Ho Sung Jeon MD , Young In Kim MD , Jung-Hee Lee MD, PhD , Young Jun Park MD , Jung-Woo Son MD , Jun-Won Lee MD, PhD , Young Jin Youn MD, PhD , Min-Soo Ahn MD, PhD , Jang-Young Kim MD, PhD , Byung-Su Yoo MD, PhD , Sung Min Ko MD, PhD , Sung Gyun Ahn MD, PhD
{"title":"Failed Thrombus Aspiration and Reduced Myocardial Perfusion in Patients With STEMI and Large Thrombus Burden","authors":"Ho Sung Jeon MD , Young In Kim MD , Jung-Hee Lee MD, PhD , Young Jun Park MD , Jung-Woo Son MD , Jun-Won Lee MD, PhD , Young Jin Youn MD, PhD , Min-Soo Ahn MD, PhD , Jang-Young Kim MD, PhD , Byung-Su Yoo MD, PhD , Sung Min Ko MD, PhD , Sung Gyun Ahn MD, PhD","doi":"10.1016/j.jcin.2024.07.016","DOIUrl":"10.1016/j.jcin.2024.07.016","url":null,"abstract":"<div><h3>Background</h3><div>Thrombus aspiration (TA) is used to decrease large thrombus burden (LTB), but it can cause distal embolization.</div></div><div><h3>Objectives</h3><div>The aim of this study was to investigate the impact of TA failure on defective myocardial perfusion in patients with ST-segment elevation myocardial infarction (STEMI) and LTB.</div></div><div><h3>Methods</h3><div>In total, 812 consecutive patients with STEMI and LTB (thrombus grade ≥3) were enrolled, who underwent manual TA during the primary percutaneous coronary intervention. TA failure was defined as the absence of thrombus retrieval, presence of prestenting thrombus residue, or distal embolization. The final TIMI flow grades and other myocardial perfusion parameters of the failed TA group were matched with those of the successful TA group.</div></div><div><h3>Results</h3><div>The proportion of final TIMI flow grade 3 was lower (74.6% vs 82.2%; <em>P</em> = 0.011) in the failed TA group (n = 279 [34.4%]) than in the successful TA group (n = 533 [65.6%]). The failed TA group also had lower myocardial blush grade, lower ST-segment resolution, and a higher incidence of microvascular obstruction than the successful TA group. TA failure was independently associated with low final TIMI flow grade (risk ratio: 1.525; 95% CI: 1.048-2.218; <em>P</em> = 0.027). Old age, Killip class ≥III, vessel tortuosity, calcification, and a culprit vessel other than the left anterior descending coronary artery were associated with TA failure.</div></div><div><h3>Conclusions</h3><div>TA failure is associated with reduced myocardial perfusion in patients with STEMI and LTB. Advanced age, hemodynamic instability, hostile coronary anatomy such as tortuosity or calcification, and non–left anterior descending coronary artery status might attenuate TA performance. (Gangwon PCI Prospective Registry [GWPCI]; <span><span>NCT02038127</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 19","pages":"Pages 2216-2225"},"PeriodicalIF":11.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142287504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marco Zuin MD, MS , Irene Lang MD, PhD , Romain Chopard MD, PhD , Andrew S.P. Sharp MD , Robert A. Byrne MD , Gianluca Rigatelli MD, PhD , Gregory Piazza MD, MS
{"title":"Innovation in Catheter-Directed Therapy for Intermediate-High-Risk and High-Risk Pulmonary Embolism","authors":"Marco Zuin MD, MS , Irene Lang MD, PhD , Romain Chopard MD, PhD , Andrew S.P. Sharp MD , Robert A. Byrne MD , Gianluca Rigatelli MD, PhD , Gregory Piazza MD, MS","doi":"10.1016/j.jcin.2024.07.033","DOIUrl":"10.1016/j.jcin.2024.07.033","url":null,"abstract":"<div><div>Although anticoagulation remains the cornerstone treatment for patients with acute pulmonary embolism (PE), catheter-directed therapy (CDT) has generated great interest as an adjunctive option for those presenting with hemodynamic decompensation or high risk for deterioration and in whom systemic thrombolysis has failed or is contraindicated. However, randomized controlled data supporting the efficacy and safety of CDT in addition to antithrombotic therapy in patients with high-risk and intermediate- to high-risk PE compared with anticoagulation and systemic thrombolysis alone are lacking. This paucity of high-quality data hampers guideline recommendations regarding the optimal therapeutic approach in such patients with PE. The aim of the present paper is to critically appraise the current evidence for CDT in patients with high-risk and intermediate- to high-risk PE and to highlight major areas of innovation in the recent literature. In addition, the authors describe unmet clinical and research needs, potential strategies to resolve these knowledge gaps, and pathways for device selection.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"17 19","pages":"Pages 2259-2273"},"PeriodicalIF":11.7,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}