Iranian Journal of Medical Sciences最新文献

{"title":"Probiotics Outperform Antioxidants in Improving Semen Parameters of Men with Idiopathic Oligoasthenoteratozoospermia: A Randomized Controlled Trial.","authors":"Farshad Gholipour, Davoud Gharakhani, Amirhossein Rahavian, Mahdi Norouzi, Mohammadreza Hajian, Serajoddin Vahidi, Mohammad Javad Nazarpour, Farbod Khorrami","doi":"10.30476/ijms.2025.105150.3888","DOIUrl":"10.30476/ijms.2025.105150.3888","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic oligoasthenoteratozoospermia (iOAT) treatment still poses significant challenges. This study aims to compare the therapeutic efficacy of probiotics on sperm parameters of iOAT patients with placebo and antioxidants.</p><p><strong>Methods: </strong>In this triple-blind, randomized controlled trial, 110 men with iOAT were assigned to receive either a probiotic (Familact^®), an antioxidant (Sperigen^®), or a placebo daily for 3 months, in two academic centers in Iran (Isfahan and Yazd). The study was conducted from July 2021 to April 2022. Sperm parameters were analyzed using computer-assisted semen analysis. The main measured outcomes included semen volume and sperm features, including motility, morphology, and concentration. Changes in semen parameters were assessed using linear mixed-effects models with fixed effects for time, group, and their interaction. Estimated marginal means were compared across groups using Bonferroni-adjusted pairwise tests.</p><p><strong>Results: </strong>Overall, 110 men (mean age of 34.3±4.5 years) were included in the final analysis. Significant Time×Group interactions were found for sperm concentration (P=0.003), motility (P<0.001), and morphology (P<0.001), but not for semen volume (P=0.71). After 3 months, the probiotic group showed significantly greater improvements in sperm concentration (10.42±1.11×10⁶/mL, P=0.007), motility (46.65±3.73%, P=0.001), and morphology (4.31±0.21%, P<0.001) compared to the placebo group. Additionally, probiotics outperformed antioxidants in morphology (P<0.001) and motility (P=0.009).</p><p><strong>Conclusion: </strong>This study is the first to directly compare probiotics and antioxidants in treating iOAT. Probiotics showed superior performance in sperm motility and morphology compared to antioxidants, although drawing a strong conclusion requires further robust studies<b>Trial Registration Number:</b> IRCT20150420021869N5.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"51 1","pages":"39-46"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12858446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel <i>AP4M1</i> Variant in an Iranian Child with Spastic Paraplegia 50: A Case Report and Molecular Docking Approach.","authors":"Hamed Esmaeil Lashgarian, Masumeh Jalalvand, Maryam Zand, Amirmasoud Jalalvand, Leila Abkhooie, Fatemeh Kazemisafa, Hamidreza Khodadadi","doi":"10.30476/ijms.2025.106981.4128","DOIUrl":"10.30476/ijms.2025.106981.4128","url":null,"abstract":"<p><p>Spastic paraplegia 50 (SPG50) is a rare autosomal recessive disorder caused by mutations in the <i>AP4M1</i> gene (OMIM 602296). It is characterized by spasticity, severe intellectual disability, and delayed or absent speech. The present study reported a case from consanguineous parents, where the affected child presented with intellectual disability, seizures, muscle weakness, and deep white matter hyperintensity. Whole exome sequencing (WES) of the proband identified a novel, homozygous frameshift variant, c.258delG:p.A87Pfs*44, in the <i>AP4M1</i> gene, which was confirmed by Sanger sequencing. This variant is predicted to cause a large truncation of the protein, leading to a loss of function. Molecular modeling and docking analyses further revealed that the loss of a substantial protein segment disrupts proper intramolecular interactions. A review of the literature on Iranian families with SPG50 yielded few reports, consistent with the disease's rarity. This study expanded the knowledge of the clinical and genetic features of SPG50 and underscored the importance of this variant for genetic diagnosis and counseling in affected families.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"51 1","pages":"70-76"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12858432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HIV Research Priorities in Iran: Reflections from the Early Years to a New Framework for Action.","authors":"Shohreh Beheshti","doi":"10.30476/ijms.2025.51468","DOIUrl":"10.30476/ijms.2025.51468","url":null,"abstract":"","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"51 1","pages":"1-2"},"PeriodicalIF":1.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12858442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Palatal Teratoma: A Rare Case of Postnatal Diagnosis and Multidisciplinary Management.","authors":"Nona Sabeti, Ezat Hajmollarezaei, Ahmad Mohamad Pour, Emad Pour Rajab","doi":"10.30476/ijms.2025.105580.3943","DOIUrl":"10.30476/ijms.2025.105580.3943","url":null,"abstract":"<p><p>Oropharyngeal teratoma (OPT) is a rare congenital tumor that may present either in isolation or in conjunction with craniofacial anomalies, often posing a major risk to infant survival. Recent advances in prenatal imaging, particularly high-resolution ultrasonography, have significantly improved the early detection and characterization of such tumors, enhancing clinical decision-making. Although prenatal sonography and MRI typically enable early diagnosis, the present study reported a case of OPT, diagnosed postpartum in an Iranian female infant weighing 4300 g. Despite the absence of prenatal diagnosis, the mass was successfully managed through prompt surgical intervention. The outcome was favorable, with no complications or recurrence. This case highlighted the critical role of early diagnosis and multidisciplinary perinatal planning in improving the prognosis of rare congenital tumors such as OPT.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"50 12","pages":"873-876"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12686947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145723246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidative Stress Influences Exosome Biogenesis by Inducing Cellular Senescence in Uterine Adenocarcinoma Ishikawa Cells.","authors":"Fatemeh Sokouti Nasimi, Behrad Alimohammadzadeh, Amir Mehdizadeh, Dhafer A F Al-Koofee, Amin Tamadon, Mahdi Mahdipour, Reza Rahbarghazi","doi":"10.30476/ijms.2025.105914.3995","DOIUrl":"10.30476/ijms.2025.105914.3995","url":null,"abstract":"<p><strong>Background: </strong>The progression of life and cellular senescence can alter the physiological activity of every cell type. Here, the possible effect of oxidative stress on exosome (Exo) biogenesis was studied in endometrial adenocarcinoma Ishikawa cells.</p><p><strong>Methods: </strong>This <i>in vitro</i> study was conducted from 2022 to 2023 at the Stem Cell Research Center affiliated with Tabriz University of Medical Sciences. Cells were treated with 20 μM hydrogen peroxide (H₂O₂) for 4 days, and physicochemical properties of Exos were analyzed using dynamic light scattering (DLS), scanning electron microscope (SEM), and western blotting. The expression of genes such as <i>ALIX</i>, <i>CD63</i>, <i>TSG101</i>, <i>Rab27a</i>, and <i>Rab27b</i>, along with aging factor senescence-associated 𝛽-galactosidase (SA-β-gal), was studied using real-time PCR analysis. The fatty acid profile was determined in isolated Exos using gas chromatography. We also measured the exosomal content of superoxide dismutase (SOD), glutathione peroxidase (GPx), and malondialdehyde (MDA).</p><p><strong>Results: </strong>The expression of SA-β-gal confirmed the successful induction of aging in Ishikawa cells after 4 days (P=0.0286). DLS analysis indicated a slight increase and decrease in mean Exo size and zeta potential, respectively, in H₂O₂-treated Exos compared to the control group. Proteomic analysis revealed the lack of changes in exosomal levels of CD63 and CD81 tetraspanins in both groups (P=0.001). Real-time PCR analysis indicated the upregulation of <i>ALIX</i> and <i>TSG101</i>, while the expression of <i>CD63</i> and <i>Rab27b</i> was reduced in H₂O₂-treated cells compared to the control group (P=0.0015 and P=0.0129). No statistically significant changes were found in exosomal levels of SOD, GPx, and MDA before and after treatment with the H₂O₂ (P=0.857, P=0.421, and P=0.3739). Data indicated an increase in exosomal polyunsaturated fatty acids and monounsaturated fatty acids in H₂O₂-treated cells compared to the control cells.</p><p><strong>Conclusion: </strong>Oxidative stress can influence Exo biogenesis and paracrine activity in endometrial tumor cells via the induction of cellular senescence.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"50 12","pages":"832-842"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12686952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145723199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Mice to Primates: Assessing Hormone-Based Endometriosis Models for Preclinical and Therapeutic Insights.","authors":"Amin Tamadon, Afshin Zare, Mahdi Mahdipour, Aria Salehpour, Nadiar M Mussin, Aliya A Mussina, Raisa A Aringazina, Ainash Duisenova, Kulyash R Zhilisbayeva, Madina A Kurmanalina, Chong Fu","doi":"10.30476/ijms.2025.105805.3975","DOIUrl":"10.30476/ijms.2025.105805.3975","url":null,"abstract":"<p><p>Endometriosis, a complex gynecological disorder characterized by ectopic endometrial-like tissue, affects over 10% of women, causing chronic pain and infertility. Despite extensive research, its pathophysiology remains incompletely understood, with proposed mechanisms including inflammation, hormonal dysregulation, and retrograde menstruation. Given ethical and practical challenges in human studies, animal models are essential for investigating endometriosis pathogenesis and evaluating therapeutic interventions. This review examines hormone-related animal models of endometriosis, comparing induction methods (autotransplantation, xenotransplantation, and spontaneous models) and their applications in studying sex steroid hormones (SSH) and the hypothalamic-pituitary-gonadal (HPG) axis. We analyzed 158 studies (2010-2024) from PubMed Central/Medline, focusing on SSH and HPG axis involvement. A novel scoring system was developed to assess the model's suitability based on species, induction method, pharmacological effects, hormonal/genetic evaluations, histological confirmation, feasibility, ethics, and cost. Non-human primate models, particularly spontaneous and hormone-induced baboon models, scored highest due to their physiological resemblance to humans. However, rodent models remain widely used due to practicality. Our findings highlight the need for improved preclinical models to enhance translational research, ultimately aiding in the development of targeted therapies for endometriosis. This comprehensive analysis provides a framework for selecting optimal animal models in future endometriosis research.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"50 12","pages":"806-818"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12686953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145723216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanocurcumin: An Innovative Strategy to Combat Virulence and Methicillin Resistance in <i>Staphylococcus aureus</i> Isolated from Burn Wounds.","authors":"Alaa Alhameedawi, Majid Sadeghizadeh, Bahaa Abdullah Al-Rubaii","doi":"10.30476/ijms.2025.105799.3976","DOIUrl":"10.30476/ijms.2025.105799.3976","url":null,"abstract":"<p><strong>Background: </strong>Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) is a pathogen that causes various infections and exhibits antibiotic resistance and virulence factors, requiring alternative therapies. This study aimed to evaluate the effects of nanocurcumin on gene expression of <i>S. aureus</i> isolates from burn wounds in Iraqi patients, focusing on inhibiting resistance and virulence genes.</p><p><strong>Methods: </strong>From March 2023 to May 2024, burn wound samples from Iraqi patients yielded 110 <i>S. aureus</i> isolates. Identification was conducted by Gram staining, biochemical assays, and culture techniques. Fifty isolates were randomly selected for antibiotic susceptibility testing using the VITEK 2 Compact System. Ten isolates showing the highest resistance to multiple antibiotics were selected for molecular characterization via Multiplex polymerase chain reaction (Multiplex PCR) to detect <i>fnbA</i>, <i>icaA</i>, <i>icaB</i>, <i>ftsZ</i>, <i>hla</i>, <i>pvl</i>, <i>femA</i>, and <i>mecA</i> genes. The ten isolates were then divided into two groups a treatment group exposed to nanocurcumin and an untreated control group. The MIC (minimum inhibitory concentration) of nanocurcumin was determined using the broth microdilution method in a 96-well plate. The 16S <i>rRNA</i> gene served as an internal control for evaluating the molecular effects. A two-tailed <i>t</i> test was used to assess the significance of gene expression differences.</p><p><strong>Results: </strong>All 110 isolates were confirmed as <i>S. aureus</i>. The 50 selected isolates were resistant to cefoxitin, amoxicillin, benzylpenicillin, ampicillin/sulbactam, piperacillin/tazobactam, cloxacillin, oxacillin, and azithromycin. MecA gene was detected in all isolates. Among the ten tested, <i>femA</i>, <i>icaA</i>, <i>hla</i>, and <i>ftsZ</i> were present in 70%; <i>pvl</i> in 50%; <i>icaB</i> in 20%; and <i>fnbA</i> in 10%. Quantitative reverse transcription polymerase chain reaction (qRT-PCR), showed significant downregulation of <i>icaA</i>, <i>hla</i>, <i>pvl</i>, <i>femA</i>, and <i>mecA</i> in treated isolates. No significant changes were seen in <i>fnbA</i> and <i>ftsZ</i>.</p><p><strong>Conclusion: </strong>Nanocurcumin inhibits <i>S. aureus</i> virulence and resistance genes, reducing biofilm formation and toxin production, but lacks effect on <i>fnbA</i> and <i>ftsZ</i>, requiring further research.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"50 12","pages":"852-862"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12686950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145723265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Propensity Score Matching in Non-Interventional Studies: A Step-by-Step Guide for Clinicians and Researchers.","authors":"Saeedeh Pourahmad, Farzan Madadizadeh","doi":"10.30476/ijms.2025.105595.3947","DOIUrl":"10.30476/ijms.2025.105595.3947","url":null,"abstract":"","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"50 12","pages":"877-881"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12686948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145723267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Information Confidentiality in Telemedicine Platforms Using Public Web Data: A Case Study of Persian Televisit Websites.","authors":"Mohammad Haddad Soleymani, Adel Mohammadpour","doi":"10.30476/ijms.2025.105205.3899","DOIUrl":"10.30476/ijms.2025.105205.3899","url":null,"abstract":"<p><strong>Background: </strong>The shift from traditional office visits to internet-based care has accelerated during the COVID-19 pandemic, increasing reliance on telemedicine platforms. This growth has led to more health-related electronic data and heightened risks of unauthorized access, making it essential to prioritize information confidentiality issues. This study aims to reveal the disclosure of confidential information on a Persian televisit website.</p><p><strong>Methods: </strong>In this observational case study, we gathered public health-related electronic data from a Persian televisit website in 2022. SAS software was used to harvest messy data about patients and doctors and create a structured dataset. Meanwhile, Microsoft Excel and RStudio software programs were used for data visualization. A hashing algorithm was applied to encode personal information, preventing the identification of individuals.</p><p><strong>Results: </strong>Our study showed how public web data about 263 patients and 194 doctors, harvested from the target website, can be used to reveal patients' private information. Using such data, we explored the patient-doctor interaction patterns. With access to the patients' identifiable information, we recognized the identity of the clients who received internet-based care services and their possible diseases.</p><p><strong>Conclusion: </strong>This analysis revealed that exposure of patients' confidential information could compromise their identities and underlying medical conditions. This highlights the need for a national framework to ensure the security of health-related electronic data. Health authorities should enforce comprehensive laws, while the owners of televisit websites should implement privacy by design principles into the development of such platforms to prevent the disclosure of sensitive information.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"50 12","pages":"843-851"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12686951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145723211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Nanoherbal <i>Paraboea leuserensis</i> as a Therapeutic Agent in Traumatic Brain Injury: <i>In Silico</i>, and <i>In Vivo</i> Approaches.","authors":"Syafruddin Ilyas, Putri Cahaya Situmorang, Hafandi Ahmad, Dina Khairani, Dini Prastyo Wati, Wardah Sawitri Polem","doi":"10.30476/ijms.2025.106167.4027","DOIUrl":"10.30476/ijms.2025.106167.4027","url":null,"abstract":"<p><strong>Background: </strong>Traumatic brain injury (TBI) is a major global health burden and one of the leading causes of death and disability worldwide, affecting up to 74 million people annually. It profoundly impairs mental health, quality of life, and daily functioning. This study aimed to explore the therapeutic potential of nanoherbal compounds from <i>Paraboea leuserensis</i> using combined <i>in silico</i> and <i>in vivo</i> approaches in a rat model of TBI.</p><p><strong>Methods: </strong>In the <i>in silico</i> phase, bioactive compounds from <i>Paraboea leuserensis</i> leaves identified by Gas Chromatography-Mass Spectrometry (GC-MS) were screened through molecular docking to assess their binding affinity and pharmacokinetic properties. For the <i>in vivo</i> study, 30 male Wistar rats were allocated into six groups: G0 (normal control), G+(TBI control), MP (TBI+methylprednisolone 30 mg/Kg BW), and treatment groups PL100, PL200, and PL300 (TBI+nanoherbal extract at 100, 200, and 300 mg/Kg BW, respectively). Antioxidant activity was evaluated through superoxide dismutase (SOD) and malondialdehyde (MDA) assays. Data were analyzed by one-way ANOVA with Tukey's post hoc test (P<0.05) using GraphPad Prism.</p><p><strong>Results: </strong>GC-MS analysis revealed bioactive compounds with favorable pharmacokinetic properties. Molecular docking showed strong interactions of 9-octadecen-12-ynoic acid methyl ester with ERK2 and CCR2, while 9-octadecenoic acid (Z) displayed notable binding to JNK3. <i>In vivo</i>, PL100 (P<0.01), PL200 (P<0.001), and PL300 (P<0.0001) significantly enhanced SOD activity and reduced MDA levels compared to the TBI control.</p><p><strong>Conclusion: </strong>Both <i>in silico</i> and <i>in vivo</i> findings highlight the neuroprotective potential of <i>Paraboea leuserensis</i>, with PL300 showing the most pronounced antioxidant effect in TBI-induced rats.</p>","PeriodicalId":14510,"journal":{"name":"Iranian Journal of Medical Sciences","volume":"50 12","pages":"819-831"},"PeriodicalIF":1.5,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12686949/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145723263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}