{"title":"From Cath Lab to C-Suite: Should Interventionalists Get an MBA?","authors":"Mohamad Alkhouli","doi":"10.1016/j.jcin.2025.03.004","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.03.004","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alfonso Jurado-Román MD, PhD , Antonio Gómez-Menchero MD , Borja Rivero-Santana MD , Ignacio J. Amat-Santos MD, PhD , Santiago Jiménez-Valero MD , Juan Caballero-Borrego MD, PhD , Soledad Ojeda MD, PhD , Gema Miñana MD, PhD , Ariana Gonzálvez-García MD , Daniel Tébar-Márquez MD , Santiago Camacho-Freire MD , Raymundo Ocaranza-Sánchez MD, PhD , Antonio Domínguez MD , Guillermo Galeote MD, PhD , Raúl Moreno MD, PhD
{"title":"Rotational Atherectomy, Lithotripsy, or Laser for Calcified Coronary Stenosis","authors":"Alfonso Jurado-Román MD, PhD , Antonio Gómez-Menchero MD , Borja Rivero-Santana MD , Ignacio J. Amat-Santos MD, PhD , Santiago Jiménez-Valero MD , Juan Caballero-Borrego MD, PhD , Soledad Ojeda MD, PhD , Gema Miñana MD, PhD , Ariana Gonzálvez-García MD , Daniel Tébar-Márquez MD , Santiago Camacho-Freire MD , Raymundo Ocaranza-Sánchez MD, PhD , Antonio Domínguez MD , Guillermo Galeote MD, PhD , Raúl Moreno MD, PhD","doi":"10.1016/j.jcin.2024.11.012","DOIUrl":"10.1016/j.jcin.2024.11.012","url":null,"abstract":"<div><h3>Background</h3><div>Coronary calcification negatively affects the safety and effectiveness of percutaneous coronary intervention. There is a lack of randomized comparisons among different plaque modification techniques.</div></div><div><h3>Objectives</h3><div>The aim of this study was to compare rotational atherectomy (RA), excimer laser coronary angioplasty (ELCA), and intravascular lithotripsy (IVL) for the treatment of patients with calcified coronary stenosis.</div></div><div><h3>Methods</h3><div>Patients with moderate to severe calcified coronary lesions were randomly assigned to percutaneous coronary intervention with RA, IVL, or ELCA. The primary endpoint was the percentage of stent expansion by optical coherence tomography. An intention-to-treat, noninferiority analysis was conducted.</div></div><div><h3>Results</h3><div>A total of 171 patients (77.2% men [n = 132], mean age 70.9 ± 8.2 years) were enrolled, 57 in each treatment arm. Clinical presentation was chronic coronary syndrome in 64.3% of patients (n = 110) and acute coronary syndrome in 35.7% (n = 61). Severe angiographic calcification was observed in 82.5% of lesions (n = 141). Procedural success rate and final minimum stent area (RA, 5.5 ± 2.1 mm<sup>2</sup>; IVL, 5.4 ± 1.8 mm<sup>2</sup>; ELCA, 5.1 ± 1.8 mm<sup>2</sup>) were similar among the 3 arms. IVL proved to be noninferior to RA, with no differences in stent expansion (RA, 86.4% ± 14.1%; IVL, 85.6% ± 13.3%; <em>P</em> = 0.77). ELCA did not reach noninferiority in the intention-to-treat analysis. The rate of complications was low, with no significant differences in the 3 arms but numerically lower with IVL.</div></div><div><h3>Conclusions</h3><div>In the first randomized trial comparing RA, IVL, and ELCA for the treatment of patients with calcified coronary lesions, IVL was noninferior to RA in terms of stent expansion. ELCA did not reach this noninferiority margin compared with RA. No significant differences were observed among the 3 arms regarding minimum stent area, procedural success rate, and complications, which were numerically lower with IVL.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 5","pages":"Pages 606-618"},"PeriodicalIF":11.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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