Chemistry - A European Journal最新文献_第4页

Boric Acid Post-Modified [Al]ZSM-5 Zeolites: Properties, Acidity, and Ethanol/Ethene Conversion. 硼酸后改性[Al]ZSM-5沸石：性质、酸度和乙醇/乙烯转化

IF 3.7 2区化学

Chemistry - A European Journal Pub Date : 2026-05-05 Epub Date: 2026-02-21 DOI: 10.1002/chem.202503502

Zheng Li, Daniel Dittmann, Dennis Strassheim, Michael Dyballa

{"title":"Boric Acid Post-Modified [Al]ZSM-5 Zeolites: Properties, Acidity, and Ethanol/Ethene Conversion.","authors":"Zheng Li, Daniel Dittmann, Dennis Strassheim, Michael Dyballa","doi":"10.1002/chem.202503502","DOIUrl":"10.1002/chem.202503502","url":null,"abstract":"The effect of boric acid post-modification on [Al]ZSM-5 zeolites is investigated. Boric acid modification reduces surface areas, and high loadings lead to agglomeration of crystals. 11B MAS NMR spectroscopy indicates boron isomorphously substituted into the framework if 1.5 wt% boric acid is applied, while above 5 wt% loading additionally surface bound BT1 species and, increasingly, boric acid deposits BT0 are found. The Brønsted acid site (BAS) density decreases with boric acid loading. 1H MAS NMR spectroscopy after acetonitrile-d3 loading reveals a similar BAS strength as the parent, thus BAS are associated with bridging Si(OH)Al from the parent's structure. A loading with trimethylphosphine oxide (TMPO) is sensitive to weaker Lewis acid sites (LAS). A subsequent hydration changes the nature of water-accessible boric acid surface species. Conversion of methanol, ethanol, or ethene over boric acid-modified MFI was tested. For 1.5 wt% loading, an increased BTEX content and lifetime in ethanol conversion was observed, while other modified catalysts were outperformed by the unmodified parent. Most boron is removed after catalytic application. It is concluded that the introduced weak surface acidity and the introduced LAS density could render the modification method interesting for synthesizing new adsorbents operated at moderate conditions.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e03502"},"PeriodicalIF":3.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13150057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146256893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Covalent to Supramolecular: Re-Thinking Lysosome-Targeting Chimeras Through Modular and Tunable Proximity Control. 从共价到超分子：通过模块化和可调接近控制重新思考溶酶体靶向嵌合体。

IF 3.7 2区化学

Chemistry - A European Journal Pub Date : 2026-05-05 Epub Date: 2026-02-20 DOI: 10.1002/chem.202503647

Nan Wang, Xiaoran Wang, Zhengyu Jiang, Xuetao Chen

{"title":"From Covalent to Supramolecular: Re-Thinking Lysosome-Targeting Chimeras Through Modular and Tunable Proximity Control.","authors":"Nan Wang, Xiaoran Wang, Zhengyu Jiang, Xuetao Chen","doi":"10.1002/chem.202503647","DOIUrl":"10.1002/chem.202503647","url":null,"abstract":"Proximity-based molecular strategies have reshaped chemical biology, yet their architectures remain dominated by covalent linkers that impose fixed stoichiometry and static control. Such rigidity limits adaptability, particularly in lysosome-targeting systems that operate within highly dynamic trafficking environments. This concept reframes molecular linkage as a regulatable interface rather than a permanent connection, proposing supramolecular host-guest interactions as a modular alternative to covalent bridges. By enabling reversible assembly and tunable stoichiometry, supramolecular proximity decouples target engagement from effector recruitment and introduces dynamic control over proximity outcomes. Extending beyond lysosome-targeting degradation, this framework offers general design principles for proximity-based modalities that rely on transient, spatially constrained, or context-dependent interactions. Collectively, these insights position supramolecular interfaces as a conceptual expansion of chemically induced proximity, opening new avenues for adaptive and controllable molecular systems.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e03647"},"PeriodicalIF":3.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146256896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deboronation and Alumination of SCM-10 Zeolites for Efficient α-Pinene Isomerization. SCM-10分子筛在α-蒎烯异构化中的吸附和铝化作用。

IF 3.7 2区化学

Chemistry - A European Journal Pub Date : 2026-05-05 DOI: 10.1002/chem.202600007

Wei Chen, Lou Gao, Yaqi Fan, Yi Luo, Weimin Yang

{"title":"Deboronation and Alumination of SCM-10 Zeolites for Efficient α-Pinene Isomerization.","authors":"Wei Chen, Lou Gao, Yaqi Fan, Yi Luo, Weimin Yang","doi":"10.1002/chem.202600007","DOIUrl":"https://doi.org/10.1002/chem.202600007","url":null,"abstract":"The weak acidity of borosilicate zeolites limits their catalytic applications. However, the labile framework boron atoms offer an opportunity to incorporate aluminum post-synthetically to tailor acidity. Herein, aluminosilicate SCM-10 zeolites (Al-SCM-10), featuring an SFE-type framework with 1D 12-membered ring channels, were prepared through boron-to-aluminum substitution of borosilicate SCM-10 using aqueous Al(NO3)3 solutions. The influences of Al(NO3)3 concentration, treatment temperature, and parent composition on framework Al incorporation were investigated. A synergistic combination of moderate Al(NO3)3 concentration (1.0 M) and temperature (150°C) was found to favor framework Al incorporation while preserving microporosity. In contrast, overly dilute solutions and/or elevated temperatures led to partial pore blockage, whereas low temperatures or excessive Al(NO3)3 concentrations resulted in inefficient Al incorporation. The resulting Al-SCM-10 zeolites exhibit tunable Si/Al molar ratios (28-79), moderate acid strength, and Lewis-acid-rich character. In α-pinene isomerization, the optimized Al-SCM-10 catalyst achieves 97.8% conversion and a combined yield of 77.2% toward high-value products camphene and limonene, outperforming conventional zeolite catalysts under identical reaction conditions. These results demonstrate that post-synthetic aluminum incorporation is an effective strategy for activating SCM-10 for selective biomass-derived transformations.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e00007"},"PeriodicalIF":3.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147831181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Magnesium-Promoted Benzidine-Type Rearrangement for Regioselective Construction of Polyfunctionalized Biaryls. 镁促进联苯胺型重排对多功能化双芳基的区域选择性构建。

IF 3.7 2区化学

Chemistry - A European Journal Pub Date : 2026-05-05 Epub Date: 2026-02-15 DOI: 10.1002/chem.202503607

Shumpei Saito, Manato Ishida, Yuki Busujima, Miki Ebihara, Kodai Kohama, Naomi Tanaka, Eitaro Toya, Minami Nakamura, Takashi Kanamori, Tadaomi Furuta, Shota Matsumoto, Satoru Karasawa, Hideya Yuasa, Takeshi Hata

{"title":"Magnesium-Promoted Benzidine-Type Rearrangement for Regioselective Construction of Polyfunctionalized Biaryls.","authors":"Shumpei Saito, Manato Ishida, Yuki Busujima, Miki Ebihara, Kodai Kohama, Naomi Tanaka, Eitaro Toya, Minami Nakamura, Takashi Kanamori, Tadaomi Furuta, Shota Matsumoto, Satoru Karasawa, Hideya Yuasa, Takeshi Hata","doi":"10.1002/chem.202503607","DOIUrl":"10.1002/chem.202503607","url":null,"abstract":"A magnesium-promoted benzidine-type rearrangement of 1,3-dihalonitroarenes with aryl Grignard reagents has been developed, enabling the highly regioselective and efficient synthesis of 1-amino-1'-hydroxy-4,4'-biaryls under simple, transition-metal-free conditions. A rational substrate design-featuring an ortho substituent (R) and two meta-substituted electron-withdrawing groups (X, Y)-steers the reaction trajectory, converting a previously minor [5,5]-sigmatropic migration into the dominant pathway. The transformation exhibits broad functional-group tolerance, excellent scalability, and provides direct and operationally straightforward access to polyfunctionalized biaryls. Furthermore, trifluoroacetamide-substituted nitroarenes undergo [5,5]-rearrangement followed by intramolecular cyclization to furnish CF3-substituted benzimidazoles with high regioselectivity. Overall, this study expands the conceptual scope of benzidine-type rearrangements and establishes a mechanistically tunable, sustainable strategy for constructing valuable biaryl and heteroaromatic scaffolds.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e03607"},"PeriodicalIF":3.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146197185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pondering the Future of Chemical Research Amid the Wider Adoption of Artificial Intelligence Technologies. 在人工智能技术广泛应用的背景下，思考化学研究的未来。

IF 3.7 2区化学

Chemistry - A European Journal Pub Date : 2026-05-05 Epub Date: 2026-02-18 DOI: 10.1002/chem.202503630

Daniil A Boiko, Mikhail V Polynski

{"title":"Pondering the Future of Chemical Research Amid the Wider Adoption of Artificial Intelligence Technologies.","authors":"Daniil A Boiko, Mikhail V Polynski","doi":"10.1002/chem.202503630","DOIUrl":"10.1002/chem.202503630","url":null,"abstract":"The rapid adoption of artificial intelligence (AI) and machine learning (ML) in chemistry coincides with increasing structural pressures on academic research, including funding constraints, talent competition, and changing attitudes toward scientific careers. In this Perspective, we argue that this combination of trends may reshape how and by whom chemical knowledge is produced, rather than simply increase research productivity. We discuss recent developments in the automation of experimentation and self-driving labs, ML-based modeling and digital twins, and the use of large language models for literature search, manuscript preparation, and review, and place them against the current financial and social pressures on universities. We outline these trends in the hope of softening the transition for the chemical research community and urging researchers, institutions, and funders to make their research ecosystems more resilient. Finally, we discuss possible shifts in the composition and structure of research groups and in the balance between universities, industry, and government laboratories, raising the central question: who will produce chemical knowledge in the research landscape changed by the wider adoption of AI technologies?","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e03630"},"PeriodicalIF":3.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

It's a Gas: Bioconjugation With Vapor-Phase Reagents. 这是一种气体：与气相试剂的生物偶联。

IF 3.7 2区化学

Chemistry - A European Journal Pub Date : 2026-05-05 Epub Date: 2026-02-21 DOI: 10.1002/chem.202503565

Yuxuan Ding, Jun Ohata, Zachary T Ball

引用次数: 0

High-Entropy Hydroxyl Carbonate With Zn, Co, Ni, Cu, and In as an Efficient Catalyst for Benzyl Alcohol Upgrading. 含Zn、Co、Ni、Cu和In的高熵碳酸羟基作为苯甲醇精制的高效催化剂。

IF 3.7 2区化学

Chemistry - A European Journal Pub Date : 2026-05-05 Epub Date: 2026-02-17 DOI: 10.1002/chem.70798

Shichen Wang, Lingfeng Gao, Liheng Sun, Haoqi Zhan, Zhibin Han, Zeyu Wang, Junfeng Xie, Xu Sun

{"title":"High-Entropy Hydroxyl Carbonate With Zn, Co, Ni, Cu, and In as an Efficient Catalyst for Benzyl Alcohol Upgrading.","authors":"Shichen Wang, Lingfeng Gao, Liheng Sun, Haoqi Zhan, Zhibin Han, Zeyu Wang, Junfeng Xie, Xu Sun","doi":"10.1002/chem.70798","DOIUrl":"10.1002/chem.70798","url":null,"abstract":"Electrocatalytic hydrogen production is pivotal for advancing the transition to green energy. However, its widespread application is hindered by the limited efficiency of electrocatalysts and the sluggish kinetics of the anodic oxygen evolution reaction (OER). Developing high-performance, durable, and cost-effective electrocatalysts, coupled with the substitution of OER with thermodynamically more favorable oxidation reactions, represents a promising strategy to address these challenges. Herein, we successfully fabricated a novel transition metal-based high-entropy hydroxyl carbonate (HE-HC) catalyst. Comprehensive experimental and computational characterizations demonstrate that the resulting catalyst exhibits superior catalytic activity for the benzyl alcohol oxidation reaction (BOR), achieving high selectivity and Faradaic efficiency (FE) toward the value-added product, benzoic acid. This work not only presents a novel metal-organic framework (MOF)-derived high-entropy catalyst for efficient alcohol oxidation co-electrolysis but also provides fundamental insights into the design principles of multi-metallic catalysts for coupled energy conversion and chemical synthesis processes.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e70798"},"PeriodicalIF":3.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal SPECT-Based Molecular Probes for Tumor Imaging and Theranostics. 基于多模态spect的分子探针在肿瘤成像和治疗中的应用。

IF 3.7 2区化学

Chemistry - A European Journal Pub Date : 2026-05-05 Epub Date: 2026-02-20 DOI: 10.1002/chem.202503646

Yuxuan Zhou, Tang Tang, Siyuan Wang, Jie Zhu, Huahua Zhang, Yongxiang Bai, Bin Zhang, Xiaoyan Wang, Haibin Shi

{"title":"Multimodal SPECT-Based Molecular Probes for Tumor Imaging and Theranostics.","authors":"Yuxuan Zhou, Tang Tang, Siyuan Wang, Jie Zhu, Huahua Zhang, Yongxiang Bai, Bin Zhang, Xiaoyan Wang, Haibin Shi","doi":"10.1002/chem.202503646","DOIUrl":"10.1002/chem.202503646","url":null,"abstract":"Single-photon emission computed tomography (SPECT) delivers exceptional molecular sensitivity and quantitative whole-body imaging, yet its intrinsically limited spatial resolution and lack of anatomical detail constrain comprehensive tumor evaluation. Recent advances in radiochemistry, molecular design, and nanotechnology have promoted the emergence of multimodal and multifunctional SPECT probes that integrate nuclear imaging with magnetic, optical, and photoacoustic modalities, while increasingly incorporating therapeutic components. These hybrid systems enable precise tumor localization, real-time intraoperative guidance, and longitudinal tracking of therapeutic responses, effectively merging diagnostic and treatment capabilities within a single molecular framework. In this review, we highlight key innovations in probe designing, elucidate structure-property relationship that govern in vivo performance, and critically examine the chemical, biological, and translational barriers that must be addressed for clinical implementation. By outlining strategic opportunities and design principles, this work aims to guide the development of next-generation SPECT-based multimodal and theranostic platforms for precision oncology.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e03646"},"PeriodicalIF":3.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146256860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generation of a Ground-State Electron Donor Utilizing Stored Light Energy. 利用储存的光能产生基态电子供体。

IF 3.7 2区化学

Chemistry - A European Journal Pub Date : 2026-05-05 Epub Date: 2026-02-17 DOI: 10.1002/chem.70795

Marc Taillefer, Éric Clot, Alexis Prieto

引用次数: 0

Artificial Intelligence-Guided Design of Fluorescent Probes for Biomedical Applications. 生物医学荧光探针的人工智能引导设计。

IF 3.7 2区化学

Chemistry - A European Journal Pub Date : 2026-05-05 Epub Date: 2026-02-20 DOI: 10.1002/chem.202503666

Pan Tao, Pengzhan Wang, Dushuo Feng, Qiyue Wang, Fangyuan Li, Daishun Ling

{"title":"Artificial Intelligence-Guided Design of Fluorescent Probes for Biomedical Applications.","authors":"Pan Tao, Pengzhan Wang, Dushuo Feng, Qiyue Wang, Fangyuan Li, Daishun Ling","doi":"10.1002/chem.202503666","DOIUrl":"10.1002/chem.202503666","url":null,"abstract":"Fluorescence imaging (FLI) has become a cornerstone for biomedical research owing to its non-invasive, high sensitivity, and exceptional spatial resolution. The effectiveness of FLI is primarily governed by the properties of fluorescent probes, including photophysical characteristics, targeting capabilities, and responsiveness. However, current probe development in FLI relies on empirical trial-and-error strategies or quantum-chemical calculations, both of which are time-consuming, labor-intensive, and often insufficient for precisely deciphering complex structure-property-function relationships. Recent advances in artificial intelligence (AI) have opened a new avenue for rational probe design through rapid property prediction, high-throughput molecular screening, and performance-guided inverse design. Nevertheless, a systematic and comprehensive review elucidating AI-guided design of fluorescent probes in biomedical applications is still lacking. This review focuses on recent advances in AI-guided design and performance optimization of fluorescent probes for bioimaging applications. First, the conceptual workflow underlying AI-based predictive frameworks is elucidated. Second, the impact of AI on optimizing key probe properties-including optical performance, targeting, and responsive capabilities-is thoroughly elaborated. Third, the biomedical applications of AI-guided probes in imaging, sensing, and therapy are reviewed. Finally, the current challenges and future perspectives to accelerate the development of AI-guided fluorescent probe design are briefly discussed.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e03666"},"PeriodicalIF":3.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146256877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0