Ru(II)-Catalyzed C-H Alkylation of Indoles at the C-3 Position with Coumarin-3-Carboxylic Acids

IF 1.9 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

ChemistrySelect Pub Date : 2025-05-22 DOI:10.1002/slct.202500281

Lina Jia, Zhikui Zhang

引用次数: 0

Abstract

A ruthenium(II)-catalyzed C3-selective C─H activation of indoles bearing a pyridyl or pyrimidine directing group and subsequent conjugated/decarboxylative addition to coumarin-3-carboxylic acids has been demonstrated. This protocol efficiently afforded a variety of coumarin-containing indoles with excellent site selectivity, satisfactory product yields, and functional group tolerance.

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Ru（II）催化吲哚在C-3位与香豆素-3羧酸的C-H烷基化反应

钌（II）催化具有吡啶或嘧啶导向基团的吲哚的c3选择性C─H活化和随后的共轭/脱羧添加到香豆素-3羧酸中。该方案有效地提供了多种含香豆素的吲哚，具有良好的位点选择性，令人满意的产物收率和官能团耐受性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemistrySelect Chemistry-General Chemistry

CiteScore

3.30

自引率

4.80%

发文量

1809

审稿时长

1.6 months

期刊介绍： ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.