{"title":"Percutaneous Coronary Intervention for Aorto-Ostial Chronic Total Occlusion","authors":"Takeshi Niizeki MD, PhD , Etsuo Tsuchikane MD, PhD , Tsuneo Konta MD, PhD , Koichi Kishi MD , Hisayuki Okada MD, PhD , Yoshiaki Ito MD, PhD , Yuji Oikawa MD , Ryohei Yoshikawa MD , Hiroyuki Tanaka MD","doi":"10.1016/j.jcin.2024.08.028","DOIUrl":"10.1016/j.jcin.2024.08.028","url":null,"abstract":"<div><h3>Background</h3><div>PCI for aorto-ostial CTO remains challenging. The techniques for guidewire in aorto-ostial CTO may differ from those used in non–aorto-ostial CTOs, influenced by clinical and angiographic characteristics.</div></div><div><h3>Objectives</h3><div>This study aimed to assess the technical aspects and outcomes of percutaneous coronary intervention (PCI) in patients with aorto-ostial chronic total occlusion (CTO).</div></div><div><h3>Methods</h3><div>This analysis included 420 patients with ostial CTO from the Japanese CTO-PCI Expert Registry, spanning January 2014 to December 2022. It examined the strategies and procedural outcomes of CTO PCI.</div></div><div><h3>Results</h3><div>Ostial CTO represented 420 of 10,814 (3.9%) of all CTO PCI cases. Within this subset, aorto-ostial CTO accounted for 218 of 420 (52%) cases. The technical success rate for aorto-ostial CTO was 88% (191/218). Aorto-ostial CTOs exhibited longer lesion lengths and were more likely to present with challenges such as distal target lumen ambiguity, calcification, and tortuosity compared with non–aorto-ostial CTOs. The retrograde approach was more commonly used in aorto-ostial CTO, with retrograde direct crossing being the most successful technique, especially in cases of flush CTO. A multivariate logistic analysis identified several factors significantly associated with unsuccessful aorto-ostial CTO PCI, including difficulties in engaging a guiding catheter, estimating the collateral channel (as assessed by the J-Channel score), and tortuosity.</div></div><div><h3>Conclusions</h3><div>Aorto-ostial CTOs are more complex and frequently require a retrograde approach. The availability of suitable interventional collateral channels is crucial for the success of these procedures.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 19","pages":"Pages 2243-2255"},"PeriodicalIF":11.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Ashwin Reddy MBBChir, Marta Peverelli MBBS, Tobias MacCarthy BA, Johnathan Vibhishanan BA, Sharad Agarwal MBBS, Rudolf Duehmke MBBS, Peter Pugh MBBS, Anna Chousou MBBS, Vassilios Vassiliou MBBS, Patrick A. Calvert MBBS
V. Vivian Dimas MD , Vasilis Babaliaros MD , Dennis Kim MD, PhD , D. Scott Lim MD , Gareth Morgan MD , Thomas K. Jones MD , Aimee K. Armstrong MD , Darren Berman MD , Jamil Aboulhosn MD , Vaikom S. Mahadevan MD , Matthew J. Gillespie MD , David Balzer MD , Thomas Zellers MD , Xiao Yu PhD , Girish Shirali MD , Anitha Parthiban MD , Jonathan Leipsic MD , Philipp Blanke MD , Evan Zahn MD , Shabana Shahanavaz MD
{"title":"Multicenter Pivotal Study of the Alterra Adaptive Prestent for the Treatment of Pulmonary Regurgitation","authors":"V. Vivian Dimas MD , Vasilis Babaliaros MD , Dennis Kim MD, PhD , D. Scott Lim MD , Gareth Morgan MD , Thomas K. Jones MD , Aimee K. Armstrong MD , Darren Berman MD , Jamil Aboulhosn MD , Vaikom S. Mahadevan MD , Matthew J. Gillespie MD , David Balzer MD , Thomas Zellers MD , Xiao Yu PhD , Girish Shirali MD , Anitha Parthiban MD , Jonathan Leipsic MD , Philipp Blanke MD , Evan Zahn MD , Shabana Shahanavaz MD","doi":"10.1016/j.jcin.2024.07.036","DOIUrl":"10.1016/j.jcin.2024.07.036","url":null,"abstract":"<div><h3>Background</h3><div>A dilated native right ventricular outflow tract (RVOT) presents unique challenges for transcatheter management using balloon-expandable valves. The Alterra Adaptive Prestent was designed to expand transcatheter therapy to treat patients with dilated RVOTs.</div></div><div><h3>Objectives</h3><div>The aim of this study was to report 2-year outcomes of the main cohort of the ALTERRA (Multicenter Study of Congenital Pulmonic Valve Dysfunction Studying the SAPIEN 3 THV With the Alterra Adaptive Prestent) pivotal trial using the prestent with transcatheter pulmonary valve replacement.</div></div><div><h3>Methods</h3><div>The prestent device used with the 29 mm SAPIEN 3 transcatheter heart valve (THV) was evaluated for the management of patients with moderate or greater pulmonary valve regurgitation (PR). The primary endpoint was THV dysfunction at 6 months, defined as a nonhierarchical composite of RVOT/pulmonary valve reintervention, moderate or greater total PR on transthoracic echocardiography, and mean RVOT/pulmonary valve gradient 35 mm Hg or greater on transthoracic echocardiography. The primary endpoint and outcomes through 2 years are presented in this analysis.</div></div><div><h3>Results</h3><div>Of 97 patients screened, 60 underwent prestent and THV implantation. There was 1 staged procedure. No patients had THV dysfunction at 6 months. At 2 years, the majority of patients (92.5%) had mild or less PR, with no reports of coronary compression, stent fractures warranting reintervention, or endocarditis. Of the 21 patients (34.4%) who experienced early (days 0-1) arrhythmias, 12 had episodes of nonsustained ventricular tachycardia that resolved with medication. One patient underwent reintervention secondary to an iatrogenic RVOT obstruction; there were no deaths or explantations through 2 years.</div></div><div><h3>Conclusions</h3><div>The Alterra prestent in combination with the SAPIEN 3 THV has excellent outcomes at 2 years, with no significant valve dysfunction in the main pivotal cohort.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 19","pages":"Pages 2287-2297"},"PeriodicalIF":11.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Athar M. Qureshi MD , Robert J. Sommer MD , Gareth Morgan MD , Joseph A. Paolillo MD , Robert G. Gray MD , Barry Love MD , Bryan H. Goldstein MD , Lissa Sugeng MD , Matthew J. Gillespie MD , GORE ASSURED Clinical Trial Investigators
{"title":"Long-Term Results of the Atrial Septal Defect Occluder ASSURED Trial for Combined Pivotal/Continued Access Cohorts","authors":"Athar M. Qureshi MD , Robert J. Sommer MD , Gareth Morgan MD , Joseph A. Paolillo MD , Robert G. Gray MD , Barry Love MD , Bryan H. Goldstein MD , Lissa Sugeng MD , Matthew J. Gillespie MD , GORE ASSURED Clinical Trial Investigators","doi":"10.1016/j.jcin.2024.07.013","DOIUrl":"10.1016/j.jcin.2024.07.013","url":null,"abstract":"<div><h3>Background</h3><div>The GORE CARDIOFORM ASD Occluder (GCA, W. L. Gore & Associates) was approved in 2019 for ostium secundum atrial septal defect (ASD) closure.</div></div><div><h3>Objectives</h3><div>This study sought to report the combined pivotal and continued access cohorts of the ASSURED (Safety and Efficacy Study of Transcatheter Closure of Ostium Secundum ASDs) trial results through 36 months.</div></div><div><h3>Methods</h3><div>This prospective, multicenter, single-arm trial evaluated procedural and clinical outcomes of ASD closure with the GCA. The primary endpoints were 6-month closure success following device implantation and composite clinical success (deployment/retention of device, safety, and closure). Technical and procedure success, safety, clinically significant new arrhythmia (CSNA) secondary endpoints, and wire frame fracture (WFF, with fluoroscopy) at 6 and 36 months were evaluated.</div></div><div><h3>Results</h3><div>Of 569 patients (median age of 10.4 years and median weight of 35.0 kg) who underwent attempted secundum ASD closure, 526 were technical successes. The mean stop-flow ASD diameter was 17.6 ± 5.3 mm. All 478 patients with 6-month imaging achieved closure success. Composite clinical success at 6 and 36 months was achieved in 87.6% (468/534) and 84.0% (351/418) of patients, respectively. Technical failure occurred in 8.1% (43/548), 30-day device- or procedure-related serious adverse event in 3.9% (21/534), and 6-month device events in 2.8% (15/534) of patients. At 30 days, 21 of 569 patients (3.7%) had CSNA. At 6 months, 138 of 436 (31.7%) patients had WFFs and 105 of 185 (56.8%) at 36 months (without sequelae).</div></div><div><h3>Conclusions</h3><div>In this large congenital ASD device trial, the GCA had acceptable results. WFFs, although common, did not result in any clinical sequelae. The unique features, size range, and safety profile expand the options for secundum ASD closure. (Safety and Efficacy Study of Transcatheter Closure of Ostium Secundum ASDs [ASSURED]; <span><span>NCT02985684</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 19","pages":"Pages 2274-2283"},"PeriodicalIF":11.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Alleviating Refractory Angina Through Coronary Sinus Narrowing: Consistent Benefits and the Pursuit of Mechanistic Insights.","authors":"Giuseppe Andò, Rocco Antonio Montone","doi":"10.1016/j.jcin.2024.09.031","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.09.031","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2024-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iván Gómez-Blázquez, Felipe Díez-Delhoyo, Julio García-Tejada, Ignacio Fernández-Herrero, Nicolás Maneiro-Melón, Rafael Salguero-Bodes, Fernando Sarnago-Cebada
{"title":"Left Ventricular Embolization During TAVR for Pure Aortic Regurgitation: Arterio-Arterial Loop as a Bailout Technique.","authors":"Iván Gómez-Blázquez, Felipe Díez-Delhoyo, Julio García-Tejada, Ignacio Fernández-Herrero, Nicolás Maneiro-Melón, Rafael Salguero-Bodes, Fernando Sarnago-Cebada","doi":"10.1016/j.jcin.2024.09.022","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.09.022","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mario García Gómez, Clara Fernández Cordón, Belén Rodríguez Rodríguez, Enrique San Norberto García, J Alberto San Román, Ignacio J Amat Santos
{"title":"Transcatheter Aortic Valve in Failing Mechanical Aortic Valve.","authors":"Mario García Gómez, Clara Fernández Cordón, Belén Rodríguez Rodríguez, Enrique San Norberto García, J Alberto San Román, Ignacio J Amat Santos","doi":"10.1016/j.jcin.2024.09.023","DOIUrl":"https://doi.org/10.1016/j.jcin.2024.09.023","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":" ","pages":""},"PeriodicalIF":11.7,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142620824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}