ChemistrySelect最新文献_第2页

Synthesis and In Vitro Bioactivity of Symmetrical Enediynes Based on Maleimide and Propargylamides 马来酰亚胺和丙烯酰胺对称烯二炔的合成及体外生物活性研究

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-05-28 DOI: 10.1002/slct.202501647

Fangxu Pu, Mengsi Zhang, Houjun Zhang, Haonan Cheng, Xiaofan Zhang, Aiguo Hu

{"title":"Synthesis and In Vitro Bioactivity of Symmetrical Enediynes Based on Maleimide and Propargylamides","authors":"Fangxu Pu, Mengsi Zhang, Houjun Zhang, Haonan Cheng, Xiaofan Zhang, Aiguo Hu","doi":"10.1002/slct.202501647","DOIUrl":"https://doi.org/10.1002/slct.202501647","url":null,"abstract":"Natural enediynes, characterized by the (Z)-1,5-diyn-3-ene core, are among the most potent antitumor agents, functioning through DNA-damaging diradicals generated via Bergman or Myers–Saito cyclization. Despite their promising therapeutic potential, their clinical application is limited due to their scarcity. To address this limitation, we developed a new class of symmetrical maleimide-based acyclic enediynes featuring propargylamide moieties, which exhibit excellent thermal reactivity through a maleimide-assisted rearrangement and cycloaromatization mechanism. These compounds demonstrated high efficiency in generating biradicals at physiological temperatures, as confirmed by electron paramagnetic resonance (EPR) analysis. Additionally, in vitro assays revealed their potent DNA cleavage ability and significant cytotoxicity against tumor cells, with half-maximal cytotoxic concentrations (CC50) as low as 1.98 µM. Confocal laser scanning microscopy indicated substantial cellular uptake and DNA damage in HeLa cells. Our findings underscore the potential of these novel enediynes in targeted cancer therapy, positioning them as candidates for both traditional chemotherapy and antibody-drug conjugate (ADC) payloads.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico and In Vitro Perspectives on the Potential Anticancer Activity and Toxicity of Anticancer Drug Modified with Carbohydrates Containing Novel Triazole Compounds 含新型三唑类化合物碳水化合物修饰抗癌药物的潜在抗癌活性和毒性的硅内和体外研究

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-05-28 DOI: 10.1002/slct.202405927

Buse Gokmen, Cem Guler, Ebru Şanci, Ramiz Demir, Cinel Köksal Karayildirim, Karrar Ali Mohammed Hasan Alsakini, Ayse Nalbantsoy, Adem Guner, Kadir Ay, Tamer Karayildirim, Nefise Ulku Karabay Yavasoglu

{"title":"In Silico and In Vitro Perspectives on the Potential Anticancer Activity and Toxicity of Anticancer Drug Modified with Carbohydrates Containing Novel Triazole Compounds","authors":"Buse Gokmen, Cem Guler, Ebru Şanci, Ramiz Demir, Cinel Köksal Karayildirim, Karrar Ali Mohammed Hasan Alsakini, Ayse Nalbantsoy, Adem Guner, Kadir Ay, Tamer Karayildirim, Nefise Ulku Karabay Yavasoglu","doi":"10.1002/slct.202405927","DOIUrl":"https://doi.org/10.1002/slct.202405927","url":null,"abstract":"5-Fluorouracil (5-FU) is one of the first-line chemotherapeutic agents used in systemic therapy of solid tumors. However, several challenges restrict the use of 5-FU such as serious side effects and short plasma half-life. Because carbohydrates and 1,2,3-triazoles have various biological activities, they have been extensively used in medicine to obtain more effective anticancer drugs in recent years. The aim of this study is to modify 5-FU with carbohydrates containing 1,2,3-triazole compounds to reduce its toxic effect, and to reveal the anticancer properties of the obtained 5-FU derivatives. These derivatives (5-FU-I, 5-FU-II, and 5-FU-III) revealed dose-dependent cytotoxic effects on CaCo-2, PANC-1, and A549 cancer cells. It was determined that cytotoxic effects of the 5-FUs change dependent on used carbohydrate types, cell lines, and administered doses. These derivatives showed apoptotic and necrotic cell deaths which used to destroy the cancer cells. 5-FUs showed no genotoxic effect in the bacterial reverse mutasyon assay. They demonstrated strong antiangiogenic properties in the HET-CAM test. In silico study results demonstrated that carbohydrate modification can increase half-life and clearance, also decrease side effects of 5-FU. In silico data supported the in vitro findings and results demonstrated 5-FU derivatives were better drug candidates. Our results reveal that 5-FUs derivatives modified carbohydrates containing 1,2,3-triazole compounds have potential in cancer therapy.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cover Picture: (ChemistrySelect 21/2025) 封面图片：（ChemistrySelect 21/2025）

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-05-28 DOI: 10.1002/slct.70307

引用次数: 0

Antimicrobial and Anticancer Potential of Chitinophaga sp. S167 Mediated Synthesis of Silver Nanoparticles 几丁食虫S167介导的银纳米颗粒合成的抗菌和抗癌潜力

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-05-28 DOI: 10.1002/slct.202500768

Swati Sihag, Gunnpreet Kaur, Sonia Sharma, Ankana Dasgupta, Dr. Khem Raj, Dr. Ramandeep Kaur

{"title":"Antimicrobial and Anticancer Potential of Chitinophaga sp. S167 Mediated Synthesis of Silver Nanoparticles","authors":"Swati Sihag, Gunnpreet Kaur, Sonia Sharma, Ankana Dasgupta, Dr. Khem Raj, Dr. Ramandeep Kaur","doi":"10.1002/slct.202500768","DOIUrl":"https://doi.org/10.1002/slct.202500768","url":null,"abstract":"Green synthesis of nanoparticles (NPs) using bacteria offers advantages of being eco-friendly, cost-effective and nontoxic. In the present study, cell cell-free culture supernatant of Chitinophaga sp. S167 was utilized for the bio-fabrication of silver nanoparticles (AgNPs). The physicochemical properties of AgNPs were studied using UV–visible spectroscopy, transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopic analysis (EDX), dynamic light scattering (DLS), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR). The biogenic synthesized AgNPs showed higher growth inhibitory efficacy against the tested Gram-positive and Gram-negative bacteria, fungi and clinical isolates of Candida glabrata as compared to the chemically synthesized AgNPs using sodium borohydride. Further, the biogenic AgNPs showed potent antiproliferative activity against the two human cancer cell lines (HCT-116 [colon cancer] and MG-63 [osteosarcoma]) as compared to the chemically synthesized AgNPs. This is the first study reporting the biogenic synthesis of AgNPs using Chitinophaga sp. S167, demonstrating their potent antibacterial, antifungal and anticancer activities.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and Application of Tussah Sericin-Modified Chitosan Adsorbent 柞蚕丝胶改性壳聚糖吸附剂的制备及应用

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-05-28 DOI: 10.1002/slct.202501152

Changli Li, Huimei Yang, Yunheng Li, Changjin Huo, Ruohua Guo, Shuang Peng, Yi Pan, Sheng Chen

{"title":"Preparation and Application of Tussah Sericin-Modified Chitosan Adsorbent","authors":"Changli Li, Huimei Yang, Yunheng Li, Changjin Huo, Ruohua Guo, Shuang Peng, Yi Pan, Sheng Chen","doi":"10.1002/slct.202501152","DOIUrl":"https://doi.org/10.1002/slct.202501152","url":null,"abstract":"This study presents a novel tussah sericin-modified chitosan composite (S-CS) with exceptional efficiency for carmine dye removal synthesized via glutaraldehyde crosslinking. The sericin used for the preparation of the adsorbent was recycled from tussah cocoon wastewater, implying its alignment with the “waste-to-wealth” principle. Further, the structural characterization of this adsorbent via SEM, FTIR, and BET analyses confirmed the formation of a porous architecture following modification with sericin, and this porous architecture enhanced adsorption efficacy as evidenced by the high BET surface area (13.3142 m2 g−1) and average pore size (22.78 nm) obtained for the material. Under optimal conditions (0.1000 g S-CS, 30 °C, and 150 rpm), the adsorbent showed a carmine adsorption capacity of 98.5 mg g−1 and its carmine removal efficacy reached 98.37% within 40 min. Via FTIR spectroscopy, we identified hydrogen bonding interactions between S-CS and carmine dye as the key adsorption mechanism. Additionally, the adsorbent retained >90% efficiency after five regeneration cycles, highlighting its reusability. These findings not only advance the valorization of sericin waste but also provide a cost-effective option for textile effluent treatment. In future, it would be necessary to investigate the scalability and industrial integration of this adsorbent to support circular economy initiatives.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 21","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photocatalytic Degradation of Tetracyclin Using Chlorine-Doped BiOBr 掺氯BiOBr光催化降解四环素的研究

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-05-26 DOI: 10.1002/slct.202501605

Jiale Sun, Yuyang Zhao

{"title":"Photocatalytic Degradation of Tetracyclin Using Chlorine-Doped BiOBr","authors":"Jiale Sun, Yuyang Zhao","doi":"10.1002/slct.202501605","DOIUrl":"https://doi.org/10.1002/slct.202501605","url":null,"abstract":"The Cl-doped BiOBr photocatalysts were used to degrade tetracyclin, which was usually difficult to degrade in wastewater, to reduce secondary pollution to the environment. In this paper, Cl-doped BiOBr composites were prepared by a hydrothermal method using bismuth nitrate as the bismuth source, potassium bromide as the bromine source, potassium chloride as the chlorine source, and deionized water as the solvent. The physical structure, chemical composition, surface morphology, optical properties, and charge transport of the Cl-doped BiOBr composites were characterized and analyzed by XRD, XPS, TEM, UV–vis DRS, photoluminescence (PL), electrochemical impedance spectroscopy (EIS), and Brunauer–Emmett–Teller (BET). The successful preparation of BiOBr and Cl-doped BiOBr with a tetragonal crystal system was confirmed by XRD characterization. SEM and TEM images confirmed that the samples have a lamellar stacking structure. PL, photocurrent, and EIS studies on the samples showed that the Cl-doped BiOBr composites had good charge separation efficiency. The catalytic performance of the Cl-doped BiOBr composites was investigated using tetracyclin (TC) as the target contaminant, and the results showed that the C2─BiOBr composites exhibited a strong photodegradation of TC, with a degradation efficiency of 76.2%. The excellent performance of the Cl-doped BiOBr was attributed to the formation of doped energy levels with improved visible light absorption and efficient charge transfer/separation. Free radical scavenger studies showed that ∙OH and h+ generated by the photocatalyst were responsible for the efficient degradation of TC. Two possible degradation pathways of TC were proposed based on HPLC-MS/MS detection and their intermediate products tended to be less toxic. Finally, the good stability and reproducibility of the catalyst were confirmed by degradation cycling experiments. This study provides a reference for photocatalysts in practical applications.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 20","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hybrid Polytypic Cadmium Sulfide Nanoparticles Templated with Harmal Leaf Extract for Antimicrobial Applications 杂化多型硫化镉纳米颗粒模板与有害叶提取物抗菌应用

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-05-26 DOI: 10.1002/slct.202405245

N. E. Moustafa, Kout Elkloub Fares mahmoud

引用次数: 0

Hydrogen Evolution Mechanism on Pt Surface in NonAcidic Media: A DFT Study 非酸性介质中铂表面析氢机理的DFT研究

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-05-26 DOI: 10.1002/slct.202501626

Chao Kong, Yanxia Han, Lijie Hou, Chao Shuai, Caili Yang, Xiaoli Song

{"title":"Hydrogen Evolution Mechanism on Pt Surface in NonAcidic Media: A DFT Study","authors":"Chao Kong, Yanxia Han, Lijie Hou, Chao Shuai, Caili Yang, Xiaoli Song","doi":"10.1002/slct.202501626","DOIUrl":"https://doi.org/10.1002/slct.202501626","url":null,"abstract":"Noble metal Pt is a very classic hydrogen evolution catalyst and its activity can be markedly affected by the pH of electrolyte solution. In acidic media, the hydrogen evolution reaction (HER) on Pt follows the Tafel-step-limited Volmer-Tafel mechanism. However, the detailed hydrogen evolution mechanism of Pt in nonacidic media and the key factors influenced its activity are still unclear. Herein, the nonacidic hydrogen evolution mechanisms of Pt were systematically investigated by the density functional theory (DFT) method. The calculations indicate that Pt catalyzes nonacidic HER by the H2O dissociation-limited Volmer-Tafel mechanism and OH originated from H2O dissociation can observably reduce the HER rate of adjacent Pt atom. The adsorbed H and OH on top site generate an increased barrier for H2O dissociation on adjacent Pt atom and the effect of OH is more remarkable. More importantly, the adsorbed OH causes that adjacent Pt atom loses its activity for catalyzing the Tafel reaction. The low activity of Pt in alkaline solution may be from the strong function of adsorbed OH− in retarding H2O dissociation reaction.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 20","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selective Conversion of CH4 by MAl2O4− (M = Au and Pd): A Theoretical Study MAl2O4−（M = Au和Pd）选择性转化CH4的理论研究

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-05-26 DOI: 10.1002/slct.202500506

Junxi Liang, Mengmeng Lu, Fang Ren, Yaoyu Zhou, Jie Gao, Xinjie Wang, Yalu Zhang, Pen Jin, Yanbin Wang, Qiong Su

{"title":"Selective Conversion of CH4 by MAl2O4− (M = Au and Pd): A Theoretical Study","authors":"Junxi Liang, Mengmeng Lu, Fang Ren, Yaoyu Zhou, Jie Gao, Xinjie Wang, Yalu Zhang, Pen Jin, Yanbin Wang, Qiong Su","doi":"10.1002/slct.202500506","DOIUrl":"https://doi.org/10.1002/slct.202500506","url":null,"abstract":"The catalytic reactions of individual noble metal atoms can offer theoretical guidance for the design of the relevant single-atom catalysts. In this paper, from MD adsorption simulation, both Au and Pd atoms rather bond to Al than O atoms of the employed Al2O3 (001) surface and display more active sites for the Au system with respect to the Pd system. Next, a detailed comparative study was conducted on the reactions of preferred MAl2O4− (M = Au and Pd) with CH4 using the DFT-B3LYP functional. The obtained results reveal that in the AuAl2O4− reaction, the CH4 tends to be transformed into syngas, H2 and CO. In contrast, the formaldehyde is generated in the reaction of PdAl2O4− + CH4. Additionally, our findings also suggest that the reactivity of AuAl2O4− is significantly higher than that of PdAl2O4−, indicating that the former can fully activate CH4 four C─H bonds. This insight provides valuable guidance for the rational design of single-atom catalysts aimed at selective CH4 conversion.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 20","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eco-Friendly Microcapsules of Clove Oil Using Collagen Hydrolysate and Chitosan Derived From Chrome Shavings 从铬屑中提取的水解胶原蛋白和壳聚糖制成的环保丁香油微胶囊

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-05-26 DOI: 10.1002/slct.202405125

S. Nisha, G. Poonam, P. Sudhakara, Shubham Sharma, S.K. Misra, Ramkumar Vanaraj

{"title":"Eco-Friendly Microcapsules of Clove Oil Using Collagen Hydrolysate and Chitosan Derived From Chrome Shavings","authors":"S. Nisha, G. Poonam, P. Sudhakara, Shubham Sharma, S.K. Misra, Ramkumar Vanaraj","doi":"10.1002/slct.202405125","DOIUrl":"https://doi.org/10.1002/slct.202405125","url":null,"abstract":"The leather industry, which utilizes by-products of the meat industry as raw materials, produces substantial waste, with chrome shavings being a major by-product. These shavings are primarily composed of collagenous Cr (III) complexes and are rich in protein. In this study, collagen hydrolysate (CH) was extracted from chrome shavings through enzymatic hydrolysis, and its chemical properties were analyzed. The CH was combined with chitosan (C) to develop microcapsules containing clove oil, known for its antifungal and antimicrobial properties, using the complex coacervation method with glutaraldehyde as a cross-linking agent. These microcapsules have potential applications in preventing biodeterioration by inhibiting microbial activity on susceptible surfaces. Encapsulation efficiency was assessed, and the effects of parameters such as the CH-to-C ratio, glutaraldehyde concentration, and clove oil release rate were examined. Results showed that encapsulation efficiency improved with a lower CH-to-C ratio and higher cross-linker concentration. Over a 60-h release study, it was observed that increasing C content and cross-linker concentration slowed clove oil release. SEM analysis revealed spherical microcapsules, whereas TGA thermograms confirmed their thermal stability up to 135 °C. The sustained release of clove oil offers promising potential for long-term protection against microbial biodeterioration.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 20","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0