Zhiqing Wang MD, PhD , Elvin Kedhi MD, PhD , Xun Liu BSc , Chunming Li PhD , Jiayue Huang PhD , Jiaxin Zhong MM , Xinkai Qu MD , William Wijns MD, PhD , Shengxian Tu PhD , COMBINE OCT-FFR Study Group
{"title":"Prognostic Implications of Angiographically Derived Coronary Radial Wall Strain in Diabetic Patients and Non–Flow-Limiting Stenosis","authors":"Zhiqing Wang MD, PhD , Elvin Kedhi MD, PhD , Xun Liu BSc , Chunming Li PhD , Jiayue Huang PhD , Jiaxin Zhong MM , Xinkai Qu MD , William Wijns MD, PhD , Shengxian Tu PhD , COMBINE OCT-FFR Study Group","doi":"10.1016/j.jcin.2025.02.009","DOIUrl":"10.1016/j.jcin.2025.02.009","url":null,"abstract":"<div><h3>Background</h3><div>Coronary radial wall strain (RWS) represents a novel approach enabling discrimination of vulnerable plaques with prognostic significance.</div></div><div><h3>Objectives</h3><div>This study sought to evaluate the prognostic impact of RWS in diabetic patients with non–flow-limiting coronary stenosis when compared with optical coherence tomography-detected vulnerability features (OCT-VFs).</div></div><div><h3>Methods</h3><div>This was a post hoc analysis of the COMBINE OCT-FFR dataset. The primary endpoint was lesion-oriented composite endpoint (LOCE), a composite of cardiac death, target vessel-related myocardial infarction, and clinically driven target lesion revascularization.</div></div><div><h3>Results</h3><div>RWS was assessed in 435 eligible non–flow-limiting lesions from 366 patients. Lesion-level maximal RWS was predictive of lesions with any OCT-VFs (area under the curve: 0.630 [95% CI: 0.571-0.688]; <em>P</em> < 0.001). The median follow-up was 3.2 years (Q1-Q3: 2.2-4.1 years). With a prespecified cutoff of ≥13.0%, the incidence of LOCE was 17.0% (15/88; 95% CI: 9.0%-25.1%) in RWS-positive vs 6.8% (19/278; 95% CI: 3.8%-9.8%) in RWS-negative patients (HR: 2.70; 95% CI: 1.37-5.32; <em>P</em> = 0.004). Positive RWS predicted LOCE independently from any OCT-VFs (direct effect β = 0.099 [95% CI: 0.029-0.168]; <em>P</em> = 0.006; indirect effect β = 0.004 [95% CI: −0.008 to 0.015]; <em>P</em> = 0.555; mediation proportion 3.9% [95% CI: −5.0% to 20.3%]). Adding RWS to any OCT-VFs mainly improved the reclassification for LOCE in the lower-risk strata (positive continuous net reclassification improvement [cNRI] −0.060 [95% CI: −0.420 to 0.318]; <em>P</em> = 0.749; negative cNRI 0.583 [95% CI: 0.474-0.681]; <em>P</em> < 0.001; integrated discrimination improvement 0.066 [95% CI: 0.013-0.182]; <em>P</em> = 0.010).</div></div><div><h3>Conclusions</h3><div>In diabetic patients with non–flow-limiting stenosis, RWS can help to localize stenoses with OCT-VFs. RWS predicts increased risk for LOCE, both independently from—and incrementally beyond—OCT-VFs. (Combined Optical Coherence Tomography Morphologic and Fractional Flow Reserve Hemodynamic Assessment of Non-Culprit Lesions to Better Predict Adverse Event Outcomes in Diabetes Mellitus Patients [COMBINE OCT-FFR]; <span><span>NCT02989740</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 10","pages":"Pages 1232-1242"},"PeriodicalIF":11.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fuk Kei Fong MBBS, Geri Ling Na Wong MBChB, Simon Chi Ying Chow MBChB, Kevin Ka Ho Kam MBChB, Alex Pui Wai Lee MBChB, Kent Chak-yu So MBChB
{"title":"Sandwiching the Flying Clip","authors":"Fuk Kei Fong MBBS, Geri Ling Na Wong MBChB, Simon Chi Ying Chow MBChB, Kevin Ka Ho Kam MBChB, Alex Pui Wai Lee MBChB, Kent Chak-yu So MBChB","doi":"10.1016/j.jcin.2025.02.015","DOIUrl":"10.1016/j.jcin.2025.02.015","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 10","pages":"Pages 1345-1347"},"PeriodicalIF":11.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lior Lupu MD, MBA , Dan Haberman MD , Kalyan R. Chitturi DO , Itsik Ben-Dor MD , Lowell F. Satler MD , Ron Waksman MD , Toby Rogers MD, PhD , Keith Horton MD , Nelson L. Bernardo MD
{"title":"A Road Less Traveled","authors":"Lior Lupu MD, MBA , Dan Haberman MD , Kalyan R. Chitturi DO , Itsik Ben-Dor MD , Lowell F. Satler MD , Ron Waksman MD , Toby Rogers MD, PhD , Keith Horton MD , Nelson L. Bernardo MD","doi":"10.1016/j.jcin.2025.02.018","DOIUrl":"10.1016/j.jcin.2025.02.018","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 10","pages":"Pages 1342-1344"},"PeriodicalIF":11.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144138020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bhavanadhar Penta, Gilbert H L Tang, Takayuki Onishi, Lucy M Safi, Stamatios Lerakis, Parasuram Krishnamoorthy, George D Dangas, Samin K Sharma, Annapoorna S Kini, Sahil Khera
{"title":"Computed Tomographic Analysis of the EVOQUE Transcatheter Tricuspid Valve Replacement System: A First-in-Human Series.","authors":"Bhavanadhar Penta, Gilbert H L Tang, Takayuki Onishi, Lucy M Safi, Stamatios Lerakis, Parasuram Krishnamoorthy, George D Dangas, Samin K Sharma, Annapoorna S Kini, Sahil Khera","doi":"10.1016/j.jcin.2025.04.002","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.04.002","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}