Luciele Guerra Minuzzi, Alexander Ferrauti, Matheus Uba Chupel, Sebastian Hacker, Christopher Weyh, Pedro L Valenzuela, Alejandro Lucia, Karsten Krüger, Thomas Reichel
{"title":"Acute Inflammatory Response to Eccentric Exercise in Young and Master Resistance-trained Athletes.","authors":"Luciele Guerra Minuzzi, Alexander Ferrauti, Matheus Uba Chupel, Sebastian Hacker, Christopher Weyh, Pedro L Valenzuela, Alejandro Lucia, Karsten Krüger, Thomas Reichel","doi":"10.1055/a-2348-0238","DOIUrl":"10.1055/a-2348-0238","url":null,"abstract":"<p><p>This study aimed to compare the acute inflammatory response following high-intensity eccentric exercise between resistance-trained young and master athletes with similar performance levels. Resistance-trained young (n=8; 22±2 years) and master (n=8; 52±4 years) male athletes of a similar performance level performed a standardized high-intensity eccentric squat exercise protocol (10 sets of half-squats at 70% of 1-repetition maximum). The serum concentration of 20 biomarkers related to tissue damage, inflammation, remodeling, and repair was measured at baseline, immediately after exercise, and over a 72 h recovery period. Both groups experienced similar muscle damage as evidenced by a comparable increase in creatine kinase activity 24 h after exercise (p<0.001). Interleukin-6 (p=0.009) and growth hormone (p<0.001) increased immediately post-exercise in both groups. Monocyte chemoattractant protein-1 increased immediately post-exercise only in young athletes (p=0.003) and then decreased 24 h later. There were no significant differences for the remaining variables, including cell markers related to neutrophil/macrophage activation or pro/anti-inflammatory cytokines. Resistance-trained young and master athletes, matched for performance level, showed an overall similar inflammatory response to eccentric exercise, possibly reflecting regulatory mechanisms or immunological adaptations to chronic stimulation in master athletes.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"897-907"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew Aceto, Joshua Cassinat, Yasmine S Ghattas, Vonda Wright
{"title":"Lower Body Weightlifting Injuries Treated in United States Emergency Departments from 2012-2021.","authors":"Matthew Aceto, Joshua Cassinat, Yasmine S Ghattas, Vonda Wright","doi":"10.1055/a-2335-4304","DOIUrl":"10.1055/a-2335-4304","url":null,"abstract":"<p><p>Weightlifting has become an increasingly popular form of exercise that has been shown to have many health benefits but can be dangerous if performed improperly. The objective of this study was to describe the epidemiology of lower body weightlifting injuries in the United States. The National Electronic Injury Surveillance System database was queried from January 1, 2012, to December 31, 2021, for lower body injuries related to using weightlifting equipment. Demographics, diagnosis, disposition, and mechanism of injury (MOI) were analyzed. There were 7,773 lower extremity weightlifting injuries identified from 2012-2021, giving a national estimate of 311,842 injuries. The most common MOI was dropped weight (n=1785, 22.96%). Deadlifts were the most cited exercise that led to lower extremity injury (n=503, 6.47%). Males were more likely than females to be injured (76% males vs. 24% females; p<0.001), especially by compound movements with free weights including squats (79.63% males vs. 19.96% females, p<0.03) and deadlifts (83.89% males vs. 16.10% females, p<0.001). Nearly all injuries were treated as outpatient but those admitted to the hospital were significantly older than those treated as outpatients (38.0 years vs. 31.2 years, p<0.05). Weightlifting carries a high risk of injury due to the intensity and technique required for the different movements involved.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"851-855"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141175440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lukas Hack, Bhagyashree Singh, Ferdinand Binkofski, Ingo Helmich
{"title":"Repetitive Subconcussive Head Impacts in Sports and Their Impact on Brain Anatomy and Function: A Systematic Review.","authors":"Lukas Hack, Bhagyashree Singh, Ferdinand Binkofski, Ingo Helmich","doi":"10.1055/a-2342-3604","DOIUrl":"10.1055/a-2342-3604","url":null,"abstract":"<p><p>Repetitive subconcussive head impacts occur regularly in sports. However, the exact relationship between their biomechanical properties and their consequences on brain structure and function has not been clarified yet. We therefore reviewed prospective cohort studies that objectively reported the biomechanical characteristics of repetitive subconcussive head impacts and their impact on brain anatomy and function. Only studies with a pre- to post-measurement design were included. Twenty-four studies met the inclusion criteria. Structural white matter alterations, such as reduced fractional anisotropy and an increase in mean diffusivity values, seem to be evident in athletes exposed to repetitive subconcussive head impacts exceeding 10 g. Such changes are observable after only one season of play. Furthermore, a dose-response relationship exists between white matter abnormalities and the total number of subconcussive head impacts. However, functional changes after repetitive subconcussive head impacts remain inconclusive. We therefore conclude that repetitive subconcussive head impacts induce structural changes, but thus far without overt functional changes.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"871-883"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141300688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jérémie Allinger, Antoine Bouyeure, Marion Noulhiane, Frederic Lemaitre
{"title":"Monitoring the Breath-Hold Training Load during an Ecological Session: A Pilot Study.","authors":"Jérémie Allinger, Antoine Bouyeure, Marion Noulhiane, Frederic Lemaitre","doi":"10.1055/a-2323-9675","DOIUrl":"10.1055/a-2323-9675","url":null,"abstract":"<p><p>This study aimed to create a training load index to measure physiological stress during breath-hold (BH) training and examine its relationship with memory performance. Eighteen well-trained BH divers (Age: 35.8±6.6 years, BH training practice: 5.3±4.5 years) participated in this study. During a standard 1.5-hour BH training in the pool, perceived exertion, heart rate, distance, and duration were measured. The training load index was modelled on the basis of a TRIMP (TRaining IMPulse) with four different equations and was used to measure the stress induced by this BH training. A reference value, based on the ratio between the average heart rate during all BHs and the lowest heart rate during BH training, was used for comparing training load index. Memory assessment was conducted both before and after this training. Of the four equations proposed, equation no. 4, named aTRIMP for \"apnoea,\" showed the strongest correlation with our reference value (r=0.652, p<0.01). No difference was found between any of the memory tests before and after the BH training. The aTRIMP was a new representative index for monitoring habitual training of well-trained BH divers. Furthermore, this training had no negative impact on memory performance.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"837-843"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141619969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"LINC00963 Represses Osteogenic Differentiation of hBMSCs via the miR-10b-5p/RAP2A/AKT Axis.","authors":"Zhixin Wu, Mingjuan Shi, Xuan Zhao, Guifu Wu, Huiyuan Zheng, Yuanyuan Cui, Yu Shang","doi":"10.1055/a-2323-9749","DOIUrl":"10.1055/a-2323-9749","url":null,"abstract":"<p><p>Osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) is important for human bone formation. Long non-coding RNAs (lncRNAs) are critical regulators in osteogenic differentiation. This study aimed to explore the function and mechanisms of long intergenic non-protein coding RNA 963 (LINC00963) in affecting osteogenesis. Cell differentiation was assessed by alkaline phosphatase (ALP) activity detection and ALP staining assay. Meanwhile, levels of osteogenic marker genes, including RUNX family transcription factor 2 (RUNX2), osteocalcin (OCN), and osteopontin (OPN), were detected by RT-qPCR and western blot. Cell proliferation and apoptosis were measured using CCK-8 assay and flow cytometry analysis. RNA immunoprecipitation (RIP), RNA pull-down and luciferase reporter assays were used to investigate the interaction between genes. LINC00963 expression was down-regulated in hBMSCs treated with osteogenic induction. LINC00963 overexpression inhibited hBMSCs differentiation, proliferation, and elevated apoptosis. LINC00963 acted as a competing endogenous RNA (ceRNA) to interact with miR-10b-5p and thereby regulated the expression level of Ras-related protein Rap-2a (RAP2A). LINC00963 regulated RAP2A to inhibit the level of phosphorylated AKT (p-AKT). LINC00963 inhibited hBMSCs differentiation, proliferation, and elevated apoptosis via the miR-10b-5p/RAP2A/AKT signaling, which might help improve the treatment of osteoporosis.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"856-866"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frederike Adammek, Tiffany Y Wences Chirino, David Walzik, Sina Trebing, Sergen Belen, Daniel Renpening, Philipp Zimmer, Niklas Joisten
{"title":"Kinetics of Immune Cell Mobilization during Acute Aerobic Exercise in Healthy Adults.","authors":"Frederike Adammek, Tiffany Y Wences Chirino, David Walzik, Sina Trebing, Sergen Belen, Daniel Renpening, Philipp Zimmer, Niklas Joisten","doi":"10.1055/a-2338-5397","DOIUrl":"10.1055/a-2338-5397","url":null,"abstract":"<p><p>While pre-post differences in immune cell mobilization after acute aerobic exercise are well investigated, less is known about when and to what extent immune cells are mobilized during acute aerobic exercise. This experimental trial aimed to investigate the detailed kinetics of circulating immune cells in twelve healthy adults (n=6 females) who completed a 40-min aerobic exercise bout at 60% of the participants' V̇O2<sub>peak</sub> on a bicycle ergometer. Cellular inflammation markers and sex-dependent differences in circulating immune cells were analyzed. Blood samples were taken immediately before, after warm-up, during exercise after 5 min, 10 min, 15 min, 30 min, 40 min (cessation), and 60 min post exercise. Significant increases in leukocytes (p<0.001), lymphocytes (p<0.001), neutrophils (p=0.003) and platelets (p=0.047) can be observed after 5 min of exercise. The cellular inflammation markers show significant alterations only post exercise. Significant sex differences were observed for neutrophils (p=0.049) and neutrophil-to-lymphocyte ratio (p=0.007) one hour post exercise. These results indicate that i) leukocytes are already mobilized after 5 min of moderate-to-vigorous aerobic exercise, ii) the magnitude of exercise induced leukocyte mobilization is dependent on exercise duration, iii) integrative cellular inflammation markers are only altered after exercise cessation, and iv) the observed effects might be sex-dependent.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"908-916"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141247467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kaila A Holtz, Jason L Zaremski, Joseph Janosky, Kenzie B Friesen, Gretchen D Oliver
{"title":"A Model for Causality of Pitching-related Overuse Injuries in Women's Fastpitch Softball.","authors":"Kaila A Holtz, Jason L Zaremski, Joseph Janosky, Kenzie B Friesen, Gretchen D Oliver","doi":"10.1055/a-2312-5051","DOIUrl":"10.1055/a-2312-5051","url":null,"abstract":"<p><p>Fastpitch softball is a popular women's sport, and athletes, particularly pitchers, are at high risk for overuse injury. Softball-related injury rates are low; however, the prevalence of overuse injuries is high. Injuries at the high school and collegiate levels occur early in the season, and approximately 50% of shoulder and elbow injuries in softball are attributable to overuse. Survey research showed 77% of high school pitchers pitch with pain, and 73% of collegiate pitchers reported an overuse injury in the previous season. Modifiable and non-modifiable intrinsic and extrinsic risk factors contribute to injury risk in a model that can be used in history taking, clinical examination, and management of softball-related injuries. In this manuscript, we present a scoping review of fastpitch softball injury research by competitive levels from 1990 to present. We also introduce a model for overuse injury causality in this athlete population. With this information, clinicians will be able to identify risk factors related to injury in softball pitchers. More research is needed to make evidence-based recommendations for injury prevention in this athlete population.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"804-809"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miguel Rebelo, Catarina Marques, Rute Crisóstomo, Marco Batista, Rui Paulo, João Rocha, João Serrano
{"title":"The Influence of Futsal Players' Initial Physical Condition on the Occurrence of Injuries.","authors":"Miguel Rebelo, Catarina Marques, Rute Crisóstomo, Marco Batista, Rui Paulo, João Rocha, João Serrano","doi":"10.1055/a-2363-1885","DOIUrl":"10.1055/a-2363-1885","url":null,"abstract":"<p><p>Although there are some studies that have linked fitness parameters and sports injuries, the literature remains controversial. The aim of the study was to prospectively analyze the influence of initial physical condition parameters on the development of injury in the first three months of the sports season in futsal players. A total of 68 players (24.26±4.63 years old) were assessed before the start of the sports season in relation to certain physical condition parameters, such as body composition (bioimpedance), lower limb power (countermovement jump, CMJ) and muscle strength (isokinetic dynamometer). The injured players showed significantly worse initial performance in the CMJ compared to the uninjured players (<i>p<</i>0.001). There were no significant differences between groups in body composition and muscle strength. Lower power values were associated with a higher risk of injury in the first few months of the sports season (OR=0.92; 95% CI=0.88-0.99). Muscle power was an independent predictor of injury in the first few months of the sports season in futsal players, indicating that improving players' physical condition could help reduce the number of injuries.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"917-922"},"PeriodicalIF":2.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Serum metabolome signature response to different types of resistance training.","authors":"Joshua Frederik Feuerbacher,Runtan Cheng,Milan Sedliak,Min Hu,Taija Juutinen Finni,Lisa Umlauff,Moritz Schumann,Shulin Cheng","doi":"10.1055/a-2412-3410","DOIUrl":"https://doi.org/10.1055/a-2412-3410","url":null,"abstract":"Pneumatic resistance training (PRT) facilitates a longer time under tension that might lead to greater changes in body composition when compared to traditional resistance training (TRT), possibly enhancing serum metabolite concentrations indicative of healthy metabolic function. To assess the impact of PRT and TRT on muscular strength, body composition and serum metabolome, sixty-nine men (age: 31.8±7.2 years, height: 179.7±5.4 cm, weight: 81.1±9.9 kg) were randomized into two 10-week intervention groups (PRT:n=24 and TRT:n=24) and one control group (CON:n=21). Serum metabolite concentrations were assessed before and after the training intervention by high-throughput nuclear magnetic resonance. Fat mass and lean mass were obtained by bioimpedance analysis. The training intervention resulted in an increase in LM for both PRT (1.85 ± 2.69%; p=0.003) and TRT (2.72 ±4.53%; p=0.004), while only PRT reduced in body fat percentage (PRT: -5.08±10.76%; p=0.019) statistically significantly. Only in PRT and TRT significant increases in small high-density lipoproteins (S-HDL-L) and small HDL particles (S-HDL-P) were observed. When controlling for fat and lean mass, the effects on S-HDL-L/S-HDL-P diminished. Network analysis may suggest that PRT and TRT result in an increase in network connectivity and robustness. It appears that the observed improvements are associated with changes in body composition.","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":"22 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142190121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ibai Garcia-Tabar, Maitane Ruiz-Rios, Cristina Martinez-Labari, Sara Maldonado-Martin, Juan Manuel Murias, Esteban M Gorostiaga
{"title":"Reassembling the Field-based Applicability of the Lactate Threshold for Old Age.","authors":"Ibai Garcia-Tabar, Maitane Ruiz-Rios, Cristina Martinez-Labari, Sara Maldonado-Martin, Juan Manuel Murias, Esteban M Gorostiaga","doi":"10.1055/a-2328-3845","DOIUrl":"10.1055/a-2328-3845","url":null,"abstract":"<p><p>This study aimed to investigate the applicability of the Lactate Threshold (LT) to predict maximal oxygen uptake (˙VO<sub>2max</sub>) and demarcate the boundary between the <i>moderate-</i> to <i>heavy-</i>intensity domain (HR<sub>m-h</sub>) in old age in comparison to the most utilized methods. A cross-sectional validation study was conducted. Participants aged 61 to 77 performed a familiarization procedure, an incremental maximal exercise treadmill test (CPX) for ˙VO<sub>2max</sub> determination, the <i>Six-minute Walk Test</i> (6MWT), and a discontinuous incremental field test for LT determination. Lower (P<0.01) internal effort was required for LT testing (76±8%HR<sub>max</sub>) compared to 6MWT (92±9%HR<sub>max</sub>). The application of the 6MWT reference equations overestimated ˙VO<sub>2max</sub> by 10-23%. LTs better estimated the ˙VO<sub>2max</sub> (r ≈0.90, SEE: ≈3.0] compared to the 6MWT (r=0.68, SEE=5.5). HR<sub>m-h</sub> determined by the CPX differed (20%; P=0.001) from that obtained by LT. HR<sub>m-h</sub> stratification indicated participants fall into the very <i>light</i> to the <i>vigorous</i> intensity domains. LT testing is more submaximal than the 6MWT, and is a valuable tool to estimate the ˙VO<sub>2max</sub> in older male adults. Implementation of LT testing in physical activity programs might help improving the quality of aerobic exercise training in older men.</p>","PeriodicalId":14439,"journal":{"name":"International journal of sports medicine","volume":" ","pages":"748-758"},"PeriodicalIF":2.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}