ChemistrySelectPub Date : 2025-07-24DOI: 10.1002/slct.202501192
Siddhima Sharma, Lalima Sharma, Narendra Pal Singh Chauhan, Renu Rathore, Afsar Ali, Neeraj Kumar, D. Vijay, Mangal Shree Dulawat
{"title":"Exploring Isopropyl and Allyl Isothiocyanates to Design 2-Aminobenzothiazoles: Synthesis, Characterization, Single-Crystal XRD, DFT, Hirshfeld Analysis, Antimicrobial Evaluation, Molecular Docking, and ADME Studies","authors":"Siddhima Sharma, Lalima Sharma, Narendra Pal Singh Chauhan, Renu Rathore, Afsar Ali, Neeraj Kumar, D. Vijay, Mangal Shree Dulawat","doi":"10.1002/slct.202501192","DOIUrl":"https://doi.org/10.1002/slct.202501192","url":null,"abstract":"<p>2-Aminobenzothiazoles constitute a significant class of heterocyclic compounds, notable for their extensive pharmacological significance. While their synthesis has typically utilized phenyl isothiocyanate, the potential of alternative isothiocyanates remains largely unexplored. This research presents an alternative synthetic route for the preparation of known substituted 2-aminobenzothiazoles, <i>N</i>-(propan-2-yl)-1,3-benzothiazol-2-amine (SISI) and <i>N</i>-(prop-2-en-1-yl)-1,3-benzothiazol-2-amine (SIAL) using isopropyl isothiocyanate (IPI) and allyl isothiocyanate (AITC) as underutilized precursors under mild copper-catalyzed conditions. Structural elucidation was conducted using FTIR, HRMS, NMR, and single-crystal XRD. DFT results (B3LYP/6-31G(d,p) level) demonstrated a strong correlation with experimental crystallographic data. Hirshfeld surface analysis identified key intermolecular interactions that contribute to crystal packing stability. The antimicrobial assay revealed substantial inhibitory effects against Gram −ve and Gram +ve strains for bacteria along with fungal species, with <i>Escherichia coli</i> exhibiting particular sensitivity. In silico ADME profiling suggested promising pharmacokinetic properties, including high GI and BBB permeability. Molecular docking results indicated strong binding interactions with bacterial DNA gyrase (6F86) and topoisomerase IV (1s14), with SISI and SIAL demonstrating higher binding affinities for topoisomerase IV than streptomycin (binding affinity SISI; −6.0 kcal mol<sup>−1</sup>, SIAL; −5.8 kcal mol<sup>−1</sup>, streptomycin; −5.5 kcal mol<sup>−1</sup>). The enhanced interaction suggests a potential mechanism for their antimicrobial activity, highlighting the synthetic and biological relevance of IPI and AITC as alternative precursors in aminobenzothiazole chemistry, through an efficient and comparative synthetic route for known derivatives.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2025-07-24DOI: 10.1002/slct.202501908
Changle Li, Yiqian Liu, Bo Li, Yanlei Zhang
{"title":"Sustainable Porous Carbon from Waste Fungal Substrates of Gastrodia Elata: A Dual-Function Material for High-Performance Supercapacitors and Lithium Batteries","authors":"Changle Li, Yiqian Liu, Bo Li, Yanlei Zhang","doi":"10.1002/slct.202501908","DOIUrl":"https://doi.org/10.1002/slct.202501908","url":null,"abstract":"<p>In this work, waste fungal substrates materials of a traditional Chinese medicine <i>Gastrodia elata</i> were used to produce porous carbon for high-performance supercapacitors and lithium batteries. The porous carbon exhibited ultrahigh specific capacitances of 550 F/g at 1.0 A/g and 280 F/g at 20 A/g in a 6 M KOH electrolyte in a three-electrode system. In the assembled supercapacitors using 6 M KOH, 1 M Na<sub>2</sub>SO<sub>4</sub>, and 1 M Et<sub>4</sub>NBF<sub>4</sub>/AN electrolytes, it showed remarkably high specific energies of 11.6 Wh kg<sup>−1</sup>, 28.2 Wh kg<sup>−1</sup>, and 44 Wh kg<sup>−1</sup>, respectively along with excellent long cycle stabilities. In addition, it has a high reversible lithium storage capacity of 1059.7 mAh g<sup>−1</sup> at 0.2 C, long cycle stability of 658.7 mAh g<sup>−1</sup> after 300 cycles, and great rate performance of 332.1 mAh g<sup>−1</sup> at 3.2 C. The capacity went as high as 241.2 mAh g<sup>−1</sup> after 1000 cycles under 3.2 C with a capacity retention of 72.6%. These excellent results proved that it is advantageous to use the discarded substrates of the Chinese medicine <i>Gastrodia elata</i> as a sustainable source to prepare porous carbon for multiple energy storage functions with high specific capacity and energy density.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144695903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2025-07-24DOI: 10.1002/slct.202501547
Neha Jarodhia, Kuldeep Joshi
{"title":"Coconut Coir-Derived CC@NiO–CuO Nanocomposite for Enhanced Removal of Crystal Violet Dye From Wastewater","authors":"Neha Jarodhia, Kuldeep Joshi","doi":"10.1002/slct.202501547","DOIUrl":"https://doi.org/10.1002/slct.202501547","url":null,"abstract":"<p>The increasing release of synthetic dyes into aquatic systems poses significant ecological and health risks due to their toxicity and persistence. This study investigates the effectiveness of a novel nanocomposite synthesized from coconut coir and nickel oxide–copper oxide (NiO–CuO) nanoparticles for the removal of crystal violet (CV) dye from water. The composite's physicochemical properties were characterized using powder X-ray diffraction (P-XRD), Fourier Transform Infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and Brunauer–Emmett–Teller (BET) surface area analysis. A series of adsorption experiments was conducted to optimize key process parameters, including adsorbent dosage, contact time, initial dye concentration, pH, sample volume, and temperature. The nanocomposite exhibited excellent adsorption efficiency, achieving approximately 99% removal of CV at pH 6 with a 5 mg adsorbent dose, 30-min contact time, and 15 ppm dye concentration. The adsorption process conformed to the Temkin isotherm model, indicating a decrease in sorption energy with increasing surface coverage due to adsorbent–adsorbate interactions. Kinetic studies revealed that the process followed a pseudo-second-order model, suggesting the predominance of chemical adsorption mechanisms. Thermodynamic analysis showed a negative Gibbs free energy (−Δ<i>G</i>), along with positive enthalpy (Δ<i>H</i>) and entropy (Δ<i>S</i>) values, confirming that the adsorption process was spontaneous, endothermic, and associated with increased randomness at the solid–liquid interface. This study underscores the potential of biomass-derived nanocomposites as sustainable and efficient materials for dye removal from wastewater.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2025-07-24DOI: 10.1002/slct.202502317
Chenxi Li, Wenbin Liu, Kai Li, Kang Li, Shina Li, Ruixin Ma
{"title":"Phase Transformation of Metal Hexacyanoferrates Containing Rubidium–Cesium to Separate Rubidium and Cesium from Each Other","authors":"Chenxi Li, Wenbin Liu, Kai Li, Kang Li, Shina Li, Ruixin Ma","doi":"10.1002/slct.202502317","DOIUrl":"https://doi.org/10.1002/slct.202502317","url":null,"abstract":"<p>Rb<sup>+</sup> and Cs<sup>+</sup> lack independent ore resources in nature, and they often coexist with K<sup>+</sup> and Na<sup>+</sup>. Hexacyanoferrates containing Rb<sup>+</sup> and Cs<sup>+</sup> are often calcinated and leaching to release Rb<sup>+</sup> and Cs<sup>+</sup> into solution to separate from co-existing Na<sup>+</sup> and K<sup>+</sup>. In this study, co-precipitate containing Rb<sup>+</sup> and Cs<sup>+</sup>, RbCs-CuZnHCF, is treated by phase- transformation method using (NH<sub>4</sub>)<sub>2</sub>S as phase-transformation agent to achieve the separation of Rb<sup>+</sup> and Cs<sup>+</sup> from each other. The kinetics and thermodynamics of the phase-transformation are studied. The results indicated that solid RbCs-CuZnHCF is transformed to Rb<sup>+</sup> and [Fe(CN)<sub>6</sub>]<sup>4-</sup> by the aid of S<sup>2-</sup>, while Cs-CuZnHCF maintains its original solid state. The removal efficiency of Rb<sup>+</sup> is 64.22%, while the loss of Cs<sup>+</sup> is 0.86% under the optimal conditions (T = 60℃, S<sup>2</sup><sup>-</sup>/(Cu<sup>2+</sup>+Zn<sup>2+</sup>) = 0.6, pH = 3-7, t = 60 min), and the separation coefficient of Rb-Cs was up to 207.89. Thermodynamics analysis reveals that the reaction is endothermic. Kinetic analysis reveals a low activation energy (17.99 kJ/mol) and pre-exponential factor of 10.18 L/ (mol·s), indicative of a diffusion-controlled process. By this method, the high-priced hexacyanoferrates can be re-used as co-precipitant agent to separate Rb<sup>+</sup> and Cs<sup>+</sup> from co-existing Na<sup>+</sup> and K<sup>+</sup>.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2025-07-24DOI: 10.1002/slct.202405335
Xudong Zhao, Tianhong Zhao, Peng Guofeng, Long Chen, Hongteng Li
{"title":"Synergistic Effects of Nano-SiO2 and Amphiphilic Polymers on Enhanced Oil Recovery","authors":"Xudong Zhao, Tianhong Zhao, Peng Guofeng, Long Chen, Hongteng Li","doi":"10.1002/slct.202405335","DOIUrl":"https://doi.org/10.1002/slct.202405335","url":null,"abstract":"<p>In this study, the polymerizable surfactant monomer DAAC<sub>12</sub> and modified nano-silica SiO<sub>2</sub>-NHMA were synthesized. These two monomers were then copolymerized with acrylamide (AM) and acrylic acid (AA) via free radical polymerization to produce a quaternary copolymer, PAMDS, which exhibits surface-active properties. The polymers were structurally characterized by FT-IR, <sup>1</sup>H NMR, TG, and SEM, and their characteristic viscosities as well as molecular weights were determined by dilution method. The effects of temperature on the copolymers were investigated, and PAMDS was evaluated for its temperature resistance, salt resistance, shear resistance, emulsification capacity, and oil–water interfacial tension. The results demonstrated that the incorporation of functional monomers significantly enhanced the polymer's temperature resistance, salt resistance, and shear resistance, while also improving its emulsification ability. Furthermore, at a polymer concentration of 3 g/L, the oil–water interfacial tension was reduced to 7.9 mN/m, representing a 75.5% decrease compared to that in pure water. Core flooding experiments were conducted to evaluate the oil displacement efficiency of PAMDS. The results revealed that PAMDS achieved a recovery rate of 22.1% at 65 °C, which was 8.6% higher than that of the HPAM. These findings indicate that PAMDS exhibits superior potential for enhanced oil recovery applications.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2025-07-24DOI: 10.1002/slct.202502425
Xi Dai, Yuanlin Li, Hua Fei, Jianmin Tong, Min Fang, Yucheng Pan
{"title":"Structural Characteristics and Thermal Performances of Eutectic Mixture Adsorbed into Modified Porous Wood Char in Vacuum Environment","authors":"Xi Dai, Yuanlin Li, Hua Fei, Jianmin Tong, Min Fang, Yucheng Pan","doi":"10.1002/slct.202502425","DOIUrl":"https://doi.org/10.1002/slct.202502425","url":null,"abstract":"<p>The rapid development of society consumes a lot of energy. Phase change materials (PCMs) can provide significant heat storage to improve natural energy applications. However, organic PCMs have the problem of easy leakage of liquid phase, which limits their application in the field of energy storage. The primary goal of this work is to improve leakage and thermal conductivity of phase change materials. In this work, CW1000 was used as a porous biomass carrier and lauric acid (LA), paraffin wax (PW), and tetradecanol (TD) were used as raw materials. Two modified biomass carbonized wood based composite phase change materials (CPCMs) were prepared by vacuum impregnation. The LA-PW/CW1000 and LA-TD/CW1000 have load rates of 50% and 60%, respectively allowing for better packing of LA-PW and LA-TD. The thermal conductivity of LA-PW/CW1000 and LA-TD/CW1000 is 67.05% and 23.59% higher than that of LA-PW and LA-TD, respectively. In addition, the undercooling of LA-PW/CW1000 decreased by 1.95 °C compared to LA-PW, while LA-TD/CW1000 decreased by 3.33 °C compared to LA-TD. Meanwhile, LA-PW/CW1000 exhibited better thermal cycling stability and chemical stability after 200 cycles.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2025-07-24DOI: 10.1002/slct.202501535
Inayá F. S. Bussolo, Cecília A. Silveira, Virgínia S. Souza, Daniel Rapachi, Marcos A. Gelesky, Jackson D. Scholten
{"title":"Synthesis of Mixed Oxides Through the Hydrolysis of Ionic Liquids and Assessment of Their Catalytic Activity in the Hydrogenation of CO2","authors":"Inayá F. S. Bussolo, Cecília A. Silveira, Virgínia S. Souza, Daniel Rapachi, Marcos A. Gelesky, Jackson D. Scholten","doi":"10.1002/slct.202501535","DOIUrl":"https://doi.org/10.1002/slct.202501535","url":null,"abstract":"<p>Mixed oxides, prepared through the hydrolysis of imidazolium ionic liquids (ILs), were investigated as potential catalysts for the hydrogenation of CO<sub>2</sub> to formate under mild reaction conditions. In this study, one-pot basic hydrolysis of two imidazolium ILs, [BMIm][MCl<i><sub>x</sub></i>] (M = Zn, Ta, Ce, and Ti; <i>x</i> = 3–6), led to the formation of mixed oxides that, after calcination at 800–1000 °C, produced perovskite-like structures (ZnTa<sub>2</sub>O<sub>6</sub>/Zn<sub>3</sub>Ta<sub>2</sub>O<sub>8</sub>, ZnTiO<sub>3</sub>/Zn<sub>2</sub>TiO<sub>4</sub>, and CeTa<sub>7</sub>O<sub>19</sub>). The hydrogenation of CO<sub>2</sub> catalyzed by the mixed oxides in the presence of a base (DBU) at 80 °C and 20 bar (10 bar CO<sub>2</sub> and 10 bar H<sub>2</sub>) gave up to 39 µmol of formate (6% yield) after 3 h of reaction.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202501535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2025-07-24DOI: 10.1002/slct.202501969
Annie Celin G, Jyoti Sahu
{"title":"High-Performance Ag–TiO2–SiO2 Hybrid Nanocomposite for Corrosion Protection: A Sustainable Solution","authors":"Annie Celin G, Jyoti Sahu","doi":"10.1002/slct.202501969","DOIUrl":"https://doi.org/10.1002/slct.202501969","url":null,"abstract":"<p>Corrosion is the progressive deterioration of metals due to chemical interactions with the environment. This involves the appearance of rust, typically in aquatic settings under moisture and oxygen. This work introduces hybrid Ag–TiO<sub>₂</sub>–SiO<sub>₂</sub> nanoparticles as a protective covering of mild steel in harsh environments. While the synthesis of TiO<sub>₂</sub>–SiO<sub>₂</sub> nanoparticles was done using the sol-gel technique, AgNPs were synthesized in green from almond leaf extract. The hybrid nanocomposite was sputtered onto mild steel to promote adhesion and ensure long-term protection. The structural and compositional investigation of XRD, SEM, and FTIR accorded the coating integrity. Electrochemical experiments revealed high corrosion resistance, minimal metal degradation, and an impressive 97.5% inhibition efficiency. In addition to corrosion protection, the coating displayed antibacterial efficiency. It was quantified using distinct and measurable zones of inhibition studies against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, which makes it suitable for applications where durability and cleanliness are desired. This study provides a sustainable and multipurpose response for high-tech maritime, biomedical, and industrial solutions in industries needing intense and persistent corrosion protection.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Triazoles Obtained by Nanocomposite-Catalyzed Click Reaction: Characterization, Theory, and Antiproliferative Action","authors":"Pradip Shit, Paromita Sarkar, Rameez Raza, Kakali Bhadra, Asoke P. Chattopadhyay","doi":"10.1002/slct.202406049","DOIUrl":"https://doi.org/10.1002/slct.202406049","url":null,"abstract":"<p>Five 1,2,3-triazole compounds were synthesized using click reaction catalyzed by a CuS-doped graphene oxide nanocomposite from sodium azide and substituted phenyl alkynes and epoxides. The products were characterized and tested against fibrosarcoma (HT-1080) and normal liver epithelial (WRL-68) cell lines. The compounds have little effect on somatic cells and suppress the growth of fibrosarcoma cells. One of the compounds, 2-(4-phenyl-[1,2,3]triazol-1-yl)-propan-1-ol, has the most effect among the set. It induces apoptosis and has antiproliferative and wound-healing properties. It also shows dose-dependent nuclear fragmentation, significant loss of mitochondrial membrane potential, and induces cell cycle arrest. Preliminary studies show minor groove binding of this compound with a DNA fragment.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ChemistrySelectPub Date : 2025-07-24DOI: 10.1002/slct.202500933
Amine Hafis Abdelsalam, Dr. Emrah Kavak, Dr. Şevki Arslan, Dr. Arif Kivrak
{"title":"Multitarget Anticancer and Anti-Inflammatory Properties of a Novel Artesunate–Indole Hybrid: Synthesis and Functional Evaluation","authors":"Amine Hafis Abdelsalam, Dr. Emrah Kavak, Dr. Şevki Arslan, Dr. Arif Kivrak","doi":"10.1002/slct.202500933","DOIUrl":"https://doi.org/10.1002/slct.202500933","url":null,"abstract":"<p>An amide-bridged artesunate–indole hybrid molecule (TRY–ART) was investigated for its anticancer and anti-inflammatory activities. Cytotoxicity studies revealed that TRY–ART exhibited significant cytotoxicity against Caco-2, LNCaP, HepG2, Ishikawa, and A549 cancer cell lines, with EC<sub>50</sub> values of 120.2 ± 1.14, 79 ± 0.54, 137.9 ± 0.78, 94 ± 2.37, and 183 ± 1.65 µM, respectively. Apoptosis analysis demonstrated that TRY–ART significantly induced apoptotic events in all tested cancer cell lines. It revealed its pro-apoptotic potential by upregulating the expression levels of pro-apoptotic genes (<i>BAX, CASP3, CASP8, CASP9</i>, and <i>P53</i>) and downregulating the anti-apoptotic gene <i>BCL2</i>. Colony-formation assays showed a reduction in colony formation capacity, and wound-healing assays indicated its efficacy against cell migration. qRT-PCR analysis revealed strong anti-migration effects by downregulating migration-related genes (<i>MMP2 and MMP9</i>) and upregulating their inhibitors (<i>TIMP1</i> and <i>TIMP2</i>). Furthermore, anti-inflammatory evaluation by the Griess method in Lipopolysaccharide (LPS)-induced RAW264.7 macrophages revealed that TRY–ART suppressed nitric oxide production by 35% and significantly downregulated pro-inflammatory genes (<i>Cox-2, Inos, Tnf-α, and Il6</i>) while upregulating the anti-inflammatory gene <i>Il10</i>. In conclusion, the newly synthesized amide-bridged artesunate–indole hybrid molecule, TRY–ART, exhibits promising anticancer and anti-inflammatory properties.</p>","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 28","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202500933","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144688256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}