JACC. Cardiovascular interventions最新文献

{"title":"Early U.S. Commercial Experience With a Novel Transcatheter Edge-to-Edge Repair System","authors":"Thomas Waggoner DO ,&nbsp;Santiago Garcia MD ,&nbsp;Tarun Chakravarty MD ,&nbsp;Moody Makar MD ,&nbsp;Azeem Latib MD ,&nbsp;Robert M. Kipperman MD ,&nbsp;Firas Zahr MD ,&nbsp;Ivan Hanson MD ,&nbsp;Anjan K. Sinha MD ,&nbsp;Rahul P. Sharma MD ,&nbsp;Jeremiah P. Depta MD ,&nbsp;Jorge A. Castellanos MD ,&nbsp;Susheel Kodali MD ,&nbsp;Amar Krishnaswamy MD ,&nbsp;Brian Whisenant MD ,&nbsp;Daniel Menees MD ,&nbsp;D. Scott Lim MD ,&nbsp;Fahad Gilani MD ,&nbsp;Carlos E. Sanchez MD ,&nbsp;Neil Gheewala MD ,&nbsp;Raj Makkar MD","doi":"10.1016/j.jcin.2025.07.019","DOIUrl":"10.1016/j.jcin.2025.07.019","url":null,"abstract":"<div><h3>Background</h3><div>The PASCAL Precision transcatheter valve repair system provides a new option for treating prohibitive surgical risk patients with significant, symptomatic degenerative mitral regurgitation (DMR).</div></div><div><h3>Objectives</h3><div>The authors report early U.S. commercial experience with the PASCAL Precision system.</div></div><div><h3>Methods</h3><div>Patients with DMR treated with the PASCAL Precision system in the United States were analyzed from the STS/ACC TVT Registry. Procedural, clinical, echocardiographic, functional, and quality-of-life outcomes to 30 days were assessed. All outcomes, including echocardiographic assessments, were site-assessed.</div></div><div><h3>Results</h3><div>In 1,995 DMR patients, the median age was 81.6 years, and 57.0% were male. Median STS-PROM for mitral valve repair was 3.6%, and 69.4% were in NYHA functional class III/IV. Mixed etiology (DMR + other etiology) was present in 11.4%, and 66.9% had complex anatomy (annular/leaflet calcification, mitral valve area &lt;4 cm², bileaflet flail/prolapse/tethering, or mitral stenosis). The device was successfully implanted in 97.7%. MR reduction was significant at 30 days with 94.2% achieving ≤moderate MR and 72.6% ≤mild MR (<em>P</em> &lt; 0.001 vs baseline). Patients experienced significant functional and quality-of-life improvements with a mean 21.0-point increase in Kansas City Cardiomyopathy Questionnaire score and 84.6% in NYHA functional class I/II (all <em>P &lt;</em> 0.001). Mitral valve reintervention and single-leaflet device attachment rates were 0.4% and 0.5%, respectively, and all-cause mortality, cardiovascular mortality, and heart failure readmission rates were 2.2%, 1.2%, and 2.6%, respectively, at 30 days.</div></div><div><h3>Conclusions</h3><div>Early U.S. STS/ACC TVT Registry commercial experience confirms the safety and effectiveness of the novel PASCAL Precision system in the treatment of a broad population of real-world DMR patients.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Pages 2036-2046"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mid-Term Outcomes of Balloon-Expandable Aortic Valve-in-Valve Replacement in the United States","authors":"Amar Krishnaswamy MD ,&nbsp;Amr E. Abbas MD ,&nbsp;Vasilis C. Babaliaros MD ,&nbsp;Adam B. Greenbaum MD ,&nbsp;Pradeep Yadav MD ,&nbsp;Issam D. Moussa MD ,&nbsp;Grant W. Reed MD ,&nbsp;Roger J. Laham MD ,&nbsp;Michael A. Morse MD ,&nbsp;Evelio Rodriguez MD ,&nbsp;Jeremiah P. Depta MD ,&nbsp;James M. McCabe MD ,&nbsp;Vinayak N. Bapat MD ,&nbsp;Vinod H. Thourani MD ,&nbsp;Samir R. Kapadia MD ,&nbsp;Tsuyoshi Kaneko MD","doi":"10.1016/j.jcin.2025.06.039","DOIUrl":"10.1016/j.jcin.2025.06.039","url":null,"abstract":"<div><h3>Background</h3><div>Aortic valve-in-valve (AViV) replacement for is approved for patients with degenerated surgical valves at high or prohibitive surgical risk, mostly on the basis of small series with short-term follow-up.</div></div><div><h3>Objectives</h3><div>The aim of this study was to analyze the outcomes of AViV therapy using contemporary balloon-expandable valves (BEVs) in a large series with mid-term outcomes.</div></div><div><h3>Methods</h3><div>BEV AViV patients (June 2015 to December 2023) in the Society for Thoracic Surgeons (STS)/American College of Cardiology TVT (Transcatheter Valve Therapy) Registry were propensity matched to native transcatheter aortic valve replacement (TAVR) patients. Primary analysis included death and stroke at 5 years. Comparisons were also made on the basis of STS score, BEV subtype, and stented vs stentless index surgical valve type.</div></div><div><h3>Results</h3><div>In total, 14,474 AViV patients were matched to 385,556 TAVR patients (13,638 pairs). The mean age was 74 years, and the mean STS Predicted Risk of Mortality was 6.1%. Emergency cardiac surgery (0.2%) and bioprosthetic valve fracture (22%) were infrequent. Death (43.1% vs 55.2%; <em>P</em> &lt; 0.001), stroke (10.5% vs 11.8%; <em>P</em> &lt; 0.001), and their composite were lower for AViV compared with TAVR at 5 years with similar findings at each STS tertile. The SAPIEN 3 Ultra RESILIA device demonstrated lower discharge echo gradients for all sizes (20 mm, 19.4 mm Hg vs 23.8 mm Hg; 23 mm, 15.1 mm Hg vs 19.2 mm Hg; 26 mm, 12.1 mm Hg vs 15.1 mm Hg; and 29 mm, 8.6 mm Hg vs 12.1 mm Hg). There was no difference in death or stroke at 5 years for stentless vs stented surgical valves (42.9% vs 46.0%; <em>P</em> = 0.12).</div></div><div><h3>Conclusions</h3><div>This large, real-world analysis confirms the safety and durability of AViV compared with TAVR at all surgical risk levels at mid-term follow-up. Consideration may be given to broadening the indication for AViV.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Pages 1989-2000"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"All-in-One Percutaneous Approach to Treat Mitral Annuloplasty Dysfunction, Aortic Regurgitation, and Aortic Root Pseudoaneurysm","authors":"Lukas Weber MD ,&nbsp;Julien Ternacle MD, PhD ,&nbsp;Johann Cattan MD ,&nbsp;Melchior Jonveaux MD ,&nbsp;Thomas Modine MD, PhD ,&nbsp;Stefano Mion MD ,&nbsp;Antoine Beurton MD ,&nbsp;Lionel Leroux MD, PhD ,&nbsp;Louis Labrousse MD, PhD ,&nbsp;Guillaume Bonnet MD, PhD","doi":"10.1016/j.jcin.2025.04.022","DOIUrl":"10.1016/j.jcin.2025.04.022","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Pages 2049-2051"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Many Devices in the Toolbox…But Which One Performs Best in Treating Calcified Lesions?","authors":"Michał Kuzemczak MD, PhD, MSc,&nbsp;Mohammad Alkhalil DPhil,&nbsp;Janusz Lipiecki MD, PhD","doi":"10.1016/j.jcin.2025.04.032","DOIUrl":"10.1016/j.jcin.2025.04.032","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Page 2073"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thirty-Day And One-Year Outcomes Of Navitor Transcatheter Aortic Valve In Low- or Intermediate-Risk Patients.","authors":"Stephen G Worthley, Arturo Giordano, Nicola Corcione, Luis Nombela-Franco, Federico De Marco, Antony Walton, Francesco Bedogni, Helge Möllmann, Ole De Backer, Lionel Leroux, Ganesh Manoharan, Didier Tchétché, Maurizio Taramasso, Lihua Li, Hai-Chien Kuo, Nicolas M Van Mieghem","doi":"10.1016/j.jcin.2025.08.021","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.08.021","url":null,"abstract":"<p><strong>Background: </strong>The Navitor transcatheter aortic valve is a self-expanding, intra-annular valve indicated for patients with severe aortic stenosis (AS) at high or extreme surgical risk.</p><p><strong>Objectives: </strong>To assess the safety and effectiveness of the Navitor valve in severe AS patients at low or intermediate surgical risk.</p><p><strong>Methods: </strong>VANTAGE is a prospective, single-arm, multicenter study. The primary effectiveness endpoint was moderate or greater paravalvular leakage (PVL) at 30 days; the primary safety endpoint was all-cause mortality or fatal stroke/stroke with disability at 12 months. Both endpoints were assessed against a performance goal (PG) when the sample size requirements were met. Clinical events and imaging assessments were evaluated by an independent committee and a core laboratory, respectively.</p><p><strong>Results: </strong>A total of 434 patients (203 low-risk, 231 intermediate-risk) underwent Navitor implantation between July 2021 and November 2024 across 36 sites in Europe, Australia, and Israel. The mean STS-PROM scores were 1.5% and 2.6% for the low- and intermediate-risk groups. Technical success was 97.0%, with no procedural mortality. At 30 days, no patients had moderate or greater PVL (0%), which was significantly below the PG of 6.6% (p<0.0001). In the first 262 patients with 12-month follow-up completed, the rate for all-cause mortality or fatal stroke/stroke with disability was 2.3%, also significantly below the PG of 11.3% (p<0.0001). Sustained hemodynamic performance (mean gradient 8.0 mmHg, effective orifice area 1.8 cm²) was seen through 12 months.</p><p><strong>Conclusion: </strong>Navitor demonstrated favorable safety and performance outcomes at 12 months, supporting its expansion to low- and intermediate-risk populations.</p>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Effect of Tricuspid Valve Transcatheter Edge-to-Edge Repair on 3-Dimensional Tricuspid Annular Dimensions.","authors":"Jennifer von Stein, Nina C Wunderlich, Maria Isabel Körber, Stephan Baldus, Juan F Granada, Roman Pfister, Philipp von Stein, Christos Iliadis","doi":"10.1016/j.jcin.2025.07.009","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.07.009","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Leaflet Thrombosis Following EVOQUE Transcatheter Tricuspid Valve Replacement.","authors":"Ioannis Skalidis, Luca Esposito, Mauro Boiago, Pietro Laforgia, Noémie Tence, Victor Boilève, Antoinette Neylon, Mariama Akodad","doi":"10.1016/j.jcin.2025.07.016","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.07.016","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Cautionary Tale: Balloon Postdilatation of Balloon-Expandable Valve to Treat a Degenerated Self-Expanding Valve Resulting in VSD.","authors":"Dan Haberman, Lior Lupu, Kalyan Chitturi, Ryan Wallace, Lowell F Satler, Ron Waksman, Toby Rogers, Itsik Ben-Dor","doi":"10.1016/j.jcin.2025.05.038","DOIUrl":"https://doi.org/10.1016/j.jcin.2025.05.038","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.4,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144954721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sentinel Cerebral Embolic Protection During Transcatheter Aortic Valve Replacement","authors":"Sunny Goel MD,&nbsp;Sahil Khera MD, MPH,&nbsp;Parasuram Krishnamoorthy MD,&nbsp;Amit Hooda MD,&nbsp;Stamatios Lerakis MD, PhD,&nbsp;Lucy M. Safi DO,&nbsp;Annapoorna S. Kini MD,&nbsp;Samin K. Sharma MD,&nbsp;George D. Dangas MD, PhD,&nbsp;Gilbert H.L. Tang MD, MSc, MBA","doi":"10.1016/j.jcin.2025.06.019","DOIUrl":"10.1016/j.jcin.2025.06.019","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 15","pages":"Pages 1948-1950"},"PeriodicalIF":11.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proximal-First Postdilation","authors":"Rita-Maria Abdo BS, MD, MM ,&nbsp;Katherine Chiswell BEc, MD ,&nbsp;Bharat Khialani MBBS, MPH, MM ,&nbsp;Kaivan Vaidya MBBS ,&nbsp;Sarah Fairley MBBChBAO, PhD ,&nbsp;Andy Yong MBBS, PhD ,&nbsp;David Brieger MMBS, MM, PhD ,&nbsp;George Touma MBBS ,&nbsp;Scott Harding MBChB ,&nbsp;Cuneyt Ada BMS, MBBS, PhD","doi":"10.1016/j.jcin.2025.05.021","DOIUrl":"10.1016/j.jcin.2025.05.021","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 15","pages":"Pages 1938-1940"},"PeriodicalIF":11.4,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}