JACC. Cardiovascular interventions最新文献

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S1936-8798(26)01088-5","DOIUrl":"10.1016/S1936-8798(26)01088-5","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"19 8","pages":"Pages I-CXXXVIII"},"PeriodicalIF":11.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pedal Loop Thrombectomy for Acute Limb Ischemia Using the Penumbra CAT RX Catheter","authors":"Shadi Halabi MD, MPH, RPVI","doi":"10.1016/j.jcin.2026.01.287","DOIUrl":"10.1016/j.jcin.2026.01.287","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"19 8","pages":"Pages 1046-1047"},"PeriodicalIF":11.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The WIfI Score","authors":"Omar Sheikh MD, Mehdi H. Shishehbor DO, MPH, PhD","doi":"10.1016/j.jcin.2026.02.032","DOIUrl":"10.1016/j.jcin.2026.02.032","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"19 8","pages":"Pages 1018-1020"},"PeriodicalIF":11.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonfatal Adverse Events and Risk for Subsequent Mortality in Patients Undergoing Percutaneous Coronary Intervention","authors":"Takahiro Suzuki MD, MPH ,&nbsp;Yasuyuki Shiraishi MD, PhD ,&nbsp;Shun Kohsaka MD ,&nbsp;Daisuke Yoneoka PhD ,&nbsp;Ikuko Ueda PhD ,&nbsp;Takanori Ohata MD ,&nbsp;Yohei Numasawa MD, PhD ,&nbsp;Keisuke Matsumura MD, PhD ,&nbsp;Kenichiro Shimoji MD, PhD ,&nbsp;Mitsuaki Sawano MD, PhD ,&nbsp;Masaki Ieda MD, PhD","doi":"10.1016/j.jcin.2026.02.010","DOIUrl":"10.1016/j.jcin.2026.02.010","url":null,"abstract":"<div><h3>Background</h3><div>Current guidelines and quality metrics after percutaneous coronary intervention (PCI) often assign equal weight to nonfatal adverse events, including heart failure hospitalization (HFH), acute coronary syndrome (ACS), and major bleeding, within composite endpoints.</div></div><div><h3>Objectives</h3><div>The aim of this study was to quantify and compare the associations of HFH, ACS, and major bleeding with subsequent mortality following PCI.</div></div><div><h3>Methods</h3><div>A Japanese multicenter prospective PCI registry (2008-2021) with 2-year postprocedural outcomes was analyzed. The primary outcome was all-cause mortality, with HFH, ACS, and major bleeding as time-varying exposures. Cumulative incidence was estimated with death as a competing risk. Cox proportional hazards models and population attributable fractions were used to assess associations between time-varying events and mortality, adjusting for conventional risk factors.</div></div><div><h3>Results</h3><div>Among 10,482 patients (mean age 69 years, 77.5% men) followed for a median of 730 days (Q1-Q3: 730-730 days), 1,021 (9.7%; 95% CI: 9.2%-10.3%) experienced adverse events. Two-year cumulative incidence rates were 4.7% (95% CI: 4.2%-5.1%) for HFH, 3.4% (95% CI: 3.0%-3.7%) for ACS, and 2.5% (95% CI: 2.2%-2.8%) for major bleeding. Cox analysis showed that HFH was associated with mortality (adjusted HR [aHR]: 6.11; 95% CI: 4.76-7.85), followed by ACS (aHR: 3.22; 95% CI: 2.14-4.84) and major bleeding (aHR: 2.62; 95% CI: 1.71-4.02). Population attributable fraction analysis demonstrated that HFH accounted for 20.1% (95% CI: 19.0%-21.0%) of mortality burden, higher than ACS (4.3%; 95% CI: 3.3%-4.9%) and major bleeding (2.9%; 95% CI: 1.9%-3.5%).</div></div><div><h3>Conclusions</h3><div>HFH shows stronger associations with mortality than ACS or major bleeding following PCI, suggesting that adverse events should not be weighted equally and underscoring the need to reconsider prioritization in clinical decision-making and endpoint definitions.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"19 8","pages":"Pages 990-1000"},"PeriodicalIF":11.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balloon Pulmonary Angioplasty for Treatment of Chronic Thromboembolic Pulmonary Hypertension","authors":"William R. Auger MD ,&nbsp;Richard A. Krasuski MD ,&nbsp;Ehtisham Mahmud MD ,&nbsp;Peter J. Leary MD, PhD ,&nbsp;Zachary L. Steinberg MD ,&nbsp;Gurpreet S. Sandhu MD, PhD ,&nbsp;Thomas Todoran MD, MSc ,&nbsp;Catalin Toma MD ,&nbsp;Amir Darki MD, MSc ,&nbsp;Sanjum Sethi MD, MPH ,&nbsp;Ada C. Stefanescu Schmidt MD, MSc ,&nbsp;Michael J. Cuttica MD ,&nbsp;Daniel R. Schimmel MD, MS ,&nbsp;Robert R. Frantz MD ,&nbsp;Ihab Haddadin MD, MS ,&nbsp;Alison Witkin MD ,&nbsp;Richard N. Channick MD ,&nbsp;Kenneth Rosenfield MD, MSc ,&nbsp;Riyaz Bashir MBBS, MD","doi":"10.1016/j.jcin.2026.02.033","DOIUrl":"10.1016/j.jcin.2026.02.033","url":null,"abstract":"<div><div>Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by fibrothrombotic pulmonary vascular obstruction and associated small-vessel vasculopathy resulting in a progressive increase in pulmonary vascular resistance and right heart failure. Pulmonary thromboendarterectomy is the first-line treatment for surgically accessible disease. However, many patients are ineligible because of surgically inaccessible distal disease, medical comorbidities, or symptomatic residual disease after pulmonary thromboendarterectomy. Balloon pulmonary angioplasty (BPA) has emerged as a very effective therapeutic option in these patients. This statement from the BPA-CTEPH Alliance reviews the role of BPA in CTEPH, describing patient selection, procedural techniques, periprocedural management, complications, and training requirements. This U.S.-focused document provides practical guidance for establishing a BPA program within a multidisciplinary CTEPH center. Technical refinement and improved patient selection have significantly enhanced the safety and efficacy of BPA. Contemporary evidence suggests that BPA is associated with significant improvements in pulmonary vascular resistance, mean pulmonary artery pressure, functional class, and quality of life. There is a considerable learning curve associated with BPA, and complication rates, once prohibitive, have substantially decreased with operator experience and with adjunct medical therapy. BPA has become a critical component of multimodality management of CTEPH, with durable hemodynamic and clinical benefits. Continued research, with a particular focus on randomized controlled trials in the United States, is crucial to defining long-term outcomes and expanding access to this lifesaving therapy.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"19 8","pages":"Pages 923-942"},"PeriodicalIF":11.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-PCI Physiological Testing","authors":"Barry F. Uretsky MD ,&nbsp;Abdul Hakeem MD","doi":"10.1016/j.jcin.2026.02.021","DOIUrl":"10.1016/j.jcin.2026.02.021","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"19 8","pages":"Pages 988-989"},"PeriodicalIF":11.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Death Following Nonfatal Events After PCI","authors":"William S. Weintraub MD","doi":"10.1016/j.jcin.2026.03.005","DOIUrl":"10.1016/j.jcin.2026.03.005","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"19 8","pages":"Pages 1001-1003"},"PeriodicalIF":11.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percutaneous Thrombectomy for LVAD Inflow and Outflow Thrombosis","authors":"René Boudreau MD ,&nbsp;Avinainder Singh MBBS ,&nbsp;Ameesh Isath MBBS ,&nbsp;Luigino Nascimben MD ,&nbsp;Amy Hackmann MD ,&nbsp;Margaret R. Connolly MD ,&nbsp;Thais Faggion Vinholo MD ,&nbsp;Mandeep R. Mehra MD ,&nbsp;Pinak B. Shah MD ,&nbsp;Mohammad Mustehsan MD ,&nbsp;Brian A. Bergmark MD","doi":"10.1016/j.jcin.2026.01.302","DOIUrl":"10.1016/j.jcin.2026.01.302","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"19 8","pages":"Pages 1050-1052"},"PeriodicalIF":11.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-Coated Balloon Angioplasty vs Drug-Eluting Stents in Noncomplex Coronary Bifurcation Lesions","authors":"Bin Zhu MD, PhD ,&nbsp;Fei Li MD, PhD ,&nbsp;Jianzheng Liu MSc ,&nbsp;Likun Ma MD, PhD ,&nbsp;Feng Yang MD, PhD ,&nbsp;Zheng Ji MD, PhD ,&nbsp;Hua Wang MD, PhD ,&nbsp;Yanqing Wu MD, PhD ,&nbsp;Zhenfei Fang MD, PhD ,&nbsp;Jingyu Zhou MD, PhD ,&nbsp;Haokao Gao MD, PhD ,&nbsp;Tao Hu MD, PhD ,&nbsp;Dongdong Sun MD, PhD ,&nbsp;Qiong Wang MD, PhD ,&nbsp;Hong Jiang MD, PhD ,&nbsp;Guotao Fu MSc ,&nbsp;Ruining Zhang BSc ,&nbsp;Xingqiang He MD, PhD ,&nbsp;Xiaoming Xu MD, PhD ,&nbsp;Zhiwei Jiang MSc ,&nbsp;Chao Gao MD, PhD","doi":"10.1016/j.jcin.2026.02.009","DOIUrl":"10.1016/j.jcin.2026.02.009","url":null,"abstract":"<div><h3>Background</h3><div>Drug-coated balloons (DCBs) are attractive for treating de novo coronary lesions, especially when involving bifurcations; however, their efficacy compared with drug-eluting stents (DES) remains uncertain.</div></div><div><h3>Objectives</h3><div>The aim of this study was to assess the prognosis of DCBs vs DES in patients with noncomplex bifurcation and nonbifurcation lesions.</div></div><div><h3>Methods</h3><div>This was a prespecified subgroup analysis of the REC-CAGEFREE I (Paclitaxel-Coated Balloon for Treatment of De-Novo Non-Complex Coronary Artery Lesions) trial, which was an investigator-initiated, noninferiority trial conducted at 43 sites in China that randomized 2,272 participants to paclitaxel-coated balloons (the DCB group) or sirolimus-eluting stents (the DES group) for the treatment of de novo lesions, regardless of vessel diameter. The primary outcome was a device-oriented composite endpoint (DoCE) at 24 months. Participants were stratified according to the presence vs absence of bifurcation, and inverse probability of treatment weighting (IPTW) was performed to adjust for between-group imbalances.</div></div><div><h3>Results</h3><div>A total of 2,257 of 2,272 participants (99.3%) with available angiographic results were included. At 24 months, the DoCE had occurred in 46 of 773 patients in the bifurcation group (6.0%) and 64 of 1,484 patients in the nonbifurcation group (4.3%) (HR_IPTW: 1.39; 95% CI: 0.87-2.21; <em>P</em> = 0.164). Of the 798 bifurcation lesions, 719 (90.1%) had DCB or DES treatment in the main vessel. A significant interaction for the DoCE was observed between bifurcation or nonbifurcation and assigned treatment (<em>P</em>_interaction = 0.031). In the nonbifurcation group, the DoCE occurred in 46 of 735 patients with DCBs (6.3%) and 18 of 749 (2.4%) with DES (HR_IPTW: 2.67; 95% CI: 1.64-4.33; <em>P</em> &lt; 0.001); the in bifurcation group, the DoCE occurred in 26 of 394 patients with DCBs (6.7%) and 20 of 379 (5.3%) with DES (HR_IPTW: 1.03; 95% CI: 0.53-2.01; <em>P</em> = 0.934).</div></div><div><h3>Conclusions</h3><div>DCBs were associated with a numerically comparable risk for DoCE compared with DES in noncomplex bifurcations at 2 years. However, these findings should be interpreted as hypothesis generating only. (Paclitaxel-Coated Balloon for Treatment of De-Novo Non-Complex Coronary Artery Lesions; <span><span>NCT04561739</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"19 8","pages":"Pages 943-957"},"PeriodicalIF":11.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Side Branch Additional Treatment for Coronary Bifurcation Lesion Revascularization","authors":"Bernard Chevalier MD ,&nbsp;Luc Cornillet MD ,&nbsp;Frederic Bouisset MD, PhD ,&nbsp;Laurent Delorme MD ,&nbsp;Stephane Champagne MD ,&nbsp;Philippe Brunel MD ,&nbsp;Katrien Blanchart MD ,&nbsp;Giuseppe Ferrante MD, PhD ,&nbsp;Manuel Pan MD ,&nbsp;Pedro Goncalves MD ,&nbsp;Antoinette Neylon MD ,&nbsp;Benoit Lattuca MD, PhD","doi":"10.1016/j.jcin.2026.02.012","DOIUrl":"10.1016/j.jcin.2026.02.012","url":null,"abstract":"<div><h3>Background</h3><div>Although provisional stenting is the recommended strategy for most coronary bifurcation lesions, the clinical benefit of additional side branch (SB) intervention remains debated.</div></div><div><h3>Objectives</h3><div>The aim of this study was to determine whether a conservative strategy without systematic SB intervention (SBI) is noninferior to systematic SB intervention regarding periprocedural events.</div></div><div><h3>Methods</h3><div>The multicenter, international KISS (Keep Bifurcation Single Stenting Simple) trial randomized patients with non–left main bifurcation lesions to 2 groups: no SBI or SBI following main branch stenting with the Resolute Onyx drug-eluting stent and a proximal optimization technique without impairment of SB flow. The primary endpoint was periprocedural myocardial infarction (MI) or myocardial injury, according to the Academic Research Consortium 2 definition. Secondary endpoints included procedural complications and 12-month clinical outcomes, including target lesion failure, defined as the composite of cardiac death, target vessel MI, and target lesion revascularization.</div></div><div><h3>Results</h3><div>Among the 616 included patients, 81% were treated for chronic coronary disease, and the bifurcation mainly involved was between the left anterior descending coronary artery and the diagonal. In the no-SBI group, an intervention on the SB was required in 2.0% of patients (n = 6). Periprocedural MI or myocardial injury occurred in 4.1% (n = 11) in the no-SBI group vs 5.7% (n = 16) in the SBI group (<em>P</em> &lt; 0.001 for noninferiority; <em>P</em> = 0.38 for superiority). There was no significant interaction with age, sex, Medina classification, or SB residual stenosis. Procedure time, radiation dose, and contrast use were significantly lower in the no-SBI group. Procedural complications were rare, but SB dissection was more frequently observed in the SBI group (2.9% vs 0.0%; <em>P</em> = 0.004). There was no difference in target lesion failure at 1 year (4.9% [n = 15] vs 6.4% [n = 20] in the no-SBI and SBI groups respectively; <em>P</em> = 0.442).</div></div><div><h3>Conclusions</h3><div>The KISS trial demonstrates that a conservative strategy without systematic SB intervention is associated with very rare procedural complications and is noninferior to a systematic SB intervention regarding periprocedural MI and myocardial injury.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"19 8","pages":"Pages 961-972"},"PeriodicalIF":11.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147753682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}