Anjali Chhablani, Vicky Jain, Dr. Jayanti Makasana
{"title":"Sulfonamides: Historical Perspectives, Therapeutic Insights, Applications, Challenges, and Synthetic Strategies","authors":"Anjali Chhablani, Vicky Jain, Dr. Jayanti Makasana","doi":"10.1002/slct.202502122","DOIUrl":null,"url":null,"abstract":"<p>Sulfonamides, one of the earliest classes of synthetic antimicrobials, hold enduring significance in medicinal chemistry. This review highlights their evolution from antibiotics to multifunctional therapeutic agents, with applications in the treatment of diuretics, hypoglycemia, glaucoma, protease and kinase inhibition, and inflammatory diseases. It also outlines key synthetic strategies-from traditional approaches to recent green and efficient methods. Environmental concerns and resistance-related challenges are addressed, along with insights into novel delivery systems and future research opportunities. Overall, the review underscores the versatility and ongoing relevance of sulfonamides in modern drug discovery.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 29","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemistrySelect","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/slct.202502122","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Sulfonamides, one of the earliest classes of synthetic antimicrobials, hold enduring significance in medicinal chemistry. This review highlights their evolution from antibiotics to multifunctional therapeutic agents, with applications in the treatment of diuretics, hypoglycemia, glaucoma, protease and kinase inhibition, and inflammatory diseases. It also outlines key synthetic strategies-from traditional approaches to recent green and efficient methods. Environmental concerns and resistance-related challenges are addressed, along with insights into novel delivery systems and future research opportunities. Overall, the review underscores the versatility and ongoing relevance of sulfonamides in modern drug discovery.
期刊介绍:
ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.