JACC. Cardiovascular interventions最新文献

{"title":"Transcatheter Edge-to-Edge Repair for Atrial and Ventricular Secondary Mitral Regurgitation","authors":"Philipp von Stein MD ,&nbsp;Lukas Stolz MD ,&nbsp;Jean Marc Haurand MD ,&nbsp;Matthias Gröger MD ,&nbsp;Felix Rudolph MD ,&nbsp;Donika Mustafa Cand Med ,&nbsp;Jannik Jobst MD ,&nbsp;Christoph Alexander Mues MD ,&nbsp;Amir Abbas Mahabadi MD ,&nbsp;Isabel A. Hoerbrand MD ,&nbsp;Carl Schulz MD ,&nbsp;Atsushi Sugiura MD ,&nbsp;Jennifer von Stein MD ,&nbsp;Christos Iliadis MD ,&nbsp;Philipp Lurz MD ,&nbsp;Muhammed Gerçek MD ,&nbsp;Patrick Horn MD ,&nbsp;Mirjam Kessler MD ,&nbsp;Guido Ascione MD ,&nbsp;Tienush Rassaf MD ,&nbsp;Laila Widmann MD","doi":"10.1016/j.jcin.2025.05.031","DOIUrl":"10.1016/j.jcin.2025.05.031","url":null,"abstract":"<div><h3>Background</h3><div>Secondary mitral regurgitation (SMR) has 2 phenotypes: atrial (aSMR) and ventricular (vSMR). The role of mitral valve transcatheter edge-to-edge repair (M-TEER) in aSMR remains less defined, with limited evidence on the PASCAL implant (Edwards Lifesciences).</div></div><div><h3>Objectives</h3><div>The authors sought to evaluate and compare outcomes of SMR phenotypes undergoing M-TEER.</div></div><div><h3>Methods</h3><div>REPAIR (REgistry of PAscal for mItral Regurgitation) is an investigator-initiated, multicenter registry of patients undergoing M-TEER. aSMR was defined by left atrial dilation with preserved left ventricular size and ejection fraction. Outcomes included MR ≤1+ at discharge, technical success, NYHA functional class improvement, and 1-year survival.</div></div><div><h3>Results</h3><div>Among 915 patients (166 [18%] aSMR, 749 [82%] vSMR), the median follow-up was 491 days (Q1-Q3: 360-833 days). MR ≤1+ was achieved in 77.2% vs 71.4% (<em>P</em> = 0.162), with technical success in 97.0% vs 98.3% (<em>P</em> = 0.446). NYHA functional class improved in both phenotypes (<em>P &lt;</em> 0.001), with 61.2% vs 61.3% in functional class ≤II at follow-up (<em>P &gt;</em> 0.999). One-year survival was 88.4% (95% CI: 82.8%-94.4%) vs 86.0% (95% CI: 83.1%-89.0%; <em>P</em> = 0.346). In aSMR patients, 1-year survival was significantly lower in patients with baseline tricuspid regurgitation (TR) grade ≥moderate compared with those with &lt;moderate TR (84.3% [95% CI: 77.0%-92.3%] vs 100.0% [95% CI: 100.0%-100.0%]; <em>P</em> = 0.041). In vSMR patients, survival was similar between ≥moderate and &lt;moderate baseline TR (83.9% [95% CI: 79.8%-88.2%] vs 89.3% [95% CI: 85.0%-93.8%]; <em>P</em> = 0.051).</div></div><div><h3>Conclusions</h3><div>M-TEER effectively reduces MR to ≤1+ and improves symptoms in both aSMR and vSMR. Particularly in aSMR, ≥moderate baseline TR is linked to worse outcomes, warranting consideration as an additional treatment target.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Pages 2020-2032"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Balloon-Expandable Valve Movement During Short-in-Tall Redo-TAVR Deployment","authors":"Takayuki Onishi MD ,&nbsp;Gilbert H.L. Tang MD, MSc, MBA ,&nbsp;Sahil Khera MD, MPH,&nbsp;Lucy M. Safi DO,&nbsp;Stamatios Lerakis MD, PhD,&nbsp;George D. Dangas MD, PhD,&nbsp;Samin K. Sharma MD,&nbsp;Annapoorna S. Kini MD,&nbsp;Parasuram Krishnamoorthy MD","doi":"10.1016/j.jcin.2025.05.012","DOIUrl":"10.1016/j.jcin.2025.05.012","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Pages 2067-2069"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing TAVR Precision","authors":"Colin M. Barker MD","doi":"10.1016/j.jcin.2025.06.037","DOIUrl":"10.1016/j.jcin.2025.06.037","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Pages 2018-2019"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PASCAL Edge-to-Edge Repair in Atrial and Ventricular Secondary Mitral Regurgitation","authors":"Frank A. Flachskampf MD, PhD","doi":"10.1016/j.jcin.2025.07.017","DOIUrl":"10.1016/j.jcin.2025.07.017","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Pages 2033-2035"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valve-Leaflet Interaction During UNICORN in Redo-TAVR","authors":"Lior Lupu MD, MBA ,&nbsp;Dan Haberman MD ,&nbsp;Kalyan R. Chitturi DO ,&nbsp;Abhishek Chaturvedi MD ,&nbsp;Waiel Abusnina MD ,&nbsp;Itsik Ben-Dor MD ,&nbsp;Lowell F. Satler MD ,&nbsp;Ron Waksman MD ,&nbsp;Toby Rogers MD, PhD","doi":"10.1016/j.jcin.2025.05.008","DOIUrl":"10.1016/j.jcin.2025.05.008","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Pages 2059-2061"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"At the Edge of Percutaneous Mitral Valve Repair","authors":"Antonio Colombo MD ,&nbsp;Antonio Mangieri MD","doi":"10.1016/j.jcin.2025.07.020","DOIUrl":"10.1016/j.jcin.2025.07.020","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Pages 2047-2048"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Ischemic Mitral Regurgitation After Transcatheter Aortic Valve Implantation Due to Anomalous Coronary Artery Compression","authors":"David M. Harmon MD ,&nbsp;Sivakumar Sudhakaran MD ,&nbsp;Kevin L. Greason MD ,&nbsp;Lawrence J. Sinak MD ,&nbsp;Rajiv Gulati MD, PhD ,&nbsp;Mohamad Alkhouli MD, MBA","doi":"10.1016/j.jcin.2025.05.019","DOIUrl":"10.1016/j.jcin.2025.05.019","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Pages 2064-2066"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"30-Day and 1-Year Outcomes From the Optimize PRO TAVR Evolut FX Addendum Study","authors":"Hemal Gada MD ,&nbsp;Ramzi F. Khalil MD ,&nbsp;Stanley J. Chetcuti MD ,&nbsp;G. Michael Deeb MD ,&nbsp;Kendra J. Grubb MD, MHA ,&nbsp;Adam B. Greenbaum MD ,&nbsp;David Lorenz MD ,&nbsp;Robert D. Jumper MD ,&nbsp;Ibrahim Sultan MD ,&nbsp;Dustin Kliner MD ,&nbsp;Paul Mahoney MD ,&nbsp;Deepak R. Talreja MD ,&nbsp;Mustafa I. Ahmed MD ,&nbsp;Joshua D. Rovin MD ,&nbsp;Lang Lin MD ,&nbsp;Paul Sorajja MD ,&nbsp;Douglas G.W. Fraser MB, BC, BA, DM ,&nbsp;Suneet Mittal MD ,&nbsp;Tamim Nazif MD ,&nbsp;Josep Rodes-Cabau MD, PhD ,&nbsp;Steven J. Yakubov MD","doi":"10.1016/j.jcin.2025.06.021","DOIUrl":"10.1016/j.jcin.2025.06.021","url":null,"abstract":"<div><h3>Background</h3><div>Primary results from the Optimize PRO study demonstrated that transcatheter aortic valve replacement (TAVR) with the cusp overlap technique (COT) resulted in low 30-day permanent pacemaker implantation (PPI) rates and no moderate or greater aortic regurgitation (AR).</div></div><div><h3>Objectives</h3><div>The aim of this study was to evaluate outcomes after Evolut FX implantation using the COT and postprocedural computed tomography (CT).</div></div><div><h3>Methods</h3><div>The Optimize PRO FX Addendum study is a postmarket, prospective, multicenter, nonrandomized study. Patients with severe aortic stenosis underwent TAVR with the Evolut FX using the COT protocol. Postprocedurally, COT adherence was evaluated to identify key steps, and CT-assessed transcatheter aortic valve orientation was compared with fluoroscopically guided commissural alignment.</div></div><div><h3>Results</h3><div>A total of 151 patients received the Evolut FX device from September 2022 to October 2023. The median duration of follow-up was 371 days (Q1-Q3: 352-388 days). Compliance with the refined COT was 86.0%. The median length of stay was 1 day. The rate of the primary endpoint of all-cause mortality or all stroke was 2.7% (95% CI: 1.0%-6.9%) at 30 days and 7.5% (95% CI: 4.2%-13.1%) at 1 year. The new PPI rate was 6.7% (95% CI: 3.7%-12.1%) at 30 days and 8.8% (95% CI: 5.2%-14.6%) at 1 year. One patient had moderate AR and none had severe AR at 1 year. The rate of commissural alignment was 91.5% (107 of 117) when assessed by marker positioning on fluoroscopy and 86.9% (113 of 130) when assessed using CT, indicating good agreement. CT indicated no severe coronary misalignment in &gt;92% of patients.</div></div><div><h3>Conclusions</h3><div>Implantation of the Evolut FX device with a refined COT was associated with low PPI rates and no severe AR at 1 year. Postprocedural CT demonstrated consistent commissural and coronary alignment.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Pages 2004-2017"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safe and Effective Treatment of Aortic Regurgitation in LVAD Patients Using a Dedicated TAVR Device","authors":"Tanja K. Rudolph MD ,&nbsp;Arseniy Goncharov MD ,&nbsp;Christoph Klein MD,&nbsp;Lauren S. Ranard MD,&nbsp;Dhairya Patel MD,&nbsp;Santiago Garcia MD,&nbsp;Dean J. Kereiakes MD,&nbsp;Raj Makkar MD,&nbsp;Torsten P. Vahl MD ,&nbsp;Axel Unbehaun MD","doi":"10.1016/j.jcin.2025.04.029","DOIUrl":"10.1016/j.jcin.2025.04.029","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Pages 2070-2071"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Troublesome Leaflet","authors":"David Elison MD,&nbsp;Christine J. Chung MD,&nbsp;James M. McCabe MD","doi":"10.1016/j.jcin.2025.04.018","DOIUrl":"10.1016/j.jcin.2025.04.018","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 16","pages":"Pages 2052-2054"},"PeriodicalIF":11.4,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}