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Iranian Journal of Toxicology最新文献

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Red Beetroot Extract is Safe to DNA and Protects Against Mutagens in Mice: A Potential Chemopreventive Agent 红甜菜根提取物对DNA是安全的，对小鼠的诱变有保护作用：一种潜在的化学预防剂
Iranian Journal of Toxicology Pub Date : 2024-07-18 DOI: 10.32592/ijt.18.3.138
Zhanataev, Aliy K, Lisitsyn, Artem A, Anisina, Elena A, Kulakova, Alla V, Kulakova, Alla V, Malikova, Aleksandra D, Pligina, Kira L, Chaika, Zlata V, Chernukha, Irina M
{"title":"Red Beetroot Extract is Safe to DNA and Protects Against Mutagens in Mice: A Potential Chemopreventive Agent","authors":"Zhanataev, Aliy K, Lisitsyn, Artem A, Anisina, Elena A, Kulakova, Alla V, Kulakova, Alla V, Malikova, Aleksandra D, Pligina, Kira L, Chaika, Zlata V, Chernukha, Irina M","doi":"10.32592/ijt.18.3.138","DOIUrl":"https://doi.org/10.32592/ijt.18.3.138","url":null,"abstract":"Background: The beetroot extract has long been widely used in the food industry. However, information on its genetic safety is insufficient. In addition, there is evidence to suggest its potential beneficial health effects. The aim of this study was to evaluate the genotoxic and antigenotoxic potentials of red beetroot extract in rats. Methods: The endpoints analyzed were chromosomal aberrations in bone marrow cells and DNA damage in peripheral blood, liver, kidneys, and gastrointestinal tract cells assessed using the alkaline comet assay. Results: There were no statistically significant differences between the analyzed data from the negative control and those of the groups treated with doses of beetroot extract up to 2000 mg/kg for both of the study endpoints. The findings demonstrated the absence of genotoxicity. The comet assay revealed considerable antigenotoxicity of the beetroot extract (5-100 mg/kg) in the liver, stomach, duodenum, and rectum versus the effects of methyl methanesulfonate and dioxidine mutagens with different mechanisms of action. No anticlastogenic activities were detected in the bone marrow cells while observing the protective effects on blood cells, indicating the tissue specificity for beetroot extract antigenotoxicity. Conclusion: Based on the study findings, the beetroot extract meets the basic requirements for being a chemopreventive agent. The advantages are low cost, practicality of use, efficacy, and safety. Moreover, this agent may be used to develop food products with chemopreventive properties.","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"1 1","pages":"138-143"},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"http://ijt.arakmu.ac.ir/files/site1/user_files_3a0bf3/alexandramalikova-A-10-1212-1-4d0c0f8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147902588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Impact of Sodium Metabisulfite on Oxidative Stress, Hormones, and Reproductive Tissue in Female Wistar Rats 焦亚硫酸钠对雌性 Wistar 大鼠氧化应激、激素和生殖组织的影响
Iranian Journal of Toxicology Pub Date : 2024-01-01 DOI: 10.61186/ijt.18.1.6
N. Amedu, Elizabeth Ajayi
{"title":"Impact of Sodium Metabisulfite on Oxidative Stress, Hormones, and Reproductive Tissue in Female Wistar Rats","authors":"N. Amedu, Elizabeth Ajayi","doi":"10.61186/ijt.18.1.6","DOIUrl":"https://doi.org/10.61186/ijt.18.1.6","url":null,"abstract":"","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"2 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140520084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective Effects of Kleinhovia Hospita Leaf Extract against Triton X-100-Induced Hypercholesterolemia in Rats Kleinhovia Hospita 叶提取物对 Triton X-100 诱导的大鼠高胆固醇血症的保护作用
Iranian Journal of Toxicology Pub Date : 2024-01-01 DOI: 10.61186/ijt.18.1.1
Andi Irma Suryani, Yulia Yusrini, Abdul Rahim, Tiara Minarfa
{"title":"Protective Effects of Kleinhovia Hospita Leaf Extract against Triton X-100-Induced Hypercholesterolemia in Rats","authors":"Andi Irma Suryani, Yulia Yusrini, Abdul Rahim, Tiara Minarfa","doi":"10.61186/ijt.18.1.1","DOIUrl":"https://doi.org/10.61186/ijt.18.1.1","url":null,"abstract":"","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"4 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the Anti-fertility Potentials of 3-Monochloropropane-1, 2-diol (Alpha-Chlorohydrin) and Testosterone in Adult Male Wild Nile Grass Rats (Arvicanthis niloticus) for Rodent Control 评估 3-甲氯丙烷-1, 2-二醇（α-氯醇）和睾酮对成年雄性尼罗河野生草鼠（Arvicanthis niloticus）的抗生育潜能，以控制鼠害
Iranian Journal of Toxicology Pub Date : 2024-01-01 DOI: 10.61186/ijt.18.1.29
Mahmoud Ashry, Zeinab Hassan, Magdy Wilson, MohsenA Moustafa, Ayat Taha
{"title":"Evaluating the Anti-fertility Potentials of 3-Monochloropropane-1, 2-diol (Alpha-Chlorohydrin) and Testosterone in Adult Male Wild Nile Grass Rats (Arvicanthis niloticus) for Rodent Control","authors":"Mahmoud Ashry, Zeinab Hassan, Magdy Wilson, MohsenA Moustafa, Ayat Taha","doi":"10.61186/ijt.18.1.29","DOIUrl":"https://doi.org/10.61186/ijt.18.1.29","url":null,"abstract":"","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"40 23","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140518062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apoptotic Effect of Phycocyanin on HT-29 Colon Cancer through Activation of Caspase Enzymes and P53 Cell Signaling Pathway 植物花青素通过激活 Caspase 酶和 P53 细胞信号通路对 HT-29 结肠癌产生凋亡效应
Iranian Journal of Toxicology Pub Date : 2024-01-01 DOI: 10.61186/ijt.18.1.39
Abbas Asoudeh-Fard, Reza Najafipour, Mitra Salehi, Mahsa Mahmoudi, Iman Salahshourifar, A. Eghdami, Asghar Parsaei, Hossein Piri
{"title":"Apoptotic Effect of Phycocyanin on HT-29 Colon Cancer through Activation of Caspase Enzymes and P53 Cell Signaling Pathway","authors":"Abbas Asoudeh-Fard, Reza Najafipour, Mitra Salehi, Mahsa Mahmoudi, Iman Salahshourifar, A. Eghdami, Asghar Parsaei, Hossein Piri","doi":"10.61186/ijt.18.1.39","DOIUrl":"https://doi.org/10.61186/ijt.18.1.39","url":null,"abstract":"","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"12 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140520857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Sodium Benzoate on Motor Coordination, Cerebellar Purkinje Cell Layer, and Oxidative Stress in Wistar Rats’ Brain 苯甲酸钠对 Wistar 大鼠运动协调性、小脑浦肯野细胞层和脑氧化应激的影响
Iranian Journal of Toxicology Pub Date : 2024-01-01 DOI: 10.61186/ijt.18.1.14
Nathaniel Amedu, Rodiat Adeleye, Habeebullahi Abdur-Rahman, Patrick Abolarin, Gabriel Omotoso
{"title":"Impact of Sodium Benzoate on Motor Coordination, Cerebellar Purkinje Cell Layer, and Oxidative Stress in Wistar Rats’ Brain","authors":"Nathaniel Amedu, Rodiat Adeleye, Habeebullahi Abdur-Rahman, Patrick Abolarin, Gabriel Omotoso","doi":"10.61186/ijt.18.1.14","DOIUrl":"https://doi.org/10.61186/ijt.18.1.14","url":null,"abstract":"","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alginate Lyase from Streptomyces olivaceus is a Safe and Effective Antibiofilm in Male Wistar Rats (Rattus norvegicus) 橄榄链霉菌的藻酸盐裂解酶对雄性 Wistar 大鼠（Rattus norvegicus）具有安全有效的抗生物膜作用
Iranian Journal of Toxicology Pub Date : 2024-01-01 DOI: 10.61186/ijt.18.1.45
Resi Tondho Jimat, S. Ethica, N. Rahmani, Siti Eka Yulianti, R. Rachmayati, Nuryati Nuryati, A. Atikana, S. Ratnakomala, P. Lisdiyanti, Yopi Yopi, D. Zilda, Maya Dian Rakhmawatie
{"title":"Alginate Lyase from Streptomyces olivaceus is a Safe and Effective Antibiofilm in Male Wistar Rats (Rattus norvegicus)","authors":"Resi Tondho Jimat, S. Ethica, N. Rahmani, Siti Eka Yulianti, R. Rachmayati, Nuryati Nuryati, A. Atikana, S. Ratnakomala, P. Lisdiyanti, Yopi Yopi, D. Zilda, Maya Dian Rakhmawatie","doi":"10.61186/ijt.18.1.45","DOIUrl":"https://doi.org/10.61186/ijt.18.1.45","url":null,"abstract":"","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140520234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure of Parental Rats to Mercury Chloride during Progenesis Affects the CNS Parameters of the Adult Offspring 亲代大鼠在生殖过程中接触氯化汞会影响成年后代的中枢神经系统参数
Iranian Journal of Toxicology Pub Date : 2024-01-01 DOI: 10.61186/ijt.18.1.21
V. Vokina, Larisa Sosedova, Natalya Yakimova, Ekaterina Kapustina
{"title":"Exposure of Parental Rats to Mercury Chloride during Progenesis Affects the CNS Parameters of the Adult Offspring","authors":"V. Vokina, Larisa Sosedova, Natalya Yakimova, Ekaterina Kapustina","doi":"10.61186/ijt.18.1.21","DOIUrl":"https://doi.org/10.61186/ijt.18.1.21","url":null,"abstract":"","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Lactobacillus acidophilus Supernatant: An Effective and Safe Alternative to Antibiotics 嗜酸乳杆菌上清液：抗生素有效而安全的替代品
Iranian Journal of Toxicology Pub Date : 2024-01-01 DOI: 10.61186/ijt.18.1.52
S. Soleymanzadeh Moghadam, Sara Minaeian, Ali Majidpour, Mahdi Adabi, Reza Hosseini Doust
{"title":"The Lactobacillus acidophilus Supernatant: An Effective and Safe Alternative to Antibiotics","authors":"S. Soleymanzadeh Moghadam, Sara Minaeian, Ali Majidpour, Mahdi Adabi, Reza Hosseini Doust","doi":"10.61186/ijt.18.1.52","DOIUrl":"https://doi.org/10.61186/ijt.18.1.52","url":null,"abstract":"","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"50 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140520318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective Effect of Ethylacetate Fraction of Antiaris Africana against Sodium Azide-Induced Neurotoxicity in the Striata of Male Wistar Rats 非洲荆芥乙酸乙酯部位对叠氮化钠致雄性Wistar大鼠纹状体神经毒性的保护作用
Iranian Journal of Toxicology Pub Date : 2023-10-01 DOI: 10.61186/ijt.17.4.1
Omotayo Ilesanmi, Mercy Inala, Abiodun Ridwan
{"title":"Neuroprotective Effect of Ethylacetate Fraction of Antiaris Africana against Sodium Azide-Induced Neurotoxicity in the Striata of Male Wistar Rats","authors":"Omotayo Ilesanmi, Mercy Inala, Abiodun Ridwan","doi":"10.61186/ijt.17.4.1","DOIUrl":"https://doi.org/10.61186/ijt.17.4.1","url":null,"abstract":"Neuroprotective Effect of Ethylacetate Fraction of Antiaris Africana against Sodium Azide-Induced Neurotoxicity in the Striata of Male Wistar Rats","PeriodicalId":14637,"journal":{"name":"Iranian Journal of Toxicology","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136198626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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