Sulfonamides: Historical Perspectives, Therapeutic Insights, Applications, Challenges, and Synthetic Strategies

IF 2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Anjali Chhablani, Vicky Jain, Dr. Jayanti Makasana
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引用次数: 0

Abstract

Sulfonamides, one of the earliest classes of synthetic antimicrobials, hold enduring significance in medicinal chemistry. This review highlights their evolution from antibiotics to multifunctional therapeutic agents, with applications in the treatment of diuretics, hypoglycemia, glaucoma, protease and kinase inhibition, and inflammatory diseases. It also outlines key synthetic strategies-from traditional approaches to recent green and efficient methods. Environmental concerns and resistance-related challenges are addressed, along with insights into novel delivery systems and future research opportunities. Overall, the review underscores the versatility and ongoing relevance of sulfonamides in modern drug discovery.

Abstract Image

磺胺类药物:历史观点、治疗见解、应用、挑战和合成策略
磺胺类药物是最早的一类合成抗菌剂,在药物化学中具有持久的意义。本文综述了它们从抗生素到多功能治疗剂的演变,在利尿剂、低血糖、青光眼、蛋白酶和激酶抑制以及炎症性疾病的治疗中应用。它还概述了关键的综合策略-从传统的方法到最近的绿色和高效的方法。解决了环境问题和与抗性相关的挑战,以及对新型输送系统和未来研究机会的见解。总的来说,该综述强调了磺胺类药物在现代药物发现中的多功能性和持续相关性。
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来源期刊
ChemistrySelect
ChemistrySelect Chemistry-General Chemistry
CiteScore
3.30
自引率
4.80%
发文量
1809
审稿时长
1.6 months
期刊介绍: ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.
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