ChemistrySelect最新文献_第5页

Enhanced Solar Photocatalysis: Vapor Pressure Synthesis of Ni-Doped SnO2 Nanoparticles for Efficient Organic Dye Degradation

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-03-26 DOI: 10.1002/slct.202500201

Bommu Padmaja, S. Dhanapandian, Prabhu Paramasivam, Abinet Gosaye Ayanie

{"title":"Enhanced Solar Photocatalysis: Vapor Pressure Synthesis of Ni-Doped SnO2 Nanoparticles for Efficient Organic Dye Degradation","authors":"Bommu Padmaja, S. Dhanapandian, Prabhu Paramasivam, Abinet Gosaye Ayanie","doi":"10.1002/slct.202500201","DOIUrl":"https://doi.org/10.1002/slct.202500201","url":null,"abstract":"In this study, pure and Ni-doped SnO₂ (Ni@SnO₂) nanoparticles (NPs) were successfully synthesized using the vapor pressure approach, with Ni concentrations ranging from 0.02 to 0.06 M. The synthesized materials were thoroughly characterized using various analytical techniques. Structural properties were examined through XRD, FTIR, and XPS analyses, whereas morphological features were investigated using SEM and HRTEM. The band structure and optical properties were analyzed via UV–vis and PL spectroscopy. Photocatalytic (PC) activity was assessed by evaluating the degradation efficiency of Alizarin Red S (ARS), brilliant green (BG), and methyl orange (MO) dyes under solar irradiation. Compared to pure SnO₂, Ni@SnO₂ NPs exhibited significantly enhanced degradation efficiency, achieving up to 94%. The PC rate constant of Ni@SnO₂ NPs was notably higher than that of pure SnO₂. Moreover, Ni@SnO₂ NPs demonstrated exceptional stability in cycling degradation tests, retaining 93% BG degradation efficiency even after 5 cycles.These findings highlight the potential of Ni-doped SnO2 NPs as highly efficient and stable photocatalysts for the effective degradation of organic pollutants, offering a promising solution for environmental remediation.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 12","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile Synthesis of CuFe2O4 Magnetic Nanospheres with High Separation Efficiency for Histidine-Rich Proteins

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-03-26 DOI: 10.1002/slct.202405569

Tong Tong, Qitong Yu, Siqi Liu, Haixia Shan, Haiyan Li

{"title":"Facile Synthesis of CuFe2O4 Magnetic Nanospheres with High Separation Efficiency for Histidine-Rich Proteins","authors":"Tong Tong, Qitong Yu, Siqi Liu, Haixia Shan, Haiyan Li","doi":"10.1002/slct.202405569","DOIUrl":"https://doi.org/10.1002/slct.202405569","url":null,"abstract":"In this study, CuFe2O4 magnetic nanospheres (MNSs) has been successfully synthesized through a one-step solvothermal method using polyethylene glycol as protective agent and surface dispersant, which can reduce the size and inhibit its agglomeration of MNSs. It shows that MNSs presented a nanosphere structure, the size can be adjusted from 130 to 210 nm, has good dispersion, favorable crystallinity, magnetism and thermal stability. CuFe2O4 MNSs were applied for the separation of histidine-rich proteins, assessing their binding capacity using bovine serum albumin (BSA), bovine hemoglobin (BHb). The results demonstrated the excellent selectivity of CuFe2O4 MNSs towards BHb. In selective adsorption experiments with BHb, equilibrium was reached in 10 min with a high saturation capacity of 5975 mg·g−1. Even after 5 cycles of adsorption experiments, the separation efficiency of the CuFe2O4 MNPs was still as high as 73%. In addition, CuFe2O4 can successfully and selectively bind and remove the abundant BHb from the liquid samples, which shows practical application value.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 12","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in Bioelectrocatalysis for Electrochemical Ammonia Production: Integrating Enzyme-Based Catalysis

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-03-25 DOI: 10.1002/slct.202500224

Dr. Kumarasamy Jayakumar, Dr. Dharmalingam Sakthilatha, Dr. Raja Venkatesan

{"title":"Advancements in Bioelectrocatalysis for Electrochemical Ammonia Production: Integrating Enzyme-Based Catalysis","authors":"Dr. Kumarasamy Jayakumar, Dr. Dharmalingam Sakthilatha, Dr. Raja Venkatesan","doi":"10.1002/slct.202500224","DOIUrl":"https://doi.org/10.1002/slct.202500224","url":null,"abstract":"Bioelectrocatalysis has advanced ammonia production by integrating enzyme-based processes into electrochemical methods, providing chemical manufacturers with a distinct alternative to the traditional Haber–Bosch process. The review discusses the latest developments in enzyme-based electrochemical catalysis that have been shown to enhance ammonia synthesis, efficiency, and sustainability. We also discuss the development of designed bioelectrocatalysts, including nitrogenase-inspired enzymes and engineered microbes, which enable the reduction of atmospheric nitrogen to ammonia under mild conditions. Also the study highlights the most recent e-BNF advancements, focusing on innovations that enhance efficiency and scalability. Nanomaterial integration simplifies ATP-independent nitrogen fixation, enhancing electron transfer and ammonia production under normal conditions, while also exploring its scalability and implications for green chemistry and industrial applications as a sustainable alternative to the Haber–Bosch process. Eventually, the study discusses the scalability of these technologies and their implications for green chemistry and industrial applications, providing a comprehensive overview of current advancements and future research directions.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 12","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicinal Plant-Derived Caffeoylquinic Acids as Inhibitors of Rift Valley Fever Virus: A Computational Study

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-03-25 DOI: 10.1002/slct.202405545

Garland K. More, Charmy Twala, Kgaugelo C. Tapala, Raymond T. Makola, Gerhard Prinsloo

{"title":"Medicinal Plant-Derived Caffeoylquinic Acids as Inhibitors of Rift Valley Fever Virus: A Computational Study","authors":"Garland K. More, Charmy Twala, Kgaugelo C. Tapala, Raymond T. Makola, Gerhard Prinsloo","doi":"10.1002/slct.202405545","DOIUrl":"https://doi.org/10.1002/slct.202405545","url":null,"abstract":"The Rift Valley fever virus (RVFV) poses a significant health threat, particularly in tropical and subtropical regions. Its symptoms include hemorrhagic fever and miscarriages, with no approved therapies available. A promising approach for treatment involves targeting host proteins that facilitate viral entry. Six bioactive caffeoylquinic acids were analyzed through molecular docking, molecular dynamics (MD) simulations, and density functional theory (DFT) against the RVFV LRP1(CR17) protein. Compounds 6 and 2 showed strong inhibitory potential with docking scores of -8.117 and -7.969 kcal/mol, respectively. The MD simulations indicated minimal deviation for these compounds, while specific protein interactions were identified. Compound 3 exhibited greater stability and lower reactivity, followed by compounds in the order: 1 > 2 > 4 > 6 > 5. Furthermore, the global electrophilicity index indicated that compound 3 (ω = 3.853 eV) is less electrophilic when accepting an electron, followed by 1 (ω = 4.192 eV), 6 (ω = 4.207 eV), 4 (ω = 4.302 eV), 2 (ω = 4.410 eV), and 5 (ω = 4.597 eV). These six caffeoylquinic acids can serve as lead compounds for drug design targeting RVFV entry proteins. Further in vitro and in vivo studies are needed to develop entry inhibitors against RVFV.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 12","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202405545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Specific Ion Effects of Divalent Cations on the Formation and Properties of Polyelectrolyte Multilayers

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-03-25 DOI: 10.1002/slct.202501185

Mia Mesić, Tin Klačić, Davor Kovačević

{"title":"Specific Ion Effects of Divalent Cations on the Formation and Properties of Polyelectrolyte Multilayers","authors":"Mia Mesić, Tin Klačić, Davor Kovačević","doi":"10.1002/slct.202501185","DOIUrl":"https://doi.org/10.1002/slct.202501185","url":null,"abstract":"Multilayer films made of strong polyelectrolytes poly(diallyldimethylammonium chloride) and poly(sodium 4-styrenesulfonate) were built-up on silicon wafer using the layer-by-layer method. The films were built-up in the presence of various divalent cations (Mg2+, Ca2+, Sr2+, Ni2+, Zn2+, and Cu2+) to examine how the nature of cations affects the properties of the film. The results have shown that the thickness, morphology, and roughness of films prepared in the presence of transition metal cations are not significantly different. In contrast, these properties varied for multilayers prepared in the presence of alkaline earth metal cations. The difference in the ion-specific behavior of these two classes of cations was explained by the difference in the hydration of these ions and by the bridging of polyelectrolyte chains with ions. While transition metal cations have similar hydration parameters, alkaline earth cations have different degrees of hydration and a better ability to form bridging bonds with polyelectrolyte monomers.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 12","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202501185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hierarchical Gum Karaya-Fabricated Layered Double Hydroxides of Ni-MgAl: A Novel Structure for Ciprofloxacin Intercalation and Release

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-03-25 DOI: 10.1002/slct.202405650

Walla Alelwani

{"title":"Hierarchical Gum Karaya-Fabricated Layered Double Hydroxides of Ni-MgAl: A Novel Structure for Ciprofloxacin Intercalation and Release","authors":"Walla Alelwani","doi":"10.1002/slct.202405650","DOIUrl":"https://doi.org/10.1002/slct.202405650","url":null,"abstract":"This study explores the bio-fabrication of Ni-MgAl layered double hydroxides (Ni-MgAl LDH) using a natural polymer called gum karaya (GK). The hydrothermal method was employed to fabricate a Ni-MgAl LDH with GK. Various characterization techniques, including PXRD, FTIR, SEM, Zeta potential analysis, DLS, BET, DSC, and TG, were utilized to confirm the synthesis of GK@Ni-MgAl LDH nanocomposite. The composite's swelling indices under varying conditions and loading parameters, such as pH and drug concentration, were explored. It is observed that an increase in the percentage of ciprofloxacin (Cip) drug loading as the medium shifts from mildly acidic to neutral. Different kinetic models, such as first-order, zero-order, Higuchi, Korsmeyer, and Hixson, were utilized to investigate the release mechanism. According to the medication kinetics results, the Korsmeyer model, with a release exponent of 0.45 ˂ n ˂ 0.89 at pH 7.4 and 9.4, adhered to the non-Fick's rule of diffusion mechanism in the release profile. The correlation coefficients acquired from the Korsmeyer and Higuchi models indicate that the release mechanism involved diffusion and dissolution characteristics in all instances. The in-vitro release is influenced by temperature and pH. The outcomes suggest significant potential of bionanocomposite in a controlled drug delivery system.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 12","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Facile and Rapid Microwave Synthesis of Nickel Oxide Nanoparticles towards Cost-Efficient Functional Nanocomposite Photoresists

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-03-25 DOI: 10.1002/slct.202405657

Prof. Margarita Chatzichristidi, Dr. Vassilis Psycharis, Petros Katsoufis, Nikolaos Stavridis, Aikaterini Kontoliou, Dr. Eleni Makarona

{"title":"Facile and Rapid Microwave Synthesis of Nickel Oxide Nanoparticles towards Cost-Efficient Functional Nanocomposite Photoresists","authors":"Prof. Margarita Chatzichristidi, Dr. Vassilis Psycharis, Petros Katsoufis, Nikolaos Stavridis, Aikaterini Kontoliou, Dr. Eleni Makarona","doi":"10.1002/slct.202405657","DOIUrl":"https://doi.org/10.1002/slct.202405657","url":null,"abstract":"Polymer-based metal oxide lithographic materials have garnered significant interest among researchers for their potential applications in gas sensing, nanoelectronics, and nanoengineering. Such materials present several advantages, especially for low-cost sensors, because of cost-effectiveness, scalability, and versatility allowing customization for various applications. Among metal oxides, nickel oxide (NiO) nanoparticles exhibit unique physicochemical properties including electrical, magnetic, and optical characteristics making them highly appealing for diverse applications. This research investigated the hydrothermal synthesis of NiO nanoparticles (NPs) to produce polymer nanocomposite photoresists. Initially, three hydrothermal synthesis methods for NiO NPs involving thermal heating of the precursor solution in a water bath, a convection oven, and a microwave oven (MW) were compared. Subsequently, the focus shifted to optimizing the MW-assisted synthesis parameters due to its efficiency and rapidity compared to the other methods. Two nickel salt precursors: Nickel Acetate Tetrahydrate and Nickel Nitrate Hexahydrate were examined. All NPs were analyze in terms of their morphology, structural characteristics, and purity. The most promising NiO NPs were then incorporated as nanofillers into two types of photoresists, a positive and a negative tone, yielding encouraging results as the lithographic properties of the resulting polymeric materials were maintained.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 12","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/slct.202405657","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Experimental and Theoretical Investigation of Structural, Spectroscopic, and Physicochemical Properties of Azobenzene-Based Compound

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-03-24 DOI: 10.1002/slct.202406141

Arini Qurrata Ayun, Merve Guzel, Pinar Tunay Tasli, Sevgi Ozdemir Kart, Metin Ak

{"title":"Experimental and Theoretical Investigation of Structural, Spectroscopic, and Physicochemical Properties of Azobenzene-Based Compound","authors":"Arini Qurrata Ayun, Merve Guzel, Pinar Tunay Tasli, Sevgi Ozdemir Kart, Metin Ak","doi":"10.1002/slct.202406141","DOIUrl":"https://doi.org/10.1002/slct.202406141","url":null,"abstract":"Azobenzene-based compounds have recently attracted a lot of attention in innovative potential applications due to their photoresponsive properties and functions. Herein, we present a comprehensive theoretical and experimental investigation of the changes in the physical and chemical properties of an azobenzene-based compound under UV-light irradiation. In this context, first a novel monomer containing fluorine-substituted photoactive azobenzene and electroactive carbazole namely (E)-9-(4-(4-((4-(trifluoromethyl)phenyl)diazenyl)phenoxy)butyl)-9H-carbazole (coded as Cz-AzoCF3) was synthesized. Theoretical studies were conducted using Density functional theory (DFT) and Time-Dependent DFT (TD-DFT) methods, utilizing the functionals of B3LYP and CAM-B3LYP (Becke-3–Lee–Yang–Parr) with the basis set of 6–31 G (d, p). The changes in structural, electronic, and vibrational properties induced by light were analyzed through a combination of theoretical and experimental approaches, utilizing techniques such as IR, NMR, and UV–vis spectroscopy. In conclusion, a high correlation was observed between experimental and calculated data. This remarkable agreement not only provides robust and guiding information on molecular design and characterization but also paves the way for new studies. From this perspective, experimental and theoretical studies are complementary to each other.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 12","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effective Adsorptive Removal of Methylene Blue and Alizarin Red S from Aqueous Solutions Through Biodegradable Polyvinyl Alcohol Based Hydrogel

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-03-24 DOI: 10.1002/slct.202404402

Maham Rakhshan, Saeed Ahmad Khan, Mansoor Khan, Wei Sun, Riaz Ullah, Mohamed A. Ibrahim, Umar Nishan, Amir Badshah

{"title":"Effective Adsorptive Removal of Methylene Blue and Alizarin Red S from Aqueous Solutions Through Biodegradable Polyvinyl Alcohol Based Hydrogel","authors":"Maham Rakhshan, Saeed Ahmad Khan, Mansoor Khan, Wei Sun, Riaz Ullah, Mohamed A. Ibrahim, Umar Nishan, Amir Badshah","doi":"10.1002/slct.202404402","DOIUrl":"https://doi.org/10.1002/slct.202404402","url":null,"abstract":"Industries use dyes as coloring agents and dyes-contaminated water can cause serious threats to aquatic life and humans. Thus, remediation strategies focused on wastewater treatment are in high demand. For this purpose, a biodegradable polyvinyl alcohol-based hydrogel (PVAH) was synthesized by using epichlorohydrin as a cross-linker for the adsorptive removal of dyes. The synthesized PVAH was characterized using SEM and FTIR. In addition, the point of zero charge and swelling ratio were calculated to be at pH 7 and 560%, respectively. The prepared hydrogel was used for the adsorptive removal of Alizarin Red S (ARS) and methylene blue (MB) from water contaminated with the mentioned dyes. Different experimental parameters, such as concentration of dye, pH, dosage of adsorbent, sample volume, time of contact, and temperature, were optimized. The maximum amount of dyes removed by the synthesized hydrogel under the optimized conditions is 9.98 mg g−1 and 19.97 mg g−1 for MB and ARS, respectively. Langmuir–Freundlich isotherm models were used, and the results showed that the adsorption mechanism followed the Freundlich isotherm model. The kinetic data results suggested that it perfectly fit the pseudo-second-order kinetic model. PVA hydrogel crosslinked with epichlorohydrin showed good removal efficiency for MB and ARS.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 12","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Applications of HDAC Inhibitors as Anticancer Agents in Prostate, Breast, Ovarian, and Cervical Cancers

IF 1.9 4区化学

ChemistrySelect Pub Date : 2025-03-24 DOI: 10.1002/slct.202405484

Saad Bakrim, Farah Atifi, Nasreddine El Omari, Younes Zaid, Tarik Aanniz, Learn-Han Lee, Gokhan Zengin, Abdelhakim Bouyahya

{"title":"Clinical Applications of HDAC Inhibitors as Anticancer Agents in Prostate, Breast, Ovarian, and Cervical Cancers","authors":"Saad Bakrim, Farah Atifi, Nasreddine El Omari, Younes Zaid, Tarik Aanniz, Learn-Han Lee, Gokhan Zengin, Abdelhakim Bouyahya","doi":"10.1002/slct.202405484","DOIUrl":"https://doi.org/10.1002/slct.202405484","url":null,"abstract":"Alongside genetic events, epigenetic processes also have a considerable impact on cancer induction and progression. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) both coordinate to modulate histone modification via acetylation, an essential component of epigenetic regulation concerning gene expression. In this context, HDAC inhibition has been extensively investigated as a therapeutic approach to discovering anticancer drugs. Nevertheless, it is still highly challenging to design HDAC inhibitors (HDACis) that are successfully operational in solid tumors such as prostate, breast, ovarian, and cervical cancers. Today, some HDACis have been investigated and adopted by the U.S. Food and Drug Administration (FDA) to medically manage these malignancies, notably vorinostat, panobinostat, romidepsin, and belinostat. In addition, they promote the immune response by increasing the expression of tumor necrosis factor (TNF), interferon-gamma receptor 1 (IFN-γR1), and programmed death ligand 1 (PD-L1) in addition to other signaling pathways. A deeper comprehension of these pathways will advance our knowledge of the defects in tumor tissue while opening up opportunities for innovative and promising therapeutic strategies based on targeted cancer therapies.","PeriodicalId":146,"journal":{"name":"ChemistrySelect","volume":"10 12","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143690030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0