Lukas Hack, Bhagyashree Singh, Ferdinand Binkofski, Ingo Helmich
{"title":"Repetitive Subconcussive Head Impacts in Sports and Their Impact on Brain Anatomy and Function: A Systematic Review.","authors":"Lukas Hack, Bhagyashree Singh, Ferdinand Binkofski, Ingo Helmich","doi":"10.1055/a-2342-3604","DOIUrl":"10.1055/a-2342-3604","url":null,"abstract":"<p><p>Repetitive subconcussive head impacts occur regularly in sports. However, the exact relationship between their biomechanical properties and their consequences on brain structure and function has not been clarified yet. We therefore reviewed prospective cohort studies that objectively reported the biomechanical characteristics of repetitive subconcussive head impacts and their impact on brain anatomy and function. Only studies with a pre- to post-measurement design were included. Twenty-four studies met the inclusion criteria. Structural white matter alterations, such as reduced fractional anisotropy and an increase in mean diffusivity values, seem to be evident in athletes exposed to repetitive subconcussive head impacts exceeding 10 g. Such changes are observable after only one season of play. Furthermore, a dose-response relationship exists between white matter abnormalities and the total number of subconcussive head impacts. However, functional changes after repetitive subconcussive head impacts remain inconclusive. We therefore conclude that repetitive subconcussive head impacts induce structural changes, but thus far without overt functional changes.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"871-883"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jérémie Allinger, Antoine Bouyeure, Marion Noulhiane, Frederic Lemaitre
{"title":"Monitoring the Breath-Hold Training Load during an Ecological Session: A Pilot Study.","authors":"Jérémie Allinger, Antoine Bouyeure, Marion Noulhiane, Frederic Lemaitre","doi":"10.1055/a-2323-9675","DOIUrl":"10.1055/a-2323-9675","url":null,"abstract":"<p><p>This study aimed to create a training load index to measure physiological stress during breath-hold (BH) training and examine its relationship with memory performance. Eighteen well-trained BH divers (Age: 35.8±6.6 years, BH training practice: 5.3±4.5 years) participated in this study. During a standard 1.5-hour BH training in the pool, perceived exertion, heart rate, distance, and duration were measured. The training load index was modelled on the basis of a TRIMP (TRaining IMPulse) with four different equations and was used to measure the stress induced by this BH training. A reference value, based on the ratio between the average heart rate during all BHs and the lowest heart rate during BH training, was used for comparing training load index. Memory assessment was conducted both before and after this training. Of the four equations proposed, equation no. 4, named aTRIMP for \"apnoea,\" showed the strongest correlation with our reference value (r=0.652, p<0.01). No difference was found between any of the memory tests before and after the BH training. The aTRIMP was a new representative index for monitoring habitual training of well-trained BH divers. Furthermore, this training had no negative impact on memory performance.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"837-843"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"LINC00963 Represses Osteogenic Differentiation of hBMSCs via the miR-10b-5p/RAP2A/AKT Axis.","authors":"Zhixin Wu, Mingjuan Shi, Xuan Zhao, Guifu Wu, Huiyuan Zheng, Yuanyuan Cui, Yu Shang","doi":"10.1055/a-2323-9749","DOIUrl":"10.1055/a-2323-9749","url":null,"abstract":"<p><p>Osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) is important for human bone formation. Long non-coding RNAs (lncRNAs) are critical regulators in osteogenic differentiation. This study aimed to explore the function and mechanisms of long intergenic non-protein coding RNA 963 (LINC00963) in affecting osteogenesis. Cell differentiation was assessed by alkaline phosphatase (ALP) activity detection and ALP staining assay. Meanwhile, levels of osteogenic marker genes, including RUNX family transcription factor 2 (RUNX2), osteocalcin (OCN), and osteopontin (OPN), were detected by RT-qPCR and western blot. Cell proliferation and apoptosis were measured using CCK-8 assay and flow cytometry analysis. RNA immunoprecipitation (RIP), RNA pull-down and luciferase reporter assays were used to investigate the interaction between genes. LINC00963 expression was down-regulated in hBMSCs treated with osteogenic induction. LINC00963 overexpression inhibited hBMSCs differentiation, proliferation, and elevated apoptosis. LINC00963 acted as a competing endogenous RNA (ceRNA) to interact with miR-10b-5p and thereby regulated the expression level of Ras-related protein Rap-2a (RAP2A). LINC00963 regulated RAP2A to inhibit the level of phosphorylated AKT (p-AKT). LINC00963 inhibited hBMSCs differentiation, proliferation, and elevated apoptosis via the miR-10b-5p/RAP2A/AKT signaling, which might help improve the treatment of osteoporosis.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"856-866"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frederike Adammek, Tiffany Y Wences Chirino, David Walzik, Sina Trebing, Sergen Belen, Daniel Renpening, Philipp Zimmer, Niklas Joisten
{"title":"Kinetics of Immune Cell Mobilization during Acute Aerobic Exercise in Healthy Adults.","authors":"Frederike Adammek, Tiffany Y Wences Chirino, David Walzik, Sina Trebing, Sergen Belen, Daniel Renpening, Philipp Zimmer, Niklas Joisten","doi":"10.1055/a-2338-5397","DOIUrl":"10.1055/a-2338-5397","url":null,"abstract":"<p><p>While pre-post differences in immune cell mobilization after acute aerobic exercise are well investigated, less is known about when and to what extent immune cells are mobilized during acute aerobic exercise. This experimental trial aimed to investigate the detailed kinetics of circulating immune cells in twelve healthy adults (n=6 females) who completed a 40-min aerobic exercise bout at 60% of the participants' V̇O2<sub>peak</sub> on a bicycle ergometer. Cellular inflammation markers and sex-dependent differences in circulating immune cells were analyzed. Blood samples were taken immediately before, after warm-up, during exercise after 5 min, 10 min, 15 min, 30 min, 40 min (cessation), and 60 min post exercise. Significant increases in leukocytes (p<0.001), lymphocytes (p<0.001), neutrophils (p=0.003) and platelets (p=0.047) can be observed after 5 min of exercise. The cellular inflammation markers show significant alterations only post exercise. Significant sex differences were observed for neutrophils (p=0.049) and neutrophil-to-lymphocyte ratio (p=0.007) one hour post exercise. These results indicate that i) leukocytes are already mobilized after 5 min of moderate-to-vigorous aerobic exercise, ii) the magnitude of exercise induced leukocyte mobilization is dependent on exercise duration, iii) integrative cellular inflammation markers are only altered after exercise cessation, and iv) the observed effects might be sex-dependent.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"908-916"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaila A Holtz, Jason L Zaremski, Joseph Janosky, Kenzie B Friesen, Gretchen D Oliver
{"title":"A Model for Causality of Pitching-related Overuse Injuries in Women's Fastpitch Softball.","authors":"Kaila A Holtz, Jason L Zaremski, Joseph Janosky, Kenzie B Friesen, Gretchen D Oliver","doi":"10.1055/a-2312-5051","DOIUrl":"10.1055/a-2312-5051","url":null,"abstract":"<p><p>Fastpitch softball is a popular women's sport, and athletes, particularly pitchers, are at high risk for overuse injury. Softball-related injury rates are low; however, the prevalence of overuse injuries is high. Injuries at the high school and collegiate levels occur early in the season, and approximately 50% of shoulder and elbow injuries in softball are attributable to overuse. Survey research showed 77% of high school pitchers pitch with pain, and 73% of collegiate pitchers reported an overuse injury in the previous season. Modifiable and non-modifiable intrinsic and extrinsic risk factors contribute to injury risk in a model that can be used in history taking, clinical examination, and management of softball-related injuries. In this manuscript, we present a scoping review of fastpitch softball injury research by competitive levels from 1990 to present. We also introduce a model for overuse injury causality in this athlete population. With this information, clinicians will be able to identify risk factors related to injury in softball pitchers. More research is needed to make evidence-based recommendations for injury prevention in this athlete population.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"804-809"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miguel Rebelo, Catarina Marques, Rute Crisóstomo, Marco Batista, Rui Paulo, João Rocha, João Serrano
{"title":"The Influence of Futsal Players' Initial Physical Condition on the Occurrence of Injuries.","authors":"Miguel Rebelo, Catarina Marques, Rute Crisóstomo, Marco Batista, Rui Paulo, João Rocha, João Serrano","doi":"10.1055/a-2363-1885","DOIUrl":"10.1055/a-2363-1885","url":null,"abstract":"<p><p>Although there are some studies that have linked fitness parameters and sports injuries, the literature remains controversial. The aim of the study was to prospectively analyze the influence of initial physical condition parameters on the development of injury in the first three months of the sports season in futsal players. A total of 68 players (24.26±4.63 years old) were assessed before the start of the sports season in relation to certain physical condition parameters, such as body composition (bioimpedance), lower limb power (countermovement jump, CMJ) and muscle strength (isokinetic dynamometer). The injured players showed significantly worse initial performance in the CMJ compared to the uninjured players (<i>p<</i>0.001). There were no significant differences between groups in body composition and muscle strength. Lower power values were associated with a higher risk of injury in the first few months of the sports season (OR=0.92; 95% CI=0.88-0.99). Muscle power was an independent predictor of injury in the first few months of the sports season in futsal players, indicating that improving players' physical condition could help reduce the number of injuries.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"917-922"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serum metabolome signature response to different types of resistance training.","authors":"Joshua Frederik Feuerbacher,Runtan Cheng,Milan Sedliak,Min Hu,Taija Juutinen Finni,Lisa Umlauff,Moritz Schumann,Shulin Cheng","doi":"10.1055/a-2412-3410","DOIUrl":"https://doi.org/10.1055/a-2412-3410","url":null,"abstract":"Pneumatic resistance training (PRT) facilitates a longer time under tension that might lead to greater changes in body composition when compared to traditional resistance training (TRT), possibly enhancing serum metabolite concentrations indicative of healthy metabolic function. To assess the impact of PRT and TRT on muscular strength, body composition and serum metabolome, sixty-nine men (age: 31.8±7.2 years, height: 179.7±5.4 cm, weight: 81.1±9.9 kg) were randomized into two 10-week intervention groups (PRT:n=24 and TRT:n=24) and one control group (CON:n=21). Serum metabolite concentrations were assessed before and after the training intervention by high-throughput nuclear magnetic resonance. Fat mass and lean mass were obtained by bioimpedance analysis. The training intervention resulted in an increase in LM for both PRT (1.85 ± 2.69%; p=0.003) and TRT (2.72 ±4.53%; p=0.004), while only PRT reduced in body fat percentage (PRT: -5.08±10.76%; p=0.019) statistically significantly. Only in PRT and TRT significant increases in small high-density lipoproteins (S-HDL-L) and small HDL particles (S-HDL-P) were observed. When controlling for fat and lean mass, the effects on S-HDL-L/S-HDL-P diminished. Network analysis may suggest that PRT and TRT result in an increase in network connectivity and robustness. It appears that the observed improvements are associated with changes in body composition.","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":"22 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142190121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ibai Garcia-Tabar, Maitane Ruiz-Rios, Cristina Martinez-Labari, Sara Maldonado-Martin, Juan Manuel Murias, Esteban M Gorostiaga
{"title":"Reassembling the Field-based Applicability of the Lactate Threshold for Old Age.","authors":"Ibai Garcia-Tabar, Maitane Ruiz-Rios, Cristina Martinez-Labari, Sara Maldonado-Martin, Juan Manuel Murias, Esteban M Gorostiaga","doi":"10.1055/a-2328-3845","DOIUrl":"10.1055/a-2328-3845","url":null,"abstract":"<p><p>This study aimed to investigate the applicability of the Lactate Threshold (LT) to predict maximal oxygen uptake (˙VO<sub>2max</sub>) and demarcate the boundary between the <i>moderate-</i> to <i>heavy-</i>intensity domain (HR<sub>m-h</sub>) in old age in comparison to the most utilized methods. A cross-sectional validation study was conducted. Participants aged 61 to 77 performed a familiarization procedure, an incremental maximal exercise treadmill test (CPX) for ˙VO<sub>2max</sub> determination, the <i>Six-minute Walk Test</i> (6MWT), and a discontinuous incremental field test for LT determination. Lower (P<0.01) internal effort was required for LT testing (76±8%HR<sub>max</sub>) compared to 6MWT (92±9%HR<sub>max</sub>). The application of the 6MWT reference equations overestimated ˙VO<sub>2max</sub> by 10-23%. LTs better estimated the ˙VO<sub>2max</sub> (r ≈0.90, SEE: ≈3.0] compared to the 6MWT (r=0.68, SEE=5.5). HR<sub>m-h</sub> determined by the CPX differed (20%; P=0.001) from that obtained by LT. HR<sub>m-h</sub> stratification indicated participants fall into the very <i>light</i> to the <i>vigorous</i> intensity domains. LT testing is more submaximal than the 6MWT, and is a valuable tool to estimate the ˙VO<sub>2max</sub> in older male adults. Implementation of LT testing in physical activity programs might help improving the quality of aerobic exercise training in older men.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"748-758"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mike Lackner, Fabian Grossmann, Claudio Perret, Joelle L Flueck, Anneke Hertig-Godeschalk
{"title":"Chasing Gold: Heat Acclimation in Elite Handcyclists with Spinal Cord Injury.","authors":"Mike Lackner, Fabian Grossmann, Claudio Perret, Joelle L Flueck, Anneke Hertig-Godeschalk","doi":"10.1055/a-2321-1832","DOIUrl":"10.1055/a-2321-1832","url":null,"abstract":"<p><p>Thermoregulation is impaired in individuals with a spinal cord lesion (SCI), affecting sweat capacity, heat loss, and core temperature. This can be particularly problematic for athletes with SCI who exercise in hot and humid conditions, like those during the Tokyo 2020 Paralympic Games. Heat acclimation can support optimal preparation for exercise in such challenging environments, but evidence is limited in endurance athletes with SCI. We evaluated whether seven consecutive days of exercise in the heat would result in heat acclimation. Five elite para-cycling athletes with SCI participated (two females, three males, median (Q1-Q3) 35 (31-51) years, four with paraplegia and one with tetraplegia). All tests and training sessions were performed in a heat chamber (30°C and 75% relative humidity). A time-to-exhaustion test was performed on day 1 (pretest) and day 7 (posttest). On days 2-6, athletes trained daily for one hour at 50-60% of individual peak power (P<sub>Peak</sub>). Comparing pretest and posttest, all athletes increased their body mass loss (p=0.04), sweat rate (p=0.04), and time to exhaustion (p=0.04). Effects varied between athletes for core temperature and heart rate. All athletes appeared to benefit from our heat acclimation protocol, helping to optimize their preparation for the Tokyo 2020 Paralympic Games.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"733-738"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141419051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Witalo Kassiano, Bruna Daniella de Vasconcelos Costa, Gabriel Kunevaliki, Felipe Lisboa, Ian Tricoli, Jarlisson Francsuel, Luis Lima, Natã Stavinski, Edilson S Cyrino
{"title":"Bigger Calves from Doing Higher Resistance Training Volume?","authors":"Witalo Kassiano, Bruna Daniella de Vasconcelos Costa, Gabriel Kunevaliki, Felipe Lisboa, Ian Tricoli, Jarlisson Francsuel, Luis Lima, Natã Stavinski, Edilson S Cyrino","doi":"10.1055/a-2316-7885","DOIUrl":"10.1055/a-2316-7885","url":null,"abstract":"<p><p>We compared the effects of different weekly calf training sets on muscle size changes. Sixty-one untrained young women performed a calf training program for 6 weeks, 3 d·wk<sup>-1</sup>, with differences in resistance training volume. The participants were randomly assigned to one of the three groups: 6-SET, 9-SET, and 12-SET weekly calf training sets. The calf raise exercise was performed in sets of 15-20 repetitions maximum. The muscle thickness measurements of medial gastrocnemius (MG), lateral gastrocnemius (LG), and soleus (SOL) were taken via B-mode ultrasound. We used the sum of the three-muscle thickness as a proxy for the triceps surae (TS<sub>SUM</sub>). The 12-SET group elicited greater increases than the 6-SET in LG (6-SET=+ 8.1% vs. 12-SET=+ 14.3%; <i>P</i>=0.017), SOL (6-SET=+ 6.7% vs. 12-SET=+ 12.7%; <i>P</i>=0.024), and TS<sub>SUM</sub> (6-SET=+ 6.9% vs. 12-SET=+ 12.0%; <i>P</i>=0.005), but there was no significant difference in MG changes (6-SET=+ 6.6% vs. 12-SET=+ 9.9%; <i>P</i>=0.067). There were no significant differences when comparing 9-SET vs. 6-SET and 12-SET (<i>P</i>≥0.099). Although all groups experienced calf muscle hypertrophy, our results suggest that the higher dose range may optimize triceps surae muscle size gains.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"739-747"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140850194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}