Michael Chiang MBBS, Alvin H.Y. Ko MBChB, Cheuk Bong Ho MBBS, Esmond Y.H. Fong MBBS, Ivan Wong MBBS, Shing Fung Chui MBChB, Ka Chun Alan Chan MBBS, Chi Yuen Wong MBBS, Kam Tim Chan MBBS, Kang Yin Michael Lee MBBS
{"title":"Transcaval Impella-Assisted CHIP-PCI and Transcaval TAVR With Impella Removal in Freshly Implanted TAVR","authors":"Michael Chiang MBBS, Alvin H.Y. Ko MBChB, Cheuk Bong Ho MBBS, Esmond Y.H. Fong MBBS, Ivan Wong MBBS, Shing Fung Chui MBChB, Ka Chun Alan Chan MBBS, Chi Yuen Wong MBBS, Kam Tim Chan MBBS, Kang Yin Michael Lee MBBS","doi":"10.1016/j.jcin.2024.08.014","DOIUrl":"10.1016/j.jcin.2024.08.014","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 21","pages":"Pages 2565-2566"},"PeriodicalIF":11.7,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas J. Stocker MD , Lukas Stolz MD , Nicole Karam MD, PhD , Daniel Kalbacher MD , Benedikt Koell MD , Teresa Trenkwalder MD , Erion Xhepa MD , Marianna Adamo MD , Maximilian Spieker MD , Patrick Horn MD , Christian Butter MD , Ludwig T. Weckbach MD , Julia Novotny MD , Bruno Melica MD , Christina Giannini MD , Ralph Stephan von Bardeleben MD , Roman Pfister MD , Fabien Praz MD , Philipp Lurz MD, PhD , Volker Rudolph MD , Francisco Sampaio MD
{"title":"Long-Term Outcomes After Edge-to-Edge Repair of Secondary Mitral Regurgitation","authors":"Thomas J. Stocker MD , Lukas Stolz MD , Nicole Karam MD, PhD , Daniel Kalbacher MD , Benedikt Koell MD , Teresa Trenkwalder MD , Erion Xhepa MD , Marianna Adamo MD , Maximilian Spieker MD , Patrick Horn MD , Christian Butter MD , Ludwig T. Weckbach MD , Julia Novotny MD , Bruno Melica MD , Christina Giannini MD , Ralph Stephan von Bardeleben MD , Roman Pfister MD , Fabien Praz MD , Philipp Lurz MD, PhD , Volker Rudolph MD , Francisco Sampaio MD","doi":"10.1016/j.jcin.2024.08.016","DOIUrl":"10.1016/j.jcin.2024.08.016","url":null,"abstract":"<div><h3>Background</h3><div>Mitral valve transcatheter edge-to-edge repair (M-TEER) reduces secondary mitral regurgitation (MR) in heart failure and impacts survival in selected patients as demonstrated in the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients with Functional Mitral Regurgitation) trial. However, long-term outcome data after M-TEER under real-world conditions are lacking.</div></div><div><h3>Objectives</h3><div>This study sought to assess long-term efficacy and survival after M-TEER in a large real-world registry.</div></div><div><h3>Methods</h3><div>We analyzed patients with significant secondary MR undergoing M-TEER from the EuroSMR (European Registry of Transcatheter Repair for Secondary Mitral Regurgitation) registry. Long-term MR reduction, functional outcomes, survival rate, and predictors for all-cause mortality were assessed.</div></div><div><h3>Results</h3><div>In this study, 1,628 patients undergoing M-TEER (mean age 73.8 years, mean EuroSCORE II [European System for Cardiac Operative Risk Evaluation II] 6.9%, 86.6% NYHA functional class ≥III) with available long-term data were included. Five-year survival was 35.0%. Long-term MR reduction (MR grade ≤2+: baseline 4.1%, discharge 92.2%, 5-year follow-up 85.5%; <em>P <</em> 0.001) and functional improvement (NYHA ≤II: baseline 13.4%, 5-year follow-up 60.1%; <em>P <</em> 0.001) was observed. The degree of residual MR was associated with 5-year survival (residual MR grade ≤1+: 38.6%; 2+: 30.5%; ≥3+: 22.6%; <em>P <</em> 0.001). Independent predictors for 5-year all-cause mortality post–M-TEER included age, renal function, residual MR, NYHA functional class, left ventricular ejection-fraction, and COAPT trial eligibility (<em>P <</em> 0.01 for all).</div></div><div><h3>Conclusions</h3><div>This extensive multicenter registry underscores the long-term efficacy of M-TEER in real-world clinical practice and identifies predictors for long-term survival. These findings contribute valuable insights for optimizing patient selection in routine clinical interventions.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 21","pages":"Pages 2543-2554"},"PeriodicalIF":11.7,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shouzheng Wang MD , Da Zhu MD , Jiaqi Dai MD , Xiangbin Pan MD
{"title":"First-in-Man Experience of Telerobotic Transcatheter Edge-to-Edge Repair With Pure Echo Guidance","authors":"Shouzheng Wang MD , Da Zhu MD , Jiaqi Dai MD , Xiangbin Pan MD","doi":"10.1016/j.jcin.2024.08.026","DOIUrl":"10.1016/j.jcin.2024.08.026","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 21","pages":"Pages 2561-2562"},"PeriodicalIF":11.7,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142465740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chetan P. Huded MD, MSc , Adnan K. Chhatriwalla MD , Miloni A. Shah MPH , Sreekanth Vemulapalli MD , Andrzej Kosinski PhD , David J. Cohen MD, MSc
{"title":"Mitral Transcatheter Edge-to-Edge Repair for Secondary Mitral Regurgitation With Preserved Left Ventricular Function","authors":"Chetan P. Huded MD, MSc , Adnan K. Chhatriwalla MD , Miloni A. Shah MPH , Sreekanth Vemulapalli MD , Andrzej Kosinski PhD , David J. Cohen MD, MSc","doi":"10.1016/j.jcin.2024.08.031","DOIUrl":"10.1016/j.jcin.2024.08.031","url":null,"abstract":"<div><h3>Background</h3><div>Outcomes of mitral transcatheter edge-to-edge repair (MTEER) in patients with secondary mitral regurgitation (sMR) and preserved left ventricular ejection fraction (LVEF) are uncertain.</div></div><div><h3>Objectives</h3><div>This study sought to describe outcomes of MTEER for sMR with preserved LVEF.</div></div><div><h3>Methods</h3><div>Using the STS/ACC TVT (Society of Thoracic Surgeons–American College of Cardiology Transcatheter Valve Therapy) Registry, we evaluated the risk-adjusted outcomes of MTEER for sMR with LVEF >50% by the severity of residual mitral regurgitation (MR), and we compared these outcomes to patients undergoing MTEER for sMR with LVEF of 20% to 50%.</div></div><div><h3>Results</h3><div>Among 12,083 patients, LVEF was >50% in 3,011 (24.9%) and 20% to 50% in 9,072 (75.1%). Technical success, in-hospital complications, the 1-year death rate, and the 1-year Kansas City Cardiomyopathy Questionnaire score were similar in patients with LVEF >50% vs LVEF of 20% to 50%. The 1-year adjusted risk of heart failure hospitalization was lower in patients with LVEF >50% vs LVEF of 20% to 50% (adjusted HR: 0.81; 95% CI: 0.68-0.97; <em>P =</em> 0.02). Among patients with LVEF >50%, residual MR was ≤ mild in 76.0% and moderate in 19.0%. Compared with ≤ mild MR, moderate residual MR was associated with increased 1-year risks of death (adjusted HR: 1.46; 95% CI: 1.01-2.10; <em>P =</em> 0.04) and heart failure hospitalization (adjusted HR: 1.82; 95% CI: 1.32-2.52; <em>P</em> < 0.001). At 1 year, the KCCQ score improved in patients with LVEF >50% treated with MTEER (residual MR grade ≤ mild, 28.7 ± 26.8; moderate MR, 25.7 ± 27.2; > moderate MR, 21.6 ± 12.0; all <em>P <</em> 0.05).</div></div><div><h3>Conclusions</h3><div>In patients with sMR and preserved LVEF, MTEER was associated with a high rate of technical success, a low rate of complications, and large improvements in health status.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 21","pages":"Pages 2515-2526"},"PeriodicalIF":11.7,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}