International journal of surgery最新文献

{"title":"Extracorporeal Shock Wave Therapy (ESWT) in burn scar microbiome modulation: critical analysis of methodological rigor and translational potential.","authors":"Bo Wang, Xiaohong Zheng, Xiaojuan Zhang","doi":"10.1097/JS9.0000000000002411","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002411","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the toxicological network in diabetic microvascular disease: The Role of Endocrine Disrupting Chemicals.","authors":"Siyuan Song, Liji Huang, Xiqiao Zhou, Jiangyi Yu","doi":"10.1097/JS9.0000000000002394","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002394","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates how endocrine-disrupting chemicals contribute to diabetic microvascular disease.</p><p><strong>Methods: </strong>This study assessed endocrine-disrupting chemical toxicity using PubChem, ProTox 3.0, and ChEMBL. Relevant EDC targets were identified via SwissTargetPrediction and Similarity Ensemble Approach. Gene targets for diabetic microvascular diseases (diabetic kidney disease, retinopathy, and sensory polyneuropathy) were retrieved from CTD, GeneCards, and OMIM. Candidate targets were identified by intersecting EDC and disease-related targets. A protein-protein interaction network was built using STRING to identify hub genes. Functional enrichment analysis was conducted via Metascape. Molecular docking of EDC compounds with hub targets was performed using Discovery Studio and CDOCKER. Hub targets were validated through immunohistochemical staining, single-cell distribution, subcellular localization assays, and gene expression analysis in external HPA and GEO datasets.</p><p><strong>Results: </strong>A total of 843, 474, and 623 potential toxic targets were identified for diabetic kidney disease, diabetic retinopathy, and diabetic sensory polyneuropathy, respectively. KEGG pathway analysis linked EDC toxicity in diabetic kidney disease to key pathways such as cancer, chemokine signaling, apoptosis, calcium signaling, and drug metabolism (cytochrome P450), with hub targets including EGFR, ALB, MYC, ESR1, and HSP90AA1. Diabetic retinopathy was associated with MAPK, ERBB, NOD-like receptor signaling, and renal cell carcinoma pathways, with ALB, EGFR, MYC, BCL2, and CD4 identified as hub targets. For diabetic sensory polyneuropathy, EDCs may influence chemokine, apoptosis, ERBB, VEGF, and JAK-STAT signaling pathways, with ALB, EGFR, MYC, ESR1, and BCL2 as key targets. Molecular docking confirmed strong binding activity between EDC components and hub targets.</p><p><strong>Conclusion: </strong>This study offers a theoretical basis for identifying toxic targets and mechanisms by which endocrine-disrupting chemicals contribute to diabetic microvascular diseases.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone grafting in pedicle screw fixation of upper cervical spine: is it necessary?","authors":"Guiguan Wang, Jie Xu","doi":"10.1097/JS9.0000000000002399","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002399","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A correspondence on higher life's essential 8 score is associated with reduced risk of related surgery and all-cause mortality among 3,232 individuals with inflammatory bowel disease in a longitudinal cohort study.","authors":"Xun Wang, Jing Wang","doi":"10.1097/JS9.0000000000002401","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002401","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reverse‑sequence endoscopic nipple‑sparing mastectomy with direct‑to‑implant breast reconstruction and air inflation adjustment technique in patients with large or severely ptotic breast: a single-center prospective cohort study.","authors":"Hui Dai, Xiaoman Cao, Hao Wu, Faqing Liang, Yanyan Xie, Kawun Chung, Qing Zhang, Tianyuan Li, Zhenggui Du","doi":"10.1097/JS9.0000000000002389","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002389","url":null,"abstract":"<p><strong>Background: </strong>The applicability of reverse-sequence endoscopic nipple-sparing mastectomy (R-E-NSM) with direct-to-implant breast reconstruction (DIBR) is worth exploring in patients with large or severely ptotic breasts (LSPB) who were not recommended or even considered contraindicated in open NSM, conventional endoscopic NSM, and robotic NSM. The study aimed to compare the safety and aesthetic outcomes between patients with LSPB and non-LSPB (NLSPB) undergoing R-E-NSM with DIBR.</p><p><strong>Materials and methods: </strong>The single-center prospective cohort study enrolled 562 patients undergoing R-E-NSM and DIBR. Surgical safety, aesthetic outcomes, and oncologic safety were compared between patients with LSPB and NLSPB.</p><p><strong>Results: </strong>After propensity score matching, 88 LSPB patients and 256 NLSPB patients were included (median [IQR] follow-up time: 21.0 [13.8, 32.4] vs. 23.0 [10.6, 32.2] months, P = 0.889). The mastectomy weight was significantly higher in the LSPB group (576.6 ± 144.8 g vs. 330.1 ± 105.7 g, P < 0.001). There were no significant differences in any complications (27.3% vs. 22.7%, P = 0.381), major complications (6.8% vs. 3.1%, P = 0.230), minor complications (20.5% vs. 21.1%, P = 0.889) and implant-related complications (21.6% vs. 24.6%, P = 0.566) between the LSPB and the NLSPB groups. In the LSPB group, the Ueda scores in patients with air inflation adjustment technique (AIAT) were better than those without AIAT, though no significant difference (P = 0.110). Compared to the NLSPB group without AIAT, the LSPB group with AIAT had similar Ueda scores (P = 0.870) and a significantly higher increase in BREAST-Q scores of breast satisfaction (P = 0.004). Oncologic outcomes had no significant difference between the two groups (all P>0.05).</p><p><strong>Conclusion: </strong>R-E-NSM with DIBR and AIAT provides comparable surgical safety and aesthetic outcomes for patients with LSPB and NLSPB, offering a new option for LSPB patients.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A commentary on \"Performance of sentinel lymph node biopsy after neoadjuvant chemotherapy in clinically node positive breast cancer patients: systematic review and meta-analysis\".","authors":"Huijuan Liu, Guohui Han, Hui Ye","doi":"10.1097/JS9.0000000000002392","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002392","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single versus dual hypothermic oxygenated perfusion in liver transplantation: a call for risk-matched outcome analyses.","authors":"Omer F Karakaya, Sangeeta Satish, Philip C Müller, Philipp Dutkowski, Andrea Schlegel","doi":"10.1097/JS9.0000000000002376","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002376","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between generation of cephalosporins and surgical site infection in open fractures: a prospective cohort study.","authors":"Zhenbang Yang, Hongyu Meng, Junyong Li, Pei Du, Hongzhi Lv, Kuo Zhao, Junzhe Zhang, Ming Li, Zhucheng Jin, Ziheng Peng, Dandan Ye, Kai Ding, Zhaohui Song, Juan Wang, Xin Xing, Yanbin Zhu, Yingze Zhang, Wei Chen","doi":"10.1097/JS9.0000000000002371","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002371","url":null,"abstract":"<p><strong>Background: </strong>The use of cephalosporins for surgical site infection (SSI) prevention has become a clinical routine, however, high-level evidence regarding the optimal generation for open fractures is currently limited. This study aims to investigate the association between the generation of cephalosporins and SSI risk in open fractures.</p><p><strong>Methods: </strong>This prospective cohort study used data from the Surgical Site Infection in Orthopedic Surgery (SSIOS), a prospectively maintained database, conducted at a tertiary orthopedic university hospital from October 2014 to December 2020. The primary outcome was occurrence of SSI within 1 year after operation, and its association with the generation of cephalosporins was examined using multivariable logistic regressions and generalized estimating equations. Generalized additive models were used to calculate the relative contribution of potential factors likely influencing SSI.</p><p><strong>Results: </strong>A total of 3582 eligible patients, 74.6% males, with a mean age of 43.7 ± 14.1 years, were included. First-, second-, and third-generation cephalosporins were used in 1957 (54.6%), 1219 (34.0%), and 406 (11.3%) patients. Compared to first-generation cephalosporins, the use of second-generation cephalosporins was significantly associated with a higher risk of SSI (absolute risk difference [ARD] = 3.70%; 95% CI, 1.90%-5.51%; adjusted OR [aOR] = 1.604; 95% CI, 1.212-2.124), whereas third-generation cephalosporins were not (ARD = 1.02%; 95% CI, -1.78% to 3.82%; aOR = 1.234; 95% CI, 0.790-1.880). Among the 28 potential factors considered, the generation of cephalosporins was ranked 9th in terms of its impact on the risk of SSI.</p><p><strong>Conclusion: </strong>Perioperative use of higher-generation cephalosporins was not associated with a reduction in postoperative surgical site infections in open fractures. Our study supports existing guidelines that recommend the use of first-generation cephalosporins as the preferred agents for preventing SSIs in open fractures.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudopregnancy: when the body mimics pregnancy without a fetus.","authors":"Dixa A Vaghela, Vivek P Chavda, Amrendra Kushwaha, Sanjit Sah","doi":"10.1097/JS9.0000000000002395","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002395","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A commentary on \"global, regional, and national burden of inguinal, femoral, and abdominal hernias: a systematic analysis of prevalence, incidence, deaths, and DALYs with projections to 2030\" [Letter].","authors":"Yujun He, Miao Zhou, Xiaoyi Wang, Xiaojun Li","doi":"10.1097/JS9.0000000000002355","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002355","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}