International Wound Journal最新文献

{"title":"Correction to “Secretome From Prolonged High-Density Human Wharton's Jelly Stem Cell Culture Accelerates Wound Healing in Both In Vitro and In Vivo Models”","authors":"","doi":"10.1111/iwj.70706","DOIUrl":"https://doi.org/10.1111/iwj.70706","url":null,"abstract":"<p>\u0000 <span>Chin, JS</span>, <span>Tan, MLL</span>, <span>Lim, PLK</span>, et al. <span>Secretome from prolonged high-density human Wharton's jelly stem cell culture accelerates wound healing in both in vitro and in vivo models</span>. <i>Int Wound J.</i> <span>2025</span>; <span>22</span>(<span>5</span>):e70033. https://doi.org/10.1111/iwj.70033\u0000 </p><p>Figure 8 is an erroneous duplicate of Figure 6. The legend for Figure 8 is correct, but the histology images and graph are wrong. The correct Figure 8 is provided below.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70706","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiff Wound Impact Schedule—Validity, Reliability and Dimensionality of the Norwegian Version","authors":"Monica Maria Schwartz,&nbsp;Tone Marte Ljosaa,&nbsp;Brita Solveig Pukstad,&nbsp;Britt Karin Utvær","doi":"10.1111/iwj.70697","DOIUrl":"https://doi.org/10.1111/iwj.70697","url":null,"abstract":"<p>The objective of this study was to test the validity, reliability and dimensionality of the Norwegian version of the Cardiff Wound Impact Schedule (CWIS), a measure for wound-specific health-related quality of life. The Norwegian CWIS and a 36-item short form health survey (SF-36) were completed by 204 patients with hard-to-heal wounds on the lower extremity. The questionnaires were filled in at three time points over 8–14 weeks (T0, T1, T2). The Patients Global Impression of Change (PGIC) was completed at T1 and T2. Demographic and clinical data were collected at T0 and T2. The three-factor model of the CWIS showed an acceptable fit to the observed data, and the dimensionality was clear as long as two correlated error terms were accepted and four items were removed (<i>χ</i>² = 426.64, <i>p</i> = 0.000, df = 204, <i>χ</i>²/df = 2.09, RMSEA = 0.074, SRMR = 0.066, CFI = 0.900, TLI = 0.880). Correlation analyses showed significant associations between the CWIS and SF-36 (0.350**–0.766**), PGIC (−0.277**), wound size (−0.156**), general wound pain intensity (−0.371**) and pain intensity at wound change (−0.240**); all aligned with the expected directions. The intraclass correlations indicated good to excellent test–retest reliability (0.724**–0.951**). The internal consistency ranged from acceptable to excellent (<i>α</i> = 0.78–0.89, ρc = 0.79–0.89). While the questionnaires' ability to detect wound-related change was low, it was adequate for differentiating between healed and non-healed ulcers. The Norwegian version of the CWIS demonstrated good reliability and construct validity, making it suitable for evaluating HRQoL in patients with hard-to-heal wounds. However, some modifications were made to achieve an acceptable model fit.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70697","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Protective Colostomy Have a Role in Pressure Injury Management? A Prospective Non-Randomised Controlled Study","authors":"Andrea Scotti,&nbsp;Franz Wilhelm Baruffaldi Preis,&nbsp;Marco Borrini,&nbsp;Vito Russo,&nbsp;Simona Lavolpicella","doi":"10.1111/iwj.70683","DOIUrl":"https://doi.org/10.1111/iwj.70683","url":null,"abstract":"<p>The purpose of this article is to evaluate the potential role of a protective colostomy after reconstructive plastic surgery in individuals with spinal cord injury and neurological bowel, where pressure injuries are a serious complication. This began as a case-control observational study. From 2019, the therapeutic protocol was modified, and colostomy was proposed to all individual. 45 people with spinal cord injuries and grade 3 or 4 of pressure injuries were recruited. The experimental group underwent colostomy, while the control group received direct lesion reconstruction. Fisher's exact test and Student's <i>t</i>-test were utilized for group comparison. Primary outcomes included the number of healed ulcers and post-operative infections. The number of lesions healed within 30 days and the rate of flap infections showed significant differences between the two groups. A crucial statistical difference was found (<i>p</i> &lt; 0.05). The complication rate was 44.44% in the control group and 17.65% in the experimental group (<i>p</i>-value &lt; 0.05). Quality of life also showed encouraging results. Protective colostomy may prevent local complications after surgery, reducing long-term hospitalization and healthcare costs. It also may improve individuals’ quality of life.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70683","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Insights Into Amputation Risk: Evaluating Wound Classification Systems in Diabetic Foot Ulcers","authors":"Farideh Mostafavi,&nbsp;Mohammad Reza Amini,&nbsp;Yadollah Mehrabi,&nbsp;Ensieh Nasli Esfahani,&nbsp;Seyed Saeed Hashemi Nazari","doi":"10.1111/iwj.70515","DOIUrl":"https://doi.org/10.1111/iwj.70515","url":null,"abstract":"<p>This study compares the performance of various wound classification systems to determine which system most effectively predicts amputation risk in diabetic foot ulcer (DFU) patients. Additionally, it identifies the key clinical and socioeconomic factors that influence this risk. A total of 616 DFUs from 400 outpatient participants in a prospective cohort study were followed over 6 months. Ten machine learning (ML) algorithms were employed to evaluate the predictive accuracy of various wound classification systems. The SHapley Additive exPlanations (SHAP) method was used to interpret the predictions of the selected model. The DIAFORA (diabetic foot risk assessment) and WIFI (Wound, Ischaemia and foot Infection) classification systems demonstrated the highest predictive power for predicting amputation within 6 months. SHAP analysis revealed that wound penetration to bone, presence of ischaemia and infection, renal failure, delayed first specialist visit, longer diabetes duration, high baseline HbA1c, low education levels and high body mass index were significant risk factors for amputation. Conversely, higher education levels served as a protective factor. Occupation showed variable effects, with private-sector employment associated with increased risk, while being a housewife was linked to lower risk. Infection and ischaemia are significant factors affecting DFU outcomes. Addressing treatment adherence barriers and implementing tailored interventions that consider patients' occupational needs can reduce amputation rates.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70515","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144206898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wound Healing Complication in Radio-Treated Limb Soft Tissue Sarcoma Patients: A Single Referral Centre Experience","authors":"Silvia Dal Pos,&nbsp;Marcodomenico Mazza,&nbsp;Carlo Maria Gianesini,&nbsp;Francesco Cavallin,&nbsp;Paolo Del Fiore,&nbsp;Saveria Tropea,&nbsp;Alessandro Parisi,&nbsp;Angelica Ghirelli,&nbsp;Maria Samaritana Buzzaccarini,&nbsp;Giovanni Scarzello,&nbsp;Simone Mocellin","doi":"10.1111/iwj.70175","DOIUrl":"https://doi.org/10.1111/iwj.70175","url":null,"abstract":"<p>Radiotherapy is recommended for G2-G3 large soft tissue sarcoma in association with radical wide excision in order to improve the local control of disease, but side-effects may develop early after radiation invalidating wound healing. We retrospective evaluated short- and long-term clinically relevant outcomes after surgery of limb STS with or without radiotherapy. All 243 patients with limb STS treated at the Veneto Institute Oncology (Padua, Italy) in 2015–2022 were retrospectively included. Outcome measures were short- and long-term wound complications, length of hospital stay and outpatient care time. Multivariable analyses were performed using linear regression models and logistic regression models. Overall, 87 patients received neoadjuvant radiotherapy, 64 received adjuvant radiotherapy and 92 underwent surgery alone. At short-term, multivariable analysis identified neoadjuvant radiotherapy as a risk factor for prolonged length of hospital stay (MD 6.4 days, 95%CI 3.9 to 9.0 days) and short-term wound complications (OR 3.45, 95%CI 1.82 to 6.62). At long-term, neoadjuvant radiotherapy was a risk factor for long-term wound complications (OR 4.87, 95%CI 2.48 to 9.84), and longer outpatient care time (MD 83 days, 95%CI 41 to 126 days); similarly, adjuvant radiotherapy was also a risk factor for long-term complications (OR 5.20, 95%CI 2.57 to 10.95) and longer outpatient care time (MD 62 days, 95%CI 19 to 106 days). Radiotherapy in limb STS was associated with impaired short- and long-term clinically relevant outcomes, potentially affecting quality of life and healthcare costs. Balancing with its well-known oncological benefits, new clinical strategies are needed to contain cutaneous radiogenic side effects. The use of negative pressure therapy can play a key role in the prevention of wound complications in oncological patients.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70175","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abstracts from a joint meeting between Medstar Georgetown Diabetic Limb Salvage and the Wound Healing Foundation conference, 10–12th April 2025, Washington DC, USA","authors":"Laura K. S. Parnell,&nbsp;John Steinberg","doi":"10.1111/iwj.70681","DOIUrl":"https://doi.org/10.1111/iwj.70681","url":null,"abstract":"<p>The Medstar Georgetown Diabetic Limb Salvage and the Wound Healing Foundation, both nonprofit organizations, recently held their 2025 meeting on the diabetic foot and healing chronic wounds in Washington D.C., USA. These groups chose the <i>International Wound Journal</i> to feature their submitted abstracts to highlight the excellent research ongoing in this important clinical area. If you wish to contact any of the authors to discuss their research, please contact us and we can connect you.</p><p>The top ten abstract authors, denoted below, were given podium presentations during the meeting in honor of Greg Schultz, PhD. At the time of his passing, Dr. Schultz was the Award Chair and a Board of Director of the Wound Healing Foundation and a Course Director for the joint meeting. Dr. Schultz was a consistent champion for quality clinical and bench science focused on improving wound healing. Presenting the best science in Dr Schultz's honor at the conference seemed like a natural extension to his legacy. Monitor https://www.woundhealingfoundation.org/g-schultz-in-memoriam-2/ for updated information on a future additional program honoring Professor Shultz in accordance with his family's wishes.</p><p>Editorial Note: We recognize the valued contribution of Professor Greg Schultz and his connection with the IWJ. We are pleased to be able to continue honoring his legacy in wound healing.</p><p>The authors declare no conflicts of interest.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70681","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144197283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prevalence and Surveillance of Surgical Site Infections in South Africa: A Literature Review","authors":"Emmy Ngoakoana Nokaneng,&nbsp;Samantha L. Holloway","doi":"10.1111/iwj.70690","DOIUrl":"https://doi.org/10.1111/iwj.70690","url":null,"abstract":"<p>Surgical site infection is a post-operative complication, which has a significant clinical impact on the affected individual as well as the healthcare system. They are associated with poor outcomes such as increased length of hospital stay, morbidity, mortality and readmissions. As a result, surgical site infections are used as an indicator of the quality of surgical care and for benchmarking. The aim of the review is to gain insight on the current prevalence/incidence and surveillance of surgical site infection in South Africa. The objective was to determine the surgical site infection rate associated with Maxillo-facial and Oral Surgery procedures. A literature review was conducted with the search strategy limited to articles published in English with no limitation to the period. Fifteen articles were deemed eligible for the review according to the inclusion criteria. Eleven articles focused on the epidemiology of surgical site infection in South Africa. The surgical site infection rate varies from 0.65-48% with heterogeneity in the characteristics of the surveillance programmes. The review showed variability in the SSI rates with similar variability in the incidence of surgical site infection as reported on sub-Saharan and African countries (7.93, 9.3, 19.1, 14.5% respectively). The above information was gleaned from institutional point/period prevalence or incidences due to a lack of an integrated national surveillance programme. Thus, there is an urgent necessity to establish an integrated national surveillance programme to facilitate monitoring as well as prevention of surgical site infection in South Africa.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70690","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144190908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Clinical Decision Support Tool for the Management of Diabetes-Related Foot Ulcers (DRFUs) Using a Topical Haemoglobin Spray","authors":"Jose Luis Lazaro-Martinez,&nbsp;David G. Armstrong,&nbsp;Paul Chadwick,&nbsp;Andrea Gledhill,&nbsp;Sandra Janssen,&nbsp;Matthew Malone","doi":"10.1111/iwj.70700","DOIUrl":"https://doi.org/10.1111/iwj.70700","url":null,"abstract":"<p>Diabetes related foot ulcers (DFUs) are complex and costly to manage, with the prevalence of non-healing wounds steadily increasing across the globe. Non-healing wounds can occur when clinicians fail to undertake an appropriate assessment, fail to recognise the importance of systemic or local complications, or provide the optimal treatment. The aetiological causes behind non-healing wounds are multifactorial; however, the purpose of this article is to focus on the role of oxygen in non-healing wounds and to introduce readers to advances in the delivery of topical oxygen therapy (TOT) via a haemoglobin spray. Importantly, this article incorporates a clinical decision support tool (CDST) to help clinicians identify the most appropriate individuals for whom topical haemoglobin may be most beneficial and the most appropriate time for introducing the intervention to improve wound healing outcomes.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70700","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Development and Evaluation of a Protocol-Based Video Education Program on Medical Device-Related Pressure Injury Prevention for Nurses in Comprehensive Nursing Care Unit","authors":"Mihyun Yoo,&nbsp;Hanna Lee,&nbsp;Jeongwon Han","doi":"10.1111/iwj.70692","DOIUrl":"https://doi.org/10.1111/iwj.70692","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>This study aims to assess the impact of a protocol-based video education program on nurses' knowledge of medical device-related pressure injuries prevention, self-efficacy in pressure injury care, and satisfaction with the educational program. This study employed a non-equivalent control group pre-test–post-test design. This study was conducted from September 6, 2024, to September 19, 2024. A total of 62 nurses from the integrated nursing care service wards of a general hospital were recruited and divided into 31 experimental and 31 control groups. The experimental group received a one-week protocol-based video education program, whereas the control group received booklet-based education. Both the experimental and control groups demonstrated statistically significant improvements in medical device-related pressure injuries prevention knowledge after the intervention. The interaction effect between group and time was also significant. Self-efficacy scores increased significantly in both the experimental and control groups, although the interaction effect was not statistically significant. Educational satisfaction showed no significant difference between the two groups. The protocol-based video education program effectively improved nurses' knowledge of medical device-related pressure injuries prevention and demonstrated its potential as a repeatable and accessible learning tool. Future research should focus on longer intervention periods, diverse hospital settings, and the inclusion of clinical outcome data such as actual pressure injury incidence to further validate the program's effectiveness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: KCT0010218.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70692","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144171640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Utility of Autofluorescence Imaging for Bacterial Detection in Wounds: A Systematic Review","authors":"Sadie Badrie,&nbsp;Zena Moore,&nbsp;Declan Patton,&nbsp;Tom O'Connor,&nbsp;Rosemarie Derwin","doi":"10.1111/iwj.70678","DOIUrl":"https://doi.org/10.1111/iwj.70678","url":null,"abstract":"<p>This systematic review evaluated the clinical utility and diagnostic accuracy of autofluorescence imaging in detecting bacterial presence in wounds. A literature search was conducted in January 2025 across PubMed, Scopus, Cochrane, and EMBASE databases. Eligible studies included clinical trials and observational studies assessing autofluorescence imaging for wound bacterial detection. Seventeen studies were included; sixteen assessed the MolecuLight i:X device, and one evaluated PRODIGI. Autofluorescence imaging demonstrated higher accuracy than White Light and Clinical Signs and Symptoms-based assessment in detecting bacterial burden. Five studies highlighted its role in enhancing swabbing techniques, with fluorescence-guided sampling yielding higher bacterial counts than conventional methods. Ten studies reported significant bacterial reduction with autofluorescence-guided debridement. Six studies emphasized its role in refining treatment decisions and accelerating wound healing. Quality appraisal was undertaken using Evidence-Based Librarianship criteria, which deemed 10 studies valid, while 7 had limitations related to population representation. In conclusion, autofluorescence imaging enhances wound assessment by improving bacterial detection and may support more targeted clinical interventions. However, further research is needed to clarify its impact on infection control and long-term healing outcomes.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 6","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70678","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}