Aikaterini Niforou, Pagona D Lagiou, Alan C Geller, Nick Dessypris, Alexander J Stratigos
{"title":"Trends in Breslow thickness of nodular and superficial spreading melanoma subtypes and associated factors: a twelve-year analysis from a tertiary referral center in Greece.","authors":"Aikaterini Niforou, Pagona D Lagiou, Alan C Geller, Nick Dessypris, Alexander J Stratigos","doi":"10.23736/S2784-8671.24.08129-5","DOIUrl":"10.23736/S2784-8671.24.08129-5","url":null,"abstract":"<p><strong>Background: </strong>Primary tumor thickness is important for prognosis of melanoma patients. To enhance prevention and quantify the true burden of melanoma, better understanding of thickness patterns and associated characteristics is crucial. Previous studies have been limited to report trends and address risk factors of thickness in specific melanoma subtypes in the Greek population. We investigated associations between epidemiological characteristics and thickness for the two most common melanoma subtypes and the trends in thickness over a twelve-year period.</p><p><strong>Methods: </strong>A retrospective study of 1201 patients with histologically confirmed primary nodular and superficial spreading melanoma (SSM) diagnosed from 2010 to 2021 in \"Andreas Sygros\" Hospital of Cutaneous and Venereal diseases was conducted. Multiple regression was performed to examine the association of variables of interest with melanoma thickness.</p><p><strong>Results: </strong>SSM thickness significantly increased by 2% per year (percent of change: 2.0, 95% CI: 0.2, 3.7) from 2010 to 2021, while a similar tendency for nodular melanoma (NM) thickness was indicated. Age at diagnosis was demonstrated to be a predictor of thickness for both subtypes. When considering all confounders, overall sun exposure was inversely associated with SSM thickness (PC: -6.2, 95% CI: -12.4, 0.5) and a similar association was indicated for NM (PC: -9.3, 95%CI: -21.1, 4.2).</p><p><strong>Conclusions: </strong>These results indicate an upward trend of SSM thickness and the associations of age at diagnosis and overall exposure to UV with thickness of both subtypes. Future research is needed to identify additional characteristics and explain differences among all melanoma types.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"20-28"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olive Anagu, Jesse Salas, Sarah Choe, Abhinav Birda, Ajay Sharma, Gabrielle Baker, Natasha Mesinkovska
{"title":"The emerging role of photodynamic therapy in the treatment of cutaneous infections.","authors":"Olive Anagu, Jesse Salas, Sarah Choe, Abhinav Birda, Ajay Sharma, Gabrielle Baker, Natasha Mesinkovska","doi":"10.23736/S2784-8671.24.07910-6","DOIUrl":"10.23736/S2784-8671.24.07910-6","url":null,"abstract":"<p><strong>Introduction: </strong>Cutaneous infections pose ongoing challenges to standard treatments due to resistance and limited efficacy. Photodynamic therapy (PDT) emerges as a promising supplement or an alternative to address complicated cases. In this review, we comprehensively review PDT's safety and efficacy in treating cutaneous infections.</p><p><strong>Evidence acquisition: </strong>A PubMed systematic review with search terms for PDT treatment, hair, skin, and nail infections.</p><p><strong>Evidence synthesis: </strong>There were a total of 43 studies on the use of PDT in cutaneous infections which discussed the treatment of viral (N.=20), bacterial (N.=11), fungal (N.=9), and protozoal (N.=3) infections. There is evidence for using PDT, mostly 5-aminolevulinic acid (5-ALA) and methyl aminolevulinate (MAL), in the treatment of cutaneous infections. Most evidence for viral infections involved treatment with 5-ALA PDT in condyloma acuminatum (CoAc), verruca vulgaris, and molluscum contagiosum. In bacterial infections, 5-ALA and MB PDT have been used to achieve complete remission in refractory Pseudomonas and atypical mycobacteria infections without recurrence. In onychomycosis, MAL PDT achieved a 40.9% cure rate and MB PDT showed a 77.8-100% cure rate with no reports of recurrence. Parasitic infections, such as leishmaniasis have also been successfully treated with both 5-ALA and MAL PDT.</p><p><strong>Conclusions: </strong>PDT is a promising treatment option for cutaneous infections, with growing evidence for its utility in treating cutaneous bacterial, viral, fungal, and parasitic infections, particularly those that fail standard treatments. Side effects were mostly limited to localized pain with good outcomes and low recurrence rates.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"40-46"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Martina Burlando, Barbara Piazza, Antonio Guadagno, Emanuele Cozzani
{"title":"Eczematous eruption after ixekizumab successfully treated with upadacitinib.","authors":"Martina Burlando, Barbara Piazza, Antonio Guadagno, Emanuele Cozzani","doi":"10.23736/S2784-8671.24.08050-2","DOIUrl":"https://doi.org/10.23736/S2784-8671.24.08050-2","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":"160 1","pages":"81-82"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antonio Podo Brunetti, Carolina DE Rosa, Vanessa Bottino, Franco Rongioletti
{"title":"The role of intravenous immunoglobulin in autoimmune diseases with dermatological implications.","authors":"Antonio Podo Brunetti, Carolina DE Rosa, Vanessa Bottino, Franco Rongioletti","doi":"10.23736/S2784-8671.24.07955-6","DOIUrl":"10.23736/S2784-8671.24.07955-6","url":null,"abstract":"<p><p>Intravenous immunoglobulin (IVIG) therapy has emerged as a promising treatment option for various dermatological autoimmune diseases due to its immunomodulatory potential and low incidence of severe side effects. Despite its widespread use, the mechanism of action of IVIG in treating autoimmune diseases remains a topic of debate. IVIG is derived from the plasma fractionation of a large pool of donors, primarily consisting of the IgG isotype. Its main mechanisms of action involve neutralizing circulating autoantibodies via the F(ab')2 portion, inhibiting complement-mediated tissue destruction, and reducing the half-life of circulating autoantibodies through the Fc portion. This paper explores the growing utilization of IVIG as an off-label therapy in dermatological autoimmune or immune-mediated diseases, including autoimmune bullous disease (AIBS), dermatomyositis (DM), lupus erythematosus (LE), systemic sclerosis, scleromyxedema, Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), pyoderma gangrenosum (PG), and necrobiotic xanthogranuloma (NXG). In this context, the sole large prospective, randomized trial was the 2022 ProDERM study, which demonstrate efficacy of IVIG in improving cutaneous manifestations among 95 DM patients compared to the placebo group. Moreover, although considered off-label, the use of IVIG is regarded as the first-line therapy for patients with scleromyxedema. As a first line of therapy, IVIg is only approved for Kawasaki Disease (KD) in the setting of vasculitis. The treatment in all other indications is mostly considered as adjuvant therapy only after failure of immunosuppressive therapy or in the presence of contraindications.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"47-54"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Keloid management: a review of treatment modalities.","authors":"Peter M Luo, Donald A Glass Ii","doi":"10.23736/S2784-8671.24.07848-4","DOIUrl":"10.23736/S2784-8671.24.07848-4","url":null,"abstract":"<p><p>Keloids are an aberrant fibroproliferative response to wound healing of the skin, leading to scar tissue that expands above and beyond the original cutaneous injury. Keloids can be difficult to treat because of their tendency to recur after treatments, including after excision. There is a myriad of treatment modalities used, which can be used as monotherapy or in combination with surgical excision or other treatment methods. This review covers many treatment approaches including surgical excision, compression, silicone sheets, steroid-impregnated tape, imiquimod, intralesional injections, cryotherapy, laser, radiation, pentoxifylline, and dupilumab.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"29-39"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giulia Briatico, Gaetano Licata, Vittorio Tancredi, Carmine Fiorentino, Camila Scharf, Francesca Pagliuca, Giuseppe Argenziano, Caterina M Giorgio
{"title":"Intralesional rifampicin for cutaneous leishmaniosis: a case report with reflectance confocal microscopy therapy assessment.","authors":"Giulia Briatico, Gaetano Licata, Vittorio Tancredi, Carmine Fiorentino, Camila Scharf, Francesca Pagliuca, Giuseppe Argenziano, Caterina M Giorgio","doi":"10.23736/S2784-8671.24.07967-2","DOIUrl":"10.23736/S2784-8671.24.07967-2","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"67-68"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Estimates of the burden of skin melanoma in Italy: update to 2024.","authors":"Emanuele Crocetti, Federica Zamagni, Fabio Falcini, Rosa Vattiato, Flavia Baldacchini, Chiara Balducci, Orietta Giuliani, Silvia Mancini, Alessandra Ravaioli, Benedetta Vitali, Lauro Bucchi","doi":"10.23736/S2784-8671.24.08033-2","DOIUrl":"10.23736/S2784-8671.24.08033-2","url":null,"abstract":"<p><strong>Background: </strong>The epidemiology of skin melanoma (SM) is rapidly changing. Therefore, we aimed at updating up to 2024 the Italian estimates on SM providing the number of incident and prevalent cases, the deaths and the distribution by stage at diagnosis.</p><p><strong>Methods: </strong>Incidence was extrapolated from age- and sex-specific International Agency for Research on Cancer (IARC) estimates from 2022 to 2025. For mortality, we applied to the most recent observed deaths, the average sex- and age-specific annual percent change estimated by the IARC from 2022 to 2025. Regarding SM prevalence, we assumed the age- and sex-specific annual change in the number of prevalent cases observed from 2010 to 2020 to be stable until 2024. Finally, we applied the average distribution by TNM-8 stages of four population-based SM series to provide a possible stage distribution at diagnosis.</p><p><strong>Results: </strong>We estimated almost 13,800 newly diagnosed SMs (54% men and 82% people older than 44 years), 2240 deaths (60% men and 49% people older than 74 years) and about 216,000 prevalent cases (51% women). At diagnosis, around 10,240 cases are expected to be stage I, 2120 stage II, 1100 stage III and 327 stage IV. As regards stage I 79% will be IA. Among stage II we expect 44% IIA, 33% IIB and 22% IIC. Among stage III, 49% case are expected to be IIIC.</p><p><strong>Conclusions: </strong>These estimates allow clinicians and policymakers to quantify and properly address the burden of SM patients' diagnostic, therapeutic and supportive needs.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"1-6"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Angioedema-like allergic contact dermatitis in a pediatric patient due to an eyebrows dye.","authors":"Lorenzo Melloni, Federico Gianessi, Chiara Bocchi, Elisa Marzola, Alessandro Borghi, Monica Corazza","doi":"10.23736/S2784-8671.24.07977-5","DOIUrl":"10.23736/S2784-8671.24.07977-5","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"69"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria E Greco, Simone Michelini, Emanuele Amore, Antonio DI Guardo, Vito V Gomes, Luca Guarino, Francesca P Sasso, Federica Trovato, Giovanni Pellacani
{"title":"Nummular eczema following brigatinib administration in patient with lung cancer.","authors":"Maria E Greco, Simone Michelini, Emanuele Amore, Antonio DI Guardo, Vito V Gomes, Luca Guarino, Francesca P Sasso, Federica Trovato, Giovanni Pellacani","doi":"10.23736/S2784-8671.24.08002-2","DOIUrl":"10.23736/S2784-8671.24.08002-2","url":null,"abstract":"","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"72-74"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Andrea Bassi, Michela Magnano, Cesare Filippeschi, Samantha Berti, Laura Bachini, Martina Vispi, Camilla Peccianti, Giordana Coronella, Teresa Oranges, Carlo Mazzatenta
{"title":"Tuscany consensus for pediatric scabies: update on clinical management and the urgent need for new guidelines.","authors":"Andrea Bassi, Michela Magnano, Cesare Filippeschi, Samantha Berti, Laura Bachini, Martina Vispi, Camilla Peccianti, Giordana Coronella, Teresa Oranges, Carlo Mazzatenta","doi":"10.23736/S2784-8671.24.07991-X","DOIUrl":"10.23736/S2784-8671.24.07991-X","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to assess the degree of agreement among pediatric dermatologists in Tuscany concerning different aspects of scabies infestation management in children, employing the Delphi method.</p><p><strong>Methods: </strong>We conducted a Delphi study involving ten pediatric dermatology centers in Tuscany, Italy. Questionnaires were distributed to a panel of experts anonymously. The questionnaires were organized into six specific topics: \"diagnosis,\" \"hygiene measures,\" \"application of topical products,\" \"treatment,\" \"treatment of exposed individuals,\" and \"clinical follow-up after therapy.\" Each question within these topics offered six different response options.</p><p><strong>Results: </strong>All participating dermatologists completed the two-round questionnaire. Full consensus was reached for all statements related to \"diagnosis,\" \"hygiene measures,\" \"treatment of exposed individuals,\" \"application of topical products,\" and \"clinical follow-up after therapy,\" since each statement met the predetermined consensus threshold of 70% or higher. However, we could not achieve a substantial consensus on the treatment of scabies, aside from agreement on the lower efficacy of permethrin therapy.</p><p><strong>Conclusions: </strong>Considering the growing recognition of Sarcoptes scabiei resistance to conventional permethrin therapy, this regional consensus offers clear insights into the overall management of scabies. However, it also reveals that each dermatologist primarily relies on their own experiences for medical treatment, which may not be universally shared among colleagues. This emphasizes the urgent necessity for updated guidelines on therapeutic strategies.</p>","PeriodicalId":14526,"journal":{"name":"Italian Journal of Dermatology and Venereology","volume":" ","pages":"12-19"},"PeriodicalIF":1.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142668068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}