{"title":"Acceleration Time/Ejection Time Ratio Compared to Mean Gradient as a Predictor of Clinical Outcomes Post-TAVR","authors":"Tamari Lomaia MD , Besir Besir MD , Shivabalan Kathavarayan Ramu MD , Judah Rajendran MD , Maryam Muhammad Ali Majeed-Saidan MD , Odette Iskandar MD , Rhonda Miyasaka MD , Serge Harb MD , James Yun MD, PhD , Grant Reed MD, MSc , Rishi Puri MD, PhD , Amar Krishnaswamy MD , Samir Kapadia MD","doi":"10.1016/j.jcin.2025.07.037","DOIUrl":"10.1016/j.jcin.2025.07.037","url":null,"abstract":"<div><h3>Background</h3><div>Transcatheter aortic valve replacement (TAVR) is a significant treatment option for patients with severe aortic stenosis. Aortic valve (AV) mean gradient (MG) is frequently used to assess prosthetic valve function. Although MG is a helpful measure of valve performance, it depends on cardiac output and pressure recovery, which can be important confounders.</div></div><div><h3>Objectives</h3><div>The aims of this study were to explore TAVR valve hemodynamic status using the acceleration time (AT)/ejection time (ET) ratio and to compare AT/ET and MG correlations with post-TAVR clinical outcomes.</div></div><div><h3>Methods</h3><div>This retrospective cohort study involves patients >18 years of age undergoing TAVR between 2016 and 2020. AV AT/ET was measured within 3 months post-TAVR. A total of 1,900 patients were classified into 2 groups: those with AV AT/ET ≥ 0.35 and those with AV AT/ET < 0.35. Baseline characteristics, echocardiographic measurements, heart failure hospitalization (HFH), and mortality were assessed between the groups.</div></div><div><h3>Results</h3><div>AT/ET ≥ 0.35 was associated with an increase in 1-year HFH (<em>P</em> < 0.001 at 1 year) and was not associated with mortality. Patients with AV MG >20 mm Hg had comparable 1-year HFH (<em>P</em> = 0.46 at 1 year) and mortality compared with those with AV MG <20 mm Hg. More patients with self-expanding valves (23.2%) had AT/ET ≥0.35 than those who received balloon-expandable valves (12.7%) (<em>P</em> = 0.001).</div></div><div><h3>Conclusions</h3><div>Post-TAVR AT/ET ≥0.35 can potentially predict clinical outcomes such as HFH. AT/ET may explain the discrepancy between self-expanding and balloon-expandable valves in measured hemodynamic status and outcomes.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 18","pages":"Pages 2270-2279"},"PeriodicalIF":11.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karol A. Sadowski MS , Malwina Gonet MD , Zofia Dzielińska MD , Piotr Kołsut MD , Jarosław Kuriata MD , Michał Kania MD , Gary S. Mintz MD , Stephanie L. Sellers MSc, PhD , David Meier MD , Marcin Demkow MD , Łukasz Kalińczuk MD
{"title":"Leaflet Folding Due to Transcatheter Heart Valve Underexpansion Detected by IVUS During Mitral Valve-in-Valve Replacement","authors":"Karol A. Sadowski MS , Malwina Gonet MD , Zofia Dzielińska MD , Piotr Kołsut MD , Jarosław Kuriata MD , Michał Kania MD , Gary S. Mintz MD , Stephanie L. Sellers MSc, PhD , David Meier MD , Marcin Demkow MD , Łukasz Kalińczuk MD","doi":"10.1016/j.jcin.2025.06.015","DOIUrl":"10.1016/j.jcin.2025.06.015","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 18","pages":"Pages 2297-2300"},"PeriodicalIF":11.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew Cannata BS , Emma Caron BS , Yasemin Ciftcikal BA , William Chung MD , Matthew Henry MD , Billal Tokhi DO , Christopher Chieh Yang Koo MD , Jaffar Khan MD, PhD
{"title":"Balloon Sizing for Mitral Valve-in-Ring in the Presence of Significant Pannus","authors":"Matthew Cannata BS , Emma Caron BS , Yasemin Ciftcikal BA , William Chung MD , Matthew Henry MD , Billal Tokhi DO , Christopher Chieh Yang Koo MD , Jaffar Khan MD, PhD","doi":"10.1016/j.jcin.2025.05.018","DOIUrl":"10.1016/j.jcin.2025.05.018","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 18","pages":"Pages 2294-2296"},"PeriodicalIF":11.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sang Yoon Lee MD , Yang Hyun Cho MD, PhD , Kiick Sung MD, PhD , Wook Sung Kim MD, PhD , Seung-Jae Lee MD, PhD , Woochan Kwon MD , Jong-Young Lee MD, PhD , Seung Hun Lee MD, PhD , Doosup Shin MD , Sang Yeub Lee MD, PhD , Sang Min Kim MD, PhD , Kyeong Ho Yun MD, PhD , Jae Young Cho MD, PhD , Chan Joon Kim MD, PhD , Hyo-Suk Ahn MD, PhD , Chang-Wook Nam MD, PhD , Hyuck-Jun Yoon MD, PhD , Yong Hwan Park MD, PhD , Wang Soo Lee MD, PhD , Ki Hong Choi MD, PhD , Joo Myung Lee MD, MPH, PhD
{"title":"Intravascular Imaging-Guided PCI vs Coronary Artery Bypass Grafting for Left Main or 3-Vessel Disease","authors":"Sang Yoon Lee MD , Yang Hyun Cho MD, PhD , Kiick Sung MD, PhD , Wook Sung Kim MD, PhD , Seung-Jae Lee MD, PhD , Woochan Kwon MD , Jong-Young Lee MD, PhD , Seung Hun Lee MD, PhD , Doosup Shin MD , Sang Yeub Lee MD, PhD , Sang Min Kim MD, PhD , Kyeong Ho Yun MD, PhD , Jae Young Cho MD, PhD , Chan Joon Kim MD, PhD , Hyo-Suk Ahn MD, PhD , Chang-Wook Nam MD, PhD , Hyuck-Jun Yoon MD, PhD , Yong Hwan Park MD, PhD , Wang Soo Lee MD, PhD , Ki Hong Choi MD, PhD , Joo Myung Lee MD, MPH, PhD","doi":"10.1016/j.jcin.2025.06.034","DOIUrl":"10.1016/j.jcin.2025.06.034","url":null,"abstract":"<div><h3>Background</h3><div>Previous trials have shown that coronary artery bypass graft (CABG) has better clinical outcomes compared with percutaneous coronary intervention (PCI) for patients with left main coronary artery or 3-vessel disease. However, it is unclear whether intravascular imaging (IVI)-guided PCI would reduce the difference in clinical events compared to CABG.</div></div><div><h3>Objectives</h3><div>The present study sought to compare the clinical outcomes of patients with left main or 3-vessel disease who underwent IVI-guided PCI with those who underwent CABG.</div></div><div><h3>Methods</h3><div>A total of 6,962 patients with left main or 3-vessel disease from the RENOVATE-COMPLEX-PCI trial (n = 1,639) and the institutional registry of Samsung Medical Center (2,972 patients underwent PCI and 6,600 patients underwent CABG) were analyzed. The primary outcome was a composite of death from any cause, nonfatal myocardial infarction, or stroke at 3 years.</div></div><div><h3>Results</h3><div>Among the study population, 848 patients underwent IVI-guided PCI, 987 patients underwent angiography-guided PCI, and 5,127 patients underwent CABG. Patients treated with PCI had significantly higher risk of primary outcome than patients who underwent CABG (13.3% vs 10.8%; HR: 1.23; 95% CI: 1.05-1.44; <em>P</em> = 0.013). However, the risk of primary outcome was comparable between IVI-guided PCI and CABG (8.7% vs 10.8%; HR: 0.77; 95% CI: 0.59-1.01; <em>P</em> = 0.058). The propensity score–matched analysis showed similar results between IVI-guided PCI and CABG (9.5% vs 9.4%; HR: 0.98; 95% CI: 0.69-1.40; <em>P</em> = 0.914).</div></div><div><h3>Conclusions</h3><div>In this hypothesis-generating study, PCI had significantly higher risk of a composite of death, nonfatal myocardial infarction, or stroke than CABG. However, IVI-guided PCI had comparable risk of clinical events compared with CABG. (Intravascular Imaging- Versus Angiography-Guided Percutaneous Coronary Intervention For Complex Coronary Artery Disease [RENOVATE-COMPLEX-PCI], <span><span>NCT03381872</span><svg><path></path></svg></span>; Institutional cardiovascular catheterization database of Samsung Medical Center (Long-Term Outcomes and Prognostic Factors in Patient Undergoing CABG or PCI, <span><span>NCT03870815</span><svg><path></path></svg></span>; Institutional coronary artery bypass grafting database of Samsung Medical Center (Long-Term Outcomes and Prognostic Factors in Patient Undergoing CABG or PCI, <span><span>NCT03870815</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2077-2088"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144924028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}