Chemistry - A European Journal最新文献_第4页

Divergent Responses of Carbon Nitride Dot-Based Amorphous Species and Small Molecule Hybrids to Trace Level Analytes. 氮化碳点基非晶态和小分子杂化物对痕量分析物的不同响应。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-23 DOI: 10.1002/chem.202501495

Michael J Holzmann, Eric R Westphal, Kenneth M Plackowski, Melissa L Meyerson, John K Grey, Koushik Ghosh

引用次数: 0

Enhanced Protein Photo-Stability Analysis Using SRCD in the Presence of Phospholipid SUVs. 磷脂存在下SRCD增强蛋白质光稳定性分析。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-23 DOI: 10.1002/chem.202500792

Claudia Honisch, Martina Rotondo, Mario Monaco, Stefano Tartaggia, Rohanah Hussain, Giuliano Siligardi, Paolo Ruzza

{"title":"Enhanced Protein Photo-Stability Analysis Using SRCD in the Presence of Phospholipid SUVs.","authors":"Claudia Honisch, Martina Rotondo, Mario Monaco, Stefano Tartaggia, Rohanah Hussain, Giuliano Siligardi, Paolo Ruzza","doi":"10.1002/chem.202500792","DOIUrl":"https://doi.org/10.1002/chem.202500792","url":null,"abstract":"The interaction between lipids and proteins impacts on a multitude of cellular processes and may contribute to the onset of several pathologies and ageing. Such processes are frequently linked to oxidative stress, whereby polyunsaturated fatty acids act as substrates for in vivo lipoxidation. The subsequent lipid peroxidation and/or isomerisation is known to affect membrane organization, as well as to modify proteins and DNA, leading to functional alterations. Aim of this study was to evaluate the capacity of UV denaturation experiments to induce lipid modification and to investigate the influence of lipid presence on the conformational stability of selected soluble model proteins. To this end, the UV-denaturation experiment developed at the B23 beamline of the Diamond Light Source (UK) is employed, which high photon flux and brilliance of the incident beamlight induce protein denaturation when repeated consecutive synchrotron radiation circular dichroism spectra are acquired in the far-UV region, diagnostic of protein folding. This allows the estimation of protein photostability. Our findings show that the presence of lipid vesicles (SUVs) significantly impacts the UV-denaturation of proteins, preserving the native structure in proteins with a high helical content. This suggests that lipids may play a protective role against light-induced damage to proteins.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202500792"},"PeriodicalIF":3.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coordination-Controlled Synthesis of Aluminum Nanoparticles: Insights from AlH3·(NMP) x Complexes. 配位控制合成纳米铝：来自AlH3·（NMP） x配合物的见解。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-23 DOI: 10.1002/chem.202500415

Yue-Qi Liu, Wen-Hao Pan, Lin-Xia He, Chenglong Han, Tong Lu, Ning-Ning Zhang, Kun Liu

{"title":"Coordination-Controlled Synthesis of Aluminum Nanoparticles: Insights from AlH3·(NMP) x Complexes.","authors":"Yue-Qi Liu, Wen-Hao Pan, Lin-Xia He, Chenglong Han, Tong Lu, Ning-Ning Zhang, Kun Liu","doi":"10.1002/chem.202500415","DOIUrl":"https://doi.org/10.1002/chem.202500415","url":null,"abstract":"The controlled chemical synthesis of Aluminum nanocrystals (Al NCs) is crucial for their applications in plasmonics, photocatalysis, and optoelectronics. However, there is still a lack of correlation between the precursor of Al hydride N-methylpyrrolidine (AlH3·(NMP)x) and the Al NC synthesis outcomes . Here, we report the synthesis of AlH3·(NMP)x complexes with different coordination numbers (x from 1.0 to 2.0) and their characterization as precursors regulating the morphology of Al NCs. We isolated AlH3·(NMP)1.0 single crystals from AlH3·(NMP)x mixtures and successfully elucidated the structure of H3Al·(NMP)1.0 through single-crystal X-ray diffraction. Importantly, H3Al·(NMP)1.0 exhibited the fastest decomposition rate, yielding highly monodisperse Al NCs with well-defined shapes and the narrowest size distribution, while higher coordination numbers led to increased polydispersity and irregular morphologies. Additionally, we observed distinct multipole plasmonic resonances in Al NCs synthesized from lower coordination number precursors, highlighting their superior optical properties. This work establishes a direct correlation between precursor coordination chemistry and Al NC synthesis outcomes, providing a foundation for optimizing nanoparticle production for advanced material applications.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202500415"},"PeriodicalIF":3.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Degree of Functionalization and Colloidal Stability of Shell-by-Shell Functionalized TiO2 Nanoparticles as a Function of Different Phosphonic Acid Chain Lengths. 不同磷酸链长度对壳-壳功能化TiO2纳米粒子的功能化程度和胶体稳定性的影响

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-23 DOI: 10.1002/chem.202501008

Lisa M S Stiegler, Vincent Wedler, İdil Büküşoğlu, Andreas Hirsch, Wolfgang Peukert, Johannes Walter

{"title":"Investigation of the Degree of Functionalization and Colloidal Stability of Shell-by-Shell Functionalized TiO2 Nanoparticles as a Function of Different Phosphonic Acid Chain Lengths.","authors":"Lisa M S Stiegler, Vincent Wedler, İdil Büküşoğlu, Andreas Hirsch, Wolfgang Peukert, Johannes Walter","doi":"10.1002/chem.202501008","DOIUrl":"https://doi.org/10.1002/chem.202501008","url":null,"abstract":"In this work, a series of Shell-by-Shell (SbS)-functionalized colloidal systems consisting of 6 nm TiO2 anatase nanoparticles (NPs), one of the phosphonic acids (PAs) propylphosphonic acid (PAC3), hexylphosphonic acid (PAC6), dodecylphosphonic acid (PAC12), tetradecylphosphonic acid (PAC14), hexadecylphosphonic acid (PAC16), octadecylphosphonic acid (PAC18) and the amphiphile sodium dodecylbenzenesulfonate (SDBS) were prepared, resulting in TiO2-PACX@SDBS (X = 3, 6, 12, 14, 16, or 18) NPs dispersed in deionized water (DIW). During the whole functionalization process, the NPs were subjected to thermogravimetric analysis (TGA) to gain insights into their degree of functionalization and respective thermal stability. In addition, the colloidal stability of the NPs as a function of PA chain length was analyzed by analytical ultracentrifugation (AUC). By combining both TGA and AUC, it was found that the resulting hierarchical NP architectures form agglomerates, with the degree of agglomeration depending on the length of the PA used for the first-shell functionalization. This allows conclusions to be drawn about the efficiency of the overlap between the PA and the SDBS carbon chain.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202501008"},"PeriodicalIF":3.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs. -突触核蛋白c端结构域的构象开关指导其纤维多态性。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-23 DOI: 10.1002/chem.202500650

Kensuke Ikenaka, Cesar Aguirre, Yohei Miyanoiri, Masatomo So, Hajime Tamaki, Takahiro Maruno, Junko Doi, Nan Wang, Keiichi Yamaguchi, Kichitaro Nakajima, Yu Yamamori, Hiroko Inoura, Chi-Jing Choong, Keita Kakuda, Takahiro Ajiki, Yasuyoshi Kimura, Tatsuhiko Ozono, Kousuke Baba, Seiichi Nagano, Yoshitaka Nagai, Hirotsugu Ogi, Susumu Uchiyama, Yoh Matsuki, Kentaro Tomii, Yuji Goto, Hideki Mochizuki

{"title":"Conformational switch in the alpha-synuclein C-terminus domain directs its fibril polymorphs.","authors":"Kensuke Ikenaka, Cesar Aguirre, Yohei Miyanoiri, Masatomo So, Hajime Tamaki, Takahiro Maruno, Junko Doi, Nan Wang, Keiichi Yamaguchi, Kichitaro Nakajima, Yu Yamamori, Hiroko Inoura, Chi-Jing Choong, Keita Kakuda, Takahiro Ajiki, Yasuyoshi Kimura, Tatsuhiko Ozono, Kousuke Baba, Seiichi Nagano, Yoshitaka Nagai, Hirotsugu Ogi, Susumu Uchiyama, Yoh Matsuki, Kentaro Tomii, Yuji Goto, Hideki Mochizuki","doi":"10.1002/chem.202500650","DOIUrl":"https://doi.org/10.1002/chem.202500650","url":null,"abstract":"α-Synuclein (αSyn) inclusions are a pathological hallmark of several neurodegenerative diseases disorders. While cryo-electron microscopy studies have revealed distinct fibril polymorphs across different synucleinopathies, the molecular switches controlling polymorphism remain unveiled. In this study, we found that fibril morphology is associated with the conformational state of monomeric αSyn. Through systematic evaluation of the ionic strength and temperature, we generated two distinct polymorphs: a twisted morphology at low ionic strength and temperature, and a rod-like morphology at higher ionic strength and temperature. Using solid-state NMR, we revealed that both polymorphs share a highly conserved core structure, with morphological differences arising probably from distinct structural arrangements at the protofilament interfaces. Furthermore, we found that a specific conformational change in the C-terminal domain of the monomeric αSyn serves as a molecular switch for the formation of polymorphs. Interestingly, this conformational change can also be triggered by calcium binding to the C-terminus, connecting environmental factors to specific fibril architectures. Our results reveal a conformational role for the C-terminal domain that influences aSyn fibril morphology, providing significant insights into the fibrogenesis of αSyn.","PeriodicalId":144,"journal":{"name":"Chemistry - A European Journal","volume":" ","pages":"e202500650"},"PeriodicalIF":3.9,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review of Metal Nitrides for Lithium-Sulfur Batteries: Design, Mechanisms and Prospects. 锂硫电池用金属氮化物的研究进展：设计、机理与展望

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-23 DOI: 10.1002/chem.202500971

Aashish Joshi, Sachidananda Mohapatra, Amit Gupta, Bhanu Nandan

引用次数: 0

On-Surface Precise Synthesis of Non-Hexagonal Ring-Embedded Graphene Nanoribbons. 非六方嵌环石墨烯纳米带的表面精确合成。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-22 DOI: 10.1002/chem.202501399

Hao Qu, Mali Zhao, Wei Xu

引用次数: 0

Cover Feature: Unveiling the Dual Nature of the Smallest Aqueous Ferrocene Complex 封面专题：揭示最小二茂铁配合物的双重性质

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-22 DOI: 10.1002/chem.202582904

Susana Blanco, Andrés Verde, Juan Carlos López, Manuel Yáñez, M. Merced Montero-Campillo, Ibon Alkorta

引用次数: 0

Intramolecular PCET of α-Keto Acids: Synthesis of Trifluoromethyl Ketones via Ketyl Radicals. α-酮酸的分子内PCET：通过酮基自由基合成三氟甲基酮。

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-22 DOI: 10.1002/chem.202501613

Rifat N Nabi, Kimberly A Jarquin, Anupam Karmakar, Kyle E Brunner, Daniel K Kim

引用次数: 0

Cover Feature: Nanosecond Hyperquenching for Electron Cryo-Microscopy Without Air-Water Interface Artifacts 覆盖特点：纳秒超淬火电子冷冻显微镜无空气-水界面伪影

IF 3.9 2区化学

Chemistry - A European Journal Pub Date : 2025-05-22 DOI: 10.1002/chem.202582903

Utz H. Ermel, Harald Schwalbe, Alexey V. Cherepanov

引用次数: 0