International Neurourology Journal最新文献

{"title":"Identifying Abnormalities in Regional Brain Activity and Functional Connectivity in Patients With Detrusor Overactivity After Spinal Cord Injury.","authors":"Yun Guo, Ziyu Wang, Dongsheng Shang, Yu Pan, Xing Li","doi":"10.5213/inj.2550210.105","DOIUrl":"10.5213/inj.2550210.105","url":null,"abstract":"<p><strong>Purpose: </strong>Changes in regional brain activity and functional connectivity (FC) in patients with neurogenic detrusor overactivity (NDO) following spinal cord injury (SCI) remain unclear. This study used resting-state functional magnetic resonance imaging (fMRI) to investigate regional brain activity and FC in NDO patients after SCI.</p><p><strong>Methods: </strong>Resting-state fMRI scans were obtained from 20 NDO patients after SCI and 20 healthy controls (HCs). Regional brain activity was measured using regional homogeneity (ReHo). Subsequently, a seed-based whole-brain FC analysis was performed using the regions with significantly different ReHo as seeds. Partial correlation analysis was conducted to examine the relationship between FC values and clinical scores in the NDO patients with SCI.</p><p><strong>Results: </strong>Compared to HC, patients with NDO exhibited significantly decreased ReHo in the right medial frontal gyrus (MFG). Furthermore, compared to HC, NDO patients demonstrated stronger FC between the seed (right MFG) and voxels in the left pyramis, right cerebellum posterior lobe, and left middle temporal gyrus. Weaker FC was observed between the seed (right MFG) and voxels in the right paracentral lobule. Correlation analyses revealed that the Overactive Bladder Symptom Score and urgency urinary incontinence scores were positively correlated with FC values between the right MFG and the left pyramis.</p><p><strong>Conclusion: </strong>SCI-related NDO patients exhibit abnormalities in both regional brain activity and FC, with supraspinal connectivity deviation extent associated with the severity of lower urinary tract symptom. This study contributes to a better understanding of the potential supraspinal neural mechanisms underlying SCI-related NDO.</p>","PeriodicalId":14466,"journal":{"name":"International Neurourology Journal","volume":"30 1","pages":"63-72"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Beyond Anticholinergic Burden: An Integral Theory Perspective on Overactive Bladder - A Commentary on \"A Retrospective Database Analysis of Anticholinergic Burden Among Older Patients With and Without Overactive Bladder in South Korea\".","authors":"Kyu-Sung Lee, Juhee Cho, Danbee Kang, Kwang Jin Ko, Chee Yoong Foo, Matthias Stoelzel, Farid Abdul Hadi, Soyoung Kim","doi":"10.5213/inj.2652006.003","DOIUrl":"10.5213/inj.2652006.003","url":null,"abstract":"","PeriodicalId":14466,"journal":{"name":"International Neurourology Journal","volume":"30 1","pages":"81-82"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photography Did Not Kill Painting: On Artificial Intelligence and the Future of Academic Medicine.","authors":"Jin Wook Kim","doi":"10.5213/inj.2626edi01","DOIUrl":"10.5213/inj.2626edi01","url":null,"abstract":"","PeriodicalId":14466,"journal":{"name":"International Neurourology Journal","volume":"30 1","pages":"1-2"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upregulated Expression of TRPV1 and TRPV4 in the Urethra Following Cyclophosphamide-Induced Cystitis in Rats: A Potential Mechanism of Bladder-Urethral Dysfunction.","authors":"Yeonwoo Jeong, Seong Hyeon Yu, Ho Seok Chung, Do Gyeong Lim, Sun-Ouck Kim","doi":"10.5213/inj.2550226.113","DOIUrl":"10.5213/inj.2550226.113","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the impact of cyclophosphamide (CYP)-induced cystitis on the expression of transient receptor potential vanilloid 1 (TRPV1) and 4 (TRPV4) in the rat urethra, and to evaluate their potential roles in urethral contribution to bladder dysfunction during inflammation.</p><p><strong>Methods: </strong>Female rats were divided into the control and CYP-treated groups to induce cystitis. After 72 hours, cystometric analysis was performed to evaluate voiding changes, and urethral TRPV1 and TRPV4 expression was assessed by Western blot and immunofluorescence.</p><p><strong>Results: </strong>Cystitis rats exhibited a significantly shorter contraction interval (5.9±1.2 minutes vs. 14.7±0.8 minutes, P<0.05) and higher contraction pressure (16.3±0.9 mmHg vs. 10.1±1.3 mmHg, P<0.05) compared to controls. TRPV1 expression was predominant in the urethral mucosal cytoplasm and smooth muscle cells, whereas TRPV4 was largely localized to the cell membranes and perimuscular connective tissues. Both TRPV1 and TRPV4 protein levels were significantly upregulated in the cystitis group (P<0.05).</p><p><strong>Conclusion: </strong>The upregulation and differential localization of TRPV1 and TRPV4 in the urethra during cystitis suggest their involvement in the pathophysiological mechanisms underlying inflammation-induced lower urinary tract dysfunction. These channels may mediate altered sensory or contractile signaling in the urethra in response to bladder inflammation.</p>","PeriodicalId":14466,"journal":{"name":"International Neurourology Journal","volume":"30 1","pages":"28-34"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Anticholinergic Burden: An Integral Theory Perspective on Overactive Bladder - A Commentary on \"A Retrospective Database Analysis of Anticholinergic Burden Among Older Patients With and Without Overactive Bladder in South Korea\".","authors":"Aybüke Tayarer","doi":"10.5213/inj.2550342.171","DOIUrl":"10.5213/inj.2550342.171","url":null,"abstract":"","PeriodicalId":14466,"journal":{"name":"International Neurourology Journal","volume":"30 1","pages":"79-80"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Time to Recovery From Acute Urinary Retention in Hospitalized Patients: Development and Validation of a Clinical Prediction Model.","authors":"Jin Wook Kim","doi":"10.5213/inj.2550208.104","DOIUrl":"10.5213/inj.2550208.104","url":null,"abstract":"<p><strong>Purpose: </strong>Acute urinary retention (AUR) is a common complication in hospitalized patients with unpredictable recovery times. We aimed to develop and validate a clinical prediction model for recovery from AUR within 14 days.</p><p><strong>Methods: </strong>A prospective cohort study was conducted from March 2024 to July 2025 at a tertiary care center. Adult patients (n=126) with AUR were enrolled upon urological consultation. Males with prostate volume >30 g were excluded. Patients underwent standardized voiding trials every 3-4 days, with success defined as postvoid residual <100 mL. Multivariable logistic regression was used to identify predictors of recovery within 14 days.</p><p><strong>Results: </strong>The cohort comprised 84 males (66.7%) and 42 females (33.3%), mean age 71.9±14.2 years. Overall, 81.7% achieved successful voiding within 14 days. The prediction model demonstrated excellent discrimination (area under the curve [AUC], 0.83; 95% confidence interval [CI], 0.76-0.90) with 4 independent predictors: age <70 years (OR, 4.11; 95% CI, 2.18-7.76; P=0.008), male sex (OR, 9.09; 95% CI, 4.35-19.01; P<0.001), postoperative etiology (OR, 4.38; 95% CI, 2.26-8.48; P=0.004), and retention volume ≤450 mL (OR, 4.55; 95% CI, 2.17-9.52; P=0.017). Bootstrap validation confirmed model stability (optimism-corrected AUC=0.81).</p><p><strong>Conclusion: </strong>Our clinical prediction model reliably identifies patients at risk for prolonged urinary retention using 4 simple bedside parameters. Implementation may optimize catheter management strategies and improve patient outcomes through risk-stratified care pathways.</p>","PeriodicalId":14466,"journal":{"name":"International Neurourology Journal","volume":"30 1","pages":"57-62"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Value of Pressure-Flow Study Parameters in Women With Anatomical Bladder Outlet Obstruction.","authors":"Burcu Hancı Sevinc, Ahmet Halil Sevinc, Fatih Tarhan","doi":"10.5213/inj.2550258.129","DOIUrl":"10.5213/inj.2550258.129","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the diagnostic value of pressure-flow study parameters in female patients with anatomical bladder outlet obstruction (BOO) and to investigate the association between obstruction location and urodynamic findings.</p><p><strong>Methods: </strong>A total of 72 women with anatomical BOO who underwent urodynamic examination between January 2007 and October 2023 were retrospectively analyzed. Based on obstruction location, patients were categorized into 3 groups: external urethral meatus stenosis (n=18), urethral stricture (n=49), and bladder neck obstruction (n=5). Urodynamic assessments included free-flow maximum flow rate (Qmax), postvoid residual urine volume, filling cystometry, and a pressure-flow study.</p><p><strong>Results: </strong>Statistically significant differences were observed between groups in free-flow Qmax, urethral caliber, and pressure-flow parameters. Bladder Outlet Obstruction Index - Female, Dybowski index, urethral resistance factor, obstruction coefficient (OCO), and Woman Obstruction Index values were significantly higher in the urethral stricture group than in the other groups (P=0.022, P=0.025, P=0.031, P=0.031, and P=0.031, respectively). The Blaivas-Groutz nomogram classified all patients as obstructed, regardless of obstruction location. Diagnostic accuracy exceeded 90% when using the Barco-Castillo, Dybowski, and OCO indices; however, the accuracy varied by obstruction location.</p><p><strong>Conclusion: </strong>In women with anatomical BOO, the diagnostic performance of pressure-flow studies varies by the anatomical location of the obstruction. While urethral strictures yield high diagnostic rates, external urethral meatus stenosis may be underdiagnosed by urodynamic assessment alone. This variability remains a challenge in standardizing BOO diagnosis in women.</p>","PeriodicalId":14466,"journal":{"name":"International Neurourology Journal","volume":"30 1","pages":"73-78"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Signatures and Biomarkers: The Renal-Vesical Axis in Alzheimer Progression.","authors":"Yebeen Kim, Jaewoon Jung, Asifiwe Clarisse Cirunduzi, Seonghyun Yoon, Seokyoung Bang, Seung-Hoon Yang","doi":"10.5213/inj.2652008.004","DOIUrl":"10.5213/inj.2652008.004","url":null,"abstract":"<p><p>Alzheimer disease (AD) has long been viewed as a disorder confined to the central nervous system. Accumulating evidence, however, indicates that systemic inflammation and peripheral organ dysfunction are closely linked to disease progression. Notably, the bladder and kidney have emerged as peripheral organs that respond sensitively to neuroinflammation and systemic inflammatory signaling. In this review, we synthesize current evidence supporting a bladder-kidney-brain axis in AD, with emphasis on inflammatory pathways that connect central neurodegeneration with peripheral organ responses. We categorize biomarkers reflecting functional alterations, cellular stress responses, and tissue injury in the bladder and kidney, highlighting mediators reported in both organs. Importantly, many of these biomarkers are measurable in serum and urine, offering accessible peripheral readouts of AD-associated systemic pathology. This integrated framework underscores the biological relevance of urological organs in AD progression and provides a conceptual basis for identifying peripheral signatures associated with early disease-related changes.</p>","PeriodicalId":14466,"journal":{"name":"International Neurourology Journal","volume":"30 1","pages":"3-10"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral Sympathetic Nervous System Activation Promotes Intrarenal Renin-Angiotensin System Activity and Salt-Induced Nocturnal Polyuria.","authors":"Go Tsujimura, Kentaro Takezawa, Teppei Wakita, Yuma Kujime, Hiroaki Kitakaze, Norichika Ueda, Shinichiro Fukuhara, Shuhei Kobuchi, Yoshihide Fujisawa, Akira Nishiyama, Hiromitsu Negoro, Yoshihisa Koyama, Shoichi Shimada, Norio Nonomura","doi":"10.5213/inj.2550326.163","DOIUrl":"10.5213/inj.2550326.163","url":null,"abstract":"<p><strong>Purpose: </strong>This study was aimed at assessing the effects of cerebral sympathetic nervous system activity and renal denervation (RD) on the intrarenal renin-angiotensin system (RAS) and salt-induced nocturnal polyuria (NP).</p><p><strong>Methods: </strong>To establish a mouse model, NP was induced by Nω-nitro-L-arginine methyl ester and a high-salt diet. Mice were subjected to dietary, pharmacological, and RD interventions, with blood pressure, urine output, renal norepinephrine, kidney protein expression, and c-Fos positive cells in the hypothalamic paraventricular nucleus (PVN) assessed using standardized physiological, biochemical, and histological methods.</p><p><strong>Results: </strong>Renal angiotensinogen (AGT) and PVN c-Fos were significantly increased in NP model mice, indicating sympathetic activation. RD lowered renal AGT and the diurnal polyuria index versus sham (1.070±0.091 vs. 1.595±0.136 arbitrary units, P<0.01; 0.182±0.018 vs. 0.338±0.021, P<0.01).</p><p><strong>Conclusion: </strong>Cerebral sympathetic activation may promote intrarenal RAS activity and salt-induced NP; therefore, RD may be a potential therapeutic strategy to improve NP.</p>","PeriodicalId":14466,"journal":{"name":"International Neurourology Journal","volume":"30 1","pages":"35-43"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Endourological Surgery for Managing Overactive Bladder Symptoms in Benign Prostatic Hyperplasia: A Systematic Review and Meta-Analysis.","authors":"Carlo Giulioni, Angelo Cafarelli, Pietro Piazza, Luca Spinozzi, Savio Domenico Pandolfo, Enrico Sicignano, Giacomo Maria Pirola, Simone Scarcella, Valentina Maurizi, Jeremy Yuen-Chun Teoh, Vineet Gauhar, Daniele Castellani","doi":"10.5213/inj.2550188.094","DOIUrl":"10.5213/inj.2550188.094","url":null,"abstract":"<p><strong>Purpose: </strong>To systematically review the outcomes of endoscopic surgery in men with benign prostatic hyperplasia (BPH) associated with preoperative overactive bladder (OAB) symptoms.</p><p><strong>Methods: </strong>Literature search was conducted on 12th May 2025 including PubMed, MEDLINE, Embase, and Scopus database. Complication rates were assessed using the Cochran-Mantel-Haenszel Method with the random effect model and reported as odds ratio, 95% confidence interval (CI), and P-values. Analyses were 2-tailed and the significance was set at P<0.05. Continuous variables were pooled using the inverse variance of the mean difference with a random effect, 95% CI, and P-values.</p><p><strong>Results: </strong>Thirteen studies were included. Overall, there were 1,436 patients, with 672 in the OAB group and 820 patients in the No OAB group. At 6 months postoperatively, the storage symptoms - International Prostate Symptom Score (IPSS) favored the OAB group (mean difference [MD], 1.06; 95% CI, 0.18-1.95; P=0.02); however, changes at 3 and 6 months demonstrated no significant differences. Total-IPSS remained comparable between groups at 3 and 6 months, whereas at 12 months, the No OAB group exhibited significantly better outcomes (MD, 3.66; 95% CI, 1.87-5.45; P<0.0001). The quality-of-life (QoL) index shows no significant difference at 3 months, though HoLEP (holmium laser enucleation of the prostate) favored the OAB group at 6 months (MD, -0.36; 95% CI, -0.62 to -0.10; P=0.006), while overall changes beyond this period favored the No OAB group (MD, -0.61; 95% CI, -1.18 to -0.05; P=0.03). Urge urinary incontinence and the need for postoperative anticholinergic therapy did not differ significantly between groups at any time.</p><p><strong>Conclusion: </strong>This meta-analysis reveals that BPH patients with preoperative OAB experienced persistently higher postoperative storage symptoms despite comparable overall symptom improvement, with a more pronounced QoL enhancement over time. These findings emphasize the need for comprehensive preoperative assessment to guide patient counseling, refine surgical expectations, and improve postoperative management.</p>","PeriodicalId":14466,"journal":{"name":"International Neurourology Journal","volume":"30 1","pages":"44-56"},"PeriodicalIF":2.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13053184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}