International Wound Journal最新文献

{"title":"Treatments for Pyoderma Gangrenosum: A Systematic Review and Single-Arm Meta-Analysis of Systemic Therapies","authors":"Manjit Kaur,&nbsp;Michael J. Diaz,&nbsp;Michelle Anthony,&nbsp;Dana Jolley,&nbsp;Anna H. Schildmeyer,&nbsp;Jacob McFeeters,&nbsp;Benjamin H. Kaffenberger","doi":"10.1111/iwj.70733","DOIUrl":"https://doi.org/10.1111/iwj.70733","url":null,"abstract":"<p>Pyoderma gangrenosum (PG) is a neutrophilic dermatosis associated with significant morbidity and mortality, with no consensus treatment to date. To review all clinical trials of treatments for PG to synthesise clinical evidence regarding the efficacy and safety of different treatments. After PROSPERO (CRD42023459180) registration, we systematically searched five databases (clinicaltrials.gov, CENTRAL, Embase, PubMed and Scopus) up until 18th May 2024 for PG treatments. Of 10 579 identified articles, 5853 deduplicated abstracts were screened. Twenty studies met the screening criteria after a full text review of 60 articles. We assessed the risk of bias using ROBIN-I for non-randomised and ROB-2 for randomised trials. Two reviewers independently performed article screening and quality assessments. Two reviewers independently extracted and recorded data on study characteristics, participants' demographics, disease characteristics, treatment regimens, and outcomes for the selected studies. A single-arm meta-analysis of available RCTs and non-randomised studies was conducted to analyse the outcomes of different systemic immunomodulators. The primary outcome was the complete healing of PG. Secondary outcomes included rates of recurrence, treatment failure, adverse events and time to complete healing. A total of twenty (20) interventional studies were included in the data synthesis: nine (9) prospective open-label studies, six (6) prospective cohort studies, three (3) open-label clinical trials, and two (2) randomised controlled trials evaluating multiple biological, systemic, and topical interventions. On random effects meta-analysis of systemic therapies including adalimumab, canakinumab, infliximab, chlorambucil, cyclosporine, cyclophosphamide and prednisolone, the pooled proportion of complete healing across 11 studies was 0.59 (95% confidence interval [CI]: 0.41–0.74; <i>Χ</i>² = 26.66, <i>p</i> &lt; 0.01; <i>I</i>² = 66%); the pooled proportion of PG recurrence across 6 studies was 0.30 (95% CI: 0.20–0.41; <i>Χ</i>² = 1.14, <i>p</i> = 0.95; <i>I</i>² = 0%); the pooled proportion of serious adverse effects from 4 studies was 0.10 (95% CI: 0.05–0.19; <i>Χ</i>² = 5.01, <i>p</i> = 0.17; <i>I</i>^<i>2</i> = 40%); and the pooled proportion of PG treatment failure across seven studies was 0.36 (95% CI: 0.24–0.49; <i>Χ</i>² = 12.78, <i>p</i> = 0.03; <i>I</i>² = 61%). The proportion of complete wound healing varies significantly across treatments and recurrence is common even in a limited follow-up period. Heterogeneity of study methods and low numbers hamper disease research. There remains a significant unmet need for better outcome measures than just complete healing as well as better treatment options to improve patient outcomes.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70733","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Diabetic Foot Osteomyelitis Presented as a Sausage Toe Treated With Internal Pedal Amputation: A Small Case Series","authors":"Kaissar Yammine,&nbsp;Joseph Mouawad,&nbsp;Youssef Jamaleddine,&nbsp;Chahine Assi","doi":"10.1111/iwj.70736","DOIUrl":"https://doi.org/10.1111/iwj.70736","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p>The treatment of a chronic diabetic foot osteomyelitis (DFO) is challenging and often necessitates a surgical intervention. When the soft tissues are preserved from infection, an internal pedal amputation (IPA) defined as the excision of the totality of at least one bone could yield excellent results in terms of infection control and limb preservation. The diabetic sausage toe is an under-researched form of DFO. Therefore, the aim of this preliminary study is to report the outcomes of IPA for the treatment of chronic diabetic sausage toes. This is a case-series of six patients presenting as chronic diabetic DFO of the toes in the form of sausage toe. Five patients presented with an open ulcer and one with a healed wound. All patients were treated with IPA. Infection healing, x-rays and MRI findings, microbiology and pathology results, postoperative complications and patient satisfaction were recorded. Four out of the six cases (66.7%) presented clear radiological signs of chronic OM. All cases showed signs of OM on MRI. A bacterial micro-organism was found in 5 out of the 6 cases (83.3%) and all specimens showed signs of chronic inflammation on pathology. No infection recurrence was noted at the last follow-up. All postoperative wounds healed within 6 weeks. All patients were extremely satisfied with the surgical result. For chronic diabetic toe osteomyelitis in the form of a sausage toe, the toe-preserving technique of internal pedal amputation has the potential to control the infection while conserving an aesthetic and functional toe.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Level of Evidence</h3>\u0000 \u0000 <p>IV.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 8","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144725706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Periorbital Ulceronecrotic Wound: A Case of Anthrax Cellulitis","authors":"Monir Sadat Emadoleslami,&nbsp;Mohsen Pourazizi,&nbsp;Fereshte Rastegarnasab,&nbsp;Bahareh Abtahi-Naeini,&nbsp;Niloofar Mohkamkar,&nbsp;Mohammad Allami","doi":"10.1111/iwj.70731","DOIUrl":"https://doi.org/10.1111/iwj.70731","url":null,"abstract":"<p>Cutaneous anthrax is a zoonotic bacterial infection that mostly involves the head, neck, and upper extremities. Periorbital involvement of cutaneous anthrax is a rare presentation that can lead to severe irreversible complications. Herein, we describe a 2.5-year-old girl with periorbital anthrax cellulitis. She presented with a severe swelling on the right side of her face and an ulceronecrotic lesion above the right eyebrow. After receiving an appropriate antibiotic regimen, her condition improved and she was discharged without any intraocular complications.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70731","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrical Burns: A Retrospective Study at the Lebanese Burn Center in Geitaoui Hospital, Lebanon (2011–2024)","authors":"Elie Moukawam,&nbsp;Charbel Bechara Aoun,&nbsp;Joseph Sfeir,&nbsp;Ziad Hankach,&nbsp;Rita Chebl,&nbsp;Georges Ghanime,&nbsp;Ziad Sleiman","doi":"10.1111/iwj.70732","DOIUrl":"https://doi.org/10.1111/iwj.70732","url":null,"abstract":"<p>Electrical burns are among the most severe burn injuries, often leading to deep tissue damage, systemic complications, and prolonged hospitalisation. In Lebanon, limited national data on electrical burn injuries limits the understanding of their epidemiology and management. This study aims to assess the prevalence and characteristics of electrical burns in patients admitted to the specialised burn care unit in Geitaoui Hospital in Lebanon. A retrospective observational study was conducted by reviewing the medical records of patients admitted from 1st January 2011 to 31st December 2024. Data on demographics, burn characteristics, hospitalisation outcomes, infections, surgical interventions, and laboratory findings were extracted and analysed using SPSS version 26. Thirty patients were included, with a male predominance (96.7%) and the mean age was 29.6 years. Third-degree burns were observed in 70.0% of cases, and 66.7% of patients had burns affecting 10%–30% of their total body surface area. High-voltage injuries accounted for 50.0% of cases. Upper extremities were the most commonly affected site (93.3%). The mean hospital stay was 25.69 days, and the mortality rate was 10.0%. Infection was documented in 43.3% of cases. The most frequently isolated pathogens were Acinetobacter (20.0%) and <i>Pseudomonas aeruginosa</i> (16.7%). Surgical intervention was required in 63.3% of patients, most frequently skin grafting (36.7%). This study contributes national data on electrical burns and emphasises the importance of preventive and multidisciplinary care strategies.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70732","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distribution of Carbapenemase Genes Associated With Global High-Risk Sequence Types in Pseudomonas aeruginosa Isolates From Chronic Leg Ulcer Patients in Northern Tanzania","authors":"Lameck Pashet Sengeruan,&nbsp;Omar Said Omar,&nbsp;Livin E. Kanje,&nbsp;Patrick Kimu,&nbsp;Boaz Wadugu,&nbsp;Marco van Zwetselaar,&nbsp;Happiness Kumburu,&nbsp;Tolbert Sonda,&nbsp;Samwel Chugulu,&nbsp;Jere Mshana","doi":"10.1111/iwj.70735","DOIUrl":"https://doi.org/10.1111/iwj.70735","url":null,"abstract":"<p>Carbapenem-resistant <i>Pseudomonas aeruginosa</i> exacerbates the healing of chronic leg ulcer among patients. Further, production and dissemination of the carbapenemase genes are associated with <i>P. aeruginosa</i> high-risk sequence types. Hence, understanding the population structure of these organisms is essential for healthcare personnel to establish effective leg ulcers care management, prevention interventions and control strategies particularly in regions with poor diagnosis. A cross-sectional study included inpatients and outpatients with chronic leg ulcers was conducted from August 2022 to April 2023 in 2 hospitals in Kilimanjaro region. Antimicrobial susceptibility testing was done by using the disc diffusion method. Further, whole genome sequencing was performed to study the genotypic characteristics of the isolates. Ten of 92 participants were positive for genus <i>Pseudomonas</i> isolates upon culture during the study period. Ambler class D carbapenemase genes were carried in all 8 isolates, and class B (<span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <msub>\u0000 <mi>bla</mi>\u0000 <mrow>\u0000 <mi>VIM</mi>\u0000 <mo>−</mo>\u0000 <mn>2</mn>\u0000 </mrow>\u0000 </msub>\u0000 </mrow>\u0000 <annotation>$$ {mathrm{bla}}_{mathrm{VIM}-2} $$</annotation>\u0000 </semantics></math>, <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 <msub>\u0000 <mi>bla</mi>\u0000 <mrow>\u0000 <mi>DIM</mi>\u0000 <mo>−</mo>\u0000 <mn>1</mn>\u0000 </mrow>\u0000 </msub>\u0000 </mrow>\u0000 <annotation>$$ {mathrm{bla}}_{mathrm{DIM}-1} $$</annotation>\u0000 </semantics></math>) in 2 isolates. The tree topology showed that all 8 <i>P. aeruginosa</i> isolates that carried any of the Ambler carbapenemase genes were in one clade with the reference strain PAO1. This study sheds light on different carbapenemase gene types (VIM-2, DIM-1, and OXA-types) harboured in the denominated global high-risk and endemic sequence types in 2 tertiary hospitals in northern Tanzania, alarming the possibility of a prolonged healing process and a high risk of treatment failure among patients because of the increased spread of antimicrobial resistance. Further, the findings underscore the need for antimicrobial surveillance to guide healthcare personnel in managing chronic leg ulcers for better patient outcomes and the implementation of antimicrobial stewardship programs.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70735","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144705438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osseous Involvement in Advanced Pressure Ulcers: Expert Insights Into Classification Challenges and Clinical Implications","authors":"Alica Hokynková,&nbsp;Petr Šín,&nbsp;Dimitri Beeckman,&nbsp;Martin Repko,&nbsp;Andrea Pokorná","doi":"10.1111/iwj.70722","DOIUrl":"https://doi.org/10.1111/iwj.70722","url":null,"abstract":"&lt;p&gt;Pressure ulcers (PUs) are complex, hard-to-heal wounds that often require a combination of secondary prevention, conservative management, and, in advanced cases, surgical intervention. Accurate classification of PUs is essential for data aggregation, benchmarking, and research, and to some extent also for clinical decision-making and care planning. While current classification systems—such as the EPUAP/NPIAP classification system [&lt;span&gt;1, 2&lt;/span&gt;], provide a useful framework for stratifying the extent of tissue damage, they do not adequately account for cases involving osseous structures, despite the significant implications such involvement has for prognosis and treatment.&lt;/p&gt;&lt;p&gt;Drawing on extensive clinical experience in the management of advanced PUs, we advocate for clearer clinical descriptors that acknowledge bone involvement as a complicating factor within existing categories—particularly Category IV—and potentially in cases of Deep Tissue Injury (DTI) or unstageable pressure ulcers. We do not propose introducing new categories or formal subcategories (e.g., IV.a and IV.b), as doing so may undermine the consistency and reliability of the classification system. Instead, we recommend the use of clear, operational definitions to distinguish between different patterns of osseous involvement.&lt;/p&gt;&lt;p&gt;This reflection and proposal stem from routine diagnostic workflows in surgical wound care. Imaging techniques such as X-ray, MRI, CT or PET are used to detect osseous pathology. Following imaging, orthopaedic consultation determines whether surgical removal of the affected osseous tissue is feasible. Where possible, multidisciplinary surgical debridement followed by flap reconstruction is undertaken. In contrast, when osseous resection is not viable—often in cases involving the sacrum or pelvic ring—conservative management remains the only option.&lt;/p&gt;&lt;p&gt;This distinction is not merely academic. Clinical pathways, therapeutic decisions and patient prognosis depend on the extent of osseous involvement and the feasibility of surgical intervention. When radical osseous resection is not possible, patients frequently face chronic infection, prolonged hospitalisation, and, in some instances, the need for palliative wound care. Extreme interventions such as hemicorporectomy—though rarely performed—underscore the severity of these cases and highlight the limitations of existing classification frameworks [&lt;span&gt;3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Rather than proposing structural changes to the current staging system, we recommend that these clinical presentations be acknowledged as complications within the existing framework—particularly under Category IV, and, where applicable, under DTI or unstageable pressure ulcers. Our aim is to enhance diagnostic clarity and enable more tailored interventions, while preserving the integrity and utility of the established classification system.&lt;/p&gt;&lt;p&gt;Integrating the aforementioned descriptions within Category IV of the EPUAP/NPIAP clas","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70722","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Reflections of Global Climate Change on Wound and Ostomy Care: Awareness, Experiences, and Strategies in Nursing Practices","authors":"Tuba Sengul,&nbsp;Aylin Ozakgul,&nbsp;Dilek Yilmaz Akyaz,&nbsp;Yusuf Aydin,&nbsp;Derya Karakaya","doi":"10.1111/iwj.70729","DOIUrl":"https://doi.org/10.1111/iwj.70729","url":null,"abstract":"<p>This study explores nurses' perceptions of how climate change may impact wound and ostomy care, focusing on their awareness, experiences, and perceived challenges in clinical practice. It also aims to contribute to the development of sustainable care strategies in nursing. A sequential mixed-methods design was used to collect quantitative data from 95 certified wound and ostomy nurses and conduct four focus group discussions with 23 nurses. The study followed the ‘Global Model for Operationalizing Sustainability in Nursing’, and qualitative data were analysed using thematic analysis. Nurses demonstrated moderate-to-high awareness of climate change, with the highest score in the ‘expectations’ subdimension (76.78 ± 10.21). Most nurses (96.9%) believed that rising temperature and humidity would increase wound infections, and 93.8% anticipated adverse effects on skin integrity based on clinical experience. Regarding stoma complications, 94.8% identified fungal infections and 89.6% reported peristomal moisture-related damage as significant concerns. Four key themes emerged: (1) Structural factors (Cultural Bridging and Resource Evaluation), (2) Process (Nurses' Actions and Educational Activities), (3) Outcome (Observed Changes and Professional Adaptation), and (4) Future perspective (Nurses' Leadership and Sustainability). This study reveals nurses' perceptions that climate change may affect wound and ostomy care. While based on subjective reports rather than empirical data, these findings reflect common clinical concerns. Highlighting the need for climate-focused education and planning, the study calls for greater integration of environmental awareness into nursing practice to support adaptive, patient-centred care.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70729","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for First-Ever Diabetes-Related Foot Ulcer: A Systematic Review and Meta-Analysis","authors":"Tao Yan,&nbsp;Zhang Dou,&nbsp;MacGilchrist Claire,&nbsp;Kirwan Ellen,&nbsp;McIntosh Caroline","doi":"10.1111/iwj.70728","DOIUrl":"https://doi.org/10.1111/iwj.70728","url":null,"abstract":"<p>We aimed to systematically review and quantify risk factors for first-ever diabetes-related foot ulcer (DFU). Four English and three Chinese electronic databases were searched for cohort and case–control studies reporting risk factors for first-ever DFU. Two researchers independently screened titles, abstracts and full text, extracted data and assessed the quality of included studies. Meta-analyses were performed for risk factors reported in at least two studies, using unadjusted odds ratios and standardised mean differences for dichotomous and continuous variables. Of 6736 potential studies screened, 23 were included in the meta-analysis and 24 in the systematic review. Twenty-eight significant risk factors for first-ever DFU were identified, including older age, obesity, male gender, unmarried status, alcohol consumption, current smoking, insufficient physical activity, longer diabetes duration, increased HbA1c, fasting plasma glucose, creatinine and triglyceride, decreased eGFR and high-density lipoprotein, high vibration perception threshold, albuminuria, low ankle-brachial pressure index ratio, cardiovascular, cerebrovascular and peripheral artery disease, retinopathy, nephropathy, neuropathy, myocardial infarction, foot deformity, skin dryness, insulin treatment and anti-hypertensive treatment. This study provides the first comprehensive synthesis of risk factors for first-ever DFU. Identifying high-risk individuals based on these factors can enhance early intervention strategies, reducing the burden of DFU in diabetes management.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70728","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Year Recurrence in People With Diabetic Foot Ulcers and Chronic Limb Threatening Ischemia Is Comparable to Cancer","authors":"Natalie S. Armstrong,&nbsp;Alexandria A. Armstrong,&nbsp;Joseph L. Mills,&nbsp;Michael S. Conte,&nbsp;Tze-Woei Tan,&nbsp;Richard S. Swanson,&nbsp;David G. Armstrong","doi":"10.1111/iwj.70724","DOIUrl":"https://doi.org/10.1111/iwj.70724","url":null,"abstract":"<p>This study aimed to compare the 3-year recurrence rates of diabetic foot ulcers (DFU) and the rate of endovascular reintervention for chronic limb-threatening ischaemia (CLTI) to recurrence rates of advanced-stage cancers. We systematically collected original data reporting 3-year DFU recurrence from studies published through 2024 and calculated a pooled mean. These findings were compared to recurrence rates for advanced breast, prostate, colorectal, and lung cancers using contemporary sources from the National Cancer Institute and American Cancer Society. CLTI reintervention data were drawn from the BEST-CLI trial. The pooled 3-year DFU recurrence rate was 58%, while the CLTI reintervention rate was 50%—comparable to cancer recurrence rates: breast (25%–40%), prostate (30%–40%), colorectal (30%–50%), and lung (60%–80%). Despite these comparable risks, DFU and CLTI remain underrecognized in terms of their recurrent burden on individuals, families, and health systems. The data presented here underscore the need to reframe healed DFU and post-intervention CLTI not as an endpoint but as a remission—a state requiring structured surveillance and proactive management, much like in oncology. Developing interdisciplinary survivorship care plans for individuals with DFU and CLTI, modelled on those used in cancer care, may improve communication, enhance secondary prevention, and foster more ulcer-free, hospital-free, and activity-rich days.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheological Assessment for Determining Form Stability of Wound Dressings","authors":"Amit Gefen,&nbsp;Daphne Weihs,&nbsp;Astrid Fremau,&nbsp;Youtha Van den Eynde,&nbsp;Eveline Torfs","doi":"10.1111/iwj.70720","DOIUrl":"https://doi.org/10.1111/iwj.70720","url":null,"abstract":"<p>The classification of wound care products as form-stable dressings remains challenging due to the lack of objective and quantitative, material-science-based criteria. This study introduces a rheological testing framework to determine <i>form stability</i> of wound dressing materials. Using dynamic, oscillatory shear rheology, we evaluated the viscoelastic properties and responses of two tube-dispensed model dressings and compared them to those of honey, a high-viscosity liquid used in wound ointments. Measurements of the material storage modulus, loss modulus and phase angle demonstrated that both model dressings exhibit predominantly solid-like responses, confirming their classification as form-stable wound dressings despite being applied from a tube. The notably low phase angles of these dressings indicate structural integrity, which is essential for the mechanical protection of wounds; honey exhibited a liquid response and a high phase angle, without structural integrity. The reported laboratory method and findings support the implementation of rheological classification as a standardised, objective and quantitative approach for wound care product categorisation, independent of the packaging or application mode. Importantly, this study establishes a foundation for a material-science-driven classification framework, with implications for informed clinical decision-making and reimbursement policies.</p>","PeriodicalId":14451,"journal":{"name":"International Wound Journal","volume":"22 8","pages":""},"PeriodicalIF":2.6,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iwj.70720","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144681447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}