JACC. Cardiovascular interventions最新文献

{"title":"Relationships of hsCRP to High-Risk Vulnerable Plaque After NSTEMI","authors":"Ole Fröbert MD ,&nbsp;Gregg W. Stone MD ,&nbsp;Alf Inge Larsen MD ,&nbsp;Zhipeng Zhou MA ,&nbsp;Lak N. Kotinkaduwa PhD ,&nbsp;Thomas Engstrøm MD ,&nbsp;Lars Kjøller-Hansen DMSc ,&nbsp;Michael Maeng MD, PhD ,&nbsp;Mitsuaki Matsumura BS ,&nbsp;Ori Ben-Yehuda MD ,&nbsp;Hans Erik Bøtker MD, PhD, DMSc ,&nbsp;Jonas Persson MD, PhD ,&nbsp;Rune Wiseth MD, PhD ,&nbsp;Lisette O. Jensen MD, PhD ,&nbsp;Jan E. Nordrehaug MD ,&nbsp;Thor Trovik MD, PhD ,&nbsp;Ulf Jensen MD, PhD ,&nbsp;Øyvind Bleie MD, PhD ,&nbsp;Stefan K. James MD ,&nbsp;Ziad A. Ali MD, DPhil ,&nbsp;Akiko Maehara MD","doi":"10.1016/j.jcin.2025.01.440","DOIUrl":"10.1016/j.jcin.2025.01.440","url":null,"abstract":"<div><h3>Background</h3><div>Inflammation is a driver of atherosclerosis and susceptibility to cardiovascular events.</div></div><div><h3>Objectives</h3><div>The authors sought to evaluate whether high-sensitivity C-reactive protein (hsCRP) levels are associated with the prevalence of high-risk coronary plaques in patients with non–ST-segment elevation myocardial infarction (NSTEMI).</div></div><div><h3>Methods</h3><div>PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) II was a multicenter, prospective study enrolling patients with recent myocardial infarction. Following treatment of all flow-limiting lesions, 3-vessel imaging with near-infrared spectroscopy and intravascular ultrasound was used to characterize untreated nonculprit lesions. We investigated the association between baseline hsCRP and plaque morphology (lipid content, plaque burden, lumen area) in 501 NSTEMI patients. hsCRP levels were categorized as low (&lt;1 mg/L), intermediate (1-3 mg/L), or high (&gt;3 mg/L).</div></div><div><h3>Results</h3><div>The percentages of patients with at least 1 highly lipidic plaque (maximum lipid core burden index for any 4-mm pullback length ≥324.7) increased from 39.4% to 57.2% to 59.3% in the low, intermediate, and high hsCRP groups, respectively (<em>P</em> = 0.01). The proportion of patients with at least 1 highly lipidic plaque with ≥70% burden increased with hsCRP levels from 22.7% to 27.2% to 36.7%, respectively (<em>P</em> = 0.01). Multivariable analyses showed that increasing hsCRP was associated with higher total coronary artery lipid core burden index and plaque volume. Higher hsCRP increased the odds of having any highly lipidic plaque and those with ≥70% plaque burden.</div></div><div><h3>Conclusions</h3><div>Among patients with recent NSTEMI, a high baseline hsCRP level was associated with the presence of pan-coronary atherosclerosis and focal high-risk plaques. (PROSPECT II &amp; PROSPECT ABSORB - an Integrated Natural History Study and Randomized Trial; <span><span>NCT02171065</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 10","pages":"Pages 1217-1228"},"PeriodicalIF":11.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making Progress Toward Complete Revascularization of Multivessel Disease After STEMI","authors":"Francis R. Joshi MBBS, PhD","doi":"10.1016/j.jcin.2025.04.006","DOIUrl":"10.1016/j.jcin.2025.04.006","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 10","pages":"Pages 1260-1262"},"PeriodicalIF":11.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter Edge-to-Edge Repair for Severe Tricuspid Regurgitation in Dextro-Transposition of Great Arteries Post Mustard Procedure","authors":"Neal Duggal MD ,&nbsp;Michael R. Joynt MD ,&nbsp;Jeffrey D. Zampi MD ,&nbsp;Matthew Romano MD ,&nbsp;Stanley J. Chetcuti MD ,&nbsp;Daniel Menees MD ,&nbsp;Devraj Sukul MD, MSc","doi":"10.1016/j.jcin.2024.12.009","DOIUrl":"10.1016/j.jcin.2024.12.009","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 10","pages":"Pages 1332-1334"},"PeriodicalIF":11.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcatheter Tricuspid Valve Replacement With the Novel System","authors":"Xiangbin Pan MD, PhD ,&nbsp;Fanglin Lu MD, PhD ,&nbsp;Yiwei Wang MD, PhD ,&nbsp;Yingqiang Guo MD, PhD ,&nbsp;Mao Chen MD, PhD ,&nbsp;Xu Meng MD, PhD ,&nbsp;Haibo Zhang MD, PhD ,&nbsp;Nianguo Dong MD, PhD ,&nbsp;Xiaoke Shang MD, PhD ,&nbsp;Jian Yang MD, PhD ,&nbsp;Yang Liu MD, PhD ,&nbsp;Jianan Wang MD, PhD ,&nbsp;Xianbao Liu MD, PhD ,&nbsp;Huiming Guo MD, PhD ,&nbsp;Jian Liu MD, PhD ,&nbsp;Fan Qiao MD, PhD ,&nbsp;Guido Ascione MD, PhD ,&nbsp;Anson Cheung MD, PhD ,&nbsp;Thomas Modine MD, PhD ,&nbsp;Ralph Stephan von Bardeleben MD, PhD ,&nbsp;Shengshou Hu MD, PhD","doi":"10.1016/j.jcin.2024.12.030","DOIUrl":"10.1016/j.jcin.2024.12.030","url":null,"abstract":"<div><h3>Background</h3><div>Transcatheter tricuspid valve replacement (TTVR) is emerging as a promising surgical alternative for high-risk patients with tricuspid regurgitation (TR). Nonetheless, the feasibility of more dedicated devices and the need for additional clinical evidence warrant further exploration.</div></div><div><h3>Objectives</h3><div>The purpose of this study was to report the 1-year outcomes of the TRAVEL (Transcatheter Right Atrial-Ventricular Valve Replacement With LuX-Valve) study with the LuX-Valve system for patients with severe TR.</div></div><div><h3>Methods</h3><div>A total of 126 patients with symptomatic severe TR were prospectively enrolled in the single-arm, multicenter TRAVEL study from June 2020 to August 2021. All patients underwent TTVR via the transatrial approach using the LuX-Valve system. The primary endpoint was all-cause mortality and hospitalization for heart failure at 1-year follow-up. Clinical and echocardiographic outcomes were reported.</div></div><div><h3>Results</h3><div>At baseline, all enrolled patients (mean age 65.8 ± 7.5 years, 79.4% women) were at high surgical risk (mean Society of Thoracic Surgeons score 9.2% ± 4.4%), with severe or greater TR and NYHA functional class ≥ III. In 1-year follow-up, all-cause mortality was 10.3%, and 4.0% of patients were hospitalized for heart failure. TR was reduced to mild or less in 95.2% (<em>P</em> &lt; 0.001), with decreases in right atrial systolic volume (−38.3 ± 21.7 mL; <em>P</em> &lt; 0.001) and mid right ventricular end-systolic diameter (−6.4 ± 2.3 mm; <em>P</em> &lt; 0.001). NYHA functional class I or II was achieved in 79.8% (<em>P</em> &lt; 0.001), and 6-minute walking distance increased by 71.3 ± 42.8 m (<em>P</em> &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>The 1-year outcomes of the TRAVEL study showed a sustained reduction in TR among patients who underwent LuX-Valve TTVR, accompanied by significant right heart reverse remodeling and improved functional status. Favorable procedural success and survival benefits were also demonstrated. (the TRAVEL Trial: Transcatheter Right Atrial-Ventricular Valve Replacement With LuX-Valve; <span><span>NCT04436653</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 10","pages":"Pages 1276-1285"},"PeriodicalIF":11.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolving Landscape of TTVR","authors":"Neil P. Fam MD, MSc,&nbsp;Sami Alnasser MD","doi":"10.1016/j.jcin.2024.07.048","DOIUrl":"10.1016/j.jcin.2024.07.048","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 10","pages":"Pages 1286-1288"},"PeriodicalIF":11.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"hsCRP, High-Risk Plaque, and Pan-Coronary Atherosclerosis","authors":"Paul M Ridker MD, MPH","doi":"10.1016/j.jcin.2025.03.030","DOIUrl":"10.1016/j.jcin.2025.03.030","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 10","pages":"Pages 1229-1231"},"PeriodicalIF":11.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of Early Device-Related Thrombosis in Post-Watchman Cases on Low-Dose Oral Anticoagulation vs Dual Antiplatelet Therapy","authors":"Sanghamitra Mohanty MD, MS,&nbsp;Prem Geeta Torlapati MD, MPH,&nbsp;Vincenzo Mirco La Fazia MD,&nbsp;Carola Gianni MD, PhD,&nbsp;Amin Al-Ahmad MD,&nbsp;John D. Burkhardt MD,&nbsp;G.J. Gallinghouse MD,&nbsp;Rodney Horton MD,&nbsp;John Allison MD,&nbsp;Weeranun Bode MD,&nbsp;Luigi Di Biase MD, PhD,&nbsp;Andrea Natale MD","doi":"10.1016/j.jcin.2025.02.025","DOIUrl":"10.1016/j.jcin.2025.02.025","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 10","pages":"Pages 1357-1359"},"PeriodicalIF":11.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revascularization Strategies in ST-Segment Elevation Myocardial Infarction With Multivessel Disease","authors":"Felix Lindberg MD, PhD ,&nbsp;Brynjölfur Mogensen MD ,&nbsp;Sergio Buccheri MD, PhD ,&nbsp;Fadi Jokhaji MD ,&nbsp;Nils Witt MD, PhD ,&nbsp;Colin Berry MD, PhD ,&nbsp;Tomas Jernberg MD, PhD ,&nbsp;Giovanna Sarno MD, PhD ,&nbsp;Dimitrios Venetsanos MD, PhD ,&nbsp;Stefan James MD, PhD ,&nbsp;Felix Böhm MD, PhD","doi":"10.1016/j.jcin.2025.02.017","DOIUrl":"10.1016/j.jcin.2025.02.017","url":null,"abstract":"<div><h3>Background</h3><div>Randomized trials support angiographic and physiology-guided complete revascularization (CR) vs incomplete revascularization (IR) in ST-segment elevation myocardial infarction (STEMI) with multivessel disease (MVD). The implementation of these strategies in clinical practice is uncertain.</div></div><div><h3>Objectives</h3><div>In patients undergoing percutaneous coronary intervention for STEMI with MVD, we assessed temporal trends in the utilization of different revascularization strategies and associated outcomes.</div></div><div><h3>Methods</h3><div>We included 20,131 patients from the SWEDEHEART (Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies) registry who underwent primary percutaneous coronary intervention for STEMI with MVD between 2009 and 2021. Primary outcome was a composite of all-cause mortality, myocardial infarction, or unplanned revascularization, landmarked at 90 days postindex to account for staged procedures during this time.</div></div><div><h3>Results</h3><div>We observed increased adoption of CR (2009: 33% [n = 397 of 1,217]; 2015: 46% [n = 767 of 1,658]; 2021: 51% [n = 816 of 1,603]; <em>P</em>-trend &lt; 0.001) and physiology-guided CR (2009: 0% [n = 0 of 1,217]; 2015: 7% [n = 119 of 1,658]; 2021: 14% [n = 218 of 1,603]; <em>P-</em>trend &lt; 0.001). Over a median follow-up of 4.2 years (Q1-Q3: 1.8-7.1 years), the adjusted risk of a primary event was lower with angiographic CR vs IR (adjusted HR [aHR]: 0.84, 95% CI: 0.79-0.89) and physiology-guided CR vs IR (aHR: 0.80, 95% CI: 0.69-0.93) but not physiology-guided CR vs angiographic CR (aHR: 0.94, 95% CI: 0.80-1.11).</div></div><div><h3>Conclusions</h3><div>In patients with STEMI and MVD, the implementation of CR and physiology-guided procedures increased over time. As of 2021, 51% of patients underwent CR and 14% physiology-guided CR. CR, whether angiographically or physiology guided, was independently associated with favorable outcomes, including mortality.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 10","pages":"Pages 1246-1259"},"PeriodicalIF":11.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Procedural Efficacy With Transcatheter Tricuspid Annuloplasty by Optimizing Patient Selection and Procedural Approach","authors":"Johannes Kirchner MD ,&nbsp;Muhammed Gerçek MD ,&nbsp;Maria Ivannikova MD,&nbsp;Felix Rudolph MD,&nbsp;Hazem Omran MD,&nbsp;Mohammad Kassar MD,&nbsp;Tanja K. Rudolph MD,&nbsp;Kai P. Friedrichs MD ,&nbsp;Volker Rudolph MD","doi":"10.1016/j.jcin.2025.01.438","DOIUrl":"10.1016/j.jcin.2025.01.438","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 10","pages":"Pages 1354-1356"},"PeriodicalIF":11.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First “Minimize” the Harm","authors":"John J. Atherton MBBS, PhD ,&nbsp;Sandhir B. Prasad MBBS, PhD","doi":"10.1016/j.jcin.2025.03.002","DOIUrl":"10.1016/j.jcin.2025.03.002","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 10","pages":"Pages 1273-1275"},"PeriodicalIF":11.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144024595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}