ChemistrySelect最新文献_第7页

Single-Particle Diffusion at the Vertical Silicone Oil-Water Interface 垂直硅油-水界面上的单粒子扩散

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-04-23 DOI: 10.1002/slct.202406040

Mary McDonald, Samuel Showunmi, Mac Crimmins, Khanh-Hoa Tran-Ba

{"title":"Single-Particle Diffusion at the Vertical Silicone Oil-Water Interface","authors":"Mary McDonald, Samuel Showunmi, Mac Crimmins, Khanh-Hoa Tran-Ba","doi":"10.1002/slct.202406040","DOIUrl":"https://doi.org/10.1002/slct.202406040","url":null,"abstract":"This paper reports single-particle tracking (SPT) measurements of the lateral mass transport behaviors of individual fluorescent particles at a vertical silicone oil-water interface. By loading each half of the polydimethylsiloxane-based microfluidic channel with silicone oil (viscosity: 20 – 200 mPas) and particle-doped water side-by-side, a vertical liquid-liquid interface was formed. Carboxylated polystyrene microspheres (diameter: 200 nm) were used as fluorescent particles to simultaneously probe the complex nanoparticle transport characteristics at the liquid interface and in the adjacent water/oil phases. A wealth of different types of probe behaviors were observed and quantitatively assessed, including interfacial adsorption and desorption, hindered and Brownian motions, and partitioning dynamics of the particle between the immiscible liquids. The vertical fluid interface also allowed for a single particle to be followed over extended time and length scales, revealing its transitional behavior from one transport mode to the other. Interestingly, the fluid interface bending by a particle's diffusive motion has offered an intriguing means to investigate and correlate the single-particle's capillary forces to its mass transport characteristics. The usefulness of a vertical oil-water interface and power of SPT methods for offering an advanced characterization of the liquid interface's nanoscale properties have been thoroughly demonstrated in this work.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Microencapsulation of Sandalwood Essential Oil with Melamine Formaldehyde and β-Cyclodextrin: Analysis of Study on Aroma Profile Components and Antibacterial Properties 用三聚氰胺甲醛和β-环糊精微胶囊化檀香精油：香气特征成分和抗菌性能研究分析

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-04-22 DOI: 10.1002/slct.202405908

Shifei Kang, Shanming Li, Shenjie Han, Limin Peng

{"title":"Microencapsulation of Sandalwood Essential Oil with Melamine Formaldehyde and β-Cyclodextrin: Analysis of Study on Aroma Profile Components and Antibacterial Properties","authors":"Shifei Kang, Shanming Li, Shenjie Han, Limin Peng","doi":"10.1002/slct.202405908","DOIUrl":"https://doi.org/10.1002/slct.202405908","url":null,"abstract":"To maintain the biological activities of sandalwood essential oil (SEO), antibacterial microcapsules were prepared through the encapsulation of SEO with melamine formaldehyde (MF) resin and β-cyclodextrin (β-CD). The micromorphology, chemical structure, and thermal stability of MF and β-CD microcapsules were characterized through scanning electron microscopy, Fourier-transform infrared spectroscopy, and thermogravimetric analysis. The results were compared to highlight the differences between the microcapsules. Additionally, the changes in the aroma components of the essential oil during the microencapsulation process were analyzed. The volatile organic compounds (VOCs) and their relative contents retained in SEO throughout the microencapsulation process were examined. VOCs in both essential oil and essential oil microcapsules were identified via headspace-solid phase microextraction combined with gas chromatography-mass spectrometry. The results revealed that β-santalol and α-santalol were the primary VOCs in SEO. Even after microencapsulation, SEO successfully retained its characteristic VOCs. Additionally, the antibacterial properties of essential oil microcapsules were evaluated using the plate coating counting method. These results confirmed that microencapsulated SEO maintained significant antibacterial activity against Escherichia coli and Staphylococcus aureus. This study provides valuable theoretical insights to support future research on the release behavior of SEO microcapsules.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing Interactions with DNA, Gene Transfection Potential, and Cytotoxicity of Amide-Bonded Cationic Gemini Surfactants: The Role of Chain Length 评估与DNA的相互作用，基因转染潜力，以及酰胺键结阳离子Gemini表面活性剂的细胞毒性：链长度的作用

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-04-22 DOI: 10.1002/slct.202502049

Homen Dahal, Sadhana Roy, Joykrishna Dey, Somdeb Bose Dasgupta

{"title":"Assessing Interactions with DNA, Gene Transfection Potential, and Cytotoxicity of Amide-Bonded Cationic Gemini Surfactants: The Role of Chain Length","authors":"Homen Dahal, Sadhana Roy, Joykrishna Dey, Somdeb Bose Dasgupta","doi":"10.1002/slct.202502049","DOIUrl":"https://doi.org/10.1002/slct.202502049","url":null,"abstract":"Gemini surfactants or simply Gemini with dual hydrophobic tails and hydrophilic head groups show promise in gene delivery applications due to their strong electrostatic interactions with negatively charged biomolecules. This study investigates the in-vitro transfection efficiency of three amide-bonded Gemini (AG-12, AG-14, AG-16) at varying charge ratios (−/+). Optimal transfection efficiency was observed between 0.6 and 0.2, with AG-16 (16-carbon chain) demonstrating the highest efficiency, although its performance declined at higher concentrations due to strong DNA binding. All three Gemini outperformed the commercial standard, Turbofectamine, highlighting their potential in gene therapy. Ethidium bromide displacement assays revealed that the Gemini bind DNA through electrostatic and hydrophobic interactions, enhancing DNA compaction without significant conformational changes. Longer alkyl chains promoted DNA condensation and increased binding affinity. Dynamic light scattering studies revealed the stability of DNA-Gemini complexes, which was influenced by charge ratio (−/+), providing insights into gene transfection outcomes. Cytotoxicity studies conducted on RAW 264.7 and HEK 293 cells revealed that the Gemini surfactants exhibited a greater toxic effect on the cancerous cells than on the healthy ones at higher concentrations. These findings underscore Gemini's potential for gene delivery, emphasizing the importance of optimizing charge ratio and chain length for efficient, low-toxicity applications.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Quinic Acid-Derived Sialylmimetics and Their Effects on T. cruzi and Trans-Sialidase 奎宁酸类唾液酸酯的合成及其对克氏体和反式唾液酸酯酶的影响

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-04-22 DOI: 10.1002/slct.202501917

Dayan Setton Amancio, Guilherme Martins da Silva, Carlos Henrique Tomich de Paula da Silva, Luis Otávio Bunhotto Zamoner, Lizandra Guidi Magalhães, Guilherme Cecilio Lima, Mariana Zaramello da Paixão, Ivone Carvalho

{"title":"Synthesis of Quinic Acid-Derived Sialylmimetics and Their Effects on T. cruzi and Trans-Sialidase","authors":"Dayan Setton Amancio, Guilherme Martins da Silva, Carlos Henrique Tomich de Paula da Silva, Luis Otávio Bunhotto Zamoner, Lizandra Guidi Magalhães, Guilherme Cecilio Lima, Mariana Zaramello da Paixão, Ivone Carvalho","doi":"10.1002/slct.202501917","DOIUrl":"https://doi.org/10.1002/slct.202501917","url":null,"abstract":"Chagas disease, caused by the protozoan Trypanosoma cruzi, affects 6–7 million people worldwide, mainly in South and Central America. A key enzyme in the disease's progression is Trypanosoma cruzi trans-sialidase (TcTS), which facilitates parasite invasion by transferring sialic acid residues from host glycoconjugates to the parasite's surface mucins. Given the potential of sialic acid-based inhibitors to block TcTS activity, we designed and synthesized novel sialylmimetics using quinic and shikimic acids. These precursors were chosen for their structural similarity to sialic acid and high enantiomeric purity. Furthermore, the potent antitrypanosomal activity previously observed for derivatives containing the 4-(4-nitrophenyl)-1H-1,2,3-triazole unit led us to hypothesize that a hybrid could achieve strong TcTS inhibition while retaining anti-parasitic activity. A lead compound, bearing the 5R-4-(4-nitrophenyl)-1H-1,2,3-triazole, emerged as the most effective TcTS inhibitor (IC50 226 ± 13 µm), while its 5S counterpart was less active. Additional analogs with modified side chains were synthesized, leading to the dimerized triazole compound, which demonstrated strong anti-T. cruzi activity (IC50 10.60 ± 2.12 µm) and a high selective index. These findings highlight the potential of sialylmimetic hybrids as promising candidates for new antitrypanosomal drugs, addressing the urgent need for improved treatments against Chagas disease.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202501917","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phosphine-Catalyzed Tandem Annulation/Rearrangement Reaction of Enynes with N-Tosylimines 膦催化烯类与n -托苯胺的串联环化/重排反应

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-04-22 DOI: 10.1002/slct.202500661

Siting Qu, Shuang Gu, Yi Tang, Dr. Bing Zheng, Prof. Dr. Hongchao Guo

引用次数: 0

In Vitro and In Silico Evaluation of the Anticancer and Antiparasitic Activities of New 2-Methoxy Azachalconium Bromides 新型2-甲氧基溴化Azachalconium的体外和硅内抗癌和抗寄生虫活性评价

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-04-22 DOI: 10.1002/slct.202500247

Mai F. AlSakhen, Sana I. Kanaan, Khaled Saleh, Salem R. Yasin, Ibrahim S. Al nasr, Waleed S. Koko, Tariq A. Khan, Kamal A. Qureshi, Rainer Schobert, Bernhard Biersack, Lubna Tahtamouni

{"title":"In Vitro and In Silico Evaluation of the Anticancer and Antiparasitic Activities of New 2-Methoxy Azachalconium Bromides","authors":"Mai F. AlSakhen, Sana I. Kanaan, Khaled Saleh, Salem R. Yasin, Ibrahim S. Al nasr, Waleed S. Koko, Tariq A. Khan, Kamal A. Qureshi, Rainer Schobert, Bernhard Biersack, Lubna Tahtamouni","doi":"10.1002/slct.202500247","DOIUrl":"https://doi.org/10.1002/slct.202500247","url":null,"abstract":"Three new N-alkylpyridinium-based 2-methoxy chalcones with long, fatty alkyl chains were prepared and tested for their anticancer and antiparasitic activities. The N-octadecyl derivative (2c) displayed considerable activity against and selectivity for BRAF-mutant HT-29 colorectal carcinoma cells. Increased mRNA expression of caspases and apoptosis induction was found. In addition, expression of MEKs and ERKs was upregulated. EGFR inhibition was identified as mechanism of action for this compound further supported by in silico molecular docking studies, which revealed a binding energy of −9.19 kcal/mol against EGFR. Additionally, a strong binding affinity for VEGFR-2 was observed with a binding energy of −11.01 kcal/mol. The development of the described chalcone as anticancer drug appears to be promising. In addition, all three tested chalcone derivatives exhibited significant activities against Toxoplasma gondii and Leishmania major parasites, albeit without selectivity. Thus, the present study describes for the first time the kinase-inhibitory, anti-leishmanial, and anti-toxoplasmal activities of N-alkyl azachalconium compounds.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valorization Using Box-Behnken Design for Phenylalkane-SJ1 from Syzygium jambos (L.) Alston Leaves and its In Vitro α-amylase and α-glucosidase Effects 用Box-Behnken设计对榛木苯烷- sj1进行鉴定阿尔斯通叶及其α-淀粉酶和α-葡萄糖苷酶的体外效应

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-04-22 DOI: 10.1002/slct.202500486

Ramya M. Subramani, Steffi Priya Jayaseelan, Bhanuvalli R. Shamprasad, Rajadurai Arumugam, Avinaash A. Saravanan, Madipakkam Sriram Prashanth, Ganesh Munuswamy Ramanujam, Arvind Sivasubramanian

{"title":"Valorization Using Box-Behnken Design for Phenylalkane-SJ1 from Syzygium jambos (L.) Alston Leaves and its In Vitro α-amylase and α-glucosidase Effects","authors":"Ramya M. Subramani, Steffi Priya Jayaseelan, Bhanuvalli R. Shamprasad, Rajadurai Arumugam, Avinaash A. Saravanan, Madipakkam Sriram Prashanth, Ganesh Munuswamy Ramanujam, Arvind Sivasubramanian","doi":"10.1002/slct.202500486","DOIUrl":"https://doi.org/10.1002/slct.202500486","url":null,"abstract":"Syzygium jambos (L.) Alston is widely cultivated for edible fruits, which possess antidiabetic activity, but the phytochemistry of S. jambos leaves has not yet been explored completely. This study explores a sustainable valorization of S. jambos leaves for secondary metabolites, especially phenylalkanes, and explores its antidiabetic activity. The S. jambos leaf extract was prepared in different green solvents such as water, aqueous methanol, and aqueous ethanol, and screened for the presence of phytochemicals. The suitable solvent for extraction was identified as water, with a total phenolic content of 157 ± 0.56 mg GAE/g dry extract and a total flavonoid content of 68 ± 0.54 mg RT/g dry extract. Salt-assisted optimization was performed for the precipitation of phenols and flavonoids with five different salt solutions and different concentrations. 1 M sodium acetate precipitated a phenylalkane (SJ1)—6-heptadeca-9′Z,12′z-dienyl salicylic acid. The Box–Behnken RSM method was designed to increase the yield of SJ1 from S. jambos leaf extract having variables such as sodium acetate concentration, solid–solvent ratio, Time, and yield of SJ1 as a response. The highest yield(11.18 mg) of SJ1 was precipitated under the optimum conditions of sodium acetate:1.057 M, solid–solvent%: 8.011, and time 43 .4 min. in vitro α-amylase and α-glucosidase antidiabetic assays exhibited SJ1 as the potent antidiabetic compound with IC50 0.104 ± 0.086 and IC50 0.229 ± 0.112 respectively.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143856782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of Sulfur Precursor Reactivity on Size-Controlled and Optical Properties of CdS Nanocrystals 硫前驱体反应活性对CdS纳米晶体尺寸控制和光学性质的影响

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-04-22 DOI: 10.1002/slct.202500203

Nguyen Minh Hoa

{"title":"Influence of Sulfur Precursor Reactivity on Size-Controlled and Optical Properties of CdS Nanocrystals","authors":"Nguyen Minh Hoa","doi":"10.1002/slct.202500203","DOIUrl":"https://doi.org/10.1002/slct.202500203","url":null,"abstract":"This study investigates the synthesis of cadmium sulfide (CdS) nanocrystals (NCs) using a hot-injection method, focusing on how sulfur precursor reactivity, controlled by its preparation temperature, influences the final nanomaterial properties. The sulfur precursor was prepared at three temperatures (120, 140, and 180 °C) to modulate its reactivity. Transmission electron microscopy, UV–vis spectroscopy, and photoluminescence spectroscopy were employed to characterize the size, morphology, and optical properties of the resulting CdS NCs. We found a clear correlation between the sulfur precursor preparation temperature and the CdS nanocrystal properties. The precursor prepared at 140 °C resulted in the most homogeneous growth, leading to the smallest size distribution and highest quality NCs, as evidenced by the higher PL intensity. The precursor prepared at 180 °C resulted in a faster growth rate, ultimately leading to larger NCs with inhomogeneous morphologies, while the 120 °C precursor exhibited the slowest growth rate, producing larger particles with a wider size distribution. These findings underscore the significant role of sulfur precursor preparation temperature in controlling the final CdS nanocrystal material properties, offering valuable insights for the tailored synthesis of high-quality CdS nanomaterials for diverse applications.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143857071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the Role of Synthesis Temperature in δ-MnO2 Nanosphere Formation for High-Performance Supercapacitors 揭示合成温度在高性能超级电容器δ-MnO2纳米球形成中的作用

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-04-22 DOI: 10.1002/slct.202500904

Dinesh P. Shinde, Yogesh A. Pathak, Aparna T. Mane, Dattatray H. Bobade, Gajanan M. Hingangavkar, Shaukat L. Tamboli, Sanjeev D. Chavan

{"title":"Unravelling the Role of Synthesis Temperature in δ-MnO2 Nanosphere Formation for High-Performance Supercapacitors","authors":"Dinesh P. Shinde, Yogesh A. Pathak, Aparna T. Mane, Dattatray H. Bobade, Gajanan M. Hingangavkar, Shaukat L. Tamboli, Sanjeev D. Chavan","doi":"10.1002/slct.202500904","DOIUrl":"https://doi.org/10.1002/slct.202500904","url":null,"abstract":"In the present research work, reported a role of controlled temperature for the synthesis of the 2D layered structure of the δ-MnO2 nanospheres, for high capacitance, were synthesized using the simple, facile hydrothermal method. The temperature taken for the synthesis of δ-MnO2 as 140, 160, and 180 °C. The highest specific capacitance 525.93 F g−1 in 1 m Na2SO4 electrolyte for 5 mV s−1 scan rate was observed for the sample prepared at a temperature 180 °C. The symmetric δ-MnO2 supercapacitor device was fabricated using a liquid-state assembly process, with EIS confirmed low charge transfer resistance and excellent cycling stability. From XRD studies, confirmed that the synthesized material is δ-MnO2 with crystalline size increases from 10 to 16 nm as the temperature increases. FESEM confirmed that the prepared sample is of nanosphere like morphology, and the average grain size decreases from 700 to 300 nm as the temperature increases. EDAX analysis reveals that the prepared sample only contains Mn and O there is no any impurity present. Advantageously, the water contact angle of the prepared electrode is hydrophilic in nature. The Raman and FTIR spectroscopy investigated the chemical structure and functional groups present in δ-MnO2. The oxidation states of Mn and O are analysed using XPS.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 16","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143861651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Native α- and β-Cyclodextrin Cobalt Complexes as Catalysts in Sulfoxidation Reaction 天然α-和β-环糊精钴配合物在亚砜化反应中的催化作用

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-04-22 DOI: 10.1002/slct.202500121

Dr. Diana C. Pinilla Peña, Dr. Laura I. Rossi

引用次数: 0