F@Ca₅P₈ NCs as a multifunctional powerhouse for water treatment, photocatalysis, and antibacterial applications, paving the way for sustainable technological breakthroughs.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Quinazoline-1,3,4-Oxadiazole Linked 1,2,3-Triazole Hybrids as Potent EGFR Targeting Antilung Cancer Agents: In Vitro, In Silico, and DFT Studies
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-23 DOI: 10.1002/slct.202500049
Sampath peddapelli, Mahadev Dattatray Bandgar, Ravikumar Kapavarapu, Joshodeep Boruwa, Rambabu Palabindela, Sirassu Narsimha
{"title":"Synthesis of Quinazoline-1,3,4-Oxadiazole Linked 1,2,3-Triazole Hybrids as Potent EGFR Targeting Antilung Cancer Agents: In Vitro, In Silico, and DFT Studies","authors":"Sampath peddapelli,&nbsp;Mahadev Dattatray Bandgar,&nbsp;Ravikumar Kapavarapu,&nbsp;Joshodeep Boruwa,&nbsp;Rambabu Palabindela,&nbsp;Sirassu Narsimha","doi":"10.1002/slct.202500049","DOIUrl":"https://doi.org/10.1002/slct.202500049","url":null,"abstract":"<p>This research focuses on the design and synthesis of novel quinazoline-1,3,4-oxadiazole linked 1,2,3-triazoles. Subsequently, it investigates their in vitro inhibitory effects on EGFR kinases and anticancer efficacy against lung cancer cell lines A-549 and H1299. Compared to the primary compound, erlotinib, most tested compounds demonstrated superior efficacy. The compounds 2-(((1-(3,5-difluorophenyl)-1<i>H</i>-1,2,3-triazol-4-yl)methyl)sulfonyl)-5-(quinazoline-5-yl)-1,3,4-oxadiazole, 2-(((1-(3,5-dichlorophenyl)-1<i>H</i>-1,2,3-triazol-4-yl)methyl)sulfonyl)-5-(quinazolin-5-yl)-1,3,4-oxadiazole, and 2-(((1-(4-fluorophenyl)-1<i>H</i>-1,2,3-triazol-4-yl)methyl)sulfonyl)-5-(quinazoline-5-yl)-1,3,4-oxadiazole showed strong anticancer activity against both cancer cell lines with IC<sub>50</sub> values ranging from 2.62 ± 0.65 to 4.21 ± 0.24 µM. The compounds exhibited notable kinase inhibitory activity with EGFR IC<sub>50</sub> values of 0.34 ± 0.03, 0.36 ± 0.04, and 0.43 ± 0.02 µM, respectively. In Silico docking experiments were conducted to assess the molecular interactions of more potent drugs with the human epidermal growth factor receptor, EGFR (PDB: 4HJO) proteins, which included a co-crystallized ligand (erlotinib). The results indicated that six active compounds exhibited significantly higher binding energies compared to standard medications. SWISS/ADME was used to estimate the in Silico pharmacokinetic profile of potent compounds. Geometric optimization was also used to determine the structural characteristics of compound 2-(((1-(3,5-difluorophenyl)-1<i>H</i>-1,2,3-triazol-4-yl)methyl)sulfonyl)-5-(quinazolin-5-yl)-1,3,4-oxadiazole. The molecular electrostatic potential (MEP) and HOMO-LUMO energy gap were determined.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
α-Aminophosphonates: Antimicrobial, Anti-Inflammatory, Antioxidant Activities, Molecular Docking, and DFT Studies
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-23 DOI: 10.1002/slct.202500015
Manel Lina Djendi, Chahrazed Benzaid, Malika Berredjem, Ismahene Grib, Rania Bahadi, Seif-Eddine Djouad, Khadidja Otmane Rachedi, Kheir Eddine Ouali, Ajmal R. Bhat, Anissa Acidi
{"title":"α-Aminophosphonates: Antimicrobial, Anti-Inflammatory, Antioxidant Activities, Molecular Docking, and DFT Studies","authors":"Manel Lina Djendi,&nbsp;Chahrazed Benzaid,&nbsp;Malika Berredjem,&nbsp;Ismahene Grib,&nbsp;Rania Bahadi,&nbsp;Seif-Eddine Djouad,&nbsp;Khadidja Otmane Rachedi,&nbsp;Kheir Eddine Ouali,&nbsp;Ajmal R. Bhat,&nbsp;Anissa Acidi","doi":"10.1002/slct.202500015","DOIUrl":"https://doi.org/10.1002/slct.202500015","url":null,"abstract":"<p>Three <i>α</i>-aminophosphonates derived from 2-hydroxybenzaldehyde were synthesized and evaluated their biological activities. The antimicrobial and antibiofilm properties of compounds 1A, 1B, and 1C were evaluated against a range of pathogenic bacteria and fungi, including four Gram-negative bacteria: <i>Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Serratia marcescens</i>; one Gram-positive bacterium: <i>Staphylococcus aureus</i>; and five yeasts of the Candida genus: <i>Candida albicans, Candida kefyr, Candida krusei, Candida lusitaniae</i>, and <i>Candida tropicalis</i>. The antioxidant activity of these compounds was assessed by DPPH (2,2-diphenyl-1-picrylhydrazyl). Determination of the anti-inflammatory activity of the compounds in vitro was carried out using bovine serum albumin (BSA) protein. Computational analysis was carried out using density functional theory (DFT) with the B3LYP 6–31G (d,p) basis set, and the theoretical results were correlated with experimental data. Molecular docking study was carried out to give insights into the interactions of three derivatives with the binding sites of thymidylate kinase (TMK) in <i>S. aureus</i>. Compound 1b uses its phenol group to create a hydrogen bond with the amino acid Gln101. Additionally, its phenyl ring engages in a π-stacking interaction with Tyr100 and Phe66 in the hydrophobic zone of the <i>S. aureus</i> TMK binding site.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ionic Liquids as Green Sustainable Materials in Textiles
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-23 DOI: 10.1002/slct.202405307
Moumita Saha, Dr. Farooq A. Wani, Dr. Manoj K. Banjare, Ambrish Kumar, Ritik Vishwakarma, Dr. Kamalakanta Behera, Dr. Shruti Trivedi
{"title":"Ionic Liquids as Green Sustainable Materials in Textiles","authors":"Moumita Saha,&nbsp;Dr. Farooq A. Wani,&nbsp;Dr. Manoj K. Banjare,&nbsp;Ambrish Kumar,&nbsp;Ritik Vishwakarma,&nbsp;Dr. Kamalakanta Behera,&nbsp;Dr. Shruti Trivedi","doi":"10.1002/slct.202405307","DOIUrl":"https://doi.org/10.1002/slct.202405307","url":null,"abstract":"<p>Textile industry is one of the major pollution causing sector which needs totally an eco-friendly process instead of traditional ones. From harvesting crops or synthesizing fibers which requires very large quantities of water with extreme chemicals, to discarded fabrics causing environmental damages, textile industry requires a complete green processing method. Green solvent like ionic liquids (ILs) are emerging as a new substitute in the textile engineering processes. ILs are formed by mainly organic cations and organic/inorganic anions having many attractive physicochemical properties like high conductivity, low vapor pressure, good thermal stability etc. Here, we have discussed how ILs can be involved in textile processing like coloring of fabric or introducing novel properties, and pollution control. Thus, great efforts are being made worldwide to show a cleaner production structure to decline the toxicity and environmental threat of textile chemicals. Ultimately the goal is to increases sustainability and provides an opportunity to make novel generations of textile processes and also produce high-valued innovative textiles for greater purpose.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Insilico Investigation of the Binding Interaction Mechanism of Vipoglanstat (GS- 248) with Microsomal Prostaglandin E Synthase-1 (mPGES1) and Bovine Serum Albumin (BSA)
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-23 DOI: 10.1002/slct.202405352
Alanthata Govindan Navaneeth, Subramani Karthikeyan
{"title":"An Insilico Investigation of the Binding Interaction Mechanism of Vipoglanstat (GS- 248) with Microsomal Prostaglandin E Synthase-1 (mPGES1) and Bovine Serum Albumin (BSA)","authors":"Alanthata Govindan Navaneeth,&nbsp;Subramani Karthikeyan","doi":"10.1002/slct.202405352","DOIUrl":"https://doi.org/10.1002/slct.202405352","url":null,"abstract":"<p>Microsomal Prostaglandin E Synthase-1 (mPGES1) is an enzyme involved in the biosynthesis of Prostaglandin E2 (PGE2), a prostanoid and pro-inflammatory lipid mediator that plays a role in both pathological and physiological functions in the human body. Elevated PGE2 levels are associated with inflammation and tissue fibrosis, key characteristics of scleroderma (systemic sclerosis). Consequently, inhibiting mPGES1 may reduce PGE2 production, thereby decreasing the severity of systemic sclerosis. Vipoglanstat (GS-248, (2-[2,6-dichloro-3-[(2,2-dimethylpropanoylamino) methyl] anilino]-6-(2,2-difluoroethoxy)-1-methyl-N-[4-(trifluoromethyl) cyclohexyl] benzimidazole-5-carboxamide), a small molecule in the carboxamide class, is a selective and potent mPGES1 inhibitor with demonstrated anti-inflammatory activity. This study investigates the molecular interactions of GS-248 with mPGES1 and the transport protein BSA using computational techniques such as molecular docking, DFT, molecular dynamics, and PCA analyses. Additionally, we compared the binding affinity of GS-248 to mPGES1 with that of the known inhibitor 4U9. Molecular docking results reveal binding scores of -6.71 kcal mol<sup>−1</sup> for the mPGES1-GS248 complex, -7.74 kcal mol<sup>−1</sup> for the mPGES1-4U9 complex, and -5.54 kcal mol<sup>−1</sup> for the BSA-GS248 complex. These findings suggest that GS-248 exhibits a binding affinity comparable to the reference inhibitor, highlighting its potential as an mPGES1 inhibitor. DFT calculations indicate that binding with mPGES1 and BSA decreases the energy gap of GS-248 from 4.74 to 1.82 eV and 1 eV, respectively, suggesting enhanced drug reactivity at the protein binding sites. Additionally, molecular dynamics simulations confirmed the stability of these protein-drug complexes. In silico toxicity evaluations using Swiss ADME and Protox2 further indicated the potential therapeutic viability of GS-248.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Divergent Access to Furans and Thiophenes by Chalcogenation of 2,3-Dihydrofurans with Elemental Chalcogens
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-23 DOI: 10.1002/slct.202501419
Quang Huy Tran, Cao Nguyen Nguyen, Ngoc Lan Chu, Dr. Thai Thanh Thu Bui, Prof. Thi Thu Tram Nguyen, Minh Tu Ha, Prof.Dr. Dinh Hung Mac, Dr. Thanh Binh Nguyen
{"title":"Divergent Access to Furans and Thiophenes by Chalcogenation of 2,3-Dihydrofurans with Elemental Chalcogens","authors":"Quang Huy Tran,&nbsp;Cao Nguyen Nguyen,&nbsp;Ngoc Lan Chu,&nbsp;Dr. Thai Thanh Thu Bui,&nbsp;Prof. Thi Thu Tram Nguyen,&nbsp;Minh Tu Ha,&nbsp;Prof.Dr. Dinh Hung Mac,&nbsp;Dr. Thanh Binh Nguyen","doi":"10.1002/slct.202501419","DOIUrl":"https://doi.org/10.1002/slct.202501419","url":null,"abstract":"<p>A switchable chalcogenation of 2,3-dihydrofurans with elemental sulfur or molecular oxygen to construct fully substituted thiophenes or furans was developed. In this version of thiophene generation, the sulfuration occurs through a cascade of sulfurative ring editing with inexpensive sulfur powder. Conversely, the production of furans is enabled by aerobic oxidation in basic media.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of Quercetin Extraction from Schisandra Chinensis by an Ultrasound-Assisted Ionic Liquid-Enzyme Composite System and Its Antioxidant Research Analysis
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-23 DOI: 10.1002/slct.202500400
Jingwei Hao, Yi Zhou, Xiangkun Zhou, Qiuxuan Li, Yingying Pei, Nan Dong, Yifan Sun, Heming Liu
{"title":"Optimization of Quercetin Extraction from Schisandra Chinensis by an Ultrasound-Assisted Ionic Liquid-Enzyme Composite System and Its Antioxidant Research Analysis","authors":"Jingwei Hao,&nbsp;Yi Zhou,&nbsp;Xiangkun Zhou,&nbsp;Qiuxuan Li,&nbsp;Yingying Pei,&nbsp;Nan Dong,&nbsp;Yifan Sun,&nbsp;Heming Liu","doi":"10.1002/slct.202500400","DOIUrl":"https://doi.org/10.1002/slct.202500400","url":null,"abstract":"<p>In this study, the effects of enzyme addition, ionic liquid concentration, and sonication time on the yield of quercetin in <i>Schisandra chinensis</i> (<i>S. chinensis</i>) were investigated by one-way experiments and their interactions were investigated with enzyme addition, ionic liquid concentration and sonication time as independent variables. The results showed that when the enzyme addition was 16.413%, the ionic liquid was 1-butyl-3-methylimidazolium chloride salt with the concentration of 0.390 mol/L, and the ultrasonication time was 43.770 min, the yield was 0.539 mg/g, which was 8.694 times higher than that of the traditional reflux extraction method. By network pharmacological analysis, 1867 antioxidant targets of quercetin in <i>S. chinensis</i> were screened out.GO and KEGG enrichment analyses indicated that the antioxidant function might be related to the chemical carcinogenesis-reactive oxygen species pathway, PI3K-Akt signalling pathway. The antioxidant activity of quercetin was also investigated by determining the scavenging ability of quercetin on DPPH and hydroxyl radicals. The results showed that the scavenging rates of quercetin on both were 94.510% and 64.922% when the quality concentration of quercetin was 0.06 and 0.4 mg/mL, respectively, and the scavenging rates basically remained unchanged with the increase of concentration.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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