Pressila Njeim, Andréa Faust, Juliette Casgrain, Antony D Karelis, Guy Hajj- Boutros
{"title":"Delayed Onset Muscle Soreness Following Acute Resistance Exercise in Untrained Females: A Comparative Study Between Vegans and Omnivores.","authors":"Pressila Njeim, Andréa Faust, Juliette Casgrain, Antony D Karelis, Guy Hajj- Boutros","doi":"10.1055/a-2350-8681","DOIUrl":"10.1055/a-2350-8681","url":null,"abstract":"<p><p>This study aimed to assess the levels of delayed onset muscle soreness (DOMS) markers in individuals adhering to vegan and omnivore diets after engaging in acute resistance exercise. A total of 54 untrained young, healthy, normal-body-weight women (age: 26.8±4.1 years; body mass index: 22.5±2.7 kg/m<sup>2</sup>) participated in the study. Participants were categorized into two groups: vegans (n=27) and omnivores (n=27) based on their dietary preferences, with all subjects having adhered to their respective diets for a minimum of 2 years. DOMS was induced by a single eccentric resistance exercise session, comprising four exercises (leg press, chest press, leg curls, and arm curls), each consisting of four sets of 10 repetitions. Various measurements, including dietary factors, state of wellness, body composition, muscle circumferences, muscle pressure point thresholds (PPTs), and muscle strength, were recorded both before and 48 hours after the exercise session. The results showed that wellness and muscle circumferences remained unchanged or displayed similar changes between the vegan and omnivore groups following acute resistance exercise. However, notable differences were observed in PPTs in favor of vegans, specifically for the right biceps (95% CI: 1.4 to 10.2; p=0.01), the left vastus medialis (95% CI: 0.5 to 6.4; p=0.02), and the right vastus lateralis (95% CI: 3.2 to 12.1; p=0.001). Furthermore, significant differences in right grip strength were found in favor of vegans after the exercise session (95% CI: 3.1 to 26.2; p=0.01). In conclusion, our findings suggest that vegans may experience more favorable changes in DOMS levels following acute resistance exercise in comparison to omnivores. This discrepancy in DOMS markers may indicate enhanced muscle recovery in vegans.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"1099-1106"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cheng-Feng Lin, Jen-Chieh Liao, Manuel Hernandez, Rahil Sadruddin, Suguna Pappu, Yih-Kuen Jan
{"title":"Comparison of Isometric and Dynamic Bridging Exercises on Low Back Muscle Oxygenation.","authors":"Cheng-Feng Lin, Jen-Chieh Liao, Manuel Hernandez, Rahil Sadruddin, Suguna Pappu, Yih-Kuen Jan","doi":"10.1055/a-2376-6255","DOIUrl":"10.1055/a-2376-6255","url":null,"abstract":"<p><p>Bridging exercises are commonly performed by people with low back pain (LBP). However, the effect of the contraction mode in a bridging exercise on the hemodynamics of the low back muscle has not been investigated in people with and without LBP. The objective of this study was to assess the effect of the mode of bridging exercise on oxygenation of the low back muscle. A near-infrared spectroscopy was used to measure hemodynamic responses of the erector spinae between isometric and dynamic bridging exercises in 16 healthy participants. The results demonstrated that during exercise, the isometric bridging exercise significantly decreased oxyhemoglobin and deoxy-hemoglobin compared to the dynamic bridging exercise (oxyhemoglobin, <i>t</i>=- 3.109, <i>p</i>=0.007, Cohen's <i>d</i>=0.68 and deoxy-hemoglobin, <i>t=</i>- 2.193, <i>P</i>=0.046, Cohen's <i>d</i>=0.60). The results also demonstrated that after exercise, the dynamic bridging exercise induced a significantly higher oxygenation response (oxygenation, <i>t=</i>- 2.178, <i>P</i>=0.048, Cohen's <i>d</i>=0.43). This study indicates that the dynamic bridging exercise is more effective in improving oxygenation of low back muscles.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"1084-1090"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Javier Pecci, Borja Sañudo, Horacio Sanchez-Trigo, Gonzalo Reverte-Pagola, Helios Pareja-Galeano
{"title":"Quadriceps Architectural Adaptations in Team Sports Players: A Meta-analysis.","authors":"Javier Pecci, Borja Sañudo, Horacio Sanchez-Trigo, Gonzalo Reverte-Pagola, Helios Pareja-Galeano","doi":"10.1055/a-2369-5900","DOIUrl":"10.1055/a-2369-5900","url":null,"abstract":"<p><p>Resistance training is the most effective strategy to modify muscle architecture, enhancing sport performance and reducing injury risk. The aim of this study was to compare the effects of high loads (HL) versus lower loads (LL), maximal versus submaximal efforts, and high frequency (HF) versus low frequency (LF) on quadriceps architectural adaptations in team sports players. Five databases were searched. Vastus lateralis thickness, fascicle length and pennation angle, and rectus femoris thickness were analyzed as main outcomes. Overall, resistance training significantly improved muscle thickness and pennation angle, but not fascicle length. LL led to greater fascicle length adaptations in the vastus lateralis compared to HL (p=0.01), while no substantial differences were found for other load comparisons. Degree of effort and training frequency did not show meaningful differences (p>0.05). In conclusion, LL lengthen the fascicle to a greater extent than HL, and training with LL twice a week could maximize architectural adaptations, whereas the degree of effort does not appear to be a determinant variable on quadriceps architectural adaptations.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"1029-1039"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141723629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Antonio Páez-Maldonado, PedroJesús Cornejo-Daza, Juan Sánchez-Valdepeñas, Miguel Sánchez-Moreno, Fábio Yuzo-Nakamura, Fernando Pareja-Blanco, Manuel Ortega-Becerra
{"title":"Acute Metabolic Response, Neuromuscular Activity, and Mechanical Performance to Different Set.","authors":"José Antonio Páez-Maldonado, PedroJesús Cornejo-Daza, Juan Sánchez-Valdepeñas, Miguel Sánchez-Moreno, Fábio Yuzo-Nakamura, Fernando Pareja-Blanco, Manuel Ortega-Becerra","doi":"10.1055/a-2179-3817","DOIUrl":"10.1055/a-2179-3817","url":null,"abstract":"<p><p>The aim of this study was to examine the acute metabolic response, neuromuscular activity, and mechanical performance of different set configurations in bench-press (BP). Twenty-two resistance-trained men performed three resistance exercise protocols consisting of 3 x 12 BP repetitions at 60% 1RM, with 4 minutes of rest between sets, but with different set configurations: (a) traditional set (TS), without rest within the set; (b) cluster-6 (CS6), with 30-second intraset rest after the sixth repetition in each set; and (c) cluster-2 (CS2), with 30-second intraset rest every two repetitions. Mean propulsive force (MPF), velocity (MPV), power (MPP), and electromyography (EMG) values were recorded for each repetition. Blood lactate, maximal voluntary isometric BP contraction, and dynamic strength in BP were assessed pre- and post-exercise. The CS2 protocol resulted in greater mechanical performance (i. e. MPF, MPV, and MPP) and lower alterations of EMG parameters (i. e. root mean square and median frequency) during the exercise compared to CS6 and TS (TS<CS6<CS2). The CS2 protocol induced smaller increases in lactate compared to TS and CS6. No significant \"protocol x time\" interactions were observed for the MVIC (maximal voluntary isometric BP contraction) variables. Introducing short but frequent intraset rest periods alleviates training-induced fatigue assessed by better performance maintenance.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"820-828"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Excessive Blood Pressure Rise and Cardiovascular Remodeling in Marathon Runners.","authors":"Hye Bin Gwag, Young-Joo Kim, Kyoung-Min Park","doi":"10.1055/a-2330-9869","DOIUrl":"10.1055/a-2330-9869","url":null,"abstract":"<p><p>Exercise-induced hypertension (EIH) is thought to be associated with increased cardiovascular (CV) risks. However, no previous studies have investigated the effects of EIH on CV systems in marathon runners without CV risk factors using both 24-hr ambulatory blood pressure (BP) monitoring and exercise stress echocardiography (ESE). This study firstly described differences in CV adaptations according to EIH assessed by both exams. Marathon runners between 35 and 64 years of age without CV risk factors were eligible. All the participants underwent both 24-hr ambulatory BP monitoring and ESE. EIH was defined as a maximal exercise systolic BP≥210 mmHg. The EIH group (n=19) had shorter training history and higher exercise intensity compared to the non-EIH group (n=23). The average systolic BP was higher in the EIH group than in the non-EIH group. Left cardiac chamber size and left ventricular mass (LVM) were also higher in the EIH group compared to the non-EIH group. Maximal BP during ESE was positively correlated with both parameters. Exaggerated BP response during exercise needs to be monitored for pre-emptive measurements before it results in progressive cardiovascular maladaptation.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"930-936"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Afonso Fitas, Miguel Gomes, Paulo Santos, André D Gonçalves, Pedro Pezarat-Correia, Goncalo V Mendonca
{"title":"Optimal Minimum-Velocity Threshold to Predict One-repetition Maximum for the Back Squat.","authors":"Afonso Fitas, Miguel Gomes, Paulo Santos, André D Gonçalves, Pedro Pezarat-Correia, Goncalo V Mendonca","doi":"10.1055/a-2335-4143","DOIUrl":"10.1055/a-2335-4143","url":null,"abstract":"<p><p>The prediction of one-repetition maximum (1RM) is highly relevant for strength and conditioning. The optimal minimum-velocity threshold (MVT) was recently proposed to increase the accuracy of 1RM predictions. Individual load-velocity profiles (LVP) were obtained in 18 athletes enrolled in recreational soccer. Reliability analyses were computed for all LVP-derived variables. Estimations of 1RM were made based on general (0.3 m.s<sup>- 1</sup>), pre-individual (mean velocity at 1RM obtained in a preliminary session) and optimal MVT (velocity that eliminates the difference between actual and predicted 1RM, determined in a preliminary session). The accuracy of 1RM predictions was examined using absolute-percent error and Bland-Altman plots. Between-day reliability of the LVP and 1RM was good (intraclass-correlation coefficients - ICCs>0.9 and coefficients of variation - CVs<5%). The individual and optimal MVT reached moderate-to-good reliability (ICCs>0.9 and CVs<10%, respectively). The predictions based on the optimal MVT displayed greater accuracy than those obtained with the individual and general MVT (absolute percent error: 2.8 vs. 5.5 vs. 4.9%, respectively). However, wide limits of agreement (LoA) were found between actual and estimated 1RM using this approach (~15 kg). Data indicate that the optimal MVT provides better estimations of 1RM for the free-weight back squat than the general and the individual MVT.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"923-929"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danica Janicijevic, Deniz Senturk, Zeki Akyildiz, Yaodong Gu, Amador García-Ramos
{"title":"Hexagonal Barbell Deadlift One-repetition Maximum Estimation Using Velocity Recordings.","authors":"Danica Janicijevic, Deniz Senturk, Zeki Akyildiz, Yaodong Gu, Amador García-Ramos","doi":"10.1055/a-2330-3001","DOIUrl":"10.1055/a-2330-3001","url":null,"abstract":"<p><p>This study aimed to determine whether the optimal minimal velocity threshold (MVT) provides more precise estimates of one-repetition maximum (1RM) in the hexagonal barbell deadlift (HBD) than the general and individual MVTs. The 1RMs of 27 resistance-trained males were predicted using three types of MVT: (i) <i>General MVT:</i> averaged across subjects' velocity of the 1RM trial (0.25 m·s<sup>-1</sup>), (ii) <i>individual MVT:</i> velocity attained during the 1RM trial, and (iii) <i>Optimal MVT:</i> MVT that eliminated the differences between the actual and predicted 1RM. Two individual load-velocity relationships were modelled considering five (30-50-70-80%1RM) or six (30-50-70-80-90%1RM) loading conditions. Negligible differences (Effect size<0.20), low absolute errors (<5% of the actual 1RM), and extremely high correlations (<i>r</i>>0.90) were observed between the actual and six predicted 1RMs. The only significant difference was the lower raw errors for the 90%1RM condition (0.60±7.34 kg) compared to the 80%1RM condition (2.27±7.54 kg; <i>p</i>=0.013). These results suggest that the individual load-velocity relationship offers an accurate estimation of the HBD 1RM in resistance-trained males, and these estimates could maintain similar levels of precision across different types of MVT (general, individual, and optimal) and final tested loads (80%1RM and 90%1RM).</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"844-850"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141071018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esdras Guedes Fonseca, Ana Paula Araújo-Ferreira, Markus Berger, Leda Maria Castro Coimbra-Campos, Roberta Silva Filha, Leticia Maria de Souza Cordeiro, Mariana Rodrigues Campos, Laura Barroso Ferreira Oliveira, Marcelo Vidigal Caliari, Lucio Ricardo Leite Diniz, Fabiana Alves, Almir Souza Martins, Diogo Barros Peruchetti, Maria Aparecida Ribeiro Vieira
{"title":"Preconditioning by Moderate-Intensity Exercise Prevents Gentamicin-Induced Acute Kidney Injury.","authors":"Esdras Guedes Fonseca, Ana Paula Araújo-Ferreira, Markus Berger, Leda Maria Castro Coimbra-Campos, Roberta Silva Filha, Leticia Maria de Souza Cordeiro, Mariana Rodrigues Campos, Laura Barroso Ferreira Oliveira, Marcelo Vidigal Caliari, Lucio Ricardo Leite Diniz, Fabiana Alves, Almir Souza Martins, Diogo Barros Peruchetti, Maria Aparecida Ribeiro Vieira","doi":"10.1055/a-2342-2154","DOIUrl":"10.1055/a-2342-2154","url":null,"abstract":"<p><p>A strict correlation among proximal tubule epithelial cell dysfunction, proteinuria, and modulation of the Renin-Angiotensin System and Kalikrein-Kinin System are crucial factors in the pathogenesis of Acute Kidney Injury (AKI). In this study, we investigated the potential protective effect of preconditioning by moderate-intensity aerobic exercise on gentamicin-induced AKI. Male Wistar rats were submitted to a moderate-intensity treadmill exercise protocol for 8 weeks, and then injected with 80 mg/kg/day s.c. gentamicin for 5 consecutive days. Four groups were generated: 1) NT+SAL (control); 2) NT+AKI (non-trained with AKI); 3) T+SAL (trained); and 4) T+AKI (trained with AKI). The NT+AKI group presented: 1) impairment in glomerular function parameters; 2) increased fractional excretion of Na <sup>+</sup> , K <sup>+</sup> , and water; 4) proteinuria and increased urinary γ-glutamyl transferase activity (a marker of tubular injury) accompanied by acute tubular necrosis; 5) an increased renal angiotensin-converting enzyme and bradykinin B1 receptor mRNA expression. Interestingly, the preconditioning by moderate-intensity aerobic exercise attenuated all alterations observed in gentamicin-induced AKI (T+AKI group). Taken together, our results show that the preconditioning by moderate-intensity aerobic exercise ameliorates the development of gentamicin-induced AKI. Our findings help to expand the current knowledge regarding the effect of physical exercise on kidneys during physiological and pathological conditions.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"884-896"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jessica Downs Talmage, Nicole Bordelon, Kyle Wasserberger, Gretchen D Oliver
{"title":"Energy Flow during Baseball Machine Hitting.","authors":"Jessica Downs Talmage, Nicole Bordelon, Kyle Wasserberger, Gretchen D Oliver","doi":"10.1055/a-2350-8567","DOIUrl":"10.1055/a-2350-8567","url":null,"abstract":"<p><p>The primary aims of the study were to perform a descriptive analysis of hitting energetics off a pitching machine and to compare between the rear- and lead-side lower and upper extremities. Eighty-five high school to minor league baseball athletes participated. Five full-effort swings off a pitching machine with the fastest exit velocity were used for analysis. Energy flow was quantified using a segment power analysis. Wilcoxon signed-rank test revealed significant differences between rear- and lead-side energetics during both swing phases. During the stride, the rear knee and shoulder generated more energy than the lead side. Throughout the swing phase the lead knee, hip, and elbow generated more energy than the rear side, but at the shoulder the rear side generated significantly more energy than the lead. Most intriguing, differing energy transfer directions between the rear and lead knee and shoulder joints were reported. Furthermore, descriptive results revealed energy is predominantly transferred across the knee, shoulder, and elbow joints, while the hips primarily display energy generation. The descriptive nature of the study provides a foundation for future research and can be used as a resource for training personnel to design effective training protocols aimed at maximizing performance.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"937-944"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luciele Guerra Minuzzi, Alexander Ferrauti, Matheus Uba Chupel, Sebastian Hacker, Christopher Weyh, Pedro L Valenzuela, Alejandro Lucia, Karsten Krüger, Thomas Reichel
{"title":"Acute Inflammatory Response to Eccentric Exercise in Young and Master Resistance-trained Athletes.","authors":"Luciele Guerra Minuzzi, Alexander Ferrauti, Matheus Uba Chupel, Sebastian Hacker, Christopher Weyh, Pedro L Valenzuela, Alejandro Lucia, Karsten Krüger, Thomas Reichel","doi":"10.1055/a-2348-0238","DOIUrl":"10.1055/a-2348-0238","url":null,"abstract":"<p><p>This study aimed to compare the acute inflammatory response following high-intensity eccentric exercise between resistance-trained young and master athletes with similar performance levels. Resistance-trained young (n=8; 22±2 years) and master (n=8; 52±4 years) male athletes of a similar performance level performed a standardized high-intensity eccentric squat exercise protocol (10 sets of half-squats at 70% of 1-repetition maximum). The serum concentration of 20 biomarkers related to tissue damage, inflammation, remodeling, and repair was measured at baseline, immediately after exercise, and over a 72 h recovery period. Both groups experienced similar muscle damage as evidenced by a comparable increase in creatine kinase activity 24 h after exercise (p<0.001). Interleukin-6 (p=0.009) and growth hormone (p<0.001) increased immediately post-exercise in both groups. Monocyte chemoattractant protein-1 increased immediately post-exercise only in young athletes (p=0.003) and then decreased 24 h later. There were no significant differences for the remaining variables, including cell markers related to neutrophil/macrophage activation or pro/anti-inflammatory cytokines. Resistance-trained young and master athletes, matched for performance level, showed an overall similar inflammatory response to eccentric exercise, possibly reflecting regulatory mechanisms or immunological adaptations to chronic stimulation in master athletes.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"897-907"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}