Raony Espíndola Moura, Rodrigo Fabio Bezerra da Silva, Lucas Morais de Souza Gomes, José Leonardo Ramos da Silva, Rafael Dos Santos Henrique, Filipe Antônio de Barros Sousa, Fabiano de Souza Fonseca
{"title":"Monitoring Bar Velocity to Quantify Fatigue in Resistance Training.","authors":"Raony Espíndola Moura, Rodrigo Fabio Bezerra da Silva, Lucas Morais de Souza Gomes, José Leonardo Ramos da Silva, Rafael Dos Santos Henrique, Filipe Antônio de Barros Sousa, Fabiano de Souza Fonseca","doi":"10.1055/a-2316-7966","DOIUrl":"10.1055/a-2316-7966","url":null,"abstract":"<p><p>We analyzed the effects of load magnitude and bar velocity variables on sensitivity to fatigue. Seventeen resistance-trained men (age=25.7±4.9 years; height=177.0±7.2 cm; body mass=77.7±12.3 kg; back-squat 1RM=145.0±33.9 kg; 1RM/body mass=1.86) participated in the study. Pre- and post-exercise changes in the mean propulsive velocity (MPV) and peak velocity (PV) in the back-squat at different intensities were compared with variations in the countermovement jump (CMJ). CMJ height decreased significantly from pre- to post-exercise (∆%=-7.5 to -10.4; p<0.01; ES=0.37 to 0.60). Bar velocity (MPV and PV) decreased across all loads (∆%=-4.0 to -12.5; p<0.01; ES=0.32 to 0.66). The decrease in performance was similar between the CMJ, MPV (40% and 80% 1RM; p=1.00), and PV (80% 1RM; p=1.00). The magnitude of reduction in CMJ performance was greater than MPV (60% 1RM; p=0.05) and PV (40% and 60% 1RM; p<0.01) at the post-exercise moment. Low systematic bias and acceptable levels of agreement were only found between CMJ and MPV at 40% and 80% 1RM (bias=0.35 to 1.59; ICC=0.51 to 0.71; CV=5.1% to 8.5%). These findings suggest that the back-squat at 40% or 80% 1RM using MPV provides optimal sensitivity to monitor fatigue through changes in bar velocity.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"624-632"},"PeriodicalIF":2.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carlos Revuelta, Lidia B Alejo, Pedro L Valenzuela, Almudena Montalvo-Perez, Víctor de la Calle, Alberto Agundez, Alejandro Lucia, David Barranco-Gil
{"title":"Time-course Changes of Field- and Laboratory-based Performance Indicators in Junior Cyclists Through a Season.","authors":"Carlos Revuelta, Lidia B Alejo, Pedro L Valenzuela, Almudena Montalvo-Perez, Víctor de la Calle, Alberto Agundez, Alejandro Lucia, David Barranco-Gil","doi":"10.1055/a-2233-0454","DOIUrl":"10.1055/a-2233-0454","url":null,"abstract":"<p><p>This study aimed to assess the seasonal evolution of field-based and laboratory-based performance indicators in cyclists. Thirteen Junior male road cyclists (age 17.4±0.5 years) were followed up during a season, which was divided in three phases: early season (involving mainly training sessions), mid-season (including the first competitions), and late season (including the major competitions of the season). During each phase, field-based power output data were registered for the assessment of maximum mean power values, and laboratory-based endurance (ramp test and simulated 8-minute time trial), muscle strength/power (squat, lunge, hip thrust) and body composition indicators (dual-energy X-ray absorptiometry) were also assessed. A progressive (p<0.01) increase in maximum mean power values (e.g., 3.8±0.3 and 4.5±0.4 watts/kg in early and late season, respectively, for 60-minute efforts) and on 8-minute time trial performance (i.e., 5.3±0.3 and 5.6±0.4 watts/kg, respectively) was observed through the season. Yet, more \"traditional\" endurance indicators (i.e., ventilatory threshold, respiratory compensation point, or maximum oxygen uptake) seemed to show a ceiling effect beyond the mid-season. In addition, neither peak power output, body composition, nor muscle strength indicators followed a similar pattern to the aforementioned field-based indicators. In summary, in Junior cyclists field-based indicators seem more sensitive to monitor endurance cyclists' changes in actual fitness and performance capacity than more \"traditional\" laboratory-based markers in Junior cyclists.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"443-449"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcos Quintana-Cepedal, Bernat de Pablo Marquez, Miguel Del Valle Soto, Hugo Olmedillas
{"title":"High Prevalence of Seasonal and Current Groin Problems in Rink Hockey Players.","authors":"Marcos Quintana-Cepedal, Bernat de Pablo Marquez, Miguel Del Valle Soto, Hugo Olmedillas","doi":"10.1055/a-2267-0262","DOIUrl":"10.1055/a-2267-0262","url":null,"abstract":"<p><p>Groin problems are common in multidirectional sports. The aim of the present study is to assess seasonal, current, and trends for groin problems in rink hockey players, irrespective of their playing position, age, or gender. Rink hockey players from three countries [n=446 (162 female, 284 male)] were invited to participate in an online questionnaire. This form evaluated the prevalence of groin problems (time-loss and non-time-loss) for the 2022-2023 season, as well as monthly prevalence of groin problems (time-loss and non-time-loss). All groin problems were compared between playing position, gender, and age to assess between-group differences. Senior males reported the highest time-loss (25%) and non-time-loss (51%) for seasonal prevalence; while U-17 males reported the lowest in both categories of groin problems (time-loss 9%, non-time-loss 27%). No significant differences between playing position or gender were found for any of the groin problems analyzed. In-season prevalence (9-15.7%) of groin problems was significantly higher than pre-season (7.4%) prevalence (p<0.01). Seasonal prevalence of groin problems is common in rink hockey, regardless of gender, playing position, or age. Preventive efforts should be directed towards all players, regardless of their individual characteristics.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"526-531"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tao Mei, Yanchun Li, Xiaoxia Li, Xiaolin Yang, Liang Li, Xu Yan, Zi-Hong He
{"title":"A Genotype-Phenotype Model for Predicting Resistance Training Effects on Leg Press Performance.","authors":"Tao Mei, Yanchun Li, Xiaoxia Li, Xiaolin Yang, Liang Li, Xu Yan, Zi-Hong He","doi":"10.1055/a-2234-0159","DOIUrl":"10.1055/a-2234-0159","url":null,"abstract":"<p><p>This study develops a comprehensive genotype-phenotype model for predicting the effects of resistance training on leg press performance. A cohort of physically inactive adults (N=193) underwent 12 weeks of resistance training, and measurements of maximum isokinetic leg press peak force, muscle mass, and thickness were taken before and after the intervention. Whole-genome genotyping was performed, and genome-wide association analysis identified 85 novel SNPs significantly associated with changes in leg press strength after training. A prediction model was constructed using stepwise linear regression, incorporating seven lead SNPs that explained 40.4% of the training effect variance. The polygenic score showed a significant positive correlation with changes in leg press strength. By integrating genomic markers and phenotypic indicators, the comprehensive prediction model explained 75.4% of the variance in the training effect. Additionally, five SNPs were found to potentially impact muscle contraction, metabolism, growth, and development through their association with REACTOME pathways. Individual responses to resistance training varied, with changes in leg press strength ranging from -55.83% to 151.20%. The study highlights the importance of genetic factors in predicting training outcomes and provides insights into the potential biological functions underlying resistance training effects. The comprehensive model offers valuable guidance for personalized fitness programs based on individual genetic profiles and phenotypic characteristics.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"458-472"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138829721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adrienn Ujvári, Alexandra Fábián, Bálint Lakatos, Márton Tokodi, Zsuzsanna Ladányi, Nóra Sydó, Emese Csulak, Hajnalka Vágó, Vencel Juhász, Kinga Grebur, Andrea Szűcs, Márk Zámodics, Máté Babity, Orsolya Kiss, Béla Merkely, Attila Kovács
{"title":"Right Ventricular Structure and Function in Adolescent Athletes: A 3D Echocardiographic Study.","authors":"Adrienn Ujvári, Alexandra Fábián, Bálint Lakatos, Márton Tokodi, Zsuzsanna Ladányi, Nóra Sydó, Emese Csulak, Hajnalka Vágó, Vencel Juhász, Kinga Grebur, Andrea Szűcs, Márk Zámodics, Máté Babity, Orsolya Kiss, Béla Merkely, Attila Kovács","doi":"10.1055/a-2259-2203","DOIUrl":"10.1055/a-2259-2203","url":null,"abstract":"<p><p>The aim of this study was to characterize the right ventricular (RV) contraction pattern and its associations with exercise capacity in a large cohort of adolescent athletes using resting three-dimensional echocardiography (3DE). We enrolled 215 adolescent athletes (16±1 years, 169 males, 12±6 hours of training/week) and compared them to 38 age and sex-matched healthy, sedentary adolescents. We measured the 3DE-derived biventricular ejection fractions (EF). We also determined the relative contributions of longitudinal EF (LEF/RVEF) and radial EF (REF/RVEF) to the RVEF. Same-day cardiopulmonary exercise testing was performed to calculate VO<sub>2</sub>/kg. Both LV and RVEFs were significantly lower (athletes vs. controls; LVEF: 57±4 vs 61±3, RVEF: 55±5 vs 60±5%, p<0.001). Interestingly, while the relative contribution of radial shortening to the global RV EF was also reduced (REF/RVEF: 0.40±0.10 vs 0.49±0.06, p<0.001), the contribution of the longitudinal contraction was significantly higher in athletes (LEF/RVEF: 0.45±0.08 vs 0.40±0.07, p<0.01). The supernormal longitudinal shortening correlated weakly with a higher VO<sub>2</sub>/kg (r=0.138, P=0.044). Similarly to the adult athlete's heart, the cardiac adaptation of adolescent athletes comprises higher biventricular volumes and lower resting functional measures with supernormal RV longitudinal shortening. Characteristic exercise-induced structural and functional cardiac changes are already present in adolescence.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"473-480"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11150038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katieli Santos de Lima, Felipe Schuch, Natiele Camponogara Righi, Léo José Rubin Neto, Guilherme Silva Nunes, Gustavo Puntel, Patrícia Chagas, Antonio Marcos Vargas da Silva, Luis Ulisses Signori
{"title":"Vitamin E Does not Favor Recovery After Exercises: Systematic Review and Meta-analysis.","authors":"Katieli Santos de Lima, Felipe Schuch, Natiele Camponogara Righi, Léo José Rubin Neto, Guilherme Silva Nunes, Gustavo Puntel, Patrícia Chagas, Antonio Marcos Vargas da Silva, Luis Ulisses Signori","doi":"10.1055/a-2221-5688","DOIUrl":"10.1055/a-2221-5688","url":null,"abstract":"<p><p>This review aimed to verify the effects of vitamin E supplementation on oxidative stress, inflammatory response, muscle damage, soreness, and strength in healthy adults after exercise. We searched the MEDLINE, EMBASE, SPORTDiscus, Cochrane CENTRAL, and Web of Science from inception to August 2023, with no language restrictions. We included randomized placebo-controlled trials evaluating the supplementation of vitamin E on the abovementioned outcomes after a bout of physical exercise in healthy participants (no restriction for publication year or language). Meta-analyses were conducted to compare vitamin E and placebo supplementations to obtain a 95% confidence interval (95%IC). Twenty studies were included (n=298 participants). The effect of supplementation was assessed between 0 h and 96 h after the exercise. Compared to placebo, vitamin E had no effects on lipid (95%IC= -0.09 to 0.42), protein (-2.44 to 3.11), SOD (-1.05 to 0.23), interleukin-6 (-0.18 to 1.16), creatine kinase (-0.33 to 0.27), muscle soreness (-1.92 to 0.69), and muscle strength (-1.07 to 0.34). Heterogeneity for the analyses on carbonyls, interleukin-6 (1 h and 3 h), and muscle soreness ranged between 70 to 94%. Supplementing with vitamin E should not be recommended to support the recovery process in healthy individuals after exercise, given the lack of efficacy in the analyzed variables following an exercise session.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"485-495"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exercise-induced Hypertension and Carotid Intima-media Thickness in Male Marathon Runners.","authors":"Eun Sun Yoon, Young-Joo Kim","doi":"10.1055/a-2270-3127","DOIUrl":"10.1055/a-2270-3127","url":null,"abstract":"<p><p>This study aimed to identify the relationship between exercise-induced hypertension and carotid artery intima-media thickness in long-distance runners. Sixty healthy male runners aged 40 to 60 years were assigned to the following three groups based on resting blood pressure and maximal systolic blood pressure during a maximal exercise test: normal blood pressure response, exercise-induced hypertension, and complex hypertension. An exaggerated systolic blood pressure response was defined as a maximal systolic blood pressure+≥+210 mmHg during the maximal exercise test, while carotid intima-media thickness was measured using B-mode ultrasonography. The carotid intima-media thickness mean values were the highest in the complex hypertension group (0.72±0.11 mm), followed by exercise-induced hypertension (0.62±0.12 mm) and normal blood pressure groups (0.55±0.13 mm), with a significant difference between the groups (p+<+0.002). In linear regression analysis, the mean intima-media thickness was independently associated with age (p=0.015) and maximal systolic blood pressure (p=0.046) but not with resting systolic blood pressure. These results suggest that exercise-induced hypertension is associated with carotid intima-media thickness, a surrogate marker of cardiovascular disease, in long-distance runners. Therefore, evaluating the blood pressure response during exercise is important for the early detection of potential cardiovascular disease risks in long-distance runners.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"519-525"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216809/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paolo Passoni, Alessandra Inzoli, Elena De Ponti, Serena Polizzi, Anna Ceccherelli, Martina Fantauzzi, Chiara Procaccianti, Alessandro Cattoni, Silvia Villa, Anna Riva, Stefano Righetti, Fabio Landoni, Robert Fruscio
{"title":"Association between Physical Activity and Menstrual Cycle Disorders in Young Athletes.","authors":"Paolo Passoni, Alessandra Inzoli, Elena De Ponti, Serena Polizzi, Anna Ceccherelli, Martina Fantauzzi, Chiara Procaccianti, Alessandro Cattoni, Silvia Villa, Anna Riva, Stefano Righetti, Fabio Landoni, Robert Fruscio","doi":"10.1055/a-2278-3253","DOIUrl":"10.1055/a-2278-3253","url":null,"abstract":"<p><p>Our study aims to evaluate clinical predictors of menstrual cycle disorders in female athletes who compete in running disciplines. This is a prospective observational study. Women were recruited between January and May 2022. Fifty-three patients were enrolled and completed a questionnaire about menstrual cycle, physical activity, and food habit characteristics. Of the women in our population, 39.6% had menstrual irregularities and reported a significantly higher number of kilometers run per week (67 vs. 35, p:0.02). The number of kilometers run per week was associated with menstrual irregularities (for 10 km, OR 1.35; IC95% 1.05-1.73; p: 0.02) after adjusting for BMI, age, level of sport and caloric intake. The variable of \"km run per week\" appeared as a diagnostic indicator of irregular menstrual cycle with statistical significance (AUC ROC curve 0.71, IC95% 0.54-0.86, p-value=0.01) and the cut-off of 65 km run per week is a good indicator of the presence of irregular menstrual cycle (sensitivity (SE) and specificity (SP) of 55% and 81.48%). Menstrual cycle disorders are very frequent in female athletes, and the variable of km run per week may play a role in screening endurance athletes at high risk for these disorders.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"543-548"},"PeriodicalIF":2.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11216807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139990042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samuel Bennett, Eve Tiollier, Daniel J Owens, Franck Brocherie, Julien B Louis
{"title":"Implications of Heat Stress-induced Metabolic Alterations for Endurance Training.","authors":"Samuel Bennett, Eve Tiollier, Daniel J Owens, Franck Brocherie, Julien B Louis","doi":"10.1055/a-2251-3170","DOIUrl":"10.1055/a-2251-3170","url":null,"abstract":"<p><p>Inducing a heat-acclimated phenotype via repeated heat stress improves exercise capacity and reduces athletes̓ risk of hyperthermia and heat illness. Given the increased number of international sporting events hosted in countries with warmer climates, heat acclimation strategies are increasingly popular among endurance athletes to optimize performance in hot environments. At the tissue level, completing endurance exercise under heat stress may augment endurance training adaptation, including mitochondrial and cardiovascular remodeling due to increased perturbations to cellular homeostasis as a consequence of metabolic and cardiovascular load, and this may improve endurance training adaptation and subsequent performance. This review provides an up-to-date overview of the metabolic impact of heat stress during endurance exercise, including proposed underlying mechanisms of altered substrate utilization. Against this metabolic backdrop, the current literature highlighting the role of heat stress in augmenting training adaptation and subsequent endurance performance will be presented with practical implications and opportunities for future research.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"422-435"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139944101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Change of Direction Asymmetry in Youth Elite Tennis Players: A Longitudinal Study.","authors":"Joachim D'Hondt, Laurent Chapelle","doi":"10.1055/a-2231-9630","DOIUrl":"10.1055/a-2231-9630","url":null,"abstract":"<p><p>Longitudinal investigations into the development of inter-limb asymmetry in sports are scarce. This study examined the development of change of direction (COD) asymmetry magnitude in youth elite tennis players. Dominant (overall best performance) and non-dominant (best performance on the other side) scores and COD asymmetry magnitude were quantified annually (up to six years) in 323 male and 235 female players (ages 6 to13 years). Linear mixed effects regression models examined the development of COD performance and asymmetry magnitude according to players' chronological age and sex. Kappa coefficients examined the consistency for the direction of asymmetry across test occasions. Regardless of sex, COD performance significantly improved (p<0.001) while COD asymmetry magnitude significantly decreased (- 0.17±0.87% / year) with increasing chronological age. Regardless of age, males showed significantly lower COD times (- 0.111±0.091 s) and lower COD asymmetry magnitude (- 0.30±1.00%) compared to females. The slight and poor (k-value=0.02-0.00) kappa coefficients for males and females, respectively, highlight the direction specificity of functional asymmetry. These data show that whereas performance of the COD test improved, the magnitude of COD asymmetry declined across chronological age in youth tennis players.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"436-442"},"PeriodicalIF":2.5,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138804303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}