ChemistrySelect最新文献_第6页

Synthesis and Characterization of Biomass Derived Modified Lignin Based PVA Hydrogel as Drug Delivery System for Ciprofloxacin

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-02-06 DOI: 10.1002/slct.202404597

Vinay Singh, Surbhi Dhukia, Lavanya Khullar, Swati Sihag, Ramandeep Kaur, Kusum Harjai, Vasundhara Singh

{"title":"Synthesis and Characterization of Biomass Derived Modified Lignin Based PVA Hydrogel as Drug Delivery System for Ciprofloxacin","authors":"Vinay Singh, Surbhi Dhukia, Lavanya Khullar, Swati Sihag, Ramandeep Kaur, Kusum Harjai, Vasundhara Singh","doi":"10.1002/slct.202404597","DOIUrl":"https://doi.org/10.1002/slct.202404597","url":null,"abstract":"In the present study, a newly extracted lignin-based hydrogel has been explored for the release of ciprofloxacin as an effective drug delivery system. The modified extracted lignin hydrogel was prepared and the Ciprofloxacin drug was used to examine the loading and release capabilities of hydrogel. The hydrogel was characterized by FT-IR, TGA-DTG, and SEM analysis as well as swelling ratio and mechanical test. The outcomes demonstrated that the hydrogel that was made shows high mechanical strength (elongation 442.85%), swelling ratio, effectively contained and released the ciprofloxacin. The developed hydrogel encapsulation effectiveness of CP was seen to rise as the drug concentration increased, reaching around 81.3 ± 4.1% at 500 µg/mL of CP. A release analysis conducted in vitro in phosphate buffer saline (PBS) demonstrated a consistent increase in the cumulative drug release, with the greatest release quantity reaching around 88.2 ± 3.2% after 10 h. As compared to hydrogel containing a lower quantity of drug (0.07 ± 0.06%), the hydrogel with high drug loading efficiency (0.78 ± 0.08%) showed a rapid and greater release rate. The CP-loaded hydrogel exhibits antibacterial activity towards S. aureus, B. subtilis, A. baumannii, P. aeruginosa. The sustained release of ciprofloxacin from the modified lignin-based hydrogel identifies them as a viable option for designing drug delivery systems.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 6","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143362477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PVP-I Catalyzed Hydroxysulfurization of α-(Trifluoromethyl)-Styrenes with Thiols: Access to Trifluoromethyl Tertiary Alcohol

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-02-06 DOI: 10.1002/slct.202405351

Qian-Ding Zeng, Xinxin Yuan, Jian Wang, Hongmiao Yao, Bu-Bing Zeng, Jiangmeng Ren, Wu-Lin Yang

引用次数: 0

Adsorption and Photodegradation of Organic Compounds in Wastewater by Hierarchical Organic Molecular Sieves

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-02-05 DOI: 10.1002/slct.202405586

Linhua Song, Tengfei Jiang, Mengmeng Sun, Yuqing Ouyang, Zi Wang, Yonghang Mu, Kuo Sun

{"title":"Adsorption and Photodegradation of Organic Compounds in Wastewater by Hierarchical Organic Molecular Sieves","authors":"Linhua Song, Tengfei Jiang, Mengmeng Sun, Yuqing Ouyang, Zi Wang, Yonghang Mu, Kuo Sun","doi":"10.1002/slct.202405586","DOIUrl":"https://doi.org/10.1002/slct.202405586","url":null,"abstract":"Dyes with aromatic structures are known for their persistence and high toxicity. Once these dyes enter aquatic environments, they pose significant threats to both the ecosystem and human health. In this study, N,N-dimethylethylenediamine(DMEN) was used as a template to synthesize the ZIF-8 material, characterized by a high specific surface area and high mesoporosity. The hierarchical ZIF-8 material is utilized to remove dyes from simulated wastewater. It can adsorb organic dye molecules and harmful metal ions from dye-laden wastewater. And the two processes do not exhibit significant interference with each other. The results indicate that the hierarchical ZIF-8 exhibits excellent adaptability to wastewater environments with high salinity and extreme pH levels. The equilibrium adsorption capacity of hierarchical ZIF-8 for methylene blue is twice that of microporous ZIF-8, and its photocatalytic efficiency is enhanced by 30% compared to microporous ZIF-8. Moreover, the photocatalytic performance significantly improves under alkaline conditions: at a pH of 12, the degradation rate of methylene blue reaches 96.9%. The study found that hierarchical ZIF-8 primarily follows the photocatalytic reaction mechanism during the catalytic degradation of methylene blue. Hierarchical ZIF-8 demonstrates significant potential for application in textile wastewater treatment.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynole-Based Dynamin Inhibitors as Novel Cytotoxic Agents

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-02-05 DOI: 10.1002/slct.202405049

Dr. Jennette A. Sakoff, Dr. Mohammed K. Amin, Dr. Mark J. Robertson, Dr. Beatrice Chiew, Dr. Mark Tarleton, Kelly A. Young, Barbara Venn-Brown, Ngoc Chau, Dr. Christopher P. Gordon, Dr. Megan Chircop, Dr. Stefan Paula, Prof. Nigel C. Jones, Prof. Terence J. O'Brien, Prof. Phillip J. Robinson, Prof. Adam McCluskey

{"title":"Dynole-Based Dynamin Inhibitors as Novel Cytotoxic Agents","authors":"Dr. Jennette A. Sakoff, Dr. Mohammed K. Amin, Dr. Mark J. Robertson, Dr. Beatrice Chiew, Dr. Mark Tarleton, Kelly A. Young, Barbara Venn-Brown, Ngoc Chau, Dr. Christopher P. Gordon, Dr. Megan Chircop, Dr. Stefan Paula, Prof. Nigel C. Jones, Prof. Terence J. O'Brien, Prof. Phillip J. Robinson, Prof. Adam McCluskey","doi":"10.1002/slct.202405049","DOIUrl":"https://doi.org/10.1002/slct.202405049","url":null,"abstract":"Dynamin plays a crucial role in mitosis, and dynamin inhibition broadly correlates with cytotoxicity. Dynole 34–2, dynamin inhibitor, is highly cytotoxic, but its poor drug-like properties limit its in vivo development. Three focused libraries of dynole-based dynamin inhibitors were synthesized enhance their druglike properties while maintaining their dynamin inhibition and cytotoxicity. Iterative modifications were undertaken to probe the effects of changes to the cyanoacrylamide linker amide, alkyl chain moieties, the N-propyl-N,N-dimethylamino moiety and the indole core. These compounds were screened against: HT29 and SW480 (colon), SMA (spontaneous murine astrocytoma), MCF-7 (breast), BE2-C (glioblastoma), SJ-G2 (neuroblastoma), MIA (pancreas), A2780 (ovarian), A431 (skin), H460 (lung), U87 (glioblastoma) and DU145 (prostate) cell lines to reveal a good correlation between dynamin inhibition and cytotoxicity. High potency against brain cancer cell lines was observed. The most dynamin active compounds returned average GI50 values of 2.26 and 1.5 µM across the cell lines examined. The most active compound against 4 brain cancer cell lines averaged a GI50 value of 4.7 µM; 10-fold improved over the gold standard for glioblastoma treatment; temozolomide. Importantly, this maintained a tPSA of 24.8Å2 and cLogP of 4.11; appropriate for blood brain barrier penetration. This active analogue in this series was (Z)-2-(3,4-dichlorophenyl)-3-(1-(3-(dimethylamino)propyl)-1H-pyrrol-3-yl)acrylonitrile (34).","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202405049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advancement in the Conversion of 1,2,3-Benzotriazin-4(3H)-One to Other Heterocyclic Systems and Their Applications: A Concise Review

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-02-05 DOI: 10.1002/slct.202404532

Zunera Khalid, Hafiz Adnan Ahmad, Munawar Ali Munawar, Rahila Huma, Noshin Afshan, Syed Salman Shafqat

{"title":"Recent Advancement in the Conversion of 1,2,3-Benzotriazin-4(3H)-One to Other Heterocyclic Systems and Their Applications: A Concise Review","authors":"Zunera Khalid, Hafiz Adnan Ahmad, Munawar Ali Munawar, Rahila Huma, Noshin Afshan, Syed Salman Shafqat","doi":"10.1002/slct.202404532","DOIUrl":"https://doi.org/10.1002/slct.202404532","url":null,"abstract":"The nitrogen containing 1,2,3-benzotriazin-4(3H)-one is structurally worthwhile system for its notable applications in the synthesis of N─, O─ and S─ heterocycles bears pivotal significant usage in the pharmaceutical and industrial chemicals. Today most of common items like dyes, cosmetics, sanitizers, insecticides and plastics are based on heterocyclic moieties. Different starting materials are used industrially for the formation of diverse heterocycles but 1,2,3-benzotriazin-4(3H)-one is a valuable structure used to prepare numerous valuable products. These conversions are radiation or metal-catalyzed denitrogenation annulation type reactions provide easy, one-step and atom-economical route. The vast applications of heterocycles and significance of their cheap synthesis make this subject interesting for scientific researchers and industrialists. This mini review summarizes the recent developments in the transformation of 1,2,3-benzotriazin-4(3H)-one ring to various other structures like phenanthridinones, isoquinolones, coumarin-1-imines, benzamides, pyrroloquinazolinones, indolin-1-ones, 1,2-benzisoselenazol-3(2H)-ones and benzofuranones. Some emerging drugs like ebselen, losartan, irbesartan, luotonin A, deoxyvasicinone and mackinazolinone have been successfully synthesized from differently substituted benzotriazinones.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indolin-2-Ones: A New Approach to Inflammation, Targeting LPS via GSK3β/NLRP3

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-02-05 DOI: 10.1002/slct.202403325

Vladlen Klochkov, Denis Babkov, Alexander Borisov, Laura Ianalieva, Roman Danilov, Elena Bezsonova, Sergey Sosonyuk, Natalia Lozinskaya, Alexander Spasov

{"title":"Indolin-2-Ones: A New Approach to Inflammation, Targeting LPS via GSK3β/NLRP3","authors":"Vladlen Klochkov, Denis Babkov, Alexander Borisov, Laura Ianalieva, Roman Danilov, Elena Bezsonova, Sergey Sosonyuk, Natalia Lozinskaya, Alexander Spasov","doi":"10.1002/slct.202403325","DOIUrl":"https://doi.org/10.1002/slct.202403325","url":null,"abstract":"Chronic inflammation is a key pathogenic driver in cardiovascular, neurodegenerative and metabolic diseases. Previously we identified highly active GSK3β inhibitors with antidiabetic potential among 3,5-disubstituted indolin-2-one derivatives. We found that these derivatives also possess a direct antioxidant activity, which was shown in in luminol-H2O2 and ABTS in vitro systems with IC50 level was up to 6.0 and 34.6 µM respectively. GSK3β is an essential part LPS-induced NF-κB and NLRP3 pathways activation. Hence, the most active compounds 3 and 5 were evaluated and found to exhibit high anti-inflammatory activity in LPS-induced activation of primary murine macrophages with IL-6 IC50 from 8.7 to 63.5 µM without cytotoxicity and also prevent LPS + ATP-induced NLRP3 activation in macrophages and peripheral blood mononuclear cells. Alongside compounds 3 and 5 retain macrophages phagocytic activity unlike dexamethasone. Animal's studies showed effective prevention of LPS-induced rat paw edema volume, NO, TNFα, and IL-1β formation after 30 mg/kg per oral administration. Hence, we identified candidates combining antidiabetic, antioxidant and anti-inflammatory activities promising as agents against inflammation-linked chronic diseases.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation on Diabetes and Mechanism of Thiadiazole–Schiff Base as Therapeutic Hybrid: Enzyme Activity and Molecular Docking Studies

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-02-05 DOI: 10.1002/slct.202404291

Tayyiaba Iqbal, Shoaib Khan, Rafaqat Hussain, Mohammed B. Hawsawi, Tariq Mehmood, Yameena Tahir, Mustafa S. Alluhaibi, Majed Alharbi

{"title":"Investigation on Diabetes and Mechanism of Thiadiazole–Schiff Base as Therapeutic Hybrid: Enzyme Activity and Molecular Docking Studies","authors":"Tayyiaba Iqbal, Shoaib Khan, Rafaqat Hussain, Mohammed B. Hawsawi, Tariq Mehmood, Yameena Tahir, Mustafa S. Alluhaibi, Majed Alharbi","doi":"10.1002/slct.202404291","DOIUrl":"https://doi.org/10.1002/slct.202404291","url":null,"abstract":"In an approach to combat diabetes mellitus, a widely spread noncommunicable disease (NCDs), a novel series of compounds (1–18) containing substituted thiadiazole bearing Schiff base derivative was synthesized and evaluated against enzymes causing diabetes mellitus. The results confirm that most of the compounds were found active and exhibit excellent biological activity as compared to the standard drug acarbose. Their minimal inhibitory concentrations for both enzymes lie in a range between 18.10 ± 0.30 and 2.10 ± 0.30 µM for α-amylase and 19.20 ± 0.30 µM and 2.70 ± 0.80 µM for α-glucosidase in contrast with the reference drug having IC50 of 4.30 ± 0.40 and 5.10 ± 0.70 µM. The most active analogs were found to be 2, 4, 7, 9, and 15, which displayed few-fold higher potency than the control drug. Structural evaluation was conducted using various spectroscopic techniques such as 1H NMR, 13C NMR and HREIMS for all the synthesized derivatives, and in silico molecular docking studies of all the active analogs confirms the interactions between ligand and binding proteins.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Simple Voltammetric Method for Estrogens Determination (E1, E2, E3, EE2, and E2Ac) in Pharmaceuticals and Human Urine Using an Unmodified Screen-Printed Carbon Sensor

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-02-05 DOI: 10.1002/slct.202404805

Diego Escobar-Olivos, Marisol Gómez, Juan José Triviño, Verónica Arancibia, Carlos Rojas-Romo

{"title":"Development of a Simple Voltammetric Method for Estrogens Determination (E1, E2, E3, EE2, and E2Ac) in Pharmaceuticals and Human Urine Using an Unmodified Screen-Printed Carbon Sensor","authors":"Diego Escobar-Olivos, Marisol Gómez, Juan José Triviño, Verónica Arancibia, Carlos Rojas-Romo","doi":"10.1002/slct.202404805","DOIUrl":"https://doi.org/10.1002/slct.202404805","url":null,"abstract":"An efficient, fast, and sensitive method for the determination of estrone (E1), 17β-estradiol (E2), estriol (E3), ethinylestradiol (EE2), and β-estradiol-17-acetate (E2Ac) in pharmaceutical formulations and spiked human urine was developed and validated using an unmodified commercial screen-printed carbon electrode. The utilization of linear sweep and square wave voltammetry was compared, and experimental conditions were optimized. In a 6.0 mmol L−1 phosphoric acid solution, the current intensity of the oxidation of the aromatic alcohol was used as the analytical response. The peak potential of each estrogen oxidation signal was found between 0.62 and 0.67 V. The detection limits were found to be for E1, E2, E2Ac, EE2, and E3 were 43, 25, 32, 42, and 44 nmol L−1 using linear sweep voltammetry and 20, 21, 37, 53, and 39 nmol L−1 using square wave voltammetry, respectively. The method was successfully applied to the determination of estrogens in a commercial and spiked drug tablets and spiked human male urine samples. The findings from this study establish a strong basis for the future application of the method in conjunction with high-performance liquid chromatography for the determination of estrogens in samples characterized by complex matrices.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Functionalization of Graphene Oxide and Its Role in Catalytic Organic Transformations: A Comprehensive Review (2018–2024)

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-02-05 DOI: 10.1002/slct.202404742

Anjali, Anupam Mishra, Mehak Khurana, Balaram Pani, Satish K. Awasthi

{"title":"Recent Advances in Functionalization of Graphene Oxide and Its Role in Catalytic Organic Transformations: A Comprehensive Review (2018–2024)","authors":"Anjali, Anupam Mishra, Mehak Khurana, Balaram Pani, Satish K. Awasthi","doi":"10.1002/slct.202404742","DOIUrl":"https://doi.org/10.1002/slct.202404742","url":null,"abstract":"Heterogeneous catalysis has become a key methodology for the sustainable synthesis of organic reactions and heterocyclic compounds. Among various catalysts, graphene oxide (GO) and its functionalized graphene oxide derivatives (fGO) stand out due to their high surface area, mechanical strength, and tunable electronic properties. This review provides a detailed overview of the role of GO in catalysis, emphasizing its structural features, functionalization strategies, and catalytic applications. Specific reactions such as oxidation, reduction, esterification, and heterocyclic synthesis are discussed, with a focus on the superior performance of functionalized graphene oxide (fGO). Challenges like stability and aggregation are explored, alongside potential solutions through chemical, thermal, and electrochemical functionalization. The review also examines future directions, highlighting graphene oxide (GO's) versatility and emerging applications in energy storage, sensors, and biomedical devices. By summarizing current advancements and addressing ongoing challenges, this review underscores the potential of fGO to revolutionize catalytic processes and contribute to sustainable chemistry.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143248447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2-Indolinone: An Anticancer Scaffold, Overview of the Studies and Approaches (2017–2024)

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-02-05 DOI: 10.1002/slct.202405357

Taha Koulani, Asu Busra Temizer, Prof. Dr. Nilgun Karali

{"title":"2-Indolinone: An Anticancer Scaffold, Overview of the Studies and Approaches (2017–2024)","authors":"Taha Koulani, Asu Busra Temizer, Prof. Dr. Nilgun Karali","doi":"10.1002/slct.202405357","DOIUrl":"https://doi.org/10.1002/slct.202405357","url":null,"abstract":"2-Indolinone is a versatile scaffold that has been the central moiety in the structure of various drugs. Since the introduction of sunitinib malate, 2-indolinones have been a principal pharmacophoric building block in many drug discovery studies, especially in the last few years. Compounds bearing the 2-indolinone ring system have shown various therapeutic effects, including but not limited to, antidiabetic, antioxidant, anti-inflammatory, anti-HIV, antimicrobial, antipsychotic, antiparkinson, and anticancer activities. Considering that cancer is among the major global causes of death, the antiproliferative activities of these compounds have been the goal of numerous studies. The present review presents an overview of the approaches and advances made during the last eight years (2017–2024) regarding the development of 2-indolinone derivatives within the field of anticancer drug discovery. The derivates gathered herein are classified according to the therapeutic target of the developed compounds, and notable structure-activity relationships as well as significant molecular docking interactions with the target enzymes have been highlighted in each instance. Accordingly, special attention has been paid to reporting derivatives with superior antiproliferative and enzymatic inhibitory effects that have emerged as lead compounds within each respective study.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 5","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0