Iranian Journal of Medical Physics最新文献_第4页

MAGIC-f gel dosimeter reading: a comparison between an in-house optical CT and MRI imaging MAGIC-f凝胶剂量计读数：内部光学CT和MRI成像的比较

Iranian Journal of Medical Physics Pub Date : 2021-02-27 DOI: 10.22038/IJMP.2021.53179.1876

Z. Mansouri, A. Mostaar, M. Shiri, M. Shahabi

{"title":"MAGIC-f gel dosimeter reading: a comparison between an in-house optical CT and MRI imaging","authors":"Z. Mansouri, A. Mostaar, M. Shiri, M. Shahabi","doi":"10.22038/IJMP.2021.53179.1876","DOIUrl":"https://doi.org/10.22038/IJMP.2021.53179.1876","url":null,"abstract":"Introduction: According to new developments in radiation therapy techniques, accurate ‎dose verification in three-dimensions has become more critical. Polymer gel dosimeters ‎‎(PGDs) are valuable tools to be used for this purpose. Nowadays, various imaging ‎modalities are employed to read out the gels. This study was aimed to investigate the ‎measured dose distribution recorded in MAGIC-f PGD with optical computed tomography ‎‎(OCT) by comparison with MRI. ‎Material and methods: We developed an in-house CCD based cone-beam OCT scanner. A ‎phantom of MAGIC-f PGD was used to measure a four-field box dose distribution. MRI and ‎OCT scanners were performed for gel readouts. Both measurement results were compared ‎by gamma index analysis with various acceptance criteria. The temporal stability of the gel ‎was also evaluated with the OCT readout system.‎Results: The percentage of isodose lines from two measured datasets agreed well together. ‎The pass rates were 99.02%, 96.8%, and 89.8% with 5%/5mm, 4%/4mm, and 3%/3mm ‎criteria, respectively, at the phantom's central axial slice. ‎Conclusion: The results indicate that the performance of this OCT system is almost the ‎same with acceptable discrepancies to the MRI as accepted standard readout modality, and ‎it can be used for three-dimensional dose verifications.‎","PeriodicalId":14613,"journal":{"name":"Iranian Journal of Medical Physics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44124135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Time-Dependent Induction of the Nucleotide Excision Repair Gene XPA and RAD51 in Homologous Recombination in Human Lymphocytes Exposed to Low Doses of Ionizing Radiation 核苷酸切除修复基因XPA和RAD51在低剂量电离辐射下人淋巴细胞同源重组中的时间依赖性诱导

Iranian Journal of Medical Physics Pub Date : 2021-02-23 DOI: 10.22038/IJMP.2021.53719.1884

M. Toossi, S. Khademi, H. Azimian

{"title":"Time-Dependent Induction of the Nucleotide Excision Repair Gene XPA and RAD51 in Homologous Recombination in Human Lymphocytes Exposed to Low Doses of Ionizing Radiation","authors":"M. Toossi, S. Khademi, H. Azimian","doi":"10.22038/IJMP.2021.53719.1884","DOIUrl":"https://doi.org/10.22038/IJMP.2021.53719.1884","url":null,"abstract":"Introduction: The aim of the present study was to understand the effect of low-doses of ionizing radiation (LDIR) on repair genes expression in blood samples that were taken from healthy donors. The next purpose was to examine the time-effect on the modified gene expression caused by low-doses of ionizing radiation. Material and method: The RNA of peripheral blood lymphocytes (PBLs) taken from four healthy donors was isolated at different time points after exposure included 4, 24, 48, 72, and 168 hours and then cDNA was synthesized. Modification of XPA and RAD51 expression levels due to LDIR (2, 5, 10 cGy) were evaluated by relative quantitative reverse transcription-polymerase chain reaction.Results: Significant up-regulation of both repair genes was observed at the 4 and 168 h following to 10 cGy. Also, this dose could increase expression levels of RAD51 at 48 and 72 h after radiation. For lower doses at 5 cGy, only XPA levels were significantly up-regulated after 168 h. A significant regression was found between the XPA levels and the dose, at 168 h after irradiation to PBLs that can represent a new potential biomarker for biological dosimetry purposes.Conclusion: The results of this study could support the hypothetical role of the different DNA repair pathways in response to LDIR. This led us to propose a molecular biodosimetry method for ionizing radiation in the range of LDIR.","PeriodicalId":14613,"journal":{"name":"Iranian Journal of Medical Physics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47429986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Energy window optimization for Bremsstrahlung Y90 SPECT-CT imaging : a phantom study 轫致辐射Y90 SPECT-CT成像的能量窗优化:一项幻象研究

Iranian Journal of Medical Physics Pub Date : 2021-02-14 DOI: 10.22038/IJMP.2021.51256.1837

D. Curto, F. Bonutti, Youssef Bouzekraoui, Hicham Asmi, F. Bentayeb

引用次数: 0

Synthesis of colloidal silver, platinum, and mixture of silver-platinum nanoparticles using pulsed laser ablation as contrast agent in computed tomography 在计算机断层扫描中使用脉冲激光烧蚀作为造影剂合成胶体银、铂和银-铂纳米颗粒混合物

Iranian Journal of Medical Physics Pub Date : 2021-01-28 DOI: 10.22038/IJMP.2021.51781.1849

A. Khumaeni, M. Alhamid, C. Anam, A. Budiono

{"title":"Synthesis of colloidal silver, platinum, and mixture of silver-platinum nanoparticles using pulsed laser ablation as contrast agent in computed tomography","authors":"A. Khumaeni, M. Alhamid, C. Anam, A. Budiono","doi":"10.22038/IJMP.2021.51781.1849","DOIUrl":"https://doi.org/10.22038/IJMP.2021.51781.1849","url":null,"abstract":"Introduction : Over the last seven years, the development of nanoparticles as computed tomography (CT) contrast agents has increased significantly. In this present work, syntheses of colloidal silver nanoparticles (Ag NPs), platinum nanoparticles (Pt NPs), and silver-platinum nanoparticles (Ag-Pt NPs) have been successfully performed using pulsed laser ablation method in deionized water media.Materials and Methods : Experimentally, an neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (1064 nm, 45 mJ, 10 Hz) was focused on a high-purity metal plate including Ag and Pt plates, which are placed in deionized water medium. Colloidal Ag NPs has been succesfully produced with a dark brownish-yellow color with an averaged diameter of 24 nm. For colloidal Pt NPs, the liquid has transparent color with an averaged diameter of 20 nm. Both colloidal nanoparticles of Ag and Pt were then mixed to obtain a mixture composition of Ag and Pt with ratios of Ag:Pt of 75:25%, 50:50%, 25:75%, respectively, with a concentration of each of 10 part per million (ppm). The Ag NPs, Pt NPs, and Ag-Pt NPs mixture were then examined as contrast agents in computed tomography (CT) scan. The CT Scan was set at 80 kV and 100 mAs. Results: The imaging results of these agents were measured in Hounsfield Unit (HU), showing 13.5, 12.8, 13.3, 14.1, and 17.3 HUs for colloidal Ag NPs only, colloidal Ag and Pt NPs with ratios of Ag:Pt of 75:25%, 50:50%, 25:75%, and colloidal Pt NPs only, respectively.Conclusion: These findings confirmed that for colloidal solution containing high concentration of platinum (Pt NPs only and colloidal Ag and Pt NPs with ratio of 25:75%) has higher HU values compared to the case of Pt NPs. The higher HU value for platinium can be attributed to its higher density.","PeriodicalId":14613,"journal":{"name":"Iranian Journal of Medical Physics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41365111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing A Method for Inter-Seed Effect Correction in 125I Interstitial Brachytherapy Using Artificial Neural Network 利用人工神经网络建立125I间质近距离治疗种子间效应校正方法

Iranian Journal of Medical Physics Pub Date : 2021-01-05 DOI: 10.22038/IJMP.2021.50066.1814

Kheibar Bayati, S. Sina, R. Faghihi, Vahed Moharram Zadeh, M. Papie

{"title":"Developing A Method for Inter-Seed Effect Correction in 125I Interstitial Brachytherapy Using Artificial Neural Network","authors":"Kheibar Bayati, S. Sina, R. Faghihi, Vahed Moharram Zadeh, M. Papie","doi":"10.22038/IJMP.2021.50066.1814","DOIUrl":"https://doi.org/10.22038/IJMP.2021.50066.1814","url":null,"abstract":"Introduction: Treatment planning systems use TG-43 dose calculation protocol for brachytherapy sources. Dose calculations based on TG-43 formalism do not correct the perturbations due to the presence of tissue inhomogeneity, applicators, and inter-seed effects. Inter-seed attenuation has an important effect on dosimetry in permanent implant brachytherapy. The aim of this study is to evaluate the inter-seed attenuation effect for I-125 permanent implants. Then, a software was developed to find the real dose distribution for different combinations of sources. Materials and methods: In the first step, a hypothetical generic source model was designed based on the configurations of different commercial source types. MCNP5 Monte Carlo code was utilized to simulate the single active generic source at the center of the phantom, and an inactive placed at various positions inside the phantom. An algorithm was introduced using artificial neural network models that can estimate the dose distribution in presence of inactive sources. Results: The Monte Carlo calculation results showed that the dose distribution is clearly affected by the inter-seed attenuation effect. Comparison of the artificial neural network results with the Monte Carlo simulation results show that the artificial neural networks can predict the inter-seed attenuation with acceptable accuracy, and with not much greater than 3% deviation.Discussion and conclusions: Inter-seed effect is dependent on the distance between the seeds. Decreasing distances would cause more effect. According to the results, it seems that the artificial neural network can be used as a tool for correction of inter-seed attenuation effect in treatment planning systems.","PeriodicalId":14613,"journal":{"name":"Iranian Journal of Medical Physics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45322657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beam Modeling in Commercial Treatment Planning System for IMRT and VMAT performance with an Elekta MLCI2 Multileaf Collimator. Elekta MLCI2多叶准直器用于IMRT和VMAT性能的商业治疗计划系统中的波束建模。

Iranian Journal of Medical Physics Pub Date : 2020-12-26 DOI: 10.22038/IJMP.2020.48297.1845

Yasser Raoui, Yassine Herrassi, Khalid Elouardy, R. Sebihi, M. Ayad, V. P. Pandey

{"title":"Beam Modeling in Commercial Treatment Planning System for IMRT and VMAT performance with an Elekta MLCI2 Multileaf Collimator.","authors":"Yasser Raoui, Yassine Herrassi, Khalid Elouardy, R. Sebihi, M. Ayad, V. P. Pandey","doi":"10.22038/IJMP.2020.48297.1845","DOIUrl":"https://doi.org/10.22038/IJMP.2020.48297.1845","url":null,"abstract":"Linear accelerator multileaf collimator requires to be tested with best possible quality assurance tools and accordingly treatment planning system input with the data for appropriate modelling of MLC. Dose calculation is affected due to MLC modelling, especially when using the high standard techniques of treatment like IMRT or VMAT. An MLCI 2 multileaf collimator is verified by 2D detector matrix (IBA dosimetry, Germany) using the quality assurance kit Express QA test package & clinical cases verification. The standard plan in QA mode is made in TPS and delivered under medical linear accelerator like pre-treatment verification.The measured and calculated fluence is compared and accordingly the Gamma analysis done. Express QA tests & clinical cases fields showed a great agreement with TPS calculations with 3% DD and 3 mm DTA Gamma criteria. The open field 10 x 10 cm² and 20 x 20 cm² found to be passed with 100% results for 3% &3mm criteria. 3ABUT test helped in setting the leaf offset value from default 0.0mm to 0.15mm. FourL test provides adjustment in leaf transmission value and leaf groove width from 0.012 to 0.0073 and 1.0mm to 0.7mm respectively. The H&N and Prostate clinical cases passed with more than 95% for set criteria (3%DD&3mm).The absolute point dose measurement agreement was found to be more than 97%.This study confirmed that the appropriate MLC check before starting IMRT and VMAT in clinic and even after any repair is required thorough quality assurance check using Express QA and TG 119 package. Small changes in the MLC parameters like leaf offset, groove width and transmission n the TPS model can cause large changes in the calculated dose.At least annually Express QA test is recommended to be performed by every user to confirm the status of changed MLC parameters in due course of time.","PeriodicalId":14613,"journal":{"name":"Iranian Journal of Medical Physics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46259794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fetal dosimetry for 18F-FDG PET Imaging during pregnancy: a comparative Monte Carlo study 妊娠期18F-FDG PET成像的胎儿剂量测定：蒙特卡罗比较研究

Iranian Journal of Medical Physics Pub Date : 2020-12-26 DOI: 10.22038/IJMP.2020.52305.1860

Nadia Zarghi, S. H. Miri-Hakimabad, E. Hoseinian-Azghadi, N. Mohammadi

{"title":"Fetal dosimetry for 18F-FDG PET Imaging during pregnancy: a comparative Monte Carlo study","authors":"Nadia Zarghi, S. H. Miri-Hakimabad, E. Hoseinian-Azghadi, N. Mohammadi","doi":"10.22038/IJMP.2020.52305.1860","DOIUrl":"https://doi.org/10.22038/IJMP.2020.52305.1860","url":null,"abstract":"Abstract:Introduction: Current reported values of fetal doses from 18F-FDG in pregnant women imaged with PET scan showed a large variation. This study aimed to evaluate fetal radiation doses using the last generation of computational pregnant phantoms and also to shed light on one of the uncertainty components of the fetal dose.Materials and Methods: In this respects, we used a BREP series of computational pregnant phantoms to evaluate radiation doses to the fetus. We also reviewed available data on fetal time-integrated activities and evaluated the confidence and prediction (95%) intervals for the existing data. By doing this, the uncertainty of fetal Biokinetic data was taken into account in fetal dose calculations.Results: The fetal doses of 2.30E-02, 1.53E-02, and 1.02E-02 mGy/MBq at 3, 6 and 9 month of gestation were estimated. The results also showed the contributions of source organs to the fetal doses. The maternal “urinary bladder contents” and “other organs and tissues” are the main source regions contributing to fetal dose. We also indicated that the Biokinetic variation caused a large uncertainty on fetal dose (with prediction interval from 1.73E-02 to 3.93E-02 mGy/MBq) at first trimester of pregnancy, while it is much lower at second and third trimesters. Furthermore, it is indicated that variations on fetal dose outside the determined intervals may be related to the geometrical differences of used computational phantoms.Conclusions: Since the fetal dose is much higher and the radiation exposure is more deterministic at first trimester of pregnancy, attempting to accurately evaluate the fetal dose is relevant at this stage.","PeriodicalId":14613,"journal":{"name":"Iranian Journal of Medical Physics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48852289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of IMRT plans with and without bone marrow sparing for the treatment of cervical cancer 骨髓保留和不保留治疗宫颈癌的IMRT方案的比较

Iranian Journal of Medical Physics Pub Date : 2020-12-15 DOI: 10.22038/IJMP.2020.51442.1841

Sri Krishna Gangarapu, Srinivas Vuppu

引用次数: 0

Sonodynamic therapy of mice breast adenocarcinoma: An in vivo study with hematoporphyrin encapsulated mesoporous silica nanoparticles 声动力治疗小鼠乳腺腺癌:血卟啉包封介孔二氧化硅纳米颗粒的体内研究

Iranian Journal of Medical Physics Pub Date : 2020-12-09 DOI: 10.22038/IJMP.2020.50881.1831

S. Souri, M. Jadidi, H. Hasanzadeh, Tahereh Khani, V. Semnani

{"title":"Sonodynamic therapy of mice breast adenocarcinoma: An in vivo study with hematoporphyrin encapsulated mesoporous silica nanoparticles","authors":"S. Souri, M. Jadidi, H. Hasanzadeh, Tahereh Khani, V. Semnani","doi":"10.22038/IJMP.2020.50881.1831","DOIUrl":"https://doi.org/10.22038/IJMP.2020.50881.1831","url":null,"abstract":"ABSTRACTIntroduction: According to high mortality rate due to cancer and side effects of invasive treatments, the noninvasive method such as sonodynamic therapy for breast adenocarcinoma is considerable. Encapsulation of sonosensitizer in nanoparticles can improve the accumulation of these agents in the tumor tissue and decrease in drug side effect. Hence, sonodynamic therapy (SDT) with 1MHz ultrasound (US), hematoporphyrin (HP) and hematoporphyrin encapsulated mesoporous silica nanoparticles (HP-MSN) in breast adenocarcinoma was carried out.Material and Methods: Female Inbred Balb/C mice with grafted breast adenocarcinoma were divided to 16 groups: control, sham, HP (2.5 and 5 mg/kg), HP-MSN (2.5 and 5 mg/kg), 1MHz US (1 and 2 W/cm2), SDT+HP (2.5 and 5 mg/kg) and SDT+HP-MSN (2.5 and 5 mg/kg). The relative volume, tumor growth inhibition ratio (TGI) and the time of tumor growth (T2 and T5-times) evaluated 30-days after treatment.Results: Analysis of data showed the groups of SDT (2 W/cm2)+HP-MSN (5 mg/kg) and SDT (1 W/cm2)+HP-MSN (5 mg/kg) indicated anti-tumor effects from days 18 to 27 after treatment. TGI% in these groups was 45 and 42% respectively and the time of T2 and T5 is greater than that in the control and sham. Kaplan-Meier analysis revealed that the 44-day survival was 95% for the group treated with SDT (2 W/cm2)+HP-MSN (5 mg/kg). All experimental groups had a poorly differentiated grading except of SDT (2 W/cm2)+HP-MSN (5 mg/kg) group which has a moderately differentiated degree based on Bloom-Richardson classification.Conclusion:Based on this study, sonodynamic therapy with 1MHz US (2 W/cm2)+HP-MSN (5 mg/kg) have an anti-tumor effect.","PeriodicalId":14613,"journal":{"name":"Iranian Journal of Medical Physics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41530741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of radiation treatment planning by computed tomography metal artifact reduction algorithm 用计算机断层扫描金属伪影减少算法评估放射治疗计划

Iranian Journal of Medical Physics Pub Date : 2020-12-09 DOI: 10.22038/IJMP.2020.52418.1864

Kyungjin Kim, Jihun Choi, Joo-Wan Hong, Jaeouk Ahn

{"title":"Evaluation of radiation treatment planning by computed tomography metal artifact reduction algorithm","authors":"Kyungjin Kim, Jihun Choi, Joo-Wan Hong, Jaeouk Ahn","doi":"10.22038/IJMP.2020.52418.1864","DOIUrl":"https://doi.org/10.22038/IJMP.2020.52418.1864","url":null,"abstract":"Introduction: The objective of this study was to evaluate the usefulness of Computed Tomography(CT) images acquired through repeated subtraction reconstruction algorithms to reduce metal artifacts in CT Treatment Planning System(TPS).Materials and methods: Origin images of Gammex phantom and Rando phantom and non orthopedic metal artifact reduction(O-MAR) images were obtained after high density implantation. O-MAR applied images were also obtained. For evaluation of images, regions of interest(ROI) were set at five tissue rods and three points directly affected by artifacts in Gammex phantom. CT number and noise were compared and analyzed. To investigate dose change according to CT number change of the surrounding artifact, a three virtual cylindrical target volume was formed on Rando phantom CT images. The average dose was then compared and analyzed.Results: CT number difference according to the application of O-MAR showed significant difference among lung and bone rod and 3 ROI directly affected. Noise difference according to O-MAR application was significantly different in rod except for bone rod. In the treatment plan using Rando phantom, non-O-MAR and O-MAR images showed -4.3 ~ 1.9% and -0.4 ~ 2.3% dose differences, respectively.Conclusion: Applying a metal artifact reduction reconstruction algorithm can reduce image distortion due to high density implantation, improve image quality, and correct CT number.","PeriodicalId":14613,"journal":{"name":"Iranian Journal of Medical Physics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45517133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0