{"title":"3-Year Outcomes of Drug-Eluting Stent vs Drug-Coated Balloon for Femoropopliteal Artery Lesions","authors":"Tatsuya Nakama MD , Mitsuyoshi Takahara MD, PhD , Yo Iwata MD, PhD , Kenji Suzuki MD , Kazuki Tobita MD , Naoki Hayakawa MD , Kazunori Horie MD , Shunsuke Mori MD , Kotaro Obunai MD , Takao Ohki MD, PhD , BEASTARS Study Investigators","doi":"10.1016/j.jcin.2025.07.034","DOIUrl":"10.1016/j.jcin.2025.07.034","url":null,"abstract":"<div><h3>Background</h3><div>Long-term comparative data on drug-eluting stents (DES) and drug-coated balloons (DCB) for femoropopliteal artery (FPA) disease remain limited.</div></div><div><h3>Objectives</h3><div>The authors sought to compare 3-year outcomes of DES vs DCB without bailout stenting in FPA disease.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 1,406 patients from a multicenter registry who underwent endovascular therapy for FPA using DES (n = 342) or DCB (n = 1,064) after the successful lesion preparation. Successful lesion preparation was defined as <50% residual stenosis and absence of Grade D or higher dissection. The primary outcomes were 3-year primary patency and freedom from clinically driven target lesion revascularization (CD-TLR), analyzed using propensity score matching.</div></div><div><h3>Results</h3><div>During a median follow-up period (Q1-Q3) of 22.5 months (8.8-37.1 months), 484 cases of patency loss were observed. Propensity score matching resulted in 314 matched pairs: 314 in the DES (Eluvia: 73.9% [232/314], Zilver PTX: 26.1% [82/314]), and 981 in the DCB (IN.PACT: 64.3% [201.8/314], Lutonix: 35.7% [112.2/314]). After matching, the 3-year primary patency was significantly higher in the DES than in the DCB group (65.3% [95% CI: 58.9%-72.4%] vs 59.5% [54.8%-64.5%]; <em>P</em> = 0.042). However, freedom from CD-TLR was similar (73.2% [67.5%-79.4%] vs 72.2% [68.0-%76.7%]; <em>P</em> = 0.27). Lesion length >150 mm and dissection Grade C showed significant interaction effects (<em>P</em> = 0.007 and 0.013, respectively), indicating greater benefit from DES in reducing the restenosis risk.</div></div><div><h3>Conclusions</h3><div>Despite successful lesion preparation, DES demonstrated significantly higher primary patency over 3 years. However, this did not translate into a clinical benefit, as freedom from CD-TLR rates remained comparable between groups.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2155-2166"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Distal Radial Access to Recanalize Radial Artery Occlusions","authors":"Thomas M. Das MD, Khaled M. Ziada MD","doi":"10.1016/j.jcin.2025.08.002","DOIUrl":"10.1016/j.jcin.2025.08.002","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2152-2154"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giuseppe Colletti MD , Gregory A. Sgueglia MD, PhD , Gabriele L. Gasparini MD , Claudiu Ungureanu MD , Grigorios Tsigkas MD, PhD , Gregor Leibundgut MD , Mihai Cocoi MD , Olivier Gach MD, PhD , Marouane Boukhris MD , Vojtěch Novotný MD , Nino Cocco MD , Laura Peter MD , Alexandre Natalis MD , Laura Novelli MD , Elias Benthakhou MD , Kornél Kákonyi MD , Carlo Tumscitz MD , Alexandru Achim MD , Zoltan Rusza MD, PhD
{"title":"Distal Radial Access for Radial Artery Recanalization","authors":"Giuseppe Colletti MD , Gregory A. Sgueglia MD, PhD , Gabriele L. Gasparini MD , Claudiu Ungureanu MD , Grigorios Tsigkas MD, PhD , Gregor Leibundgut MD , Mihai Cocoi MD , Olivier Gach MD, PhD , Marouane Boukhris MD , Vojtěch Novotný MD , Nino Cocco MD , Laura Peter MD , Alexandre Natalis MD , Laura Novelli MD , Elias Benthakhou MD , Kornél Kákonyi MD , Carlo Tumscitz MD , Alexandru Achim MD , Zoltan Rusza MD, PhD","doi":"10.1016/j.jcin.2025.07.003","DOIUrl":"10.1016/j.jcin.2025.07.003","url":null,"abstract":"<div><h3>Background</h3><div>Radial artery occlusion complicates transradial access, limiting future access and precluding bypass grafting and dialysis. Distal radial access offers a promising solution by allowing retrograde recanalization of occluded radial arteries.</div></div><div><h3>Objectives</h3><div>The authors sought to evaluate multicenter outcomes of radial artery recanalization though distal radial access (DRA), focusing on its safety, efficacy, and reproducibility, while identifying procedural strategies to optimize patency.</div></div><div><h3>Methods</h3><div>This international registry included 110 patients with radial artery occlusion from 7 centers. Operators with substantial DRA experience (>200 procedures) performed retrograde recanalization through DRA in the anatomical snuffbox using mainly a drilling or knuckling technique to cross the occlusion and dotter dilation (“dotterization”) or balloon angioplasty to dilate it. Outcomes included procedural success and radial artery patency at 31 (30-32) days.</div></div><div><h3>Results</h3><div>Procedural success was achieved in 94% of cases (95% CI: 88%-97%), with acute complications managed conservatively. Radial artery patency at 30 days was 80% (95% CI: 72%-86%). Multivariable analysis identified sheathless approach as the only significant predictor of patency (OR: 3.07; 95% CI: 1.10-8.59), whereas use of sheaths >6-F (OR: 0.15; 95% CI: 0.02-0.97) and balloon >2.25 mm (OR: 0.10; 95% CI: 0.01-0.92) were associated with decreased patency.</div></div><div><h3>Conclusions</h3><div>Recanalization of occluded radial arteries through DRA is a safe, effective, and reproducible procedure with the primary benefit to maintaining the safest vascular access option. A dotterization technique using sheaths ≤6-F or, even better, a sheathless approach should be preferred as it appears to be associated with improved patency at 30 days.</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2140-2151"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Max Potratz MD, Akhil Narang MD, Muhammed Gerçek MD, Felix Rudolph MD, Mohammad Kassar MD, Maria Isabel Koerber MD, Tanja K. Rudolph MD, Paul C. Cremer MD, Volker Rudolph MD, Charles J. Davidson MD
{"title":"Performance of the TRI-SCORE in a Multicenter Cohort Undergoing Transcatheter Tricuspid Valve Repair and Replacement","authors":"Max Potratz MD, Akhil Narang MD, Muhammed Gerçek MD, Felix Rudolph MD, Mohammad Kassar MD, Maria Isabel Koerber MD, Tanja K. Rudolph MD, Paul C. Cremer MD, Volker Rudolph MD, Charles J. Davidson MD","doi":"10.1016/j.jcin.2025.07.011","DOIUrl":"10.1016/j.jcin.2025.07.011","url":null,"abstract":"","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2192-2194"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145020572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kai Xu MD , Guosheng Fu MD , Xiaozeng Wang MD , Lei Song MD , Ling Tao MD , Lang Li MD , Yuqing Hou MD , Xi Su MD , Quan Fang MD , Lianglong Chen MD , Huiliang Liu MD , Bin Wang MD , Zuyi Yuan MD , Chuanyu Gao MD , Shenghua Zhou MD , Changdong Guan MD , Yi Li MD , Yaling Han MD, PhD , Gregg W. Stone MD , NeoVas Randomized Controlled Trial Investigators
{"title":"5-Year Outcomes With a Novel Coronary Sirolimus-Eluting Bioresorbable Scaffold","authors":"Kai Xu MD , Guosheng Fu MD , Xiaozeng Wang MD , Lei Song MD , Ling Tao MD , Lang Li MD , Yuqing Hou MD , Xi Su MD , Quan Fang MD , Lianglong Chen MD , Huiliang Liu MD , Bin Wang MD , Zuyi Yuan MD , Chuanyu Gao MD , Shenghua Zhou MD , Changdong Guan MD , Yi Li MD , Yaling Han MD, PhD , Gregg W. Stone MD , NeoVas Randomized Controlled Trial Investigators","doi":"10.1016/j.jcin.2025.06.036","DOIUrl":"10.1016/j.jcin.2025.06.036","url":null,"abstract":"<div><h3>Background</h3><div>Previous trials have demonstrated increased 5-year risks for adverse clinical events after coronary artery implantation of poly-l-lactic acid–based bioresorbable scaffolds (BRS) compared with cobalt chromium (CoCr) everolimus-eluting stents (EES).</div></div><div><h3>Objectives</h3><div>The aim of this study was to evaluate the 5-year clinical outcomes of the novel sirolimus-eluting NeoVas BRS compared with CoCr EES.</div></div><div><h3>Methods</h3><div>A total of 560 patients with single de novo native coronary artery lesions with reference vessel diameter 2.5 to 3.75 mm and lesion length ≤20 mm were randomized 1:1 to NeoVas BRS vs CoCr EES and followed for 5 years. Optical coherence tomography and fractional flow reserve were performed in a prespecified subgroup of 166 patients at 3-year follow-up.</div></div><div><h3>Results</h3><div>The 5-year target lesion failure rates were 9.5% in the NeoVas group and 7.2% in the CoCr EES group (HR: 1.33; 95% CI: 0.74 to 2.38; <em>P</em> = 0.33). The 5-year rates of device thrombosis were not different between the groups (1.5% vs 0.7%, respectively; HR: 2.05; 95% CI: 0.37 to 11.16; <em>P</em> = 0.45). In a subset of patients in whom optical coherence tomography was performed at 3 years, it demonstrated that NeoVas was substantially absorbed (72.3% ± 13.2%). Fractional flow reserve was not significantly different between the 2 groups either postprocedure or at 3 years (0.89 ± 0.07 vs 0.90 ± 0.05, respectively; <em>P</em> = 0.11).</div></div><div><h3>Conclusions</h3><div>At 5-year follow-up, target lesion failure and stent thrombosis rates were comparable after NeoVas BRS and CoCr EES implantation in noncomplex lesions. However, comparability or the potential signs of harm of NeoVas BRS should be investigated in appropriately sized randomized trials in the future. (NeoVas Bioresorbable Coronary Scaffold Randomized Controlled Trial; <span><span>NCT02305485</span><svg><path></path></svg></span>)</div></div>","PeriodicalId":14688,"journal":{"name":"JACC. Cardiovascular interventions","volume":"18 17","pages":"Pages 2107-2115"},"PeriodicalIF":11.4,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}