Iranian Journal of Toxicology最新文献_第10页

Anticonvulsive and Antioxidant Effects of Pioglitazone on Pilocarpine-induced Seizures in Mice 吡格列酮对匹洛卡平致小鼠癫痫发作的抗惊厥和抗氧化作用

Iranian Journal of Toxicology Pub Date : 2021-01-01 DOI: 10.32598/ijt.15.4.833.1

S. Rostamian, Samaneh Keshavarz hedayati, Sara Khosraviani, E. Aali, Y. Naderi

{"title":"Anticonvulsive and Antioxidant Effects of Pioglitazone on Pilocarpine-induced Seizures in Mice","authors":"S. Rostamian, Samaneh Keshavarz hedayati, Sara Khosraviani, E. Aali, Y. Naderi","doi":"10.32598/ijt.15.4.833.1","DOIUrl":"https://doi.org/10.32598/ijt.15.4.833.1","url":null,"abstract":"Background: Epilepsy is a neurological disorder caused by uncontrollable discharge of action potentials from neurons in the brain. After a seizure, oxidative stress may cause a significant neuronal damage. In the current study, we assessed the anticonvulsant and antioxidant properties of pioglitazone, a peroxisome proliferated activated receptor-γ (PPAR-γ) agonist that is used in type-2 diabetes, on pilocarpine-induced seizure in mice. Methods: Pilocarpine (400 mg/kg) or normal saline was injected intraperitoneally 4 hours after oral administration of Pioglitazone (80 mg/kg). Also, carboxymethyl cellulose was administered orally in control and Pilocarpine groups. After the administration of Pilocarpine all of the mice were observed for 1 hour to measure the seizure latency time. Pilocarpine-induced seizures were categorized using the Racine scale. Then all animals were decapitated, brain was removed and hippocampus was dissected. Finally, the level of Malondialdehyde (MDA) and Catalase (CAT) activity, Superoxide Dismutase (SOD), and Glutathione Reductase (GR) levels were quantified in hippocampus by biochemical methods. Results: Pioglitazone significantly increased the latency to seizure onset of stages 1-4 (P≤0.01-0.001). Also, pioglitazone prevented the development of stage 5 of the pilocarpine-induced seizure. After the seizure, pioglitazone significantly decreased the level of MDA (P<0.01) and elevated the levels of CAT (P<0.01), SOD (P<0.01) and GR (P<0.001) enzymes in the mice hippocampus compared to those in the pilocarpine group. Conclusion: The findings of this study indicate that the antioxidant effect of pioglitazone may play an important role in its protective effects against neuronal damage caused by pilocarpine-induced seizure.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69706947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Effect of Saffron (Crocus Sativus) on Oxymetholone-induced Hepatic and Renal Injury in Rats 藏红花对氧甲氧酮所致大鼠肝肾损伤的影响

Iranian Journal of Toxicology Pub Date : 2021-01-01 DOI: 10.32598/ijt.15.4.435.2

R. Kheirandish, M. Saberi, S. Azizi, Reza Khakdan, Zahra Kordzadeh Kermani

{"title":"The Effect of Saffron (Crocus Sativus) on Oxymetholone-induced Hepatic and Renal Injury in Rats","authors":"R. Kheirandish, M. Saberi, S. Azizi, Reza Khakdan, Zahra Kordzadeh Kermani","doi":"10.32598/ijt.15.4.435.2","DOIUrl":"https://doi.org/10.32598/ijt.15.4.435.2","url":null,"abstract":"Background: Oxymetholone, an anabolic-androgenic steroid, has been used to treat some diseases. The abuse of this compound, especially for muscle growth, has severe oxidative side effects on the liver and kidneys. Oxidative stress and free radicals are responsible for the development of various diseases. Phytochemicals are sources of polyphenols, flavonoids, saponins, etc. and may act as scavengers of free radicals. Saffron (Crocus sativus) has considerable antioxidant properties, which may be useful in reversing or preventing these negative effects. Methods: To evaluate the effects of saffron on the liver and kidneys degenerative changes induced by oxymetholone, 24 male Wistar rats were used. The rats were randomly divided into four groups of six rats each as: a) sham (normal saline, 40 mg/kg/day), b) saffron control (40 mg/kg/day), c) oxymetholone (50 mg/rat), and d) treatment group [saffron (40 mg/kg/day)+oxymetholone (50 mg/rat)]. The course of examination was 30 days. Results: After one month, the sham and saffron control groups had normal histological findings. The treatment group with saffron showed a significant reduction in the hepatic and renal degenerative changes induced by oxymetholone compared to those observed in group. Conclusion: Based on the histopathological results, the use of saffron produced protective effects against the degenerative changes in rats’ liver and kidneys induced by oxymetholone.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69707076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Omega-lycotoxin on the Cognitive Impairment Induced by Kainic Acid in Rats omega -番茄毒素对葵酸所致大鼠认知功能障碍的影响

Iranian Journal of Toxicology Pub Date : 2021-01-01 DOI: 10.32598/IJT.15.1.740.1

A. Hosseini-Sharifabad, M. Mofid, M. Moradmand, M. Keimasi

引用次数: 4

Determination of Amphetamine and Methamphetamine by Dispersive Liquid Phase Micro-extraction: A Novel Experimental Approach 分散液相微萃取法测定苯丙胺和甲基苯丙胺的新实验方法

Iranian Journal of Toxicology Pub Date : 2020-10-10 DOI: 10.32598/ijt.14.4.693.2

Daruish Badakhshan, M. Ramezani

引用次数: 0

Effect of Sodium Benzoate on Apoptosis and Mitochondrial Membrane Potential After Aluminum Toxicity in PC-12 Cell Line 苯甲酸钠对PC-12细胞铝中毒后细胞凋亡及线粒体膜电位的影响

Iranian Journal of Toxicology Pub Date : 2020-10-01 DOI: 10.32598/IJT.10.4.677.1

M. Rashedinia, Jamileh Saberzadeh, Forouzan Khodaei, Najmeh Mashayekhi Sardoei, Mahshid Alimohammadi, R. Arabsolghar

引用次数: 4

Carvedilol: A Promising Drug Combined With Lipid-lowering Medications for Patients With Hypertension and Heart Failure 卡维地洛:一种有前途的药物与降脂药物联合用于高血压和心力衰竭患者

Iranian Journal of Toxicology Pub Date : 2020-10-01 DOI: 10.32598/IJT.14.4.708.1

M. Zabihi, F. Askarian, Seyed Hossein Hekmati Moghaddam, Majid Rajaee

{"title":"Carvedilol: A Promising Drug Combined With Lipid-lowering Medications for Patients With Hypertension and Heart Failure","authors":"M. Zabihi, F. Askarian, Seyed Hossein Hekmati Moghaddam, Majid Rajaee","doi":"10.32598/IJT.14.4.708.1","DOIUrl":"https://doi.org/10.32598/IJT.14.4.708.1","url":null,"abstract":"BackgroundStatins frequently cause myopathy especially in combination with fibrates, and physical activity is considered a trigger for the muscle disorder. Elevated plasma levels of creatine kinase (CK), lactate dehydrogenase (LDH) and aldolase, are the main indicators of the severity of myopathy. Carvedilol is commonly used with lipid-lowering drugs in the management of heart failure, hypertension and dyslipidemia. It is not yet clear whether carvedilol, an alpha and β blocker, and anti-oxidant, may influence the development of myopathy when combined with statins and fibrates in cardiac patients. MethodsIn this animal experiment, a 10 days regimen containing oral atorvastatin and gemfibrozil at doses of 80 and 1000 mg/kg/day, respectively, was used to induce myopathy in rats. The animals were forced to swim in a pool on days 8, 9 and 10 into the study. Carvedilol (2.5 mg/kg/day) was added to atorvastatin and gemfibrozil during the 10-day study period, in addition to the exercise protocol given to the treatment groups only. The mean of swimming tolerance times and the serum levels of CK, LDH and aldolase were measured at the completion of the study. ResultsCarvedilol did not significantly alter the swimming tolerance time or the plasma levels of CK, LDH and aldolase in the rats receiving ATV, GMF and carvedilol plus the exercise protocol, compared with those that did not receive carvedilol (P>0.05).ConclusionCarvedilol may be used in combination with lipid-lowering drug in the management of patients with heart failure and hypertension, pending its safety approval by clinical studies in humans.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"14 1","pages":"245-252"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44620783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acalypha wilkesiana ‘Inferno’ Is Nephroprotective Against Gentamicin and Cisplatin: Biochemical, Histological and Immunohistochemical Evidence 对庆大霉素和顺铂有肾保护作用:生化、组织学和免疫组织化学证据

Iranian Journal of Toxicology Pub Date : 2020-10-01 DOI: 10.32598/ijt.14.4.658.1

Christopher Larbie, B. Emikpe, A. Oyagbemi, T. Jarikre, C. O. Adjei

引用次数: 1

The Toxicity Evaluation of Salvia rhytidea and Glycine Max Extracts versus the Biochemical and Histological Indices of Liver and Kidney Functions in Mice 鼠尾草和甘氨酸提取物对小鼠肝肾功能生化和组织学指标的毒性评价

Iranian Journal of Toxicology Pub Date : 2020-10-01 DOI: 10.32598/IJT.14.4.642.1

A. Mandegary, R. Kheirandish, Sepideh Heidari, M. Mirtadzadini, A. Asadi, Navid Hassanabadi, F. Sharififar

引用次数: 0

Does Ginger Protect Against Ovarian Damage in Rats Induced by Sodium Metabisulfite Toxicity? An Experimental Evidence 生姜对偏亚硫酸氢钠毒性引起的大鼠卵巢损伤有保护作用吗？实验证据

Iranian Journal of Toxicology Pub Date : 2020-10-01 DOI: 10.32598/ijt.14.4.316.2

S. Shekarforoush, N. Rezaee, Elaheh Farzanfar

{"title":"Does Ginger Protect Against Ovarian Damage in Rats Induced by Sodium Metabisulfite Toxicity? An Experimental Evidence","authors":"S. Shekarforoush, N. Rezaee, Elaheh Farzanfar","doi":"10.32598/ijt.14.4.316.2","DOIUrl":"https://doi.org/10.32598/ijt.14.4.316.2","url":null,"abstract":"Background: Sulfites including Sodium Metabisulfite (SMB) are commonly used as food preservatives and pharmaceutical products. Despite their worldwide use, there is evidence suggesting their toxicity on human organs and tissues. The purpose of this study was to evaluate the effect of SMB with or without Zingiber officinale (ginger) extract on the rat ovary. Methods: A total of 32 adult, female Wistar rats were divided into four groups of eight each. They consisted of, a) control group, b) ginger group (500 mg/kg/day), c) SMB group (260 mg/kg/day), and d) combined SMB and ginger group at identical doses. After 28 days, the rats were sacrificed and the ovarian tissue Malondialdehyde (MDA), as a marker of lipid peroxidation was measured. The volume and weight of the ovaries and the number of follicles at different stages were counted by stereological methods. Results: The SMB treatment caused a significant decrease in the ovarian volume and the number of follicles with simultaneous increase in the number of degenerate follicles (P≤0.001) and MDA level (P≤0.01). Ginger treatment of the rats exposed to SMB significantly increased the number of follicles at various stages and partially reversed the ovarian tissue level of MDA, compared to that in the control group (P≤0.05). Conclusion: The SMB treatment induced structural changes in the rats’ ovaries and the concomitant treatment with ginger largely reversed the damages caused by SMB.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46790598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Tween 80 Toxicity in Chicken Embryos and Effect on the Kinetics of Newcastle Disease Virus Replication Tween 80对鸡胚毒性及对新城疫病毒复制动力学的影响

Iranian Journal of Toxicology Pub Date : 2020-10-01 DOI: 10.32598/ijt.14.4.671.1

S. Shahsavandi, M. Ebrahimi, M. Ghadiri, M. Samiee

引用次数: 2