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Iranian Journal of Toxicology最新文献

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Synthesis, Characterization of Pyrano-[2,3-c]-Pyrazoles Derivatives and Determination of Their Antioxidant Activities 吡喃-[2,3-c]-吡唑衍生物的合成、表征及抗氧化活性测定
Iranian Journal of Toxicology Pub Date : 2021-07-01 DOI: 10.32598/IJT.15.3.798.1
Boutaina Addoum, B. E. Khalfi, Mohamed Idiken, Souraya Sakoui, Reda Derdak, O. Filali, A. Elmakssoudi, A. Soukri
{"title":"Synthesis, Characterization of Pyrano-[2,3-c]-Pyrazoles Derivatives and Determination of Their Antioxidant Activities","authors":"Boutaina Addoum, B. E. Khalfi, Mohamed Idiken, Souraya Sakoui, Reda Derdak, O. Filali, A. Elmakssoudi, A. Soukri","doi":"10.32598/IJT.15.3.798.1","DOIUrl":"https://doi.org/10.32598/IJT.15.3.798.1","url":null,"abstract":"Background: Antioxidants are developed to assist the immune system and overcome oxidative stress, the aggression of cellular constituents due to imbalance between reactive oxygen species and the inner antioxidant system. The main objective of this study was to search for new and potent antioxidants to protect humans against diseases associated with oxidative stress. Methods: In this study, three pyrano-[2,3-c]-pyrazole derivatives were synthesized via Multicomponent Reaction (MCR) approach and were characterized, using a melting point, High-Performance Liquid Chromatography (HPLC), and spectroscopic analyses (IR; 1H-NMR; 13C-NMR). All of the generated compounds were screened for their antioxidant properties in vivo, using ciliate “Tetrahymena” as a model organism exposed to oxidative and nitrative stress. They were then studied in vitro by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) assays. Results: The results demonstrated that the three compounds (5a, b, c) are biologically active and possess potent antioxidant activities, especially the 5a and 5b derivatives. On the other hand, the in vitro bioassays revealed that the 5a derivative possessed a significant antioxidant activity much greater than ascorbic acid. Accordingly, the in silico data are consistent with the experimental data. Conclusion: These findings confirmed the potent antioxidant property of the synthesized compounds, providing us with new inspiration and challenges to design a library of pharmaceutical compounds with strong activity and low toxicity in the future.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42109669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Pentoxifylline Protects Against Hippocampal Damage and Memory Impairment Induced by Trimethyltin 己酮茶碱对三甲基锡诱导的海马损伤和记忆障碍的保护作用
Iranian Journal of Toxicology Pub Date : 2021-04-01 DOI: 10.32598/IJT.15.2.738.1
M. Sakhaie, Atefeh Mohammad-Hosseini, M. Sadegh, B. Khansarinejad, S. Babaei
{"title":"Pentoxifylline Protects Against Hippocampal Damage and Memory Impairment Induced by Trimethyltin","authors":"M. Sakhaie, Atefeh Mohammad-Hosseini, M. Sadegh, B. Khansarinejad, S. Babaei","doi":"10.32598/IJT.15.2.738.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.738.1","url":null,"abstract":"Methods: Sixty male Wistar rats were divided into five groups of 12 each. Group 1 received normal saline while Group 2 received a single dose of TMT (8 mg/kg). The other four groups received TMT at 8 mg/kg plus 60, 100 or 120 mg/kg PTX twice daily for six consecutive days. The rats’ working and reference memory were investigated, using radial arm maze tasks. At the end of the experiments, the rats’ brains were removed and processed for histological study of the hippocampus.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"83-90"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48632411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lead and Cadmium Contaminations in Fruits and Vegetables, and Arsenic in Rice: A Cross Sectional Study on Risk Assessment in Iran 水果和蔬菜中的铅和镉污染以及大米中的砷:伊朗风险评估的横断面研究
Iranian Journal of Toxicology Pub Date : 2021-04-01 DOI: 10.32598/IJT.15.2.784.1
Reza Tajik, A. Alimoradian, M. Jamalian, M. Shamsi, Rahmatolah Moradzadeh, Behnoosh Ansari Asl, Mohaddeseh Asafari
{"title":"Lead and Cadmium Contaminations in Fruits and Vegetables, and Arsenic in Rice: A Cross Sectional Study on Risk Assessment in Iran","authors":"Reza Tajik, A. Alimoradian, M. Jamalian, M. Shamsi, Rahmatolah Moradzadeh, Behnoosh Ansari Asl, Mohaddeseh Asafari","doi":"10.32598/IJT.15.2.784.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.784.1","url":null,"abstract":"Article info: Received: 20 Dec 2020 Accepted: 09 Mar 2021 Online Published: 01 Apr 2021 Research Paper: Lead and Cadmium Contaminations in Fruits and Vegetables, and Arsenic in Rice: A Cross Sectional Study on Risk Assessment in Iran * Corresponding author: Mohaddeseh Asafari, MSc. Address: Deputy of Food and Drug, Arak University of Medical Sciences, Arak, Iran. E-mail: m.asafari@arakmu.ac.ir","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"73-82"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44620503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Cytotoxic Effects of Bisphenol A as an Endocrine Disruptor on Human Lymphocytes 双酚A作为内分泌干扰物对人淋巴细胞的细胞毒性作用
Iranian Journal of Toxicology Pub Date : 2021-04-01 DOI: 10.32598/IJT.15.2.753.1
M. Özgür, Ş. Yılmaz, Ash Uçar, S. Yılmaz
{"title":"Cytotoxic Effects of Bisphenol A as an Endocrine Disruptor on Human Lymphocytes","authors":"M. Özgür, Ş. Yılmaz, Ash Uçar, S. Yılmaz","doi":"10.32598/IJT.15.2.753.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.753.1","url":null,"abstract":"Methods: 0.1 mL heparinized 0.2 mL peripheral blood taken from a healthy male and a female were plated in culture media under sterile conditions. To prepare the reference dose at a concentration of 0.05 mg/mL, 0.027g BPA was dissolved in 1 L dimethyl sulfoxide and the highest dose of 50 μg/mL BPA solution was prepared. After separating the stock solution, 50 μg/mL BPA was diluted to prepare 20, 10 or 5 μg/mL doses.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"115-120"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45841852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Effects of Exposure to Aflatoxin G1 on the Plasma Biochemical Factors and Histopathological Properties of Renal Tissue in Mice 黄曲霉毒素G1对小鼠血浆生化因子及肾组织病理特性的影响
Iranian Journal of Toxicology Pub Date : 2021-04-01 DOI: 10.32598/IJT.15.2.787.1
Touraj, A. Ahmadi, Mona Pazhouhi, C. Jalili, K. Rezaei
{"title":"Effects of Exposure to Aflatoxin G1 on the Plasma Biochemical Factors and Histopathological Properties of Renal Tissue in Mice","authors":"Touraj, A. Ahmadi, Mona Pazhouhi, C. Jalili, K. Rezaei","doi":"10.32598/IJT.15.2.787.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.787.1","url":null,"abstract":"1. Department of Anatomy, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran. 2. Department of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran. 3. Department of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. 4. Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"127-134"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46108550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Protective Effects of Nicotine and Bucladesine on Impaired Avoidance Memory Caused by Sodium Arsenate Toxicity in Mice 烟碱和布氯地辛对砷酸钠中毒小鼠回避记忆损伤的保护作用
Iranian Journal of Toxicology Pub Date : 2021-04-01 DOI: 10.32598/IJT.15.2.772.1
S. Najafi, M. Hashemzaei, M. Sadeghi, Sajedeh Seyed Mousavi, A. Bazi, Sahar Fanoudi, M. Belaran, Hanieh Rezaei, Hamideh Arezoomandan, H. Mirzaei, K. Tabrizian
{"title":"The Protective Effects of Nicotine and Bucladesine on Impaired Avoidance Memory Caused by Sodium Arsenate Toxicity in Mice","authors":"S. Najafi, M. Hashemzaei, M. Sadeghi, Sajedeh Seyed Mousavi, A. Bazi, Sahar Fanoudi, M. Belaran, Hanieh Rezaei, Hamideh Arezoomandan, H. Mirzaei, K. Tabrizian","doi":"10.32598/IJT.15.2.772.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.772.1","url":null,"abstract":"1. Department of Pharmaceutical Care, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. 2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran. 3. Students Research Committee, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran. 4. Department of Hematology, Faculty of Allied Health Sciences, Zabol University of Medical Sciences, Zabol, Iran. 5. Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. 6. Department of Physiology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran. 7. Department of Biotechnology, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran. 8. Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran. 9. Toxicology and Addiction Research Center, Zabol University of Medical Sciences, Zabol, Iran.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"99-108"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44864499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The Measurement of Cadmium, Zinc and Silver in Chicken Meat in Isfahan Province, Iran 伊朗伊斯法罕省鸡肉中镉、锌和银的测定
Iranian Journal of Toxicology Pub Date : 2021-04-01 DOI: 10.32598/IJT.15.2.434.1
M. Gholami-Ahangaran, A. Ahmadi-Dastgerdi, S. Azizi
{"title":"The Measurement of Cadmium, Zinc and Silver in Chicken Meat in Isfahan Province, Iran","authors":"M. Gholami-Ahangaran, A. Ahmadi-Dastgerdi, S. Azizi","doi":"10.32598/IJT.15.2.434.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.434.1","url":null,"abstract":"Results: The mean contents of cadmium in the chicken thigh, breast, liver and heart samples were 0.055±0.021, 0.048±0.023, 0.074±0.031, and 0.012±0.004 mg/kg, respectively. The mean contents of zinc in the chicken thigh, breast, liver and heart samples were 17.19±8.10, 15.70±5.75, 22.10±10.87, and 19.70±10.38 mg/kg, respectively. The concentrations of cadmium and zinc were below the international permissible limits in all samples. The mean concentrations of silver in some chicken thigh, breast, liver and heart samples were 0.0080±0.0044, 0.0048±0.0013, 0.012±0.009 and 0.0036±0.006, respectively. Of note, silver was not detected in most chicken samples.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"121-126"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43029809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Antioxidant Effects of Pinus eldarica Extracts Against Cisplatin-induced Cytotoxicity in Human Hepatoma (HepG2) Cell Line 接骨木提取物对顺铂诱导的人肝癌（HepG2）细胞毒性的抗氧化作用
Iranian Journal of Toxicology Pub Date : 2021-04-01 DOI: 10.32598/IJT.15.2.764.1
Amin Sharifan, M. Etebari, B. Zolfaghari, M. Aliomrani
{"title":"Antioxidant Effects of Pinus eldarica Extracts Against Cisplatin-induced Cytotoxicity in Human Hepatoma (HepG2) Cell Line","authors":"Amin Sharifan, M. Etebari, B. Zolfaghari, M. Aliomrani","doi":"10.32598/IJT.15.2.764.1","DOIUrl":"https://doi.org/10.32598/IJT.15.2.764.1","url":null,"abstract":"Methods: Using the maceration technique, we obtained the ethanolic extract of Pinus eldarica’s bark (BHAEPE). Folin-ciocalteu reagent was used to determine the total phenolic content of BHAEPE. The Needle’s Volatile Oil of Pinus eldarica (NVOPE) was obtained by Clevenger hydrodistillation method. The main components of NVOPE were identified by Gas Chromatography and Mass Spectrophotometry (GC-MS). We used DPPH assay to investigate the antioxidant activity of both NVOPE and BHAEPE. Also, MTT assay was performed to test the protective effects of both BHAEPE and NVOPE against cisplatin.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"91-98"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42287137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Extracts of Epilobium Parviflorum Inhibit MCF-7 Breast Cancer Cells 西红花提取物对癌症MCF-7细胞的抑制作用
Iranian Journal of Toxicology Pub Date : 2021-01-10 DOI: 10.32598/IJT.15.1.752.1
Bhenaz Hatefi Kia, Sakineh Kazemi Noureini, M. R. Vaezi Kakhki
{"title":"The Extracts of Epilobium Parviflorum Inhibit MCF-7 Breast Cancer Cells","authors":"Bhenaz Hatefi Kia, Sakineh Kazemi Noureini, M. R. Vaezi Kakhki","doi":"10.32598/IJT.15.1.752.1","DOIUrl":"https://doi.org/10.32598/IJT.15.1.752.1","url":null,"abstract":"Methods: The root, aerial parts and flowers of the plant were, collected and dried separately at ambient temperature and away from direct sunlight. The aquatic and methanolic extracts of each part was prepared. The effect of each extract on the growth of MCF-7 breast carcinoma cells and HEK293 normal cell line was evaluated, using MTT assay. Each experiment was repeated at least three times independently. The IC50 values for each treatment time point were analyzed, using ANOVA at P<0.05.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"15 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41803061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Preserved Ovarian Function Following Toxicity With Doxorubicin in Rats: Protective Effect of Nasturtium Officinale Extract 阿霉素毒性大鼠卵巢功能的保存:旱金莲提取物的保护作用
Iranian Journal of Toxicology Pub Date : 2021-01-10 DOI: 10.32598/IJT.15.1.747.1
P. Rad, F. Safari, J. Mohammadi, H. Delaviz
{"title":"Preserved Ovarian Function Following Toxicity With Doxorubicin in Rats: Protective Effect of Nasturtium Officinale Extract","authors":"P. Rad, F. Safari, J. Mohammadi, H. Delaviz","doi":"10.32598/IJT.15.1.747.1","DOIUrl":"https://doi.org/10.32598/IJT.15.1.747.1","url":null,"abstract":"1. Department of Nursing, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran. 2. Department of Biology, Cellular and Molecular Research Center, Shiraz University, Shiraz, Iran. 3. Department of Physiology, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran. 4. Cellular and Molecular Research Center, School of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":" ","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42147243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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