Italian Journal of Dermatology and Venereology最新文献_第8页

The emerging role of dual specificity phosphatase 3 in melanocytic cancer: from oncogenesis to clinical value. 双特异性磷酸酶3在黑色素细胞癌中的新作用：从肿瘤发生到临床价值。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-06-01 DOI: 10.23736/S2784-8671.25.08210-6

Emmanouil Chousakos, Nikolaos Katsoulas, Nikolaos I Vlachogiannis, Irene Theochari, Nikolaos Kavantzas, Alexandros Stratigos, Andreas C Lazaris

{"title":"The emerging role of dual specificity phosphatase 3 in melanocytic cancer: from oncogenesis to clinical value.","authors":"Emmanouil Chousakos, Nikolaos Katsoulas, Nikolaos I Vlachogiannis, Irene Theochari, Nikolaos Kavantzas, Alexandros Stratigos, Andreas C Lazaris","doi":"10.23736/S2784-8671.25.08210-6","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08210-6","url":null,"abstract":"Background: Dual specificity phosphatase 3 (DUSP3) participates in various cancers, whereas its involvement in melanocytic oncogenesis needs to be identified.Methods: One hundred seventy-two biopsied lesions were immunohistochemically stained for DUSP3, divided in 4 groups: common nevi (CN), dysplastic nevi (DN), nevus and melanoma components of nevus-associated melanomas (N-NAMs and M-NAMs, respectively). Positivity was based on the numerical and categorical Immunoreactive Score after evaluation of staining's intensity and proportion.Results: A decrease of DUSP3 positivity was observed along the 4 groups (mean [SD] numerical IRS scores: CN: 7.5 [3.5]; DN: 6.2 [3.6]; N-NAMs: 4.0 [2.9]; M-NAMs: 1.9 [1.1], P<0.001). Remarkably, no strongly positive M-NAMs were observed while 21.4% of them developed from a negative nevus. Paired analysis of the 84 matched NAM cases underscored a downgrade in positivity of M-NAM vs. N-NAM per tumor (Wilcoxon Signed-Rank Test: P<0.001). Multivariate analysis revealed that probability of any nevus diagnosis against M-NAM was increased 3-11 times (adjusted OR CN vs. M-NAM: 11.333, 95% CI: 2.995-42.876; adjusted OR DN vs. M-NAM: 6.495, 95% CI: 2.496-16.900; OR N-NAM vs. M-NAM: 3.225, 95% CI: 1.745-5.961. P<0.001).Conclusions: DUSP3 seems to act as a tumor-suppressor, and its depletion seems to contribute to the progression of NAM. This is the first study validating DUSP3's association with melanocytic neoplasms, improving the understanding of their oncogenesis and diagnostics. Additional studies are required for clarifying its utility in the clinical setting.","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 3","pages":"195-203"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The underestimated skin cancer risk after liver transplantation: a systematic review and meta-analysis. 肝移植后被低估的皮肤癌风险：一项系统回顾和荟萃分析。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-06-01 Epub Date: 2025-04-02 DOI: 10.23736/S2784-8671.25.07990-3

Amr E El-Qushayri, Abdalla R Mahmoud, Abdelrahman G Tawfik, Abdullah Reda, Beatrice Nardone

{"title":"The underestimated skin cancer risk after liver transplantation: a systematic review and meta-analysis.","authors":"Amr E El-Qushayri, Abdalla R Mahmoud, Abdelrahman G Tawfik, Abdullah Reda, Beatrice Nardone","doi":"10.23736/S2784-8671.25.07990-3","DOIUrl":"10.23736/S2784-8671.25.07990-3","url":null,"abstract":"Introduction: The aim of this this systematic review and meta-analysis was to assess the prevalence of skin cancer in post-liver transplant recipients (LTRs).Evidence acquisition: Five databases were systematically searched until 20th April 2023. Search terms included (\"liver transplantation\" OR \"liver transplant\") AND (\"skin cancer\" OR \"melanoma\" OR \"squamous cell carcinoma\" OR \"non-melanoma skin cancer\" OR \"post-transplant cancer\" OR \"post transplant cancer\"). Random effect model were used to overcome the significant heterogeneity observed.Evidence synthesis: A total of 34 studies were included. The overall skin cancer prevalence in LTRs was 4.6% (95% CI: 3.4-6.1). Subgroup analysis based upon the follow-up duration of each study indicated that skin cancer prevalence increased with longer follow-up durations: 0-4 years, 0.8% (95% CI: 0.4-1.9), 4-8 years, 4.3% (95% CI: 3.1-5.8), and 8-12 years, 5.3% (95% CI: 1.9-14). Furthermore, subgroup analysis based upon continental distribution of skin cancer indicated that Australia 21% (95% CI: 13-31) followed by South America 9.4% (95% CI: 5.8-15) had the highest prevalence of skin cancer. SCC was the most common type of skin cancer with a prevalence of 2.6% (95% CI: 1.5-4.5), subsequently followed by BCC 2.5% (95% CI: 1.5-4.2).Conclusions: Skin cancer following liver transplantation is not a rare condition. Substantial dermatological surveillance programs are recommended in post-liver transplant recipients to improve the quality of life as well as the associated mortality; especially with the increased prevalence after long follow-up durations.","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"234-241"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Scabies with acral pustules mimicking infantile acropustulosis. 疥疮与肢端脓疱模仿婴儿肢端脓疱病。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-06-01 Epub Date: 2025-04-22 DOI: 10.23736/S2784-8671.25.08177-0

Luca Rapparini, Marco A Chessa, Iria Neri

引用次数: 0

Drug survival, long-term safety and efficacy of anti-TNF-alpha biosimilars: a monocentric retrospective study. 抗tnf - α生物仿制药的药物生存期、长期安全性和有效性：一项单中心回顾性研究

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-06-01 DOI: 10.23736/S2784-8671.25.08060-0

Giulia Nunziati, Antonella DI Cesare, Elia Rosi, Ilaria Scandagli, Gianmarco Silvi, Prisca Guerra, Francesca Prignano

{"title":"Drug survival, long-term safety and efficacy of anti-TNF-alpha biosimilars: a monocentric retrospective study.","authors":"Giulia Nunziati, Antonella DI Cesare, Elia Rosi, Ilaria Scandagli, Gianmarco Silvi, Prisca Guerra, Francesca Prignano","doi":"10.23736/S2784-8671.25.08060-0","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08060-0","url":null,"abstract":"Background: In the current landscape of psoriasis therapeutic management, despite the more recent market introduction of highly targeted molecules such as anti-interleukins, anti-tumor necrosis factor alpha (anti-TNF-α) biologic agents still play a key role, partly due to the availability of cost-effective biosimilar alternatives. Retention rate, long-term safety and effectiveness of these drugs have rarely been investigated.Methods: We carried out a retrospective monocentric study including patients treated with biosimilar adalimumab, biosimilar etanercept, and biosimilar infliximab to assess drug survival, safety and effectiveness of these drugs over an extended period.Results: A total of 93 patients were included in this study, with a median treatment duration of 86 months. Drug survival at 12 months was 91.4%, declining to <50% at 86 months. Interestingly, no significant differences were observed among the three anti-TNF-α biosimilars in terms of drug survival. The presence of psoriatic arthritis (PsA) correlated with increased drug survival. Adverse drug reactions were reported in 61.3% of patients, with infections being the most common issue. Treatment discontinuation was predominantly due to loss of efficacy.Conclusions: Despite certain limitations, such as the retrospective design and the monocentric nature of the study, our findings underscore the long-term effectiveness and safety of anti-TNF-α biosimilars in psoriasis and PsA management, emphasizing the importance of considering disease characteristics in treatment decisions.","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 3","pages":"204-211"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lichen striatus: a review. 纹状地衣：综述。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-06-01 Epub Date: 2024-10-03 DOI: 10.23736/S2784-8671.24.07998-2

Astrid Herzum, Gianmaria Viglizzo, Corrado Occella, Lodovica Gariazzo, Valerio G Vellone, Silvia M Orsi, Giulia Ciccarese

{"title":"Lichen striatus: a review.","authors":"Astrid Herzum, Gianmaria Viglizzo, Corrado Occella, Lodovica Gariazzo, Valerio G Vellone, Silvia M Orsi, Giulia Ciccarese","doi":"10.23736/S2784-8671.24.07998-2","DOIUrl":"10.23736/S2784-8671.24.07998-2","url":null,"abstract":"Introduction: Lichen striatus (LS) is an acquired blaschkitis, with typical linear and unilateral distribution. It occurs mainly in children and is self-resolving, yet its etiopathogenesis remains widely unknown.Evidence acquisition: A review of the literature on LS cases was performed using the keyword \"lichen striatus\" to retrieve all relevant articles through PubMed and Google Scholar.Evidence synthesis: A total of 27 articles describing 440 LS patients were included in the present review. Mean age of patients was 3.8 years; male: female: ratio was 1:1.9. The present review confirms LS as a primarily pediatric condition, mainly affecting females. Dysregulation of the immune system might be involved in its pathogenesis, with cytotoxic T-cells attacking mosaic keratinocytes after loss of immune tolerance. The review confirms LS is mainly diagnosed clinically (80%) based on its clinical characteristics: erythematous (70%) or hypopigmented (24%) papules, distributed along the lines of Blashko. The benignity of this clinical entity is suggested by the rather short duration of disease (9.5 months on average) and by the uncommonness of therapy, adopted in only 20% of cases, and when needed, administered topically.Conclusions: This review examines the complexities of LS but acknowledges limitations in data sources and calls for further research.","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"242-247"},"PeriodicalIF":1.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Legius Syndrome: the importance of molecular differential diagnosis with neurofibromatosis type 1. Legius综合征：1型神经纤维瘤病分子鉴别诊断的重要性。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-06-01 Epub Date: 2025-04-02 DOI: 10.23736/S2784-8671.25.08024-7

Francisco Cammarata-Scalisi, Colin E Willoughby, Antonio Cárdenas Tadich, Carmen Ludeña Mendoza, Carolina Peralta Aros, Maykol Araya Castillo, Michele Callea

引用次数: 0

Cutaneous adverse events related to skin lymphoma therapies. 与皮肤淋巴瘤治疗相关的皮肤不良事件。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-06-01 DOI: 10.23736/S2784-8671.25.07924-1

Stephano Cedirian, Corrado Zengarini, Massimo Lepri, Bianca M Piraccini, Alessandro Pileri

引用次数: 0

Italian Consensus on the treatment of oral lichen planus. 意大利治疗口腔扁平苔藓的共识。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-04-01 DOI: 10.23736/S2784-8671.25.08143-5

Elisa Cinotti, Martina D'Onghia, Laura Calabrese, Federico Bardazzi, Monica Corazza, Emanuele C Cozzani, Federica Filippi, Andrea Gabusi, Giulia Galluccio, Giulia Gasparini, Anna M Offidani, Manuela Papini, Aurora Parodi, Stefano Piaserico, Pietro Rubegni, Oriana Simonetti, Jacopo Tartaglia, Alessandro Borghi

{"title":"Italian Consensus on the treatment of oral lichen planus.","authors":"Elisa Cinotti, Martina D'Onghia, Laura Calabrese, Federico Bardazzi, Monica Corazza, Emanuele C Cozzani, Federica Filippi, Andrea Gabusi, Giulia Galluccio, Giulia Gasparini, Anna M Offidani, Manuela Papini, Aurora Parodi, Stefano Piaserico, Pietro Rubegni, Oriana Simonetti, Jacopo Tartaglia, Alessandro Borghi","doi":"10.23736/S2784-8671.25.08143-5","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08143-5","url":null,"abstract":"Oral lichen planus (OLP) is a chronic inflammatory condition of uncertain etiology affecting oral mucosae by T-cell mediated chronic inflammation. It affects between 1% and 3% of the global population, predominantly middle-aged adults (50-60 years), with a higher incidence in women. The immune response is thought to target keratinocytes, leading to cell death, particularly through CD8+ T lymphocytes. OLP manifests in various clinical forms, such as reticular, papular, erosive, and atrophic, with the reticular subtype being the most common. Erosive OLP is the most severe, characterized by widespread oral erosions, while atrophic OLP often follows erosive stages, affecting the tongue with a depapillated surface. Currently, no curative treatment exists for OLP, and the management focuses on symptom relief, including reducing pain and discomfort. Thus, a multidisciplinary approach involving dermatologists, oral surgeons, and dentists is often required. For this reason, the scientific community represented in Italy by the Mucosal Diseases Study Group of SIDeMaST (Italian Society of Dermatology and Venereology) reports its experience in the management of OLP, providing clinical recommendations for dermatologists based on the latest scientific evidence to optimize the treatment and management of OLP.","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 2","pages":"83-96"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of nanofat in treatment-refractory penile lichen sclerosus: results from a pilot retrospective single-center case series. 纳米脂肪治疗难治性阴茎硬化性地衣的有效性：来自一项回顾性单中心病例系列试验的结果。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-04-01 DOI: 10.23736/S2784-8671.25.08247-7

Massimiliano Brambilla, Valentina Benzecry, Carlo A Maronese, Francesco Barberi, Marco Cusini, Veronica Boero, Angelo V Marzano

{"title":"Effectiveness of nanofat in treatment-refractory penile lichen sclerosus: results from a pilot retrospective single-center case series.","authors":"Massimiliano Brambilla, Valentina Benzecry, Carlo A Maronese, Francesco Barberi, Marco Cusini, Veronica Boero, Angelo V Marzano","doi":"10.23736/S2784-8671.25.08247-7","DOIUrl":"https://doi.org/10.23736/S2784-8671.25.08247-7","url":null,"abstract":"Background: Penile lichen sclerosus (PLS) is a chronic inflammatory skin disorder that may lead to progressive architectural distortion of male genitalia, with a dramatic impact on quality of life and a high unmet therapeutic need. In keeping with vulvar disease, nanofat grafting could represent a viable option in this setting.Methods: Patients aged 18 years or above with biopsy-proven, medical and/or surgical treatment-resistant PLS were offered nanofat and were evaluated at baseline, 1 and 24 months.Results: Fourteen male patients with a median age of 46 years (interquartile range [IQR]: 37.25-51.5) were included. Median modified Investigator Global Assessment (mIGA) scores changed from 18 (IQR: 14.75-22.75) at the baseline, to 15.5 (IQR: 13-20.25) at 1 month (P=0.002), to 14 (IQR: 8-17) at 24 months (P=0.001). mIGA subscores for erythema improved significantly after just one month (P=0.002) and the improvement was maintained throughout the 24 months of follow-up (P=0.001). At 24 months, a statistically significant reduction relative to the baseline was demonstrated also for itch (P=0.014), burning sensation (P=0.02) and dyspareunia (P=0.02). Median Patient Global Impression of Change at 24 months was 6 (IQR: 4.75-6.25) (\"much improved\"). No adverse effects or complications were recorded.Conclusions: Nanofat grafting not only seems to improve genital tissue quality, but appears to act also on the inflammatory component of the disease. Further research will be needed to validate and optimize this approach for PLS.","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 2","pages":"116-122"},"PeriodicalIF":1.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lebrikizumab approval for the treatment of moderate to severe atopic dermatitis in Italy. 意大利批准 Lebrikizumab 用于治疗中度至重度特应性皮炎。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-04-01 Epub Date: 2024-09-26 DOI: 10.23736/S2784-8671.24.08058-7

Giuseppe Argenziano, Paolo Amerio, Cataldo Patruno, Luca Stingeni

引用次数: 0