M. Samarawickrama, R. Senavirathna, U. Hapuarachchi
{"title":"Drain Site Abdominal Hernia: Known but Rare Complication of Abdominal Drains, a Case Report and a Review of Drain Site Complications","authors":"M. Samarawickrama, R. Senavirathna, U. Hapuarachchi","doi":"10.9790/3013-0704011014","DOIUrl":"https://doi.org/10.9790/3013-0704011014","url":null,"abstract":"Drains are being used in abdominal surgery since Hippocrates time therapeutically and prohpylactically aiming to reduce morbidity and early recovery of patients. But these drains are not without complications. The complications range from simple drain site infection to drain site hernia of bowel leading to strangulation and necrosis. We report a case of drain site hernia (DSH) in a 47 year-old women who presented with obstructed large incisional hernia through a previous laparotomy scar. During surgery for the incisional hernia an incarcerated DSH was identified at her right iliac fossa region. Both herniae were repaired successfully and patient’s recovery was uneventful. We reviewed the literature regarding the drain site hernia and other complications of abdominal drains. The article describes types of drains, their complications and predisposing factors for those complications and the steps to be taken for the prevention.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"15 1","pages":"10-14"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89525021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medicinal plants possessed antioxidant and free radical scavenging effects (part 3)- A review","authors":"A. Al-Snafi","doi":"10.9790/3013-0704014862","DOIUrl":"https://doi.org/10.9790/3013-0704014862","url":null,"abstract":"Antioxidants are substances that remove, prevent or delay oxidative damage to a target molecule. Therefore, an antioxidant may act to control the level of free radicals to counteract oxidative damage. The effects of medicinal plants in prevention and treatment of many diseases have been widely attributed to their antioxidants activities. This review was designed to highlight the antioxidant effects and free radical scavenging activity of medicinal plants as a third part of our previous reviews.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"256 1","pages":"48-62"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73608889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Aframomum melegueta aqueous seed extract on food and water consumption in albino rats","authors":"C. Nosiri, C. Anyanwu, C. Nwaogwugwu","doi":"10.9790/3013-0704012326","DOIUrl":"https://doi.org/10.9790/3013-0704012326","url":null,"abstract":"This experiment was carried out to evaluate the effect of seed extract of Aframomum melegueta on water and feed intake in albino rats. The aqueous seed extract of Aframomum melegueta was administered (p.o) to the animals for 28 days and water and food given 7hrs daily. The animals were divided into four groups of six rats both of the males and females comprising of control groups, 200, 400 and 600mg/kg extract. There was a gradual increase in food intake which affected their body weights dose dependently. Water consumption by all the treated groups from both male and female increased significantly (P≤0.05) when compared with the control groups. The reason could be that there was alteration in the hypothalamus which is a centre that controls appetite and thirst. Conclusively, it induced Polydypsia which represents a compensatory mechanism that maintains total body fluids within normal limits and therefore could be used safely for the management of diseases.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"8 1","pages":"23-26"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79562817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Nivethitha, S. Manickavasagam, N. Balasubramanian, G. SaiThaejesvi
{"title":"A Study of Cutaneous Adverse Drug Reactions in A Tertiary Care Teaching Hospital","authors":"T. Nivethitha, S. Manickavasagam, N. Balasubramanian, G. SaiThaejesvi","doi":"10.9790/3013-0704011822","DOIUrl":"https://doi.org/10.9790/3013-0704011822","url":null,"abstract":"Adverse drug reactions (ADR’s) are the major cause of morbidity and mortality and most of the adverse drug reactions become evident only when the drug enters into the market, as clinical trials conducted on drugs involve only a limited number of subjects. Cutaneous manifestations of ADR’s occur more frequently, hence this study was conducted to detect the morphological pattern, the common drugs causing cutaneous ADR’s and to assess the severity of the same using Naranjo’s algorithm. This was a prospective study conducted over a period of one year in the department of Dermatology and the department of Pharmacology. All the ADR’s reported during the study period were confirmed by a dermatologist and assessed using Naranjo’s algorithm. A total of 90 Cutaneous Adverse Drug Reactions (CADR’s) were reported during the study period. Fixed drug eruption was the most common morphological pattern of ADR. Antibiotics were the most common drugs involved in causing CADR’s. Most of the CADR’s belonged to Probable category. Hence this study showed that CADR’s are common to the drugs widely used, and the detection of the same will enable the treating physician to withdraw the use of the suspected drug. Also spontaneous reporting of ADR’s will strengthen the Indian Pharmacovigilance database.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"10 1","pages":"18-22"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83304260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of the Matching of Keywords of Abstracts of Articles Latin Selected Journals of Iranian Dental Indexed in Pubmed with Medical Subject Headings (MeSH)","authors":"S. J. Ghazi-Mirsaeid, F. Masoudi","doi":"10.9790/3013-0704014347","DOIUrl":"https://doi.org/10.9790/3013-0704014347","url":null,"abstract":"Background: This study evaluates the quality of keywords of abstracts of Latin Selected Journals of Iranian Dental indexed in PubMed with Medical Subject Headings (MeSH). Materials and Methods: The study is comparative descriptive. The data gathering tool is a researcher-made checklist. The Statistical population of the study is two Latin Journals of Iranian Dental approved by the Ministry of Health that indexed in PubMed. The Access 2013 software was used to describe data. Results: In total, 866 keywords of 208 articles were studied. On average, 4.2 keywords were in per article of selected Journals. The amount of the Exact match, Relatively match and Not match keywords in selected Journals is 39.5%, 35.8% and 24.8% respectively. More keywords of articles of both selected journals are the type of partial match with MeSH Headings or Entry Terms, and then keywords that are consistent with Entry Terms. Conclusions: Despite the higher rate of consistent keywords of articles of the journal \"J Dent (Tehran)\" to the journal \"Dent Res J (Isfahan)\", the precision in the use of MeSH in both of the selected journal was not at a desirable level and the authors of the selected journals must have more attention in selecting their words index based on MeSH.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"39 1","pages":"43-47"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88370709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Medicinal plants for prevention and treatment of cardiovascular diseases - A review","authors":"A. Al-Snafi","doi":"10.9790/3013-070401103163","DOIUrl":"https://doi.org/10.9790/3013-070401103163","url":null,"abstract":"There were substantial evidences that many medicinal plants decreased the risk of cardiovascular diseases. With the high prevalence of herbal medicine use worldwide, the information regarding the therapeutic use or safety of herbal remedies usually obtained from books and pamphlets, most of which base their information on traditional reputation rather than relying on existing scientific research. This review will cover the plants with vascular, hypotensive, cardiac, cardioprotective, antiarrhythmic, hypolipidemic, hemostatic, fibrinolytic and anticoagulant effects.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"3 1","pages":"103-163"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87079059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N’dri Jean Stéphane, K. M. Guy-Richard, Kodjo Charles Guillaume, Affi Sopi Thomas, Kablan Ahmont Landry Claude, O. Adama, Ziao Nahossé
{"title":"Quantitative Structure antifungal Activity Relationship (QSAR) study of a series of Schiff bases derivatives from4- aminobenzenesulphonamide by DFT method","authors":"N’dri Jean Stéphane, K. M. Guy-Richard, Kodjo Charles Guillaume, Affi Sopi Thomas, Kablan Ahmont Landry Claude, O. Adama, Ziao Nahossé","doi":"10.9790/3013-0704012733","DOIUrl":"https://doi.org/10.9790/3013-0704012733","url":null,"abstract":"1 N’dri Jean Stéphane, 1 Koné M. Guy-Richard, 1,2* Kodjo Charles Guillaume, 1 Affi Sopi Thomas, 3 Kablan Ahmont Landry Claude, 2 Ouattara Zana Adama and 1 Ziao Nahossé 1 Laboratoire de Thermodynamique et de Physico-Chimie du Milieu, UFR SFA, Université Nangui Abrogoua 02 BP 801 Abidjan 02, Côte-d’Ivoire, 2 Laboratoire de Chimie BioOrganique et de Substances Naturelles, Université Nangui Abrogoua, UFR-SFA, 02 B.P. 801 Abidjan 02 Côte-d’Ivoire, 3 UFR des Sciences Biologiques, Université Péléforo Gon Coulibaly de Korhogo, BP 1328 Korhogo, Côte d’Ivoire ABSTRACT : In this work we will focus on a series of Schiff bases derived from 4aminobenzenesulphonamide. By implementing quantum chemistry methods, at B3LYP/6-311 G (d, p) level, we have identified two QSAR models from quantum descriptors and antifungal activities against Candida albicans and Aspergillus niger strains that were accredited of good statistical performance. For model 1 statistical indicators were: correlation coefficient R 2 = 0.984, standard deviation S=0.514 , Fischer test F=90.753 and the correlation coefficient of cross-validation QCV 2 = 0.983. Wereas the statistical datas of model 2 were: correlation coefficient R 2 =0.952, standard deviation S=0.596, Fischer test F=79.022 and the correlation coefficient of crossvalidation QCV 2 = 0.951. These two models showed that quantum descriptors namely dipole moment and index of electrophilie were the bases for antifungal activity of these Schiff bases. These models were validated with the criteria of acceptance Eriksson et al. for training set and Tropsha et al. for the validation set.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"116 3 1","pages":"27-33"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77950377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Physiological effect of Natural Penicillin Extract on Cassava Peel Media by Penicillium chrysogenum PCL501 on E.coli Infected Wistar Rats","authors":"Onyegeme-Okerenta, B.M, Ebuehi O. A. T.","doi":"10.9790/3013-0704013442","DOIUrl":"https://doi.org/10.9790/3013-0704013442","url":null,"abstract":"Some physiological effect of natural penicillin extract produced on cassava peel media by Penicillium chrysogenum PCL501 on E.coli infected Wistar rats were evaluated. Fermentation of P. chrysogenum PCL501 with cassava peels – an agro-wasteproduced natural antibiotics. In vitro antibiotic activity of cassava peels culture extract was tested against two clinical bacterial isolates, namely, Bacillus subtilis, and Escherichia coli. The culture extract and standard drug (commercial Benzyl Penicillin) inhibited the growth B. subtilis and E. coli. Antibiotic activity of the culture extract was comparable with that of the standard drug. In vivo antibiotic action on Wistar Wistar rats infected with E. coli showed that the penicillin produced on cassava peel was potent as its administration leads to the recovery of the infected animals. Evaluation of biochemical indices of E. coli infected Wistar rats and treatment with extract confirms that the extract is a potent antibiotic. The haematological evaluation showed a significant decrease (p<0.05) in platelet count in animals administered with both the extract and reference drug. Cassava peels are indicated as a suitable and cheap carbon source for the production of penicillin by P. chrysogenum PCL501.","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"59 1","pages":"34-42"},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83099025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Chemical contents and medical importance of Dianthus caryophyllus- A review","authors":"A. Al-Snafi","doi":"10.9790/3013-0703016171","DOIUrl":"https://doi.org/10.9790/3013-0703016171","url":null,"abstract":"","PeriodicalId":14540,"journal":{"name":"IOSR Journal of Pharmacy","volume":"162 1","pages":"61-71"},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91018311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}