ChemistrySelect最新文献_第3页

The Ethonomedical Profiles and Pharmacological Properties of Phytochemicals From Curcuma longa Linn. - A Decade Update

IF 1.9 4区化学

ChemistrySelect Pub Date : 2024-12-15 DOI: 10.1002/slct.202402443

Sudipta Saha

{"title":"The Ethonomedical Profiles and Pharmacological Properties of Phytochemicals From Curcuma longa Linn. - A Decade Update","authors":"Sudipta Saha","doi":"10.1002/slct.202402443","DOIUrl":"https://doi.org/10.1002/slct.202402443","url":null,"abstract":"The rhizomatous herbaceous perennial plant (Zingiberaceae family) turmeric (Curcuma longa) contains curcumin as a major pharmacologically active phytochemical which can alleviate many serious health issues such as inflammation, diabetics, osteoarthritis and rheumatoid arthritis, cancer, hepatobiliary illness, diarrhea, gastric and peptic ulcers, and psoriasis. Its origins trace back to India, yet it's extensively grown in regions like China, Sri Lanka, West, and East Africa, as well as other tropical nations. Referred to as Jianghuang or Huangjiang in China, this plant plays a significant role in Chinese traditional medicine (TCM) for therapeutic purposes. Recent study also reported that Curcuma longa bioactive substances possess neuroprotective activity, antiobesity activity, cardio protective activity, antioxidant activities, and antimicrobial activities. The various bioactive phytochemicals present in C. longa is the hallmark of its bioactivity. Various in vitro and in vivo studies on C. longa in the animal model supports its ethonomedical activities of its numerous phytochemical constituents. Still the proper analysis of its fluctuating prospective is not applied into the emerging innovative treatments in finest situation. The full exploitation of the application and mechanism of action of various biologically active phytochemicals of C. longa has to be done. Although, human medical trials and quality control studies are essential to determine the adequate and innocuous quantity of C. longa and its key phytochemical curcumin along with other pharmacologically active phytochemicals for the management of various health issues. This review will offer platforms to the pharmaceutical industries to improve pharmaceutical materials based on turmeric. The added advantage is that the turmeric-based natural products are safe, nontoxic, inexpensive, and widely available.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 47","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Practical Spectroscopic Protocol Based on Sialic Acid-S-Protein Interaction for SARS-CoV-2 Detection

IF 1.9 4区化学

ChemistrySelect Pub Date : 2024-12-13 DOI: 10.1002/slct.202405064

Assos. Vasfiye Hazal Özyurt, Dr. Burak Ekrem Çitil, Prof. Dr. Ülkü Anik

{"title":"A Practical Spectroscopic Protocol Based on Sialic Acid-S-Protein Interaction for SARS-CoV-2 Detection","authors":"Assos. Vasfiye Hazal Özyurt, Dr. Burak Ekrem Çitil, Prof. Dr. Ülkü Anik","doi":"10.1002/slct.202405064","DOIUrl":"https://doi.org/10.1002/slct.202405064","url":null,"abstract":"This work aims to investigate the possible role of sialic acids as host cell receptors for SARS-CoV-2 infection and hence to develop a practical spectroscopic protocol that relies on the interaction between fetuin and spike protein (S-protein) for SARS-CoV-2 detection. For that purpose, firstly, synthesized gold nanoparticles (AuNPs) were functionalized with fetuin. Then, fetuin functionalized AuNPs were incubated with S-protein and the difference in absorbance value of AuNPs at 530 nm was measured spectroscopically. The interaction between fetuin and S-protein was characterized by using fourier transform infrared spectroscopy and atomic force microscopy methods whereas sole AuNP structure was investigated by using transmission electron microscopy technique. The experimental parameters such as fetuin amount (0, 5, 10, and 20 µg/mL) and incubation duration (0, 10, 20, 30, and 40 min) were optimized and analytical characteristics of developed biosensors were investigated. The detection limit value was calculated as 2.40 ng/mL, the linear range of detection was between 4.98 and 95.2 ng/mL, and the relative standard deviation value was 0.72% for 9.95 ng/mL S-protein. Finally, the developed biosensor was applied to real samples that were taken from SARS-CoV-2 non-infected and infected individuals.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 47","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Determination of Antioxidant, Antimicrobial and Anticancer Properties of Newly Synthesized 2-methoxyphenyl Thiophene Derivatives

IF 1.9 4区化学

ChemistrySelect Pub Date : 2024-12-13 DOI: 10.1002/slct.202404367

Doğan Çetin, Dr. Metin Konuş, Dr. Can Yılmaz, Dr. Şevki Arslan, AmineHafis Abdelsalam, Elena Daniela Hutanu, Dr. Aslıhan Kurt Kızıldoğan, Çiğdem Otur, AzadKhalaf Hama, Dr. Arif Kivrak

{"title":"Determination of Antioxidant, Antimicrobial and Anticancer Properties of Newly Synthesized 2-methoxyphenyl Thiophene Derivatives","authors":"Doğan Çetin, Dr. Metin Konuş, Dr. Can Yılmaz, Dr. Şevki Arslan, AmineHafis Abdelsalam, Elena Daniela Hutanu, Dr. Aslıhan Kurt Kızıldoğan, Çiğdem Otur, AzadKhalaf Hama, Dr. Arif Kivrak","doi":"10.1002/slct.202404367","DOIUrl":"https://doi.org/10.1002/slct.202404367","url":null,"abstract":"In this study, antioxidants, anticancer, and antimicrobial properties of four newly synthesized thiophene derivatives were investigated. In addition, basic ADME properties were calculated in silico. According to the study's findings, tested compounds antioxidant activity was weaker than the standards in both the FRAP and ABTS assays. The MTT analysis revealed that the chemicals 3 and 4 were cytotoxic to every cancer cell line that was tested. 3 and 4 increased the rate of apoptosis in the tested cancer cells at levels close to that in the positive control group. The gene expression levels of apoptotic markers (BAX, Bcl-2, Casp-3, -8, and -9) detected at all cell lines after incubation with 3 and 4 were changed as expected for apoptotic agents, except Bcl-2 of HT-29. It was concluded that the addition of bromine to C2 of thiophene cycle of 3, resulted 4 with greater apoptotic potential probably because of a change in molecular conformation and ligand exchange kinetics. Compound 3 was found to have antifungal activity against Aspergillus niger, while 4 was found to have antibacterial activity on gram-positive bacteria. In silico ADME/T analysis revealed that 3 and 4 were able to pass through the gastrointestinal tract lumen and blood-brain barrier.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 47","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of Green and Smart Anti-Corrosion PDA@Bio-MOF-11@Nano-Curcumin Coating for Mild Steel

IF 1.9 4区化学

ChemistrySelect Pub Date : 2024-12-13 DOI: 10.1002/slct.202403888

Shokoufeh Rezvani Niya, Ali Benvidi, Hamid R. Zare, Marzieh Dehghan Tezerjani

{"title":"Fabrication of Green and Smart Anti-Corrosion PDA@Bio-MOF-11@Nano-Curcumin Coating for Mild Steel","authors":"Shokoufeh Rezvani Niya, Ali Benvidi, Hamid R. Zare, Marzieh Dehghan Tezerjani","doi":"10.1002/slct.202403888","DOIUrl":"https://doi.org/10.1002/slct.202403888","url":null,"abstract":"Corrosion is a destructive phenomenon which occurs spontaneously in the environment and leads to economic, environmental, and safety problems. The focus of recent studies in the field of corrosion is on replacing harmful inhibitors with biocompatible and cheap ones. In this research, the purpose is to synthesize a smart and self-healing coating based on a poly dopamine biopolymer containing Bio-MOF-11@ nano-curcumin as a green inhibitor. The characteristics and morphology of the synthesized materials and the effectiveness of these materials as corrosion-protective coatings were investigated with various techniques including Fourier-Transform infrared spectroscopy (FT-IR), X-Ray diffraction (XRD), ultraviolet–visible spectroscopy (UV–vis), scanning electron microscopy (SEM), and energy dispersive X-Ray analysis (EDS). The UV–vis technique was also used to evaluate the effect of the inhibitor release at pH 4 and 7. The maximum amount of the inhibitor release after 72 hours was 86.61 ppm at pH 4.0. The corresponding electrochemical studies were conducted through electrochemical impedance spectroscopy (EIS) and Tafel plot. Finally, the inhibition rate of the coating was found to be 95.08%, which indicates the good performance of the PDA@Bio-MOF-11@Cur NPs coating for corrosion protection of MS in 3.5% NaCl.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 47","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Next-Generation Electrode Materials: La/Ce Doping for Superior Anodic Oxidation

IF 1.9 4区化学

ChemistrySelect Pub Date : 2024-12-13 DOI: 10.1002/slct.202403672

Melike Ceren Okur, Dilara Öztürk, Abdurrahman Akyol

引用次数: 0

Novel Antiviral Phytochemicals Against Dengue Virus 2 NS2B-NS3 Protease: An In Silico Drug Development Approach

IF 1.9 4区化学

ChemistrySelect Pub Date : 2024-12-13 DOI: 10.1002/slct.202404053

Muhammad Abdul Bari, Sabbir Ahmed, Faria Farzana Perveen, Mahfuza Akter, Nasim Ahmed, Jakaria Hossain, Md. Nasrulla, Khadiza Akter, Md. Nurul Islam

{"title":"Novel Antiviral Phytochemicals Against Dengue Virus 2 NS2B-NS3 Protease: An In Silico Drug Development Approach","authors":"Muhammad Abdul Bari, Sabbir Ahmed, Faria Farzana Perveen, Mahfuza Akter, Nasim Ahmed, Jakaria Hossain, Md. Nasrulla, Khadiza Akter, Md. Nurul Islam","doi":"10.1002/slct.202404053","DOIUrl":"https://doi.org/10.1002/slct.202404053","url":null,"abstract":"Dengue fever, a viral disease transmitted by mosquitoes, presents a major public health risk in tropical and subtropical regions globally. Currently, there is no treatment to fight against this disease. The dengue virus 2 (DENV2) NS2B-NS3 protease is critical for viral replication, making it a promising target for drug discovery. This study aims to identify potential inhibitors against the DENV2 NS2B-NS3 protease using in silico methods, including molecular docking, ADMET analysis, molecular dynamics simulations, MMGBSA, and DFT calculations. We screened 1138 phytochemicals from the NuBBE database against the NS2B-NS3 protease (PDB ID: 2FOM) and compared their binding affinities to policresulen, reported as DENV2 NS2B-NS3 protease inhibitor. Four novel phytochemicals: 3′,4′-methylenedioxy-7,8-(2″,2″-dimethylpyrano)-flavone; limonianin; gnetin-B; and 5,4′-dihydroxy-3′,5′-dimethoxy-6,7-(2″,2″-dimethylpyran)flavonen revealed binding affinities of −8.7, −8.0, −7.8, and −7.8 kcal/mol, respectively, surpassing the reference compound's affinity of −7.0 kcal. Additionally, MD simulations over 100 ns confirmed the stability of these compounds bound with the target protein. Moreover, ADMET analysis demonstrated favorable pharmacokinetic and toxicity profiles, whereas MMGBSA and DFT calculations supported their binding consistency and reactivity. In conclusion, this study discovered promising novel phytochemicals against DENV2 NS2B-NS3 protease, which could serve as potential leads for developing effective antiviral therapies for the treatment of dengue fever.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 47","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roles of Ce0.8Zr0.2O2 Catalysts in Boosting the Efficient Combustion of Waste Plastics

IF 1.9 4区化学

ChemistrySelect Pub Date : 2024-12-13 DOI: 10.1002/slct.202404876

Qiang Yan, Xu Hou, Hao Zhou, Xinyao Sun, Jing Huang, Li Yin, Tingting Cui

{"title":"Roles of Ce0.8Zr0.2O2 Catalysts in Boosting the Efficient Combustion of Waste Plastics","authors":"Qiang Yan, Xu Hou, Hao Zhou, Xinyao Sun, Jing Huang, Li Yin, Tingting Cui","doi":"10.1002/slct.202404876","DOIUrl":"https://doi.org/10.1002/slct.202404876","url":null,"abstract":"Because of superior oxygen storage and release capability, Ce-based catalysts were widely used in the oxidation reaction, while seldomly mentioned in waste plastics combustion. Herein, Ce0.8Zr0.2O2 catalysts were prepared by the complexed hydrothermal method (CeZr(C)), oxalic acid gel method (CeZr(O)), and hydrothermal method (CeZr(N)); and then, used in PE (polyethylene) combustion. Compared with PE noncatalytic combustion that exhibited an initial combustion temperature of 269 °C, CeZr(C) slightly reduced the initial combustion temperature to 263 °C, while CeZr(N) and CeZr(O) significantly reduced the initial combustion temperature to 245 and 251 °C, respectively. It was deduced that the activity of CeZr(N) and CeZr(O) in PE catalytic combustion was significantly higher than that of CeZr(C). Based on the systematic characterization, two reaction mechanisms were proposed to explain the excellent performance of CeZr(O) and CeZr(N) in PE combustion: (1) Because of the abundant surface area and O2 adsorption, CeZr(O) enhanced the activation of molecular oxygen and the formation of active oxygen, which was easier to attack C─C/C─H bond and initiate PE combustion than molecular oxygen. (2) Because of the strong acidity, CeZr(N) enhanced the activation of C─C/C─H bond in polymer molecules, which benefited the attack of molecular oxygen, and reduced the reaction temperature.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"9 47","pages":""},"PeriodicalIF":1.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142868195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-Pot Synthesis of Fluorinated Amino Pyrimidines: Molecular Docking, ADME, and DFT Insights for SARS-CoV-2 MPro Inhibition 氟化氨基嘧啶的单锅合成：抑制 SARS-CoV-2 MPro 的分子对接、ADME 和 DFT 见解

IF 1.9 4区化学

ChemistrySelect Pub Date : 2024-12-12 DOI: 10.1002/slct.202403683

Dr. Gunjan, Nishtha Bhagat, Avinabh Choudhary, Dr. Poonam Kumari, Dr. Pradeep Kumar, Prof. Dr. Sunita Bhagat

引用次数: 0

Enhancement of Proton Transport in Nafion Membranes via Azol Functional Silica Nanoparticles for PEMFC Applications 通过用于 PEMFC 的 Azol 功能性二氧化硅纳米粒子增强 Nafion 膜中的质子传输

IF 1.9 4区化学

ChemistrySelect Pub Date : 2024-12-12 DOI: 10.1002/slct.202403873

Ayşe Aslan

引用次数: 0

Generation and Application of Reactive Oxygen Radicals in Cancer Treatment