Japanese Journal of Radiology最新文献

{"title":"Atypical ovarian fibroma and thecoma mimicking malignancy: clue for differentiation from malignant solid tumors.","authors":"Takanori Aonuma, Ayumi Ohya, Daiya Takekoshi, Kazuki Oyama, Yasunari Fujinaga","doi":"10.1007/s11604-026-02088-1","DOIUrl":"https://doi.org/10.1007/s11604-026-02088-1","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the characteristic findings of ovarian fibroma and thecoma (FT) with atypical magnetic resonance imaging (MRI) findings that mimic malignancy and to validate the improvement in diagnostic performance in differentiating between FTs and malignant solid tumors.</p><p><strong>Materials and methods: </strong>This retrospective study included 114 patients (119 lesions: 34 FT and 85 malignant tumors) with pathologically confirmed solid ovarian tumors who underwent preoperative MRI. Signal intensity on T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) maps, and time-intensity curves from dynamic contrast-enhanced MRI (DCE-MRI) were evaluated. FT lesions showing low signal intensity on both T2WI and DWI were defined as classic, whereas others were considered atypical. The diagnostic performance of combined imaging findings was also assessed. A reader study was also performed by three radiologists.</p><p><strong>Results: </strong>Among the FT lesions, 55.9% demonstrated intermediate signal intensity on T2WI, and 32.4% showed diffusion restriction. Atypical FT accounted for 56% of all FT cases. The combination of T2WI and DWI showed high specificity (98.8%) but low sensitivity (44.1%) for diagnosing FT as benign. In contrast, for the diagnosis of benign lesions, the combination of T2WI and DCE-MRI demonstrated superior diagnostic performance, with a sensitivity, specificity, positive predictive value, and negative predictive value of 84.0%, 95.9%, 87.5%, and 94.6%, respectively. Reader performance improved when the combined interpretation of T2WI and DCE-MRI findings was emphasized. Using this approach, the estimated misdiagnosis rate of FT as malignant decreased from approximately 40% to 16%.</p><p><strong>Conclusion: </strong>Atypical FT frequently mimics malignant ovarian tumors on MRI. The combination of T2WI and DCE-MRI findings provides the best diagnostic performance and significantly reduces misdiagnosis. However, a subset of FT remains indistinguishable from malignancy, highlighting the need for careful interpretation.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The seventh asian radiology summit: governance of asian radiological societies: shared challenges and future directions.","authors":"Yoko Satoh, Minako Azuma, Kei Yamada, Noriyuki Tomiyama","doi":"10.1007/s11604-026-02086-3","DOIUrl":"https://doi.org/10.1007/s11604-026-02086-3","url":null,"abstract":"","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generative AI versus physicians in diagnostic radiology: a systematic review and meta-analysis.","authors":"Hirotaka Takita, Daijiro Kabata, Shannon L Walston, Yasuhito Mitsuyama, Hiroyuki Tatekawa, Kenichi Saito, Yukio Miki, Daiju Ueda","doi":"10.1007/s11604-026-02090-7","DOIUrl":"https://doi.org/10.1007/s11604-026-02090-7","url":null,"abstract":"<p><strong>Purpose: </strong>Generative artificial intelligence (AI) models are increasingly evaluated for diagnostic tasks in radiology, yet accuracy, study designs, endpoints, and comparators vary widely. The purpose was to synthesize diagnostic accuracy of generative AI for radiology and compare performance with physicians.</p><p><strong>Materials and methods: </strong>A systematic review and meta-analysis was prospectively registered in PROSPERO (CRD420251040000) and conducted in accordance with PRISMA-DTA guidance. Searches of Medline, Scopus, Web of Science, Cochrane Central, and medRxiv (June 2018-March 2025) identified studies validating generative AI on diagnostic tasks in radiology. Two reviewers independently screened, extracted data, and assessed risk of bias with PROBAST+AI, with disagreements resolved by a third reviewer. Multilevel random-effects meta-regression was performed to compare AI performance with physician performance and identify sources of heterogeneity, with study-clustered robust inference to account for multiple estimates per study.</p><p><strong>Results: </strong>In total, 48 studies met inclusion criteria. Pooled diagnostic accuracy of generative AI was 42.9% (95% CI, 35.8-50.1%) for free-text tasks and 58.1% (95% CI, 50.0-66.2%) for choice tasks. Generative AI overall showed significantly lower accuracy than expert physicians (difference in accuracy [physicians minus AI], +13.0 percentage points [95% CI, 0.9-25.2]; P = .038). Text-only input was associated with higher accuracy than image-only input (difference in accuracy [image-only minus text-only], -25.9 percentage points [95% CI, -39.1 to -12.8]; P = .001) and text-and-image input (- 10.6 percentage points [95% CI, -20.8 to -0.3]; P = .046).</p><p><strong>Conclusion: </strong>Generative AI remained less accurate than expert physicians on diagnostic tasks in radiology. Text-oriented assistive use warrants further evaluation, but the observed accuracy difference may reflect task difficulty and information content rather than the input modality itself. Standardized, transparently reported, adequately powered evaluations are warranted before clinical deployment.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal neuroimaging in dementia and neurodegenerative disorders: complementary roles of clinically available nuclear medicine and MRI in the era of disease-modifying therapies.","authors":"Yoshitaka Inui, Hajime Takechi, Hirohisa Watanabe, Takashi Kato, Kengo Ito, Ryota Kobayashi, Hiroshi Toyama, Masanori Inoue","doi":"10.1007/s11604-026-02080-9","DOIUrl":"https://doi.org/10.1007/s11604-026-02080-9","url":null,"abstract":"<p><p>The introduction of anti-amyloid-β antibody therapies has fundamentally changed the clinical landscape of dementia, shifting the role of neuroimaging from diagnosis toward therapeutic decision-making. Amyloid positron emission tomography (PET) has become essential for confirming amyloid pathology and determining treatment eligibility. However, amyloid deposition is frequently observed in cognitively normal elderly individuals and in non-Alzheimer neurodegenerative disorders, indicating that amyloid status alone is insufficient to explain clinical symptoms. In this context, imaging modalities reflecting neurodegeneration, including structural magnetic resonance imaging (MRI) and functional imaging such as ¹⁸F-FDG-PET and brain perfusion single-photon emission computed tomography (SPECT), remain important for assessing disease severity and functional impairment. Furthermore, discrepancies between imaging biomarkers-such as the presence of neurodegeneration without amyloid pathology in cases clinically suspected of Alzheimer's disease, and atypical imaging patterns-are commonly encountered in clinical practice and may reflect underlying pathological heterogeneity. A multimodal imaging approach that integrates multiple biomarkers provides complementary information and may improve diagnostic accuracy and clinical interpretation. In addition, other imaging modalities, including dopamine transporter (DAT) imaging and cardiac sympathetic imaging, can contribute to the evaluation of non-Alzheimer pathologies. This review summarizes the current roles of clinically available multimodal imaging in dementia, with a focus on nuclear medicine and MRI, highlighting their complementary value and clinical implications in the era of disease-modifying therapies.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of ¹⁸F-PSMA-1007 PET/CT and bone scintigraphy for detecting bone metastases in prostate cancer.","authors":"Kazuhiro Kitajima, Sadahiro Naka, Koji Hatano, Motohide Uemura, Hidetaka Sasaki, Takashi Kamiya, Kenta Kurimoto, Daisuke Katayama, Hiroki Kato, Yuwei Liu, Jens Cardinale, Frederik L Giesel, Norio Nonomura, Tadashi Watabe","doi":"10.1007/s11604-026-02081-8","DOIUrl":"https://doi.org/10.1007/s11604-026-02081-8","url":null,"abstract":"<p><strong>Objective: </strong>The performance of ¹⁸F-labeled prostate-specific membrane antigen (¹⁸F-PSMA-1007) positron emission tomography/computed tomography (PET/CT) and bone scintigraphy (BS) for detecting bone metastases in prostate cancer patients was compared.</p><p><strong>Materials and methods: </strong>One hundred prostate cancer patients (initial staging, n = 9; biochemical recurrence, n = 63; metastatic castration-resistant prostate cancer (mCRPC), n = 15; m0CRPC, n = 13) underwent ¹⁸F-PSMA-1007 PET/CT and BS. The patient-, region-, and lesion-based performances of ¹⁸F-PSMA-1007 PET/CT and BS for detecting bone metastases were evaluated by experienced readers using a five-point scale.</p><p><strong>Results: </strong>Bone metastases were identified in 46 (46.0%) patients, 99 (24.8%) of the 400 regions, and 528 lesions. In the analysis, the area under the receiver-operating-characteristic curve (AUC), sensitivity, specificity, and accuracy values for ¹⁸F-PSMA-1007 PET/CT were 0.9985, 100%, 94.4%, and 97.0%, respectively, whereas those for BS were 0.8507, 71.7%, 88.9%, and 81.0%, respectively. AUC, sensitivity, and accuracy were significantly higher for ¹⁸F-PSMA-1007 PET/CT than for BS (p = 0.00021, p = 0.00087, and p = 0.00018, respectively; McNemar test). ¹⁸F-PSMA-1007 PET/CT detected 527 of the 528 metastatic lesions (99.8%), whereas BS detected 253 (47.9%) (p < 0.0001). The numbers of patients with (a) no bone metastases, (b) oligometastatic disease (1-3 lesions), (c) 4-5 lesions, (d) 6-20 lesions, and (e) > 20 lesions for BS were 13, 21, 0, 8, and 4, respectively, compared with 0, 27, 3, 9, and 7, respectively, on ¹⁸F-PSMA-1007 PET/CT. In addition, ¹⁸F-PSMA-1007 PET/CT detected local recurrence (n = 51), nodal metastases (n = 37), and visceral metastases (n = 4).</p><p><strong>Conclusions: </strong>¹⁸F-PSMA-1007 PET/CT demonstrated higher sensitivity and accuracy than BS for detecting bone metastases in prostate cancer patients.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term results of stereotactic body radiotherapy boost in patients with cervical cancer considered unsuitable for intracavitary brachytherapy.","authors":"Kei Ito, Yujiro Nakajima, Hiroaki Ogawa, Akiko Furusawa, Satoshi Kito, Nao Kino, Toshiharu Yasugi, Takashi Uno, Keiko Nemoto Murofushi","doi":"10.1007/s11604-026-02089-0","DOIUrl":"https://doi.org/10.1007/s11604-026-02089-0","url":null,"abstract":"<p><strong>Purpose: </strong>Although stereotactic body radiotherapy (SBRT) boost represents a promising treatment option for patients with locally advanced cervical cancer who were considered unsuitable for brachytherapy, its long-term efficacy and safety remain unclear. This study assessed long-term oncologic outcomes and late toxicities in a patient cohort from a previous phase I/II trial.</p><p><strong>Materials and methods: </strong>This secondary analysis included 21 patients enrolled in an open-label, multicenter, single-arm, prospective phase I/II trial between January 2016 and October 2020. Patients with cervical cancer considered unsuitable for intracavitary brachytherapy received whole-pelvic radiotherapy (45 Gy in 25 fractions), followed by an SBRT boost to the primary tumor (21 Gy delivered in three consecutive daily fractions). The endpoints of this analysis included long-term oncological outcomes and late radiotherapy-related toxicities.</p><p><strong>Results: </strong>The cohort comprised 21 patients, of whom 52% were aged ≥ 75 years, 81% had clinical stage III disease, and 43% had a maximum primary tumor size ≥ 70 mm. The median follow-up was 61.1 months (range, 10.4-111.0) for all patients and 71.9 months (range, 60.0-111.0) for surviving patients. The 5-year loco-regional control, progression-free survival, and overall survival rates were 84%, 62%, and 62%, respectively. Grade 3 late toxicity occurred in one patient (urinary tract obstruction), and no grade 4-5 toxicities were observed. Six patients experienced grade 2 late toxicities (proctitis, n = 3; fractures, n = 3).</p><p><strong>Conclusion: </strong>This secondary analysis demonstrated encouraging long-term oncologic outcomes and an acceptable long-term safety profile following SBRT boost. These findings suggest that SBRT may represent a feasible treatment approach in carefully selected patients with locally advanced cervical cancer who are unable or unwilling to undergo brachytherapy.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From lesion-level non-inferiority to screening-level substitution.","authors":"Alexander Reyes Lobo","doi":"10.1007/s11604-026-02087-2","DOIUrl":"https://doi.org/10.1007/s11604-026-02087-2","url":null,"abstract":"","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panventricular high-grade glioma mimicking ventriculitis: pitfalls of modest ventriculomegaly.","authors":"Najeebuddin N Patel, Adithya S Nair","doi":"10.1007/s11604-026-02038-x","DOIUrl":"10.1007/s11604-026-02038-x","url":null,"abstract":"","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1891-1892"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI-based assessment for optimal breast cancer local therapy in the era of BI-RADS v2025.","authors":"Maya Honda, Masako Kataoka, Mami Iima, Azusa Nishimoto, Yuji Nakamoto","doi":"10.1007/s11604-026-02033-2","DOIUrl":"10.1007/s11604-026-02033-2","url":null,"abstract":"<p><p>Preoperative breast magnetic resonance imaging (MRI) is the most sensitive modality for assessing disease extent in newly diagnosed breast cancer, detecting additional ipsilateral disease in approximately 20% of patients. While its impact on patients' prognosis is debated, MRI may refine surgical management when it is appropriately evaluated. This review provides a practical framework for optimizing MRI interpretation for individualized surgical planning, incorporating the updated American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) v2025 recommendations. Key updates in BI-RADS v2025 include the introduction of \"Additional Close Findings\" to streamline the management of suspicious lesions within 2.0 cm of the index cancer. For oncoplastic procedures, MRI provides critical metrics: a tumor-nipple distance of > 1.0 cm has been reported as a significant threshold under specific study conditions for predicting nipple involvement in nipple-sparing mastectomy, while an MRI-to-skin distance of 5 mm is a suggested threshold for predicting margin positivity in skin-sparing mastectomy. This review also addresses the assessment of pectoralis muscle involvement and the new BI-RADS section dedicated to lymph node evaluation. Furthermore, MRI is highlighted as an essential tool for identifying eligible candidates for radiofrequency ablation by precisely excluding multifocality and extensive intraductal components to satisfy strict clinical criteria. The integration of these standardized, surgically-relevant metrics allows radiologists to provide a detailed anatomical roadmap, which is essential to maximize cosmetic outcomes through conservative mastectomy techniques without compromising oncological safety.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1745-1757"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148251564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative agreement between AMYclz and CortexID for ¹⁸F-florbetapir amyloid PET: a retrospective study of 103 patients.","authors":"Yoichi Otomi, Takayoshi Shinya, Hideki Otsuka, Yushi Kamei, Manduukhai Badarchin, Tomoki Matsushita, Yukiko Takaoka, Yuka Hiroshima, Tomoyasu Matsubara, Koji Fujita, Yukiko Tomioka, Masahito Nakataki, Shusuke Numata, Yuishin Izumi, Masafumi Harada","doi":"10.1007/s11604-026-02026-1","DOIUrl":"10.1007/s11604-026-02026-1","url":null,"abstract":"<p><strong>Purpose: </strong>Quantitative analysis of amyloid PET images is increasingly used to support visual interpretation and to provide objective measures of amyloid burden. However, quantitative values may vary depending on the analysis software used. This study aimed to evaluate the quantitative agreement between two analysis platforms, AMYclz and CortexID, for ¹⁸F-florbetapir amyloid PET.</p><p><strong>Materials and methods: </strong>This retrospective study included 103 consecutive patients who underwent ¹⁸F-florbetapir PET for evaluation of cognitive impairment. Visual interpretation was used to classify scans as amyloid-positive or amyloid-negative. Quantitative analysis was performed using CortexID and AMYclz software to obtain global cortical standardized uptake value ratios (SUVr). AMYclz additionally provided Centiloid scale (CL) values. The ability of quantitative metrics to differentiate visually positive and negative scans was evaluated using receiver operating characteristic (ROC) analysis, and agreement between software platforms was assessed using correlation, linear regression, and Bland-Altman analysis.</p><p><strong>Results: </strong>Among 103 patients, 59 were visually classified as amyloid-positive and 44 as amyloid-negative. CortexID SUVr values were significantly higher in amyloid-positive patients than in amyloid-negative patients (1.30 ± 0.14 vs. 0.97 ± 0.09, p < 0.001). AMYclz SUVr showed similar separation between groups (1.34 ± 0.14 vs. 0.99 ± 0.09, p < 0.001). ROC analysis demonstrated excellent discrimination for CortexID SUVr (AUC = 0.986), AMYclz SUVr (AUC = 0.996), and CL values (AUC = 0.996). CortexID and AMYclz SUVr values showed strong correlation (r = 0.957) with minimal systematic bias. Discordant classification between the two software platforms was observed in three cases (2.9%), all near the diagnostic threshold.</p><p><strong>Conclusion: </strong>AMYclz and CortexID demonstrated excellent quantitative agreement for ¹⁸F-florbetapir amyloid PET. Both AMYclz SUVr and CL values showed excellent ability to differentiate visually amyloid-positive and amyloid-negative scans, supporting the reliability of quantitative amyloid PET analysis across different software platforms in clinical practice.</p>","PeriodicalId":14691,"journal":{"name":"Japanese Journal of Radiology","volume":" ","pages":"1829-1835"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148198888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}