JACC. Cardiovascular interventions最新文献

{"title":"Comparison of Vascular Injury From Intravascular Lithotripsy, Cutting, or Ultra-High-Pressure Balloons During Coronary Calcium Modification","authors":"Teruo Sekimoto MD ,&nbsp;Kazuhiro Fujiyoshi MD ,&nbsp;Rika Kawakami MD ,&nbsp;Anna Madra PhD ,&nbsp;Takamasa Tanaka MD ,&nbsp;Doosup Shin MD ,&nbsp;Eric H. Wolff ,&nbsp;Tatsuya Shiraki MD ,&nbsp;Takafumi Nakayama MD ,&nbsp;Tomoyo Hamana MD ,&nbsp;Renu Virmani MD ,&nbsp;Ziad A. Ali MD ,&nbsp;Aloke V. Finn MD","doi":"10.1016/j.jcin.2025.06.035","DOIUrl":"10.1016/j.jcin.2025.06.035","url":null,"abstract":"<div><h3>Background</h3><div>Effective modification of heavily calcified coronary lesions is critical for successful percutaneous coronary intervention (PCI). Intravascular lithotripsy (IVL), cutting balloons (CBs), and ultra-high-pressure balloons (UHBs) are used commonly, yet data comparing their effectiveness and safety for calcified lesion modification remain unavailable.</div></div><div><h3>Objectives</h3><div>The aim of this study was to compare the effects of IVL, a CB, and a UHB on calcified coronary lesions in human cadaveric arteries, focusing on calcium fracture formation and vascular injury.</div></div><div><h3>Methods</h3><div>Seventeen calcified lesions from 6 cadavers were randomized to treatment with IVL (n = 5), the CB (n = 6), or the UHB (n = 6). Pre- and post-treatment optical coherence tomography, micro–computed tomography (CT), and histology were coregistered to evaluate calcium fractures and medial injury.</div></div><div><h3>Results</h3><div>Fractures confirmed by micro-CT and histology were observed in 80% of IVL-treated lesions, 66.7% treated with the CB, and 33.3% treated with the UHB (<em>P</em> = 0.350). Medial injury occurred significantly less frequently with IVL (20.0%) compared with the CB (83.3%) and the UHB (100%) (<em>P</em> = 0.012). In histologic sections with a calcium arc of ≥180°, IVL induced fractures in 100% of sections, all without medial injury, while the CB and UHB caused fractures without medial injury in 16.7% and 20.0% of sections, respectively (<em>P</em> = 0.007). For calcium arcs &lt;180°, IVL produced fractures in 57.1% of sections, all without medial injury, compared with the CB (11.1% without medial injury) and UHB (0% without medial injury) (<em>P</em> = 0.008).</div></div><div><h3>Conclusions</h3><div>IVL effectively modifies calcified lesions with less medial vascular injury compared with a CB and a UHB.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2093-2104"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspirin vs Clopidogrel 1 Month After Acute Coronary Syndrome With High-Bleeding Risk or ST-Segment Elevation","authors":"Yuki Obayashi MD ,&nbsp;Masahiro Natsuaki MD ,&nbsp;Hirotoshi Watanabe MD ,&nbsp;Takeshi Morimoto MD ,&nbsp;Ko Yamamoto MD ,&nbsp;Ryusuke Nishikawa MD ,&nbsp;Tomoya Kimura MD ,&nbsp;Kenji Ando MD ,&nbsp;Satoru Suwa MD ,&nbsp;Tsuyoshi Isawa MD ,&nbsp;Hiroyuki Takenaka MD ,&nbsp;Tetsuya Ishikawa MD ,&nbsp;Hideo Tokuyama MD ,&nbsp;Hiroki Sakamoto MD ,&nbsp;Takanari Fujita MD ,&nbsp;Mamoru Nanasato MD ,&nbsp;Hideki Okayama MD ,&nbsp;Tenjin Nishikura MD ,&nbsp;Hidekuni Kirigaya MD ,&nbsp;Koji Nishida MD ,&nbsp;Takeshi Kimura MD","doi":"10.1016/j.jcin.2025.03.029","DOIUrl":"10.1016/j.jcin.2025.03.029","url":null,"abstract":"<div><h3>Background</h3><div>High bleeding<span> risk (HBR) and acute coronary syndrome<span> (ACS) subtypes (ST-segment elevation myocardial infarction [STEMI] and non–ST-segment elevation ACS [NSTE-ACS]) might be key determinants of appropriate antiplatelet strategies.</span></span></div></div><div><h3>Objectives</h3><div>The aim of this study was to investigate the effects of aspirin<span> versus clopidogrel within 1 year after percutaneous coronary intervention in patients with ACS, on the basis of HBR or non-HBR and STEMI or NSTE-ACS.</span></div></div><div><h3>Methods</h3><div>Patients with ACS in the STOPDAPT-3 (Short and Optimal Duration of Dual Antiplatelet Therapy-3) trial were included. Aspirin and clopidogrel monotherapy<span><span> were compared beyond 30 days and up to 1 year in the prespecified subgroups stratified by HBR or non-HBR and STEMI or NSTE-ACS. The coprimary cardiovascular endpoint was a composite of cardiovascular death, myocardial infarction, definite stent thrombosis, or </span>ischemic stroke; the coprimary bleeding endpoint was major bleeding (Bleeding Academic Research Consortium type 3 or 5).</span></div></div><div><h3>Results</h3><div>Among 4,353 patients, 1,711 had HBR and 2,457 had STEMI. Throughout the 335-day follow-up period, the crude HRs for aspirin compared with clopidogrel were not statistically significant for cardiovascular endpoints in both the HBR or non-HBR (HR: 0.89 [95% CI: 0.61-1.30] and HR: 1.08 [95% CI: 0.61-1.90]; <em>P</em> for interaction = 0.59) and STEMI or NSTE-ACS (HR: 1.01 [95% CI: 0.68-1.50] and HR: 0.81 [95% CI: 0.48-1.37]; <em>P</em> for interaction = 0.51) subgroups. Similarly, the HRs for bleeding endpoints were not significant in both the HBR or non-HBR (HR: 0.73 [95% CI: 0.40-1.33] and HR: 0.71 [95% CI: 0.23-2.24]; <em>P</em> for interaction = 0.97) and STEMI or NSTE-ACS (HR: 0.96 [95% CI: 0.46-2.01] and HR: 0.53 [95% CI: 0.24-1.17]; <em>P</em> for interaction = 0.28) subgroups.</div></div><div><h3>Conclusions</h3><div>In patients with ACS, aspirin and clopidogrel demonstrated comparable effects on both cardiovascular and bleeding outcomes beyond 1 month and up to 1 year after percutaneous coronary intervention, irrespective of HBR or non-HBR and STEMI or NSTE-ACS. (Short and Optimal Duration of Dual Antiplatelet Therapy-3 Study [STOPDAPT-3]; <span><span>NCT04609111</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2120-2135"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-Eluting Stenting vs Drug-Coated Ballon Angioplasty","authors":"Peter Henke MD","doi":"10.1016/j.jcin.2025.07.029","DOIUrl":"10.1016/j.jcin.2025.07.029","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2167-2168"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recommended Steps for UNICORN With Balloon-Expandable Valves","authors":"Kwong-Yue Eric Chan MBBS,&nbsp;Chun-Ka Wong MBBS,&nbsp;Tai-Leung Chan MBBS,&nbsp;Gilbert H.L. Tang MD, MSc, MBA,&nbsp;Simon Cheung-Chi Lam MBBS","doi":"10.1016/j.jcin.2025.05.034","DOIUrl":"10.1016/j.jcin.2025.05.034","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Page 2195"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144515235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Temporary Balloon Occlusion of Chest Wall Branches to Determine the Impact of Coil Embolization on LIMA Graft Flow","authors":"Ghasaq Saleh MD ,&nbsp;Sivakumar Sudhakaran MD ,&nbsp;Kelley Chen MD,&nbsp;Rajiv Gulati MD, PhD,&nbsp;Mohamad Alkhouli MD, MBA","doi":"10.1016/j.jcin.2025.05.036","DOIUrl":"10.1016/j.jcin.2025.05.036","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2183-2185"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vascular Restoration With Bioresorbable Scaffolds","authors":"Michael Joner MD ,&nbsp;Salvatore Cassese MD, PhD","doi":"10.1016/j.jcin.2025.07.010","DOIUrl":"10.1016/j.jcin.2025.07.010","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2116-2119"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When the Stent Gets Gift-Wrapped","authors":"Taha Ettachfini MD ,&nbsp;Guillaume Godeau MD ,&nbsp;Elodie Blicq MD ,&nbsp;Badreddine Ajlani MD ,&nbsp;Grégoire Lefèvre MD ,&nbsp;Bernard Livarek MD ,&nbsp;Jean-Louis Georges MD ,&nbsp;Géraldine Gibault Genty MD","doi":"10.1016/j.jcin.2025.06.013","DOIUrl":"10.1016/j.jcin.2025.06.013","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2180-2182"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Full Issue PDF","authors":"","doi":"10.1016/S1936-8798(25)02204-6","DOIUrl":"10.1016/S1936-8798(25)02204-6","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages I-CXXIV"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiplatelet Monotherapy After Short DAPT in ACS","authors":"Antonio Greco MD, PhD","doi":"10.1016/j.jcin.2025.04.042","DOIUrl":"10.1016/j.jcin.2025.04.042","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2136-2139"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antianginal Therapy in Patients With Impaired Coronary Flow Reserve but Normal Minimal Microvascular Resistance","authors":"Aish Sinha PhD,&nbsp;Haseeb Rahman PhD,&nbsp;Holly P. Morgan PhD,&nbsp;Kalpa De Silva PhD,&nbsp;Matthew E. Li Kam Wa MBBS,&nbsp;Matthew Ryan PhD,&nbsp;Ozan M. Demir PhD,&nbsp;Saad Ezad MBBS,&nbsp;Howard Ellis BSc,&nbsp;Divaka Perera MD","doi":"10.1016/j.jcin.2025.06.033","DOIUrl":"10.1016/j.jcin.2025.06.033","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2189-2191"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144794478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}