ChemistrySelect最新文献

筛选
英文 中文
Sustainable Approaches for Pharmaceutical Pollutant Removal: Advances in Chitosan-Based Nanocomposite Adsorbents
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-02 DOI: 10.1002/slct.202405962
Hossein Dinarvand, Omid Moradi
{"title":"Sustainable Approaches for Pharmaceutical Pollutant Removal: Advances in Chitosan-Based Nanocomposite Adsorbents","authors":"Hossein Dinarvand,&nbsp;Omid Moradi","doi":"10.1002/slct.202405962","DOIUrl":"https://doi.org/10.1002/slct.202405962","url":null,"abstract":"<p>The growing presence of pharmaceutical pollutants in aquatic environments poses significant threats to both human health and ecosystems. Despite their crucial role in healthcare, pharmaceuticals enter water systems through various sources, making them some of the most critical environmental contaminants. Traditional wastewater treatments, which are classified into physical, chemical, and biological techniques, often struggle to effectively remove pharmaceuticals. Among these methods, adsorption stands out as a reliable and versatile approach for removing organic pollutants and enhancing the efficiency of wastewater treatment processes. Biopolymers, particularly chitosan, are gaining attention due to their numerous advantages, including biocompatibility, biodegradability, affordability, high adsorption capability, non-toxicity, and availability from diverse natural sources. Chitosan, a hydrophilic biopolymer, can be chemically modified by incorporating various nanoparticles (e.g., metal oxides, carbon-based materials, and magnetic particles) to boost its adsorption efficiency. These advancements enable chitosan-based nanocomposites to effectively remove a range of pharmaceuticals, including antibiotics, analgesics, and hormones, from water. This review examines the latest developments in chitosan-based nanocomposite adsorbents, emphasizing their fundamental adsorption mechanisms, optimization conditions, kinetic behaviors, and isotherm models. These factors collectively determine the efficiency of nanocomposites in capturing pharmaceutical pollutants. Moreover, the review underscores the potential of these materials for environmental remediation, offering valuable insights into their application and future research directions. Ultimately, the aim of this review is to provide insight into chitosan-based nanocomposite adsorbents, which offer an innovative and effective solution to the challenge of pharmaceutical contamination in water. By addressing key challenges and utilizing advanced material designs, these adsorbents hold great promise for the sustainable and efficient removal of pollutants in environmental systems.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 13","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bovine Serum Albumin Nanoparticles as Versatile Carriers for Enhancing the Multifunctional Efficacy of Protocatechuic Acid
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-02 DOI: 10.1002/slct.202405320
Alaa I. Ibrahim, Adel M. Attia, Heba A. Sahyon, Ashraf A. El-Shehawy
{"title":"Bovine Serum Albumin Nanoparticles as Versatile Carriers for Enhancing the Multifunctional Efficacy of Protocatechuic Acid","authors":"Alaa I. Ibrahim,&nbsp;Adel M. Attia,&nbsp;Heba A. Sahyon,&nbsp;Ashraf A. El-Shehawy","doi":"10.1002/slct.202405320","DOIUrl":"https://doi.org/10.1002/slct.202405320","url":null,"abstract":"<p>Protocatechuic acid (PCA) has antioxidant, anticancer, and antidiabetic properties. However, its poor water solubility affects its absorption and bioavailability. Bovine serum albumin nanoparticles (BSA-NPs) can encapsulate significant amounts of hydrophobic substances by attracting charged molecules through electrostatic adsorption. This study aimed to prepare PCA-loaded BSA nanoparticles, producing PCA-BSA-NPs, and subsequently characterize the resulting nanocomposite using zeta potential, dynamic light scattering, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). In vitro, PCA-BSA-NPs were evaluated for their anticancer, antioxidant, and free radical scavenging properties. Our data indicated that the average particle size of PCA-BSA-NPs was 202 nm. The in vitro study demonstrated that PCA-BSA-NPs exhibited potent anticancer activity comparable to doxorubicin. Additionally, PCA-BSA-NPs displayed highly antioxidant activity (2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide dismutase (SOD) like activity, and catalytic activity) and a strong antidiabetic effect (<i>α</i>-amylase inhibition). The drug release study indicated the effective release of PCA from PCA-BSA-NPs at pH = 6.5, which is suitable for targeting cancer cells. In conclusion, PCA-BSA-NPs could provide a more effective and safer alternative to traditional chemotherapeutic agents like doxorubicin. Moreover, their higher antioxidant and antidiabetic activities could expand their therapeutic applications, making them valuable in treating oxidative stress-related diseases and diabetes.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 13","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green Plasma Technology for Converting Agricultural Residues Into High-Performance Activated Carbon for Energy Devices
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-02 DOI: 10.1002/slct.202405834
N. Karthikeyan, K. A. Vijayalakshmi, K. T. Maheswari
{"title":"Green Plasma Technology for Converting Agricultural Residues Into High-Performance Activated Carbon for Energy Devices","authors":"N. Karthikeyan,&nbsp;K. A. Vijayalakshmi,&nbsp;K. T. Maheswari","doi":"10.1002/slct.202405834","DOIUrl":"https://doi.org/10.1002/slct.202405834","url":null,"abstract":"<p>In order to increase the performance of rice husk-derived activated carbon (RHAC) in energy storage devices such as supercapacitors and aluminum-air (Al-air) batteries, this study explores the improvement of RHAC using atmospheric air plasma treatment. The surface features and electrochemical properties of RHAC were altered through plasma treatment. Several characterization methods, including electrochemical analysis, FE-SEM, XRD, FTIR, and Raman spectroscopy, revealed significant increases in surface area, porosity, and functional group formation, confirming the advantages of plasma treatment. Following plasma treatment, the RHAC exhibited considerable enhancement in specific capacitance, reaching 1298 F g⁻¹, and surface hydrophilicity, with the contact angle decreasing from 113° to 67°. By combining sustainable materials with innovative modification techniques, this research contributes to the development of eco-friendly and efficient energy storage solutions.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 13","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced Integrated Molecular Simulations Based Prediction of Sulfonamide Natural Compound Binding to Cytosolic Carbonic Anhydrase Enzymes
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-02 DOI: 10.1002/slct.202500158
Showkat Ahmad Mir, Archana Padhiary, Aiswarya Pati, Sherey Somam Tete, Nirius Jenen Ekka, Rajesh Kumar Meher, Iswar Baitharu, Mehboob Hoque, Binata Nayak
{"title":"Advanced Integrated Molecular Simulations Based Prediction of Sulfonamide Natural Compound Binding to Cytosolic Carbonic Anhydrase Enzymes","authors":"Showkat Ahmad Mir,&nbsp;Archana Padhiary,&nbsp;Aiswarya Pati,&nbsp;Sherey Somam Tete,&nbsp;Nirius Jenen Ekka,&nbsp;Rajesh Kumar Meher,&nbsp;Iswar Baitharu,&nbsp;Mehboob Hoque,&nbsp;Binata Nayak","doi":"10.1002/slct.202500158","DOIUrl":"https://doi.org/10.1002/slct.202500158","url":null,"abstract":"<p>This study explores the intricate interactions between sulfonamide natural compounds and the human cytosolic carbonic anhydrase (CA) isoform. hCA-II, the most commonly targeted physiological isoform for inhibiting glaucoma owing to its distribution in the cellular region of the eye. Here, we extensively analyzed natural compounds for their specific interaction with hCA-II, emphasizing the nature of their molecular associations and potential implications in biological processes. Over half a million natural compounds were filtered from two databases based on their structure-activity relationship (SAR) with 4-hydroxy-3-nitro-5-({[4-(trifluoromethyl)phenyl]carbamoyl}amino)benzene-1-sulfonamide (J3 V) and 628 SAR scaffolds were identified. Those molecules went through different toxicity checks and forty leads were discovered. All lead molecules were docked to the hCA-II active site among them thirty-two molecules showed better docking scores. The top hits compounds with higher drug-likeness, including J3V were explored further. MD simulation studies revealed that all four leads displayed comparable stability to the J3V with hCA-II for 200 ns. Umbrella sampling revealed that S32 had a lower <i>ΔG</i> (−57.88 kJ/mol) than J3V (−54.86 kJ/mol), indicating stronger binding. These results suggest undiscovered sulfonamide natural compounds, particularly S32, exhibit superior binding affinity and stability compared to J3V, potentially offering effective hCA-II inhibition for glaucoma management.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 13","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Highly Conductive Ni-Co Based Bimetallic Metal-Organic Framework and Coordinated Water Induced Selective Adsorption and Separation of Trace Amount of Methyl Blue from Aqueous System
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-01 DOI: 10.1002/slct.202501098
Uddit Narayan Hazarika, Arati Chetry, Jitupon Gogoi, Rinki Brahma, Ankur K. Guha, Kangkan Sarmah, Prithiviraj Khakhlary
{"title":"Highly Conductive Ni-Co Based Bimetallic Metal-Organic Framework and Coordinated Water Induced Selective Adsorption and Separation of Trace Amount of Methyl Blue from Aqueous System","authors":"Uddit Narayan Hazarika,&nbsp;Arati Chetry,&nbsp;Jitupon Gogoi,&nbsp;Rinki Brahma,&nbsp;Ankur K. Guha,&nbsp;Kangkan Sarmah,&nbsp;Prithiviraj Khakhlary","doi":"10.1002/slct.202501098","DOIUrl":"https://doi.org/10.1002/slct.202501098","url":null,"abstract":"<p>A bimetallic MOF (<b>NiCo-F</b>) was solvothermally crystallized in monoclinic unit cell with <i>P2<sub>1</sub>/c</i> space group containing in situ generated ligand, Ni<sup>2+</sup> and Co<sup>3+</sup> ions. The theoretical band gap was found to be 2.5 eV indicating its semiconducting nature. However, conductivity was higher with respect to the theoretical band gap. Therefore, besides through bond electrical conduction, coordinated water facilitated proton conductivity to significantly increase the overall conductivity. The MOF exhibits capacitance of 497 F/g at scan rate of 10 mV/s which impressive considering the specific capacitance of MOF derived supercapacitors. The coordinated water molecule induced selective adsorption of methyl blue (MeB) from the mixture of dyes in 100% aqueous system. High sensitivity enabled adsorption of trace amount of the target dye (upto 0.5 ppm) and efficiency reaches upto 90% within 40 min. The selective adsorption of MeB was attributed to the synthon type interactions between coordinated water molecule of <b>NiCo-F</b> and ─SO<sub>3</sub><sup>−</sup> group of MeB. The adsorption kinetics follows pseudo-second-order with Langmuir type adsorption indicating monolayer chemisorption at uniform sites. Moreover, <b>NiCo-F</b> exhibits impressive dye desorption behaviors which establishes the recyclability of the dye, stability of the MOF, and also the potentiality of reuse of the adsorbent for multiple times.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 13","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Novel Schiff Bases with Piperidine Rings and Investigation of Their Antioxidant Capacities and Anticholinesterase and Carbonic Anhydrase Enzyme Inhibition Properties
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-01 DOI: 10.1002/slct.202500365
Sertan Aytaç
{"title":"Synthesis of Novel Schiff Bases with Piperidine Rings and Investigation of Their Antioxidant Capacities and Anticholinesterase and Carbonic Anhydrase Enzyme Inhibition Properties","authors":"Sertan Aytaç","doi":"10.1002/slct.202500365","DOIUrl":"https://doi.org/10.1002/slct.202500365","url":null,"abstract":"<p>The use of Schiff bases especially in chemistry, medicine, pharmacy, and various industries has increased the importance of these compounds. Schiff bases and their derivatives show important bioactive properties in a wide range. Compounds containing phenol and its derivatives in their molecular structures have the potential to capture free radicals associated with various diseases. In this study, five new Schiff bases (13–17) having piperidine rings containing phenol groups, which have the potential to be used as antioxidants, were synthesized for the first time using microwave energy. The antioxidant effects of the compounds used in the syntheses (7–12) and the obtained new Schiff bases (13–17) and their inhibitory abilities against some metabolic enzymes including acetylcholinesterase (AChE) and human carbonic anhydrases I and II (hCAs I and hCAs II) were determined. In addition to the experimental findings, molecular docking studies of the compounds against human acetylcholinesterase were performed in order to provide ideas on structure-based drug design (PDB ID: 4EY6). In light of the results obtained, it is thought that this study will be useful and guide in the food, medical, and pharmaceutical industries in the future.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 13","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of Alkynyl Phosphite Ligands on the Curing of Pt(0)-Catalyzed Preparation of One-Component Silicone Rubber
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-01 DOI: 10.1002/slct.202405461
Shipeng Yuan, Peilong Jiang, Guiyou Zhu, Jianwei Guo
{"title":"Influence of Alkynyl Phosphite Ligands on the Curing of Pt(0)-Catalyzed Preparation of One-Component Silicone Rubber","authors":"Shipeng Yuan,&nbsp;Peilong Jiang,&nbsp;Guiyou Zhu,&nbsp;Jianwei Guo","doi":"10.1002/slct.202405461","DOIUrl":"https://doi.org/10.1002/slct.202405461","url":null,"abstract":"<p>The development of wide-range temperature-stabilized catalysts for one-component silicone rubber is challenging because the high room temperature activity of Karstedt's catalyst greatly diminishes the storage stability period of one-component silicone rubber. In this work, three catalyst ligands were constructed based on a transesterification reaction between alkynyl alcohols and phosphite, then were complexed with Karstedt's catalyst. The results of research and testing showed that the platinum-alkynyl phosphite catalysts have better room temperature stability, in which the catalyst synthesized with the ligand tris(trimethyldodecynyl) phosphite (<b>L2</b>) enabled the silicone rubber to be stored at room temperature for more than 30 days and cured rapidly at 120 °C. Adding this catalyst not only preserved the original performance properties of silicone rubber but also enhanced its thermal stability and mechanical properties. The ligand acted as a substituent to complex with Karstedt's catalyst to inhibit its activity, thus solving the problem of poor storage stability of one-component silicone rubber at room temperature.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 13","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Amidoquinoline-Isatin-Linked 1,2,3-Triazole: Selective Pb(II) Sensor and In Silico Biological Insights
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-01 DOI: 10.1002/slct.202500312
Pooja Duhan, Bajrang Lal, Gurleen Singh, Jandeep Singh, Gurpreet Kaur, Ram Kumar Tittal
{"title":"Amidoquinoline-Isatin-Linked 1,2,3-Triazole: Selective Pb(II) Sensor and In Silico Biological Insights","authors":"Pooja Duhan,&nbsp;Bajrang Lal,&nbsp;Gurleen Singh,&nbsp;Jandeep Singh,&nbsp;Gurpreet Kaur,&nbsp;Ram Kumar Tittal","doi":"10.1002/slct.202500312","DOIUrl":"https://doi.org/10.1002/slct.202500312","url":null,"abstract":"<p>Amidoquinoline-isatin-linked 1,2,3-triazole based probe was synthesized for Pb(II) sensing. The probe demonstrated a notable hypochromic shift at λ<sub>max</sub> = 305 nm, with a hyperchromic response around λ<sub>max</sub> = 265 nm, and an isosbestic point at λ = 270 nm. The LOD and LOQ for Pb(II) sensing were 0.026 and 0.087 mM, respectively. The job's plot analysis revealed a 1:1 stoichiometry between the probe and Pb(II) ions. The metal complex was found stable at varying time and temperature. The DFT/TD-DFT calculations offered valuable insights into the molecular interactions of probe and its complex. Additionally, in silico pharmacological studies and molecular docking results augmented the importance of the probe.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 13","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the Interaction between the Antineoplastic Drug Bexarotene and Double-stranded DNA Using Electrochemical, Spectroscopic, and Molecular Docking Studies
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-01 DOI: 10.1002/slct.202405000
Ruqia Khan, Çiğdem Kanbeş Dindar, Arzu Karayel, Hülya Silah, Selda Zengin Kurnalı, Ali Haider, Bengi Uslu
{"title":"Evaluating the Interaction between the Antineoplastic Drug Bexarotene and Double-stranded DNA Using Electrochemical, Spectroscopic, and Molecular Docking Studies","authors":"Ruqia Khan,&nbsp;Çiğdem Kanbeş Dindar,&nbsp;Arzu Karayel,&nbsp;Hülya Silah,&nbsp;Selda Zengin Kurnalı,&nbsp;Ali Haider,&nbsp;Bengi Uslu","doi":"10.1002/slct.202405000","DOIUrl":"https://doi.org/10.1002/slct.202405000","url":null,"abstract":"<p>Developing precise, quick, and affordable calf thymus double stranded deoxyribonucleic acid, ct-dsDNA, detection methods and understanding the structural alterations of ct-dsDNA following exposure to antineoplastic drugs is extraordinarily prominent. In this context, the destination of this search is to thrive an electrochemical ct-dsDNA biosensor to quantify bexarotene (BEX) and elucidate its DNA interaction mechanism. The interaction mechanism between DNA and BEX was analyzed by differential pulse voltammetry, fluorescence spectroscopy, and molecular docking analysis. The electrochemical experiment results indicated a significant interplay between BEX and ct-dsDNA, as seen by the reduced oxidation signals of deoxyadenosine (dAdo) and deoxyguanosine (dGuo) in the presence of BEX. The binding constant value (<i>K</i><sub>b</sub>) between ct-dsDNA and BEX was computed as 2.33×10<sup>4</sup> L/mol at room temperature by using spectrofluorimetric measurements. Also, quantitative evaluation of thermodynamic data (Δ<i>S</i> = −10.24 cal mol<sup>−1</sup> K<sup>−1</sup> and ΔH = −18.17 kcal mol<sup>−1</sup> for BEX – ct-dsDNA complex predicted the contribution of van der Waals interplays and hydrogen bonds in the BEX–ct-dsDNA, as did molecular docking analysis. In molecular docking analysis, the binding energy of BEX with DNA is −7.2 kcal mol<sup>−1</sup>, and it creates one powerful inter-molecular hydrogen bond besides van der Waals interactions.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 13","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Technologies for the Determination of SARS-CoV-2 in Wastewater
IF 1.9 4区 化学
ChemistrySelect Pub Date : 2025-04-01 DOI: 10.1002/slct.202404698
Nolwazi T. Gazu, Aoife Morrin, Xolile Fuku, Prof. Bhekie B. Mamba, Usisipho Feleni
{"title":"Recent Technologies for the Determination of SARS-CoV-2 in Wastewater","authors":"Nolwazi T. Gazu,&nbsp;Aoife Morrin,&nbsp;Xolile Fuku,&nbsp;Prof. Bhekie B. Mamba,&nbsp;Usisipho Feleni","doi":"10.1002/slct.202404698","DOIUrl":"https://doi.org/10.1002/slct.202404698","url":null,"abstract":"<p>The COVID-19 pandemic outbreak raised major concerns in public health globally, raising the crucial need for the development of methods to monitor the spread of COVID-19 in communities worldwide. Wastewater-based epidemiology (WBE) surveillance has been used as a novel tool to monitor outbreaks in communities because of its affordability and efficiency in tracking infectious contaminants. Unlike other means of public health tracking, wastewater is independent of individuals having accessibility to healthcare, doctor visits, or infection testing availability. Consequently, raising considerable awareness and complete tracking of infections, including COVID-19 at a community level. In WBE studies, polymerase chain reaction-based (PCR) techniques are referred to as the “gold-standard” method for detecting SARS-CoV-2 in many countries. Nevertheless, despite the extensive development of sensitive and selective PCR-based methods, these techniques have shown some limitations that hinder their application, such as the requirement of repeated heating and cooling cycles and analysis time of 3–4 h. The development of alternative techniques that do not rely on the same consumables as the conventionally employed methods, such as electrochemical biosensing, for detecting SARS-CoV-2 in environmental water samples offers favorable advantages such as improved turnaround times and portability. However, the currently employed techniques are highly focused on clinical applications than wastewater. This review focuses on the advantages and disadvantages associated with conventional and a novel alternative: electrochemical-bioreceptor-based technique for detecting SARS-CoV-2. In addition, highlights the broad use of these techniques in clinical applications than WBE, the binding affinity of the various bioreceptors toward SARS-CoV-2 viral proteins, and their use in enhancing the analytical properties of electrochemical biosensors and the integration of electrochemical biosensors with conventional techniques. The integrated systems, especially, electrochemical-CRISPR based, have shown high sensitivities (down to concentrations of atto-molar), with potential application in low-resource areas.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 13","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202404698","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信