Italian Journal of Dermatology and Venereology最新文献

{"title":"Are biological therapies for the treatment of psoriasis safe in patients with systemic mastocytosis? A case report and review of the literature.","authors":"Giulia Rech, Davide Geat, Riccardo Balestri, Carla Lombardo","doi":"10.23736/S2784-8671.26.08343-X","DOIUrl":"10.23736/S2784-8671.26.08343-X","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"289-291"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147728922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolated nail psoriasis: diagnostic challenges and therapeutic advances.","authors":"Natalia V Chalupczak, Shari R Lipner","doi":"10.23736/S2784-8671.26.08455-0","DOIUrl":"10.23736/S2784-8671.26.08455-0","url":null,"abstract":"<p><p>Isolated nail psoriasis, defined as psoriatic nail disease with no or little involvement of the skin, is a clinically significant yet frequently underrecognized condition. Its presentation often mimics other nail disorders such as onychomycosis or lichen planus which can lead to delayed diagnosis and inappropriate treatment. Patients may experience substantial functional impairment and psychosocial distress. This review highlights current knowledge of the epidemiology, clinical manifestations, and diagnostic challenges of isolated NP, with emphasis on populations where disease recognition is particularly difficult, including children, older adults, and patients with skin of color. Therapeutic options range from topical corticosteroids and vitamin D analogs to intralesional injections and systemic therapies. Despite recent therapeutic advances, response rates are often slower and less complete than in cutaneous psoriasis due to slow physiologic nail growth and treatment dissatisfaction is common. There is a need for standardized diagnostic criteria, validated outcome measures, and greater representation of diverse patient populations in clinical studies. Early identification and individualized treatment approaches are essential to reducing the burden of isolated NP on patient quality of life and long-term outcomes.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"236-247"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147771594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-life experience from a tertiary phototherapy center on solar urticaria: clinical features, management, and long-term outcomes from a twenty-year cohort.","authors":"Stefano Bighetti, Luca Bettolini, Marina Venturini, Piergiacomo Calzavara-Pinton, Benedetta Galli, Isacco Cattaneo, Alessia Loda, Andrea Carugno, Nicola Zerbinati, Mariateresa Rossi","doi":"10.23736/S2784-8671.26.08542-7","DOIUrl":"10.23736/S2784-8671.26.08542-7","url":null,"abstract":"<p><strong>Background: </strong>Solar urticaria (SU) is a rare, chronic photodermatosis characterized by immediate whealing upon exposure to ultraviolet (UV) or visible light. Tolerance-induction phototherapy (photohardening), delivered as action-spectrum desensitization or cross-spectrum photohardening, represents the mainstay of management in antihistamine-refractory cases, yet data on its long-term real-world efficacy and safety remain limited. The aim of the study was to evaluate the clinical and photobiological characteristics, therapeutic outcomes, and long-term efficacy of tolerance-induction phototherapy in patients with SU managed at a tertiary phototherapy center.</p><p><strong>Methods: </strong>A retrospective observational study was conducted on 53 patients with phototest-confirmed SU treated with UVA or narrowband UVB (NB-UVB) phototherapy between January 2005 and June 2025. Treatment regimens were tailored to individual action spectra and, in selected cases, applied as cross-spectrum photohardening according to clinical practice and safety considerations. Clinical responses, phototolerance (minimal urticarial dose, MUD), and adverse events were recorded. Long-term outcomes, including remission persistence, relapse, and patient satisfaction, were assessed through complete follow-up (median 4.7 years).</p><p><strong>Results: </strong>At the end of therapy, 33 patients (62%) achieved complete remission, 15 (28%) partial improvement, and 5 (9%) showed no change; overall, 91% experienced at least partial benefit. Remission was maintained in 31 patients (58%), while 22 (42%) relapsed after a mean of 4.2±1.6 years. In patients with available post-treatment phototesting, those maintaining remission exhibited a mean fourfold increase in phototolerance. The mean satisfaction score was 8.8±0.7 (median 9). Only mild transient erythema (15%) and pruritus (7%) were reported, with no serious adverse events.</p><p><strong>Conclusions: </strong>Tolerance-induction phototherapy with UVA or NB-UVB is a safe and highly effective first-line treatment for solar urticaria, providing durable phototolerance and long-term remission in most patients. The extended follow-up confirms its sustained efficacy and favorable safety profile in real-world clinical practice.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"271-277"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Juvenile pityriasis rubra pilaris in an adolescent successfully treated with secukinumab.","authors":"Andrea Diociaiuti, Ludovico Rao, Dario F D'Urso, Claudia Carnevale, May El Hachem","doi":"10.23736/S2784-8671.26.08356-8","DOIUrl":"https://doi.org/10.23736/S2784-8671.26.08356-8","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"161 3","pages":"291-292"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the ABCDE and EFG rules and the \"ugly duckling\" sign to face and body recognition: a pragmatic shift to patient-led early detection of melanoma and fast-growing skin cancers.","authors":"Andrea Astorino, Alessandro Laghi, Donato DI Nunno, Giorgio Troiani, Stefano Astorino","doi":"10.23736/S2784-8671.26.08471-9","DOIUrl":"10.23736/S2784-8671.26.08471-9","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"311"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of antibody class and target on subepidermal blistering disease phenotype and management.","authors":"Raphaella A Lambert, Christiaan H Noot, Zachary Frost, Zachary C Ney, Annika M Hansen, Areeba Ahmed, Hannah Verma, Grace Rabinowitz, Nicholas Gulati, Shreya Sreekantaswamy, John J Zone, Jamie L Rhoads, Christopher Hull, Jonas A Adalsteinsson, Zachary H Hopkins","doi":"10.23736/S2784-8671.25.08359-8","DOIUrl":"10.23736/S2784-8671.25.08359-8","url":null,"abstract":"<p><p>Subepidermal blistering diseases are driven by autoantibodies targeted to the basement membrane zone. These autoantibodies can stem from multiple antibody classes (e.g., IgE, IgG, IgM, IgA) and differing antibody classes and antibody targets can impact disease phenotype and potentially management. Despite significant advances, there remains a paucity of data and funding for further elucidating subepidermal blistering disease pathophysiology and the impact this has on management. This review highlights current understanding of subepidermal blistering disease antibody targets, classes, and the impact these have on disease clinical phenotype and management. Highlighted conditions will include bullous pemphigoid, mucous membrane pemphigoid, including ocular cicatricial pemphigoid, linear IgA disease, and epidermolysis bullosa acquisita.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"222-235"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vesicular mycosis fungoides: a rare disease with diagnostic dilemmas.","authors":"François Rosset, Gabriele Roccuzzo, Gianluca Avallone, Michele Panzone, Luca Conti, Paolo Fava, Simone Ribero, Pietro Quaglino","doi":"10.23736/S2784-8671.26.08444-6","DOIUrl":"https://doi.org/10.23736/S2784-8671.26.08444-6","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"161 3","pages":"306-307"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Line-field confocal optical coherence tomography of cutaneous sarcoidosis: LC-OCT of cutaneous sarcoidosis.","authors":"Anna P Lugli, Gerardo Palmisano, Clara DE Simone, Alessandro DI Stefani, Ketty Peris","doi":"10.23736/S2784-8671.26.08431-8","DOIUrl":"10.23736/S2784-8671.26.08431-8","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"301-303"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spitz nevi in children: insights from an Italian survey on real-world management.","authors":"Bruno Brunetti, Vincenzo Greco, Camila Scharf, Eugenia V DI Brizzi, Giuseppe Argenziano, Vincenzo Piccolo, Giulia Briatico","doi":"10.23736/S2784-8671.26.08437-9","DOIUrl":"10.23736/S2784-8671.26.08437-9","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"304-305"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emotional regulation and personality in systemic sclerosis: evaluating autogenic training in real-world setting.","authors":"Tonia Samela, Giulia Raimondi, Stefania Alfani, Giorgia Cordella, Valeria Antinone, Paride Sarandrea, Maria B Pupa, Anna R Giampetruzzi, Damiano Abeni","doi":"10.23736/S2784-8671.26.08454-9","DOIUrl":"10.23736/S2784-8671.26.08454-9","url":null,"abstract":"<p><strong>Background: </strong>Systemic sclerosis (SSc) is a chronic connective tissue disease characterized by skin and organ fibrosis, with high prevalence of emotional distress and impaired quality of life (QoL). Autogenic training (AT), a relaxation method, was found to be effective for managing symptoms in chronic illnesses, including SSc.</p><p><strong>Methods: </strong>The current observational, longitudinal study aimed at evaluating the feasibility and the effects of a four-month AT program on dispositional traits, emotional regulation, coping strategies, and physical function perceptions in SSc patients.</p><p><strong>Results: </strong>This longitudinal observational study included 44 patients with confirmed SSc, from a dermatological research hospital. Participants underwent six therapist-guided AT sessions with daily self-practice. Outcomes were assessed pre- and post-intervention using the Systemic Sclerosis Questionnaire (SySQ), Emotion Regulation Questionnaire (ERQ), COPE-NVI, and Millon Clinical Multiaxial Inventory-III. Statistical analyses included paired t-tests and Cohen's d for effect sizes. Significant improvements were observed in SySQ scores (P<0.001, d=0.919), reflecting better QoL; in emotional regulation (P<0.001, d=1.255); in approach-oriented coping (P=0.005, d=0.489). Patients with specific personality traits (e.g., melancholic) showed greater QoL gains, while others (e.g., avoidant) reported worsened perceptions.</p><p><strong>Conclusions: </strong>AT enhanced QoL, emotional regulation, and coping in SSc patients, though outcomes varied by personality traits. Personalizing interventions may optimize benefits according to patient's psychological profiles.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"256-261"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147981666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}