John D Corl, Daniel Clair, Patrice Mwipatayi, Manar Khashram, Nicolas W Shammas, Peter Soukas, Anderson Mehrle, Anvar Babaev, Iftekhar Baig, Ryan Shields, Nick E J West, Andrew Holden
{"title":"FORWARD PAD IDE/Feasibility Studies: Primary Endpoint Analysis of a Novel Non-Balloon-Based Peripheral IVL Catheter.","authors":"John D Corl, Daniel Clair, Patrice Mwipatayi, Manar Khashram, Nicolas W Shammas, Peter Soukas, Anderson Mehrle, Anvar Babaev, Iftekhar Baig, Ryan Shields, Nick E J West, Andrew Holden","doi":"10.1016/j.jcin.2024.10.035","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.10.035","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hafiz M. Imran MD , Phinnara Has MS , Nicholas Kassis MD , Ernie Shippey MS , Ahmed Elkaryoni MD , Paul C. Gordon MD , Barry L. Sharaf MD , Peter A. Soukas MD , Omar N. Hyder MD , Frank Sellke MD , Afshin Ehsan MD , Neel Sodha MD , Amgad Mentias MD, MS , Islam Y. Elgendy MD , Mohamad Alkhouli MD , J. Dawn Abbott MD , Herbert D. Aronow MD, MPH , Marwan Saad MD, PhD
{"title":"Characteristics, Trends, and Outcomes of Intravascular Lithotripsy-Assisted Transfemoral Transcatheter Aortic Valve Replacement in United States","authors":"Hafiz M. Imran MD , Phinnara Has MS , Nicholas Kassis MD , Ernie Shippey MS , Ahmed Elkaryoni MD , Paul C. Gordon MD , Barry L. Sharaf MD , Peter A. Soukas MD , Omar N. Hyder MD , Frank Sellke MD , Afshin Ehsan MD , Neel Sodha MD , Amgad Mentias MD, MS , Islam Y. Elgendy MD , Mohamad Alkhouli MD , J. Dawn Abbott MD , Herbert D. Aronow MD, MPH , Marwan Saad MD, PhD","doi":"10.1016/j.jcin.2024.08.033","DOIUrl":"10.1016/j.jcin.2024.08.033","url":null,"abstract":"<div><h3>Background</h3><div>Transfemoral (TF) access is the preferred approach for transcatheter aortic valve replacement (TAVR). Limited data exist regarding the outcomes of intravascular lithotripsy (IVL)-assisted TF TAVR in patients with peripheral artery disease.</div></div><div><h3>Objectives</h3><div>This study sought to examine contemporary characteristics, trends, and outcomes of IVL TAVR in the United States.</div></div><div><h3>Methods</h3><div>The Vizient Clinical Database was queried for patients who underwent percutaneous TAVR between October 1, 2020, and November 30, 2023. Outcomes with IVL TAVR vs non–IVL TAVR were examined after propensity score matching. The primary outcome was a composite of in-hospital death, stroke, vascular complications, surgical vascular intervention, and major bleeding.</div></div><div><h3>Results</h3><div>Over the study period, 129,655 patients (mean age of 78.4 years, 42.2% women, 87.1% White) underwent percutaneous TAVR at 361 hospitals, 1,242 (0.96%) of whom underwent IVL TAVR. There was an uptrend in IVL TAVR, but the frequency remained low. IVL TAVR patients had a higher median Elixhauser comorbidity score (5 [Q1-Q3: 4-7] vs 4 [Q1-Q3: 3-6]) compared to non–IVL TAVR. TAVR was completed via the TF approach in 1,238 (99.7%) IVL TAVR patients. In a 3:1 propensity score matching analysis, IVL TAVR was associated with a higher rate of the primary composite outcome (21.9% vs 13.7%; <em>P</em> < 0.001) driven by higher rates of vascular complications, surgical vascular intervention, and major bleeding. In-hospital death and stroke were similar in both groups.</div></div><div><h3>Conclusions</h3><div>In the United States, IVL is increasingly adopted to facilitate TF TAVR. IVL TAVR patients exhibited a higher burden of comorbidities and experienced more complications compared to non–IVL TAVR patients. Further studies are needed to identify appropriate anatomical and clinical use criteria for IVL TAVR and to compare its outcomes vs alternative non–TF TAVR.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 20","pages":"Pages 2367-2376"},"PeriodicalIF":11.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eric Van Belle MD, PhD , Flavien Vincent MD, PhD , Ole De Backer MD, PhD
{"title":"Stay Calm and Carry On With Intravascular Lithotripsy–Assisted Transfemoral-TAVR in Patients With Calcific-Iliofemoral Artery Disease?","authors":"Eric Van Belle MD, PhD , Flavien Vincent MD, PhD , Ole De Backer MD, PhD","doi":"10.1016/j.jcin.2024.09.049","DOIUrl":"10.1016/j.jcin.2024.09.049","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 20","pages":"Pages 2377-2378"},"PeriodicalIF":11.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nickpreet Singh MD , David J. Cohen MD, MSc , Miloni A. Shah MPH, MSc , Andrzej S. Kosinski PhD , Leo Brothers MPH , Sreekanth Vemulapalli MD , Sammy Elmariah MD, MPH
{"title":"Trends, Predictors, and Outcomes of Bleeding Complications After Mitral Transcatheter Edge-to-Edge Repair","authors":"Nickpreet Singh MD , David J. Cohen MD, MSc , Miloni A. Shah MPH, MSc , Andrzej S. Kosinski PhD , Leo Brothers MPH , Sreekanth Vemulapalli MD , Sammy Elmariah MD, MPH","doi":"10.1016/j.jcin.2024.09.035","DOIUrl":"10.1016/j.jcin.2024.09.035","url":null,"abstract":"<div><h3>Background</h3><div>Bleeding events after arterial transcatheter procedures are associated with increased morbidity and mortality. The frequency and clinical implications of bleeding after mitral transcatheter edge-to-edge repair (M-TEER) have not been well-studied.</div></div><div><h3>Objectives</h3><div>The authors sought to explore the association of in-hospital bleeding events after M-TEER with patient outcomes.</div></div><div><h3>Methods</h3><div>Patients undergoing M-TEER who were included in the TVT (Transcatheter Valve Therapy) Registry between 2013 and 2022 were included. Rates of the primary endpoint, the composite of death or hospital readmission at 30 days, were compared between patients who experienced in-hospital major or life-threatening bleeding vs those without bleeding. Secondary analyses examined the association between in-hospital bleeding and death or readmission at 1 year, as well as independent predictors of major in-hospital bleeding.</div></div><div><h3>Results</h3><div>Over the study period, in-hospital major bleeding occurred in 1,205 (2.3%) of 51,533 patients. Rates of bleeding decreased over time (from 7.1% in 2013 to 2.0% in 2021; <em>P</em> < 0.001). In-hospital bleeding was associated with increased rates of death or readmission at both 30 days (adjusted OR: 2.15 [95% CI: 1.81-2.54]; <em>P</em> < 0.0001) and 1 year (adjusted HR: 1.43 [95% CI: 1.27-1.60]; <em>P</em> < 0.0001). The strongest correlates of in-hospital bleeding included female sex, prior percutaneous coronary intervention, baseline hemoglobin, greater procedure acuity, and longer procedure duration.</div></div><div><h3>Conclusions</h3><div>Bleeding after M-TEER is associated with increased risk of subsequent death and hospital readmission. Although reductions in bleeding complications over time are encouraging, continued efforts are needed to further mitigate hemorrhagic complications of M-TEER.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 20","pages":"Pages 2337-2349"},"PeriodicalIF":11.7,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142535111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}