Italian Journal of Dermatology and Venereology最新文献_第7页

Novel transethosome coencapsulated combination for acne treatment: in-vitro efficacy and ex-vivo biodistribution studies. 新型转酶体共包合治疗痤疮：体外疗效和体外生物分布研究。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-02-01 DOI: 10.23736/S2784-8671.24.07982-9

Alfredo Martinez-Gutierrez, Javier Sendros, Teresa Noya, Mari C González

{"title":"Novel transethosome coencapsulated combination for acne treatment: in-vitro efficacy and ex-vivo biodistribution studies.","authors":"Alfredo Martinez-Gutierrez, Javier Sendros, Teresa Noya, Mari C González","doi":"10.23736/S2784-8671.24.07982-9","DOIUrl":"10.23736/S2784-8671.24.07982-9","url":null,"abstract":"Background: Acne vulgaris is a skin condition affecting approximately 85% of young adults. It is influenced by androgens and primarily occurs in the pilosebaceous unit, where inflammation and obstruction happen. Hyperseborrhea and hyperkeratinization lead to increased levels of fatty acids and necrotic keratinocytes, promoting the proliferation of C. acnes phylotype IA1.Methods: Here, the in-vitro efficacy of a novel combination on the main processes involved in acne was studied. Furthermore, the combination was coencapsulated in transethosomes to target the pilosebaceous unit, and the biodistribution was analyzed ex vivo by fluorescence microscopy.Results: The combination of compounds reduced inflammatory markers levels, sebum production and 5α-Reductase levels while it induced autophagy and FOXO1 nuclear levels in sebocytes. The compounds coencapsulated in transethosomes reached the pilosebaceous unit as proven by the ex vivo analysis.Conclusions: The proposed combination of compounds is a promising approach to be included in topical products for the treatment of acne vulgaris.","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 1","pages":"7-11"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New onset vitiligo induced by dupilumab therapy for severe asthma: a case report and a short review of the literature. dupilumab治疗严重哮喘引起的新发白癜风：一个病例报告和简短的文献回顾。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-02-01 Epub Date: 2024-11-29 DOI: 10.23736/S2784-8671.24.07987-8

Giulia Bazzacco, Filippo Chersi, Enrico Zelin, Vanessa Mazzoletti, Nicola DI Meo, Iris Zalaudek, Raffaele D Caposiena Caro

引用次数: 0

Prurigo pigmentosa and bariatric surgery: not a simple coincidence. 色素性瘙痒症与减肥手术：并非巧合。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-02-01 Epub Date: 2024-11-04 DOI: 10.23736/S2784-8671.24.07961-1

Eleonora Natale, Elia Esposto, Edoardo Cammarata, Federica Veronese, Andrea Carletti, Jacopo Colombo, Carlotta Melotti, Elisa Zavattaro, Paola Savoia

引用次数: 0

Dupilumab facial redness induced by Rhodotorula mucilaginosa infection. 粘膜红斑癣菌感染引起的杜比卢单抗面部发红。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-02-01 Epub Date: 2024-11-19 DOI: 10.23736/S2784-8671.24.08021-6

Elia Esposto, Federica Veronese, Edoardo Cammarata, Paola Savoia

引用次数: 0

Coexistence of psoriasis vulgaris and lichen planus pemphigoids in an elderly patient. 寻常型银屑病和类天疱疮扁平苔藓共存的老年患者。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-02-01 Epub Date: 2024-11-29 DOI: 10.23736/S2784-8671.24.08011-3

Dario Didona, Julia Hinterseher, Antonio M Sequeira Santos, Michael Hertl

引用次数: 0

Update on the role of color Doppler ultrasound in hidradenitis suppurativa: a game-changer. 彩色多普勒超声在化脓性扁桃体炎中的最新作用：改变游戏规则。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-02-01 Epub Date: 2024-11-19 DOI: 10.23736/S2784-8671.24.08025-3

Ximena Wortsman

{"title":"Update on the role of color Doppler ultrasound in hidradenitis suppurativa: a game-changer.","authors":"Ximena Wortsman","doi":"10.23736/S2784-8671.24.08025-3","DOIUrl":"10.23736/S2784-8671.24.08025-3","url":null,"abstract":"Hidradenitis suppurativa has greatly benefited from the insights of color Doppler ultrasound. Thus, ultrasonography has helped prove the follicular link of this disease and has ruled out the primary involvement of the apocrine glands, which, in the old days, was supposedly the cause of the disease. Importantly, ultrasound can detect subclinical anatomical information in HS that cannot be deducted from the clinical examination. Moreover, high-frequency (≥15 MHz) and ultra-high-frequency (≥50 MHz) ultrasound present a much higher axial spatial resolution compared to magnetic resonance imaging. Ultrasound allows us to detect better subclinical cutaneous anatomical abnormalities and, therefore, arrive earlier and more accurately at diagnosis and staging. Ultrasonographic diagnostic criteria can discriminate HS from other clinical simulators, which is also critical in diagnosing mild and moderate stages and is relevant for the severe stages. This imaging technique supports the severity (mSOS-HS) and activity (US-HSA) scorings more accurately, which can help assess the actual stage of the disease. This is important to decide the type of treatment and to perform a more objective follow-up of the patients. Magnetic resonance imaging has been reported as helpful in diagnosing deep perianal tunnels; however, it presents a lower axial spatial resolution compared with high and ultra-high frequency ultrasound. Nowadays, there is solid evidence of the usefulness of ultrasound in HS, which implies that it is a game-changer and should be recommended as the first-choice imaging technique and a standard of care tool for HS patients.","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"55-63"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-pustular primary annular plaque-type psoriasis. 非脓疱型原发性环状斑块型银屑病。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-02-01 Epub Date: 2024-09-09 DOI: 10.23736/S2784-8671.24.08040-X

Italo F Aromolo, Lorenzo Rocca, Chiara Benaglia, Domenico Simeoli, Gabriele Perego, Angelo Cattaneo, Carlo G Carrera, Angelo V Marzano, Carlo A Maronese

引用次数: 0

Facial psoriasis treated with tildrakizumab. tildrakizumab治疗面部牛皮癣。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2025-02-01 Epub Date: 2024-11-29 DOI: 10.23736/S2784-8671.24.07979-9

Emanuele Trovato, Martina Dragotto, Eugenio Capalbo, Arianna Lamberti, Pietro Rubegni

引用次数: 0

Unveiling new entities in the PAPA spectrum. 揭开 PAPA 频谱中新实体的面纱。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2024-12-01 Epub Date: 2024-11-07 DOI: 10.23736/S2784-8671.24.07985-4

Alessia Paganelli, Elena Rossi, Olga Calabrese, Laura Bigi, Biagio Cuffari, Anna M Cesinaro, Alberico Motolese

引用次数: 0

Comparing adalimumab biosimilars in the clinical practice of psoriatic patients. 比较阿达木单抗生物类似药在银屑病患者临床实践中的应用。

IF 1.8 4区医学

Italian Journal of Dermatology and Venereology Pub Date : 2024-12-01 DOI: 10.23736/S2784-8671.24.07914-3

Domenico Giordano, Antonio Di Guardo, Annamaria Larosa, Andrea Vizzaccaro, Giulia Maretti, Federica Rega, Flavia Persechino, Nazareno Gagliostro, Severino Persechino

{"title":"Comparing adalimumab biosimilars in the clinical practice of psoriatic patients.","authors":"Domenico Giordano, Antonio Di Guardo, Annamaria Larosa, Andrea Vizzaccaro, Giulia Maretti, Federica Rega, Flavia Persechino, Nazareno Gagliostro, Severino Persechino","doi":"10.23736/S2784-8671.24.07914-3","DOIUrl":"10.23736/S2784-8671.24.07914-3","url":null,"abstract":"Background: Biologic drugs have revolutionized the treatment of psoriasis and other chronic inflammatory diseases. In recent years, numerous biosimilar molecules that target cytokines such as TNF-alpha or its receptors have been developed. The approval of biosimilars has made it possible to reduce the costs of biologic drugs, thereby increasing access to these therapies for more patients and enhancing psoriasis treatment globally. Imraldi and Idacio are both biosimilars of Adalimumab, approved for treating moderate to severe psoriasis.Methods: Our study aims to compare these two adalimumab biosimilars in psoriasis patients who have previously undergone treatment with other biologic drugs or systemic therapy in a real-life setting. Our cohort comprised 32 psoriatic patients. Of these patients, 15 were prescribed Imraldi, while the remaining were on Idacio. To assess the efficacy of these therapies, we utilized various measures including the Psoriasis Area and Severity Index, the Pruritus Visual Analog Scale, the Visual Analog Scale, the Dermatology Life Quality Index, and the Psoriasis Global Assessment, monitoring the patients over a 24-week period.Results: Our results indicated that the use of Idacio led to greater decreases in all scores compared to Imraldi. However, in terms of safety and efficacy, the two drugs were found to be comparable.Conclusions: The findings of this study support the efficacy and safety of Idacio and Imraldi in managing psoriasis, with Idacio demonstrating superior efficacy in reducing disease severity. Future studies could benefit from expanding the patient cohort and conducting further analyses to evaluate individual responses to treatment.","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"159 6","pages":"599-606"},"PeriodicalIF":1.8,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0