{"title":"Nutrition as an Overlooked Component of Hidradenitis Suppurativa Management: A Focus on Brewer's Yeast Exclusion.","authors":"Nana-Hawwa Abdul-Rahman, Sonal Choudhary","doi":"10.1111/iwj.71071","DOIUrl":"10.1111/iwj.71071","url":null,"abstract":"","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"23 10","pages":"e71071"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13648161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David G. Armstrong, Dennis P. Orgill, Robert D. Galiano, John C. Lantis, Paul Glat, Alexander M. Reyzelman, Robert J. Snyder, Adam L. Isaac, Marissa J. Carter, Charles M. Zelen
{"title":"A Composite Ovine Forestomach Matrix and Hyaluronic Acid CAMP for the Treatment of Full Thickness Wounds of the Foot in People With Diabetes: A Randomized Controlled Trial","authors":"David G. Armstrong, Dennis P. Orgill, Robert D. Galiano, John C. Lantis, Paul Glat, Alexander M. Reyzelman, Robert J. Snyder, Adam L. Isaac, Marissa J. Carter, Charles M. Zelen","doi":"10.1111/iwj.71056","DOIUrl":"10.1111/iwj.71056","url":null,"abstract":"<p>Diabetic foot ulcers (DFUs) are a devastating complication of diabetes that markedly affects quality of life and generates significant socioeconomic and healthcare burdens. When DFUs fail to respond to standard of care (SOC), advanced therapies including Cellular, Acellular and Matrix-like Products (CAMPs) are often employed. A novel composite CAMP comprising ovine forestomach matrix and high molecular weight hyaluronic acid, termed ‘OFM-HA’ has been developed for the treatment of chronic wounds and evaluated in a prospective multi-centre controlled trial. For this trial, 143 subjects were randomized to receive OFM-HA plus SOC or SOC alone for the treatment of chronic full thickness wounds of the foot in people with diabetes meeting prespecified eligibility criteria. The primary endpoint was the proportion of wounds healed by 12 weeks. Secondary endpoints included healing time, percentage area reduction, adverse events and changes in pain and quality of life. For the modified intent-to-treat population, 46% (31/68) of the OFM-HA plus SOC group healed by 12 weeks compared to 24% (17/72) in the SOC alone group (<i>p</i> = 0.008). Kaplan–Meier analysis favoured OFM-HA plus SOC over 12 weeks (log-rank <i>p</i> = 0.023). No unexpected safety-related occurrences were observed. OFM-HA plus SOC increased 12-week closure in this selected population. Interpretation is limited by post-randomization exclusions, differential withdrawal and an adjusted comparison close to the significance threshold (<i>p</i> = 0.045).</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"23 10","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicoletta Frescos, Laura E Prendergast, Windy Cole
{"title":"The Impact of Wound-Related Pain on Quality of Life, Psychosocial Well-Being and Pain Beliefs in Individuals With Chronic Lower Limb Wounds.","authors":"Nicoletta Frescos, Laura E Prendergast, Windy Cole","doi":"10.1111/iwj.71070","DOIUrl":"10.1111/iwj.71070","url":null,"abstract":"<p><p>Chronic lower limb wounds are frequently accompanied by persistent wound-related pain (WRP), which can impair physical functioning, emotional well-being and coping capacity. Despite its prevalence, the multidimensional impact of WRP remains under-recognised in routine wound care. This study examined the relationship of WRP on quality of life (QoL), physical health, psychosocial well-being and pain-related beliefs. A cross-sectional survey of 105 patients attending an outpatient wound clinic was conducted. Participants were stratified by the presence or absence of WRP. Validated self-report instruments assessed pain severity, physical function, emotional distress, depressive symptoms and coping strategies. Participants with WRP completed additional measures of psychological distress and pain catastrophising. Data were analysed using t-tests, ANOVA and Spearman's correlations. Patients with WRP reported significantly higher pain severity (SF-MPQ: 17.2 vs. 3.8, p < 0.001), greater physical disability (M-RMDQ: 11.1 vs. 5.3, p < 0.001) and increased stress (DASS-21: 4.7 vs. 2.4, p = 0.007). WRP was associated with maladaptive coping, including catastrophising and praying/hoping. Continuous pain was linked to higher catastrophising, particularly magnification and rumination. Younger patients demonstrated greater maladaptive pain beliefs. WRP in chronic wounds is a complex biopsychosocial phenomenon. Integrating pain management with psychological support and patient education may improve coping, reduce distress and healing outcomes.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"23 10","pages":"e71070"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13670424/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Misha Sidapra, Judith Long, Louise Hitchman, Jane Nixon, Paul Tiffin, Catherine Arundel, Ian C Chetter
{"title":"National Clinician Survey of Outcomes for Trials in Surgical Wounds Healing by Secondary Intention (SWHSI).","authors":"Misha Sidapra, Judith Long, Louise Hitchman, Jane Nixon, Paul Tiffin, Catherine Arundel, Ian C Chetter","doi":"10.1111/iwj.71066","DOIUrl":"10.1111/iwj.71066","url":null,"abstract":"<p><p>Surgical wounds healing by secondary intention are often complex, costly and slow to heal. Consistent outcome reporting ensures that interventional trials are directly comparable and less vulnerable to reporting bias, thereby enhancing the efficiency of evidence generation. Currently, no framework for outcome reporting from interventional studies of SWHSI exists. We present a national survey of clinicians as the first step to producing a core outcome set for studies involving interventions for this wound type. A pre-piloted online survey was administered in September 2024 via the Qualtrics system, comprising three sections: perceptions, decision-making and key outcomes in SWHSI management. Recruitment was via professional organisations, membership mailing lists and social media. One hundred and two clinician responses were received. The most common reasons reported for choosing secondary intention healing were concerns about infection (46%, 35/76), primary wound closure (48.7%, 37/76) and potential reintervention (89.5%, 68/76). All-cause mortality at 30 days (73%, 49/67) and 1 year (70%, 47/67), wound healing at 30 days (100%, 67/67), surgical site infection (98%, 66/67), pain score (94%, 63/67), wound size (94%, 63/67), quality of life (99%, 66/67), length of hospital stay (85%, 57/67) and reintervention requirement (90%, 60/67) were reported to be important clinical trial outcomes in this population. This survey explored the main decision-driving factors in choosing secondary intention healing and identified important trial outcomes for clinicians in this research area.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"23 10","pages":"e71066"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Cellular, Acellular, and Matrix-Like Placental Products for Diabetic Foot Ulcers: A 12-Week Randomised-Trial Meta-Analysis","authors":"George Theodorakopoulos, David G. Armstrong","doi":"10.1111/iwj.71058","DOIUrl":"10.1111/iwj.71058","url":null,"abstract":"<p>Placental-derived cellular, acellular, and matrix-like products (CAMPs) are widely used as adjuncts to standard care for diabetic foot ulcers (DFUs), but trials differ in product class, comparator, and healing window. We estimated the effect of adjunctive placental-derived CAMPs on complete wound closure at a single, clinically meaningful 12-week endpoint. The review was registered in the International Prospective Register of Systematic Reviews (PROSPERO; CRD420261399700) and reported per Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020, with search reporting guided by PRISMA-S. PubMed/MEDLINE, Scopus, and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched through 21 June 2026 for randomised or quasi-randomised trials comparing a placental, amniotic, chorionic, amnion-chorion, placental membrane, or umbilical cord-derived product plus standard care against standard care or a non-placental control in adults with active DFUs. The primary outcome was complete wound closure at 12 weeks. Risk ratios (RRs) were pooled in a random-effects model (inverse-variance, restricted maximum likelihood [REML], Hartung-Knapp). Risk of bias was assessed with the Cochrane Risk of Bias 2 tool (RoB 2) for the 12-week outcome and certainty with the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Prespecified sensitivity analyses included odds ratios, leave-one-out, product-class subgroups, and exclusion of high-risk-of-bias studies. Of 474 records, 14 randomised articles were retained; 9 standard-care-controlled comparisons (944 participants) provided extractable 12-week complete-closure data for the primary analysis. Complete closure occurred in 298 of 505 product-treated participants (59.0%) versus 157 of 439 controls (35.8%). Adjunctive CAMPs increased the likelihood of closure (RR 1.70, 95% confidence interval [CI] 1.31–2.20). Heterogeneity was moderate (I<sup>2</sup> = 51.9%) and the prediction interval crossed the null (0.93–3.11). The effect was robust to leave-one-out analysis (RR 1.59–1.81), an odds-ratio model (odds ratio [OR] 3.36, 95% CI 1.68–6.71), and exclusion of the single high-risk-of-bias trial (RR 1.73, 95% CI 1.29–2.33). Certainty was moderate, downgraded once for inconsistency. Adjunctive placental-derived CAMPs improve 12-week complete closure of DFUs compared with standard care, with moderate certainty. The wide prediction interval indicates that the average benefit may not be reproduced by every product, population, or setting, underscoring the need for product-specific, standard-care-anchored trials and for coverage policy grounded in endpoint-specific randomised evidence.</p><p><b>Trial Registration:</b> Registration number: CRD420261399700.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"23 10","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13628562/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Early Outpatient bFGF-Based Wound Care for Foot Lesions in Haemodialysis Patients: A Real-World Stepwise Limb-Salvage Strategy From Japan","authors":"Sadanori Akita, Motoyuki Tamaki, Hiroyuki Hayashi, Masanori Tamaki, Masaharu Tamaki","doi":"10.1111/iwj.71059","DOIUrl":"10.1111/iwj.71059","url":null,"abstract":"<p>Haemodialysis patients face a markedly elevated risk of foot lesions because of coexisting diabetes mellitus (DM), peripheral arterial disease (PAD) and uremia-related impairment of wound healing. Structured outpatient strategies and the optimal place of basic fibroblast growth factor (bFGF) within a stepwise algorithm remain poorly defined. To report complete healing and its durability in haemodialysis patients treated with bFGF for foot lesions, and to propose a stepwise limb-salvage algorithm with prespecified escalation criteria in which bFGF precedes dehydrated human amnion/chorion membrane (dHACM) or surgery. Retrospective observational case series of 20 haemodialysis patients receiving bFGF (trafermin; Fiblast Spray) for foot lesions across three outpatient wound-care programmes. Wound status was documented by area, depth, tissue exposure and WIfI classification; perfusion was assessed in every patient by toe-brachial and ankle-brachial indices, duplex ultrasonography and angiography, independently of any pre-existing recorded diagnosis. Complete healing was defined a priori as 100% re-epithelialization confirmed on two consecutive visits at least 2 weeks apart. Tier entry criteria and escalation triggers were prespecified, using a wound-area reduction below 50% at 4 weeks as the principal threshold. The broader haemodialysis population (<i>n</i> = 212) served as contextual comparator. Mean age was 75.0 ± 7.3 years (range, 59–92); there were six men and 14 women. DM was present in 15 patients (75.0%) and registry-recorded PAD in 8 (40.0%), against 56.6% and 17.9% in the broader population; objective testing identified hemodynamically significant PAD in 12 patients (60.0%), all of whom were revascularized. Mean baseline wound area was 5.5 ± 3.4 cm (2), and WIfI stages 1–4 comprised 5, 8, 6 and 1 patients. Twelve patients (60.0%) were managed with bFGF alone, five (25.0%) required dHACM and three (15.0%) required surgery. Complete healing was achieved in 18 of 20 patients (90.0%) at a mean of 8.9 ± 4.4 weeks, with no amputation of any level. Over a median follow-up of 13.0 months (range, 6–28), recurrence at the same site occurred in two patients (10.0%); amputation-free survival at 12 months was 100% and overall survival 95%. The bFGF-treated cohort carried a disproportionate burden of DM and PAD, supporting targeted early biologic intervention in this highest-risk subgroup. Within a stepwise algorithm combining objective perfusion assessment with prespecified escalation criteria, 90% of wounds healed completely without amputation, providing a practical limb-salvage framework for this vulnerable population.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"23 10","pages":""},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630851/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149109672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tassilo Dege, Vanessa Borst, Luisa Deutzmann, Jan Hendrik Maiwald, Samuel Kounev, Astrid Schmieder
{"title":"AI-Based Wound Measurement in a Telemedicine-Style Workflow: Agreement With In-Person Reference Measurements Compared With Individual Physicians and Expert Consensus.","authors":"Tassilo Dege, Vanessa Borst, Luisa Deutzmann, Jan Hendrik Maiwald, Samuel Kounev, Astrid Schmieder","doi":"10.1111/iwj.71043","DOIUrl":"10.1111/iwj.71043","url":null,"abstract":"<p><p>Accurate wound size measurement is essential for monitoring healing, yet visual estimates are variable-especially in telemedicine-style assessments. To compare AI-based wound size estimates with physician image-based estimates using in-person measurements as ground truth (GT). In a prospective dataset of bedside wound photographs (Dec 2024-Apr 2025), GT height and width were measured in person by two experienced raters using a calibrated ruler. A set of ArUco markers placed adjacent to the wound at the same skin level enabled image-based retrieval of real-world size information. Five physicians estimated height and width from images in a telemedicine-style workflow. Two deep-learning segmentation architectures (TransNeXt-Tiny [TransNeXt] and VWFormerConvNeXtS [VW-Conv]) generated automated size estimates. Agreement and error were quantified using ICC(2,1), Pearson's r, MAE, bias and Bland-Altman limits of agreement. In addition, pixel-level segmentation performance of both models was quantified against expert-annotated reference masks using Intersection-over-Union (IoU), the Dice coefficient, precision and recall, reported as macro-averaged (per-image) and micro-averaged (pixel-pooled) values. AI achieved excellent agreement for height (TransNeXt ICC = 0.96, MAE = 0.82 cm; VW-Conv ICC = 0.95, MAE = 0.68 cm) with minimal bias. For width, AI showed moderate-to-strong agreement with a tendency to underestimation (TransNeXt ICC = 0.86, MAE = 0.69 cm, bias = -0.42 cm; VW-Conv ICC = 0.77, MAE = 0.74 cm, bias = -0.64 cm). Individual physician performance was heterogeneous, while a human consensus improved agreement (height ICC = 0.94, MAE = 0.82 cm; width ICC = 0.91, MAE = 0.65 cm). At the pixel level, TransNeXt reached a macro-averaged Dice of 0.886 (IoU 0.805) and VW-Conv a macro-averaged Dice of 0.818 (IoU 0.733), with TransNeXt showing the more consistent per-image performance. AI-based wound measurement was more consistent than single physician estimates and reached agreement comparable to, but not exceeding, a consensus of experts. Within the constraints of this single-centre validation study, these findings support AI-assisted measurement as an objective aid for standardised wound monitoring in telemedicine and clinical research; confirmation in larger, multicentre and prospectively recruited cohorts is required.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"23 10","pages":"e71043"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673234/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149193747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Knowledge, Attitudes, and Practice Determinants of Wound Management Among Nurses and Midwives in Central Ethiopia: A Cross-Sectional Study.","authors":"Deginet Tesfaye Lonsako, Ermias Sigebo Sugebo","doi":"10.1111/iwj.71073","DOIUrl":"10.1111/iwj.71073","url":null,"abstract":"<p><p>Surgical site infection rates in Sub-Saharan African tertiary hospitals remain high. As primary frontline caregivers, nurses' and midwives' theoretical knowledge and bedside practice directly govern clinical outcomes. However, empirical data evaluating baseline competence and its determinants in Wachemo University Nigist Eleni Mohamed Memorial Comprehensive Specialized Hospital remain limited. To evaluate knowledge, attitudes, self-reported practices, and associated determinants regarding wound care among nurses and midwives at Wachemo University Nigist Eleni Mohamed Memorial Comprehensive Specialized Hospital. An institutional cross-sectional study was conducted from January 15 to 30, 2026. Systematic random sampling selected 188 participants from a source population of 337 registered nurses and midwives. Data were collected via a validated questionnaire adapted from national guidelines and analysed using SPSS v25. Multivariable logistic regression computed Adjusted Odds Ratios (AOR) with 95% Confidence Intervals (CI). Spearman correlation (ρ) and Chi-square tests evaluated domain relationships. Among 178 respondents (94.7% response rate), 33.7% demonstrated good theoretical knowledge (> 6.0), 49.4% held an excellent attitude (> 4.0), and 42.1% reported exemplary practice (> 4.0). Multivariable regression revealed formal in-service training as the sole independent predictor of good knowledge (AOR = 6.12, 95% CI: [2.45, 15.28], p < 0.001). Independent predictors of exemplary practice were clinical experience > 5 years (AOR = 2.68, 95% CI: [1.39, 5.17], p = 0.003) and good knowledge (AOR = 2.14, 95% CI: [1.08, 4.24], p = 0.029). Knowledge and practice scores showed a significant positive correlation (ρ = 0.398, p < 0.001). Although nurses maintain favourable attitudes, theoretical knowledge regarding evidence-based wound care remains suboptimal. This gap is driven primarily by a lack of post-service training rather than basic academic qualifications. Structured continuous professional development programs are urgently required.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"23 10","pages":"e71073"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13657856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Unified Concept of Skin Failure: Primary and Secondary Forms.","authors":"Anna B Chapman, Christopher B Bunker","doi":"10.1111/iwj.71072","DOIUrl":"10.1111/iwj.71072","url":null,"abstract":"","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"23 10","pages":"e71072"},"PeriodicalIF":2.2,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13645454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}