{"title":"Evaluation of the Efficacy and Limitations of the TRILUMINATE Pivotal Single-Arm Study of Tricuspid TEER.","authors":"Nina C Wunderlich","doi":"10.1016/j.jcin.2024.09.029","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.09.029","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 23","pages":"2761-2763"},"PeriodicalIF":11.7,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karol A Sadowski, Gary S Mintz, Olgierd Woźniak, Ewa Warchoł-Celińska, Elżbieta K Biernacka, Magda Lipczyńska, Piotr Hoffman, Lars Sondergaard, Marcin Demkow, Łukasz Kalińczuk
{"title":"Intravascular Ultrasound for Guiding Venus-P-Valve Deployment.","authors":"Karol A Sadowski, Gary S Mintz, Olgierd Woźniak, Ewa Warchoł-Celińska, Elżbieta K Biernacka, Magda Lipczyńska, Piotr Hoffman, Lars Sondergaard, Marcin Demkow, Łukasz Kalińczuk","doi":"10.1016/j.jcin.2024.10.053","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.10.053","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Karl-Patrik Kresoja, Uwe Zeymer, Tharusan Thevathasan, Tienush Rassaf, Christian Jung, Janine Pöss, Steffen Schneider, Steffen Desch, Anne Freund, Holger Thiele
{"title":"The Influence of Extracorporeal Life Support on Patients in Cardiogenic Shock Assessed by Machine Learning: A Machine Learning Subanalysis From the ECLS-SHOCK Trial.","authors":"Karl-Patrik Kresoja, Uwe Zeymer, Tharusan Thevathasan, Tienush Rassaf, Christian Jung, Janine Pöss, Steffen Schneider, Steffen Desch, Anne Freund, Holger Thiele","doi":"10.1016/j.jcin.2024.10.043","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.10.043","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marie-Annick Clavel, Paolo Springhetti, Philippe Pibarot
{"title":"Low-Gradient Severe Aortic Stenosis Is Not Mainstream: Insights From the CURRENT AS Registry-2.","authors":"Marie-Annick Clavel, Paolo Springhetti, Philippe Pibarot","doi":"10.1016/j.jcin.2024.10.039","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.10.039","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gennaro Giustino, Jonathan X Fang, Tiberio M Frisoli, James C Lee, Felix Nguyen, Pedro Engel, Pedro A Villablanca, William W O'Neill, Brian P O'Neill
{"title":"Early Outcomes of Transjugular Transcatheter Tricuspid Valve Replacement.","authors":"Gennaro Giustino, Jonathan X Fang, Tiberio M Frisoli, James C Lee, Felix Nguyen, Pedro Engel, Pedro A Villablanca, William W O'Neill, Brian P O'Neill","doi":"10.1016/j.jcin.2024.10.058","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.10.058","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Low-Gradient Severe Aortic Stenosis: Insights From the CURRENT AS Registry-2.","authors":"Tomohiko Taniguchi, Takeshi Morimoto, Yasuaki Takeji, Shinichi Shirai, Kenji Ando, Hiroyuki Tabata, Ko Yamamoto, Ryosuke Murai, Kohei Osakada, Hiroki Sakamoto, Tomohisa Tada, Koichiro Murata, Yuki Obayashi, Masashi Amano, Takeshi Kitai, Chisato Izumi, Mamoru Toyofuku, Norio Kanamori, Makoto Miyake, Hiroyuki Nakayama, Masayasu Izuhara, Kazuya Nagao, Kenji Nakatsuma, Yutaka Furukawa, Moriaki Inoko, Masahiro Kimura, Mitsuru Ishii, Shunsuke Usami, Fumiko Nakazeki, Manabu Shirotani, Yasutaka Inuzuka, Koh Ono, Kenji Minatoya, Takeshi Kimura","doi":"10.1016/j.jcin.2024.09.044","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.09.044","url":null,"abstract":"<p><strong>Background: </strong>Low-gradient (LG) aortic stenosis (AS) has not been fully characterized compared with high-gradient (HG) AS in terms of cardiac damage, frailty, aortic valve calcification, and clinical outcomes.</p><p><strong>Objectives: </strong>The aim of this study was to compare the clinical characteristics and outcomes between each hemodynamic type of LG AS and HG AS.</p><p><strong>Methods: </strong>The current study included 3,363 patients in the CURRENT AS (Contemporary outcomes after sURgery and medical tREatmeNT in patients with severe Aortic Stenosis) Registry-2 after excluding patients without indexed stroke volume or left ventricular ejection fraction (LVEF) data. Patients were divided into 4 groups (LG AS with reduced LVEF: n = 285; paradoxical low flow, low gradient [LFLG]: n = 220; normal flow, low gradient [NFLG]: n = 872; HG: n = 1,986).</p><p><strong>Results: </strong>Compared with HG AS, LG AS with reduced LVEF more often had cardiovascular comorbidities, advanced cardiac damage, and frailty with less severe valve calcification and paradoxical LFLG AS more often had atrial fibrillation, advanced cardiac damage, and frailty with less severe valve calcification, while NFLG AS had comparable cardiac damage and frailty with less severe valve calcification. Cumulative 3-year incidence of death or heart failure hospitalization was higher in LG AS with reduced LVEF and paradoxical LFLG than in HG AS. After adjusting for confounders, LG AS with reduced LVEF and paradoxical LFLG compared with HG AS were independently associated with higher risk for death or heart failure hospitalization (HR: 1.82; 95% CI: 1.49-2.23; P < 0.001; and HR: 1.43; 95% CI: 1.13-1.82; P = 0.003, respectively) but NFLG AS was not (HR: 1.03; 95% CI: 0.88-1.21; P = 0.68).</p><p><strong>Conclusions: </strong>Clinical outcomes were significantly worse in LG AS with reduced LVEF and paradoxical LFLG AS and comparable in NFLG AS compared with HG AS.</p>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marco Roffi MD , Antonio Landi MD , Dik Heg PhD , Enrico Frigoli MD , Konstantina Chalkou PhD , Bernard Chevalier MD , Alexander J.J. Ijsselmuiden MD, PhD , Robert Kastberg MD , Nobuyuki Komiyama MD , Marie-Claude Morice MD , Yoshinobu Onuma MD , Yukio Ozaki MD, PhD , Aaron Peace MD, PhD , Stylianos Pyxaras MD, PhD , Paolo Sganzerla MD , Rupert Williams MD , Panagiotis Xaplanteris MD , Pascal Vranckx MD, PhD , Stephan Windecker MD , Pieter C. Smits MD, PhD , Prof Ngoc Quang Nguyen
{"title":"Abbreviated or Standard Antiplatelet Therapy After PCI in Diabetic Patients at High Bleeding Risk","authors":"Marco Roffi MD , Antonio Landi MD , Dik Heg PhD , Enrico Frigoli MD , Konstantina Chalkou PhD , Bernard Chevalier MD , Alexander J.J. Ijsselmuiden MD, PhD , Robert Kastberg MD , Nobuyuki Komiyama MD , Marie-Claude Morice MD , Yoshinobu Onuma MD , Yukio Ozaki MD, PhD , Aaron Peace MD, PhD , Stylianos Pyxaras MD, PhD , Paolo Sganzerla MD , Rupert Williams MD , Panagiotis Xaplanteris MD , Pascal Vranckx MD, PhD , Stephan Windecker MD , Pieter C. Smits MD, PhD , Prof Ngoc Quang Nguyen","doi":"10.1016/j.jcin.2024.08.030","DOIUrl":"10.1016/j.jcin.2024.08.030","url":null,"abstract":"<div><h3>Background</h3><div>Abbreviated antiplatelet therapy (APT) reduces bleeding without increasing ischemic events in largely unselected high bleeding risk (HBR) patients undergoing percutaneous coronary intervention (PCI). Diabetes mellitus (DM) is associated with higher ischemic risk, and its impact on the safety and effectiveness of abbreviated APT in HBR PCI patients remains unknown.</div></div><div><h3>Objectives</h3><div>This study sought to investigate the comparative effectiveness of abbreviated (1 month) vs standard (≥3 months) APT in HBR patients with and without DM after biodegradable polymer sirolimus-eluting coronary stent implantation.</div></div><div><h3>Methods</h3><div>This was a prespecified analysis from the MASTER DAPT (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With a Abbreviated Versus Prolonged DAPT Regimen) trial, which randomized 4,579 HBR patients (1,538 [34%] with DM) to abbreviated (n = 2,295) or standard (n = 2,284) APT. The coprimary outcomes were net adverse clinical events (NACEs; composite of all-cause death, myocardial infarction, stroke, and major bleeding), major adverse cardiac or cerebral events (MACCEs; all-cause death, myocardial infarction, and stroke), and major or clinically relevant nonmajor bleeding at 11 months.</div></div><div><h3>Results</h3><div>HBR patients with DM had higher risks of MACCEs (HR: 1.28; 95% CI: 1.00-1.63) and similar net adverse or bleeding events compared with nondiabetic subjects. Abbreviated compared with standard APT was associated with similar NACEs and MACCEs (<em>P</em><sub>interaction</sub> = 0.47 and 0.59, respectively) and reduced major or clinically relevant nonmajor bleeding (<em>P</em><sub>interaction</sub> = 0.55) irrespective of diabetes status.</div></div><div><h3>Conclusions</h3><div>MACCE and NACE rates were similar, and bleeding rates were lower with abbreviated APT in patients with or without diabetes. Therefore, diabetes status did not modify the treatment effects of abbreviated vs standard APT in HBR patients after biodegradable polymer sirolimus-eluting coronary stent implantation. (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With a Abbreviated Versus Prolonged DAPT Regimen [MASTER DAPT]; <span><span>NCT03023020</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 22","pages":"Pages 2664-2677"},"PeriodicalIF":11.7,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142702521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}