Dongming Hou , Wenqi Liu , Zhao Wang , Wendy Zhang , Allen Fan , Yongfeng Li , Cuifen Li , Faye Gu
{"title":"100.53 Applying 3Rs Principles for Large Animal Research: A Case Example From Preclinical Mechanical Thrombectomy Study","authors":"Dongming Hou , Wenqi Liu , Zhao Wang , Wendy Zhang , Allen Fan , Yongfeng Li , Cuifen Li , Faye Gu","doi":"10.1016/j.jcin.2025.01.116","DOIUrl":"10.1016/j.jcin.2025.01.116","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Page S34"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"100.79 Does Inclusion of Warfarin Instead of Direct-Acting Oral Anticoagulants to Antiplatelets Reduce Risk of Major/minor Bleeding: Insight From a Network Meta-Analysis of Randomized Trials of Patients Undergoing Coronary Interventions","authors":"Supraja Achuthanandan , Hakob Harutyunyan , Marlon Rivera-Boadla , Nnamdi Chukwuka , Saurav Chatterjee","doi":"10.1016/j.jcin.2025.01.031","DOIUrl":"10.1016/j.jcin.2025.01.031","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Page S8"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"200.29 Catheter-Based Transvascular RF Neural Ablation for Severe Pancreatic Cancer Pain: First Results From the ELPIS Study","authors":"Robert Schwartz , Askar Sabirov","doi":"10.1016/j.jcin.2025.01.129","DOIUrl":"10.1016/j.jcin.2025.01.129","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Page S38"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"200.10 Blood Pressure Response Following Radiofrequency Renal Denervation in the Largest Real-World US Cohort Including Older Patients","authors":"Jeremy Seth Bock","doi":"10.1016/j.jcin.2025.01.123","DOIUrl":"10.1016/j.jcin.2025.01.123","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Page S36"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Decade of Follow-Up by the DECADE Cooperation: A Final \"Nail in the Coffin\" of the Outdated \"Smoker's Paradox\"?","authors":"Michael A Kutcher","doi":"10.1016/j.jcin.2025.01.449","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.01.449","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Junho Ha MD , Seung Hun Lee MD, PhD , Ki-Hong Choi MD, PhD , Doosup Shin MD , David Hong MD , Darae Kim MD, PhD , Jeong Hoon Yang MD, PhD , Yang Hyun Cho MD, PhD , Kiick Sung MD, PhD , Meesoon Park RN , Jung-Sun Kim MD, PhD , Taek-Kyu Park MD, PhD , Young Bin Song MD, PhD , Joo-Yong Hahn MD, PhD , Seung-Hyuk Choi MD, PhD , Hyeon-Cheol Gwon MD, PhD , Jae K. Oh MD, PhD , Jin-Oh Choi MD, PhD , Joo Myung Lee MD, MPH, PhD
{"title":"Microvascular Resistance Reserve and Prognosis After Heart Transplantation","authors":"Junho Ha MD , Seung Hun Lee MD, PhD , Ki-Hong Choi MD, PhD , Doosup Shin MD , David Hong MD , Darae Kim MD, PhD , Jeong Hoon Yang MD, PhD , Yang Hyun Cho MD, PhD , Kiick Sung MD, PhD , Meesoon Park RN , Jung-Sun Kim MD, PhD , Taek-Kyu Park MD, PhD , Young Bin Song MD, PhD , Joo-Yong Hahn MD, PhD , Seung-Hyuk Choi MD, PhD , Hyeon-Cheol Gwon MD, PhD , Jae K. Oh MD, PhD , Jin-Oh Choi MD, PhD , Joo Myung Lee MD, MPH, PhD","doi":"10.1016/j.jcin.2024.11.011","DOIUrl":"10.1016/j.jcin.2024.11.011","url":null,"abstract":"<div><h3>Background</h3><div>Impaired microcirculatory function after heart transplantation is associated with increased risk for acute cellular rejection. Microvascular resistance reserve (MRR) is a novel index for assessing microcirculatory function, irrespective of epicardial coronary artery stenosis, but it has not been validated in transplanted hearts.</div></div><div><h3>Objectives</h3><div>The aim of this study was to investigate the prognostic impact of MRR in heart transplantation.</div></div><div><h3>Methods</h3><div>The present study prospectively enrolled 154 heart transplant recipients who underwent scheduled coronary angiography and invasive coronary physiological assessment 1 month after transplantation. Coronary microcirculatory dysfunction was defined as MRR ≤3.0. Elevated microcirculatory resistance was defined as an index of microcirculatory resistance ≥15. The presence of epicardial coronary stenosis was assessed by fractional flow reserve. The primary outcome was a composite of death or biopsy-proven acute cellular rejection of grade ≥ 2R after transplantation.</div></div><div><h3>Results</h3><div>Among the total patients, 22.1% (34 of 154) had impaired microcirculatory function (MRR ≤3.0), and 77.9% (122 of 154) had preserved microcirculatory function (MRR >3.0). During median follow-up of 730 days (Q1-Q3: 730-730 days), patients with MRR ≤3.0 showed increased risk for a composite of death or acute cellular rejection (adjusted HR: 5.31; 95% CI: 2.65-10.64; <em>P</em> < 0.001), acute cellular rejection (adjusted HR: 4.83; 95% CI: 2.20-10.60; <em>P</em> < 0.001), and death (adjusted HR: 5.19; 95% CI: 1.24-21.62; <em>P</em> = 0.024). MRR was significantly associated with increased risk for death or acute cellular rejection, regardless of epicardial coronary artery stenosis (HR adjusted for fractional flow reserve: 1.89 per 1-U decrease in MRR; 95% CI: 1.46-2.46; <em>P</em> < 0.001) or elevated microcirculatory resistance (HR adjusted for index of microcirculatory resistance: 1.90 per 1-U decrease in MRR; 95% CI: 1.43-2.52; <em>P</em> < 0.001).</div></div><div><h3>Conclusions</h3><div>Impaired microcirculatory function, determined by MRR early after heart transplantation, identified patients at high risk for death or acute cellular rejection, regardless of epicardial coronary artery stenosis or elevated microcirculatory resistance. (Physiologic Assessment of Microvascular Function in Heart Transplant Patients; <span><span>NCT02798731</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 4","pages":"Pages 439-452"},"PeriodicalIF":11.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143479987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}