Analysis of CYP2D6 Gene Variant Frequencies in Iranian Population.

IF 1.5 Q2 MEDICINE, GENERAL & INTERNAL

Iranian Journal of Medical Sciences Pub Date : 2025-05-01 DOI:10.30476/ijms.2024.102645.3570

Mahsa Hokmabadi, Elnaz Asadifard, Sepideh Arbabi-Bidgoli, Anoosh Naghavi, Mandana Hasanzad

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引用次数: 0

Abstract

Background: The cytochrome P450 (P450s or CYPs) enzyme family, particularly CYP2D6, significantly influences drug metabolism, handling approximately 20-25% of prescribed medications. Understanding genetic polymorphisms is crucial for personalized medicine and optimizing drug therapy in specific geographic and racial contexts. Given the complex nature of studying CYP2D6 genotypes, this study aimed to assess the prevalence of rare CYP2D6 star alleles, including rs267608319 (CYP2D6*31), rs1931013246 (CYP2D6*55), rs569439709 (CYP2D6*113), and rs747089665 (CYP2D6*135), within the Iranian population.

Methods: Blood samples were obtained from 389 individuals across several ethnic groups in Tehran, Iran, from May to December 2022. PCR was used to amplify the region containing the desired variant. Genotyping was performed using the Sanger sequencing method.

Results: Our analysis revealed a high frequency of normal alleles for all four studied variants, indicating the absence of the risk allele in the Iranian population. These findings suggest that the studied alleles have no apparent effect on various ethnic groups in Iran.

Conclusion: The Iranian population has a typical genetic makeup for CYP2D6 variations, impacting medication prescribing. Understanding genetic differences is crucial for personalized drug therapies. Further research into Iranian genetic variations is essential for advancing personalized medicine.

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伊朗人群CYP2D6基因变异频率分析

背景：细胞色素P450 （P450或CYPs）酶家族，特别是CYP2D6，显著影响药物代谢，处理约20-25%的处方药。了解遗传多态性对于个性化医疗和优化特定地理和种族背景下的药物治疗至关重要。鉴于CYP2D6基因型研究的复杂性，本研究旨在评估伊朗人群中罕见CYP2D6星型等位基因的患病率，包括rs267608319 （CYP2D6*31）、rs1931013246 （CYP2D6*55）、rss569439709 （CYP2D6*113）和rs747089665 （CYP2D6*135）。方法：从2022年5月至12月在伊朗德黑兰的几个民族中采集了389名个体的血液样本。用PCR扩增含有所需变异的区域。采用Sanger测序法进行基因分型。结果：我们的分析显示，所有四种研究变异的正常等位基因频率很高，表明伊朗人群中没有风险等位基因。这些发现表明，所研究的等位基因对伊朗的不同种族群体没有明显的影响。结论：伊朗人群具有典型的CYP2D6变异基因构成，影响药物处方。了解基因差异对于个性化药物治疗至关重要。对伊朗遗传变异的进一步研究对于推进个性化医疗至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian Journal of Medical Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

3.20

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： The Iranian Journal of Medical Sciences (IJMS) is an international quarterly biomedical publication, which is sponsored by Shiraz University of Medical Sciences. The IJMS intends to provide a scientific medium of communication for researchers throughout the globe. The journal welcomes original clinical articles as well as clinically oriented basic science research experiences on prevalent diseases in the region and analysis of various regional problems.