IOSR Journal of Pharmacy最新文献_第6页

Development of Analytical Procedure for the Quantification of “Fatsiflogin” “Fatsiflogin”定量分析方法的研制

IOSR Journal of Pharmacy Pub Date : 2017-03-01 DOI: 10.9790/3013-0703019699

M. Getia, V. Mshvildadze, A. Pichette, G. Dekanosidze, Z. Kemoklidze

{"title":"Development of Analytical Procedure for the Quantification of “Fatsiflogin”","authors":"M. Getia, V. Mshvildadze, A. Pichette, G. Dekanosidze, Z. Kemoklidze","doi":"10.9790/3013-0703019699","DOIUrl":"https://doi.org/10.9790/3013-0703019699","url":null,"abstract":"“Fatsiflogin” is an original, nonsteroidal para-medical preparation from the leaves of Fatsia japonica with anti-rheumatic, anti-inflammatory and analgesic activities. Fatsioside D (tetraosid of hederagenin) as one of the major compound of “Fatsiflogin”, was selected as a chemical markerfor the quantitative validation. The objective of this study is to develop a simple and reliable HPLC method for the determination of Fatsiosid D for quality control studies of “Fatsiflogin”. FatsiosideD was purified by preparative HPLC and the structure of the compound was determined by NMR. HPLC separation was performed on an intertsil prep-ODS C18 column, with a solvent system water-acetonitrile. The UV detection is performed at 205 nm. The proposed HPLC method is linear in the range studied (r 2 > 0.999) for all the analytes. The method is precise with intraand inter-day variations of less than 3.34%. The mean recoveries of the analytes range from 99.68 to 100.29%. The method is successfully applied to the quantification of Fatsioside D. The results indicated that developed HPLC method could be used for the quality control of “Fatsiflogin”.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"75 1","pages":"96-99"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86338869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Evaluation Of Skeletal Muscle Relaxant Activity Of Ethanol Extract Of Chromoleana Odorata 桔梗乙醇提取物骨骼肌松弛活性的评价

IOSR Journal of Pharmacy Pub Date : 2017-03-01 DOI: 10.9790/3013-0703019295

A. Shetty, N. Vinutha, Sagar F. Udasimath, Kalleshappa C.M., Krupanidhi A.M., A. Akshara

引用次数: 1

A review on Fagopyrum esculentum: A potential medicinal plant 药用植物荞麦的研究进展

IOSR Journal of Pharmacy Pub Date : 2017-03-01 DOI: 10.9790/3013-0703012132

A. Al-Snafi

引用次数: 25

The pharmacological and therapeutic importance of Eucalyptus species grown in Iraq 伊拉克桉树的药理和治疗意义

IOSR Journal of Pharmacy Pub Date : 2017-03-01 DOI: 10.9790/3013-0703017291

A. Al-Snafi

引用次数: 43

Chemical composition, free radical scavenging and antifungal activity ofZanthoxylumleprieuriiessential oils against Epidermophytonfloccosum and Trichophytonrubrum 花椒精油对絮状表皮植物和毛癣菌的化学成分、自由基清除及抗真菌活性研究

IOSR Journal of Pharmacy Pub Date : 2017-03-01 DOI: 10.9790/3013-0703010106

Tchabong Tchabong, Jazet, Sameza D.P.M., T. M.L., N. S. Mounbain, F. Mouelle, Menut S.A., F. Tchoumbougnang

{"title":"Chemical composition, free radical scavenging and antifungal activity ofZanthoxylumleprieuriiessential oils against Epidermophytonfloccosum and Trichophytonrubrum","authors":"Tchabong Tchabong, Jazet, Sameza D.P.M., T. M.L., N. S. Mounbain, F. Mouelle, Menut S.A., F. Tchoumbougnang","doi":"10.9790/3013-0703010106","DOIUrl":"https://doi.org/10.9790/3013-0703010106","url":null,"abstract":"Background: These investigations were carried out to analyze the chemical composition, to evaluate the radical scavenging, and the anti-fungal activities of essential oils from leaves and fruits of Zanthoxylumleprieurii. Methods: Oils were obtained by hydro distillation using Clevenger-type apparatus. The compounds were identified by gas chromatography and gas chromatography coupled with Mass Spectrometry. Antifungal activity of the essential oils was tested in vitro against Epidermophytonfloccosum and Trichophytonrubrumwhile free radical scavenging activity evaluation was done using 2,2-diphenyl picrylhydrazyl method. Results: Results showed that, the major components of the leaves oil were (E)-ß-ocimene (91.5 %) while the most abundant component from fruits oil were (E)-ß-Ocimene (90.3 %). The total growth inhibition of the pathogens by fruits essential oil occurred at 4.0 mg/ml and 3.0 mg/ml respectively, forEpidermophytonfloccosum and Trichophytonrubrum. The leaves oil exhibited total growth inhibition at 4.0 mg/ml against both pathogens. These oils also showed antioxidant activities with SC50 values at 2.0 mg/ml and 5.0 mg/ml respectively, for fruits and leaves. There were positive and significant correlations between mycelia growth inhibition of both pathogens and the antioxidant activities of the tested oils noted. Conclusion: These results showed that, Z. leprieurii essential oils could be used as a resource of antioxidant and antidermatophitic compounds with may find applications in pharmaceutical industries.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"42 2 1","pages":"01-06"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86805829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Pharmacology and therapeutic potential of Euphorbia hirta (Syn: Euphorbia pilulifera)- A review 大戟(Euphorbia pilulifera)的药理作用及治疗潜力综述

IOSR Journal of Pharmacy Pub Date : 2017-03-01 DOI: 10.9790/3013-0703010720

A. Al-Snafi

引用次数: 45

Nutritional and pharmacological importance of Ficus carica - A review 无花果的营养和药理作用综述

IOSR Journal of Pharmacy Pub Date : 2017-03-01 DOI: 10.9790/3013-0703013348

A. Al-Snafi

引用次数: 36

Pharmacology of Ficus religiosa- A review 榕树的药理研究进展

IOSR Journal of Pharmacy Pub Date : 2017-03-01 DOI: 10.9790/3013-0703014960

A. Al-Snafi

引用次数: 32

Comparative study on anointment promoted for Vitiligo Vis-À- Vis Tolenormointment in causing Immediate Pigment Darkening 白癜风药膏促进剂-À-白癜风即刻色素变黑的比较研究

IOSR Journal of Pharmacy Pub Date : 2017-01-01 DOI: 10.9790/3013-0701010103

Aruna., R. Priya, S. Mukherjee, G. Rajagopal

引用次数: 0

Assessment of Anti Hypertensive Drugs In Ckd Patients Ckd患者抗高血压药物的评价

IOSR Journal of Pharmacy Pub Date : 2016-08-01 DOI: 10.9790/3013-068021621

N. D. Devi, M. Priyanka, A. Swathi, Jasti.Krishna Sai, Kishore Babu

{"title":"Assessment of Anti Hypertensive Drugs In Ckd Patients","authors":"N. D. Devi, M. Priyanka, A. Swathi, Jasti.Krishna Sai, Kishore Babu","doi":"10.9790/3013-068021621","DOIUrl":"https://doi.org/10.9790/3013-068021621","url":null,"abstract":"Hypertension is common in hemodialysis patients and can often be difficult to control. Considering the high cardiovascular burden in hemodialysis patients, control of blood pressure is important to improve outcomes. This study is conducted to assess the anti hypertensive drugs treatment in chronic kidney disease (CKD) patients. This is a prospective observational study and includes information regarding CKD patients with co-morbidities like T2DM and HTN and it is conducted among 15 patients which were of both males and females of above 20 yrs of age upto 80 yrs. For these 15 patients e GFR is calculated and stage of severity of CKD was found. Patients with T2DM and Hypertensive are mostly diagnosed with CKD. Loop diuretic (Furosemide)+ calcium channel blocker (Amlodipine) this combination is prescribed more which is found to be safe for CKD patients as for this combination dosage adjustment is not required. In our study among 15 CKD patients 7 dialysis patients were included, majority of the patients have controlled SBP with the anti- hypertensive combinations. acute myocardial infarction 1-3 . They remain the firstline therapy for patients with cardiovascular (CV) disease. Similarly, in patients with diabetic and non-diabetic kidney disease, several large trials have demonstrated their effectiveness in reducing proteinuria and delaying progression of chronic kidney disease. The major adverse effects associated with ACEI and ARB use are hyperkalemia, decrease in glomerular filtration rate (GFR), and erythropoietin resistance. The risk of hyperkalemia increases with the degree of decrease in GFR in the nondialysis population 4 . The most common pattern of BP in dialysis patients is systolic hypertension associated with a wide pulse pressure due to atherosclerotic arterial stiffness. The main pathogenic mechanisms of hypertension in dialysis patients. Extracellular fluid overload is the most common feature in hypertensive dialysis patients. Indeed, insufficient volume removal is often the major factor responsible for dialysis-refractory hypertension 5-9","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"22 3 1","pages":"16-21"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79809171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0