IOSR Journal of Pharmacy最新文献_第7页

Different subgroups regarding the absence of rescue therapy in intravenous immunoglobulin-resistant Kawasaki disease 关于静脉免疫球蛋白抵抗性川崎病缺乏抢救治疗的不同亚组

IOSR Journal of Pharmacy Pub Date : 2016-08-01 DOI: 10.9790/3013-068014047

T. Nakada

{"title":"Different subgroups regarding the absence of rescue therapy in intravenous immunoglobulin-resistant Kawasaki disease","authors":"T. Nakada","doi":"10.9790/3013-068014047","DOIUrl":"https://doi.org/10.9790/3013-068014047","url":null,"abstract":"The objective of this study is the description of clinical outcomes regarding the absence of rescue therapy of intravenous immunoglobulin (IVIG)-resistant Kawasaki disease. I investigated the clinical outcomes of 33 IVIG-resistant patients who received the initial single IVIG therapy with the delayed use of anti- inflammatory drugs (DUA). These patients were divided into two groups: 11 patients who received rescue therapies (rescue group) and 22 patients who did not receive rescue therapy (non-rescue group). One patient of rescue group developed coronary artery lesions (CAL). None of the patients of non-rescue group developed CAL. The prevalence of persistent fever between rescue and non-rescue groups at 3 days and 4 days after initial IVIG therapy was 100% vs. 77% ( P = 0.144 ) and 100% vs. 18% ( P < 0.001 ), respectively. The C-reactive protein value, neutrophil counts, serum albumin levels, and sodium levels were significantly different between two groups at median 3 days after initial IVIG therapy. Two-thirds of the IVIG-resistant patients diagnosed at 24 h after completion of the initial IVIG therapy with DUA did not develop CAL after 30 days of illness without rescue therapies. The rescue therapy at this time may lead to overtreatment.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"21 1","pages":"40-47"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82647302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Human Body Fluid Ions In colchicine complexes ESI MS, MADLI MS, Spectroscopic, DFT Studies and Fungicidal Activity of colchicine complexes With Sodium, Potassium, Magnesium and calcium carbonates and Sulphates 与钠、钾、镁、碳酸钙和硫酸盐配合物的秋水仙碱人体体液离子的ESI质谱、MADLI质谱、光谱、DFT研究及杀真菌活性

IOSR Journal of Pharmacy Pub Date : 2016-08-01 DOI: 10.9790/3013-068024055

Joanna Kurek, G. Bartkowiak, W. Jankowski, Patrycja Kwaśniewska-Sip, G. Schroeder, M. Hoffmann, G. Cofta, P. Barczyński

引用次数: 4

Dipeptidyl Peptidase-4 Inhibitors and Cardiovascular Risk in Patients with Diabetes: Fact or Fiction? 二肽基肽酶-4抑制剂与糖尿病患者心血管风险:事实还是虚构?

IOSR Journal of Pharmacy Pub Date : 2016-08-01 DOI: 10.9790/3013-068020107

Omaima Mahmood, S. Mahmood, Zahraa M. Mohammed

引用次数: 0

Knowledge of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and its Management: A Survey among Saudi People in Taif; Kingdom of Saudi Arabia 中东呼吸综合征冠状病毒(MERS-CoV)知识及其管理——对塔伊夫沙特民众的调查沙特阿拉伯王国

IOSR Journal of Pharmacy Pub Date : 2016-08-01 DOI: 10.9790/3013-068023339

A. Elbur, A. Alharthi, Abdulrahman Aljuaid, N. Almalki

{"title":"Knowledge of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and its Management: A Survey among Saudi People in Taif; Kingdom of Saudi Arabia","authors":"A. Elbur, A. Alharthi, Abdulrahman Aljuaid, N. Almalki","doi":"10.9790/3013-068023339","DOIUrl":"https://doi.org/10.9790/3013-068023339","url":null,"abstract":"Background: Assessment of the public general knowledge on Middle East Respiratory Syndrome is crucial to the development of health policies for containment of the disease. Objectives: To measure the level of public knowledge on Middle East Respiratory Syndrome and to identify its predicators. Methods: A cross –sectional survey was conducted during June –October 2015, whereby adult (> 18 years old) Saudi people residing in Taif Area were recruited. Convenience method of sampling was adopted. Data was collected by a structured questionnaire. Face-to-face interview method was used to collect the data. Data was processed and analyzed by the Statistical Package for Social Sciences (SPSS version 21). Logistic regression analysis was performed. P values < 0.05 were considered statistically significant. Results: A total of 377 participants was recruited (age range 1885 years). The majority was males and 65% were university graduates. Of all the interviewees 56 % believed that the disease transmission can occurs through infected camel and bats. The fact that the disease has no specific treatment was known by 53.8% and 42.7% of them denied any role for traditional medicines in the prevention or treatment of the disease. Participants had satisfactory knowledge about the disease and its management were 216 (57.3%). Significant predictors of satisfactory knowledge were age more than 40 years [OR= 0.4; 95% CI (0.2-0.7); P = 0.001], university education [OR= 1.6; 95% CI (1.0-2.6); P = 0.042] and being employed in the medical field [OR= 2.8; 95% CI (1.7-4.5); P < 0.001]. Conclusions: Despite the great effort done by the health authorities in the country to educate the people and to raise their awareness about the disease, there are gaps in public knowledge. Future planned educational interventions should focus on younger people and those with educational background below the university level.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"51 1","pages":"33-39"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76935704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 22

Review of current trends in enhancing bioavailability of poorly water soluble drugs by liposomal interventions 通过脂质体干预提高难水溶性药物生物利用度的当前趋势综述

IOSR Journal of Pharmacy Pub Date : 2016-08-01 DOI: 10.9790/3013-068013039

S. Majekodunmi

{"title":"Review of current trends in enhancing bioavailability of poorly water soluble drugs by liposomal interventions","authors":"S. Majekodunmi","doi":"10.9790/3013-068013039","DOIUrl":"https://doi.org/10.9790/3013-068013039","url":null,"abstract":"One of the several ways of enhancing the solubility of poorly soluble drugs is liposomes formulations. Research on liposomes formulations has progressed from that of conventional vesicles to new generation liposomes, such as cationic liposomes, temperature sensitive liposomes, and virosomes, by modulating the formulation techniques and lipid composition. Thermosensitive liposomes are also a promising tool for external targeting of drugs to solid tumors when used in combination with local hyperthermia or high intensity focused ultrasound. In vivo results have demonstrated strong evidence that external targeting is superior over passive targeting achieved by highly stable long-circulating drug formulations like PEGylated liposomal doxorubicin. This review is to compare the therapeutic effect of current clinically approved liposomebased drugs with free drugs and summarize the historical development and effects of particular phospholipids and surfactants on the biophysical properties and in vivo efficacy of thermosensitive liposome formulations. Drug delivery guided by magnetic resonance imaging is also discussed. The combination of external targeting with thermosensitive liposomes and magnetic resonance-guided drug delivery will be the unique characteristics of this nanotechnology approach in medicine.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"1 1","pages":"30-39"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72748541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Analgesic and Anti-Inflammatory activities of Rothmannia Longiflora Salisb In Mice And Rats 罗思莲对小鼠和大鼠的镇痛和抗炎作用

IOSR Journal of Pharmacy Pub Date : 2016-08-01 DOI: 10.9790/3013-068010107

D. Mallam, A. AnukaJ., U. ZeziAbdulkadir, G. MagajiM., A. ChindoBen, B. SaniMohammed

{"title":"Analgesic and Anti-Inflammatory activities of Rothmannia Longiflora Salisb In Mice And Rats","authors":"D. Mallam, A. AnukaJ., U. ZeziAbdulkadir, G. MagajiM., A. ChindoBen, B. SaniMohammed","doi":"10.9790/3013-068010107","DOIUrl":"https://doi.org/10.9790/3013-068010107","url":null,"abstract":"In this study, the analgesic and anti-inflammatory activities of the methanolic leaf extract of Rothmannialongiflora were investigated. The methanolic leaf extract of the plant at the doses of 250, 500, and 1000mg/kg orally was evaluated for analgesic activity using acetic acid-induced writhing test, hot plate test and formalin test. The anti-inflammatory potential of the extract was evaluated using carrageenan-induced paw oedema test in rats. The methanolic leaf extract exhibited significant dose dependent analgesic and antiinflammatory effects comparable to piroxicam (20mg/kg body weight orally), which is a standard analgesic and anti-inflammatory drug. The preliminary phytochemical screening of the methanolic leaf extract of Rothmannialongiflora revealed the presence of flavonoids, tannins, saponins, glycosides, steroids/terpanoids, and carbohydrates. The oral median lethal dose (LD50) of the extract in mice and rats were found to be greater than 5000mg/kg, suggesting that the methanolic leaf extract of Rothmannialongiflora is non-toxic. The present findings suggest that the methanolic leaf extract of the plant possesses analgesic and anti-inflammatory activities, and supports the ethno medical claims of the use of the plant in the management of pain and inflammatory conditions.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"19 1","pages":"01-07"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91221111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antimicrobial Sensitivity Pattern in Surgical PatientsAdmitted to Intensive Care Unit, Northwest Region, Kingdom of Saudi Arabia 沙特阿拉伯王国西北地区重症监护病房外科患者抗菌药物敏感性分析

IOSR Journal of Pharmacy Pub Date : 2016-08-01 DOI: 10.9790/3013-068025660

I. Albalawi

{"title":"Antimicrobial Sensitivity Pattern in Surgical PatientsAdmitted to Intensive Care Unit, Northwest Region, Kingdom of Saudi Arabia","authors":"I. Albalawi","doi":"10.9790/3013-068025660","DOIUrl":"https://doi.org/10.9790/3013-068025660","url":null,"abstract":"Antimicrobial resistance is challenging for the health care professionals especially in intensive care unit. Most of the hospitals in developing countries yet to understand this phenomenon in order to succeed in antimicrobial therapy among the critically ill patients. The present study aimed to investigate the commonly available bacteria in ICU and antimicrobial sensitivity pattern of those bacteria in King Khalid Hospital, Tabuk, Kingdom of Saudi Arabia. The study has recruited 85 surgical patients admitted to intensive care unit (ICU) and bacterial isolation was carried out from their blood samples. Over all, gram negative bacteria is most common isolated in the study site (54%). However, 42% staphylococcus was isolated from the blood culture of the study population. Gram negative bacteria divided into two categories as enterobacteriaceae species and non- enterobacteriaceaespecies. Staphylococcus species is the most common isolated bacteria found to have higher sensitive to ceftriaxone, aztreonam, amoxicillin-clavulanic acid, colisitin, amikacin, cefepime, nitrofurantoin;however, high resistance was evident tocarbapenemantimicrobials (meropenem, ertapenem, imipenem) and fluroquinolones.Acinetobacter second common isolated bacteria only sensitive to colistin and sulphamethoxazole + trimethoprim antimicrobials. Antimicrobials sensitivity pattern highly differs between enterobacteriaceae and non-enterobacteriaceae bacteria's. Hence, the careful selection of antimicrobials is recommended in order to succeed in antimicrobial therapy.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"1 1","pages":"56-60"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79909440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of patient’s knowledge and perceptions regarding generic medicines – pilot study in Saragossa (Spain) 评估患者对仿制药的知识和认知——萨拉戈萨(西班牙)试点研究

IOSR Journal of Pharmacy Pub Date : 2016-08-01 DOI: 10.9790/3013-068022232

M. Gimeno, I. Gil, M. Gómez, L. Lomba

{"title":"Evaluation of patient’s knowledge and perceptions regarding generic medicines – pilot study in Saragossa (Spain)","authors":"M. Gimeno, I. Gil, M. Gómez, L. Lomba","doi":"10.9790/3013-068022232","DOIUrl":"https://doi.org/10.9790/3013-068022232","url":null,"abstract":"Objective The aim is to review the actual knowledge and perception of generic medicines in Spain to see if more training and information for the patients is necessary. Method Self-administered questionnaires were used to survey the patient’s knowledge and perceptions of generic medicines. The questionnaires were built with an expert panel. The pilot was conducted in Saragossa province (Spain). Results Patients with a low educational level and those older than 51 years had a worse attitude to generics regarding their equivalence, quality and efficacy. Also showed the general non-acceptance of the substitution policy switching from branded to generic medicines. Conclusions More educational actions and campaigns directed to patients were shown to be necessary in order to improve the knowledge of generic drugs, specially focused on groups with negative perceptions. Practice implications Educational activities, direct and individual about security and efficacy of generic medicines increase its acceptance and appreciation. Health professionals (doctors, pharmacists and nurses) are the ones in the best position to develop this educational work. There is a need of a bigger effort in the country on generics information, especially in the group of older than 50 years old and in the lower education group.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"11 1","pages":"22-32"},"PeriodicalIF":0.0,"publicationDate":"2016-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82281847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Enhancement of Dissolution rate of Naproxen by Solid Dispersions with cyclodextrin Complex’s 环糊精配合物固体分散体提高萘普生溶出率

IOSR Journal of Pharmacy Pub Date : 2016-08-01 DOI: 10.9790/3013-068010825

Dr.Rohini Pilli, Sdvskiran Kadali, M. Nagabhushanam

引用次数: 1

Nutritional value and pharmacological importance of citrus species grown in Iraq 伊拉克柑橘品种的营养价值和药理重要性

IOSR Journal of Pharmacy Pub Date : 2016-08-01 DOI: 10.9790/3013-0680176108

A. Al-Snafi

引用次数: 90