International journal of surgery最新文献

{"title":"Global burden of liver cancer from 1990 to 2021 and 20-year projections: findings from the global burden of disease study 2021.","authors":"Yikai Wang, Yaping Li, Liu Yang, Meng Zhang, Zihan Liu, Mei Li, Juanjuan Shi, Wenjun Wang, Calvin Q Pan, Pengbo Liu, Shuangsuo Dang","doi":"10.1097/JS9.0000000000005129","DOIUrl":"10.1097/JS9.0000000000005129","url":null,"abstract":"<p><strong>Background: </strong>Liver cancer poses a significant global health burden, characterized by substantial regional disparities. We analyzed liver cancer incidence and mortality across 204 countries and territories from 1990 to 2021 and projected trends from 2021 to 2041.</p><p><strong>Materials and methods: </strong>Data from the Global Burden of Disease (GBD) Study 2021 were used to calculate age-standardized rate (ASR), average annual percentage change (AAPC), and estimated annual percentage change (EAPC). Risk factors, human development index (HDI), and sociodemographic index (SDI) were evaluated. The Nordpred and Bayesian Age-Period-Cohort (BAPC) models projected future trends.</p><p><strong>Results: </strong>Globally, according to the analysis of AAPC, the ASR of liver cancer incidence rose by 0.115% (95% CI: 0.07-0.159) annually, while the mortality ASR trend remains stable (-0.113%, 95% CI: -0.35-0.124). Viral hepatitis B and C remained primary causes, but non-alcoholic steatohepatitis (NASH) contributions increased. The summary exposure value (SEV) for drug use increased by 12% globally, with a dramatic increase of 308% in North America. High-HDI/SDI countries exhibited higher ASR than expected, which may be attributed to aging populations and the rising incidence of metabolic diseases. Projections indicated a rising number of cases but declining ASR for both males and females by 2041.</p><p><strong>Conclusions: </strong>Tailored prevention strategies are needed to address region-specific risk factors and mitigate the growing burden of liver cancer.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 7","pages":"13190-13206"},"PeriodicalIF":9.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of HSK16149 for postoperative pain in Chinese patients after orthopedic surgery: a phase 2 randomized clinical trial.","authors":"Lina Yang, Shijin Ma, Shaoxing Liu, Saiying Wang, Jing Zhao, Jun Li, Chuiliang Liu, Fangqiong Li, Jia Deng, Mengchang Yang","doi":"10.1097/JS9.0000000000005071","DOIUrl":"10.1097/JS9.0000000000005071","url":null,"abstract":"<p><strong>Importance: </strong>Some Chinese patients undergoing orthopedic surgery may require more effective and safer analgesics to adequately relieve moderate to severe postoperative pain.</p><p><strong>Objective: </strong>To evaluate the efficacy and safety of crisugabalin (HSK16149), a calcium channel α2δ subunit ligand oral capsule, in managing postoperative pain in Chinese patients undergoing orthopedic surgery.</p><p><strong>Methods: </strong>This Phase 2 trial was conducted from 8 March to 5 July 2023, across 20 clinical hospitals in China and employed a double-blind, randomized design, which enrolled Chinese patients scheduled for elective orthopedic surgery under general anesthesia. Patients were randomized 1:1:1:1:1 to receive HSK16149, 40 mg twice before surgery (80 mg used in total), 60 mg twice (120 mg used in total), 40 mg four times before and after surgery (160 mg used in total), 60 mg four times (240 mg used in total), and receive placebo four times before and after surgery. The primary outcome was the total morphine dose within the 24-hour postoperative period, including usage from the patient-controlled analgesia device and any additional remedial analgesia.</p><p><strong>Results: </strong>A total of 24 patients were excluded from the analysis, resulting in 235 participants randomized into the following groups: 80 mg (<i>n</i> = 47), 120 mg (<i>n</i> = 47), 160 mg (<i>n</i> = 48), 240 mg (<i>n</i> = 46), and placebo (<i>n</i> = 47). Total morphine consumption within 24 hours post-surgery was significantly lower in the HSK16149 groups compared to the placebo group (Kruskal-Wallis test, <i>P</i> = 0.048). The means (SD) of morphine consumption were 11.00 (7.59) for the 80 mg group, 9.94 (8.15) for the 120 mg group, 10.28 (8.80) for the 160 mg group, 9.72 (10.07) for the 240 mg group, and 15.66 (12.13) for the placebo group. The <i>P</i> values calculated from the Wilcoxon rank sum test comparing the four HSK16149 groups to the placebo were 0.0824, 0.0239, 0.0261, and 0.0076, respectively.</p><p><strong>Conclusions: </strong>HSK16149 capsules reduced postoperative opioid consumption in Chinese patients undergoing orthopedic surgery, showing that receiving 240 mg HSK16149 was recommended and appeared to be well tolerated.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 6","pages":"12711-12719"},"PeriodicalIF":9.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FANS-UAS-assisted RIRS under local anesthesia: promising results, but are we ready for definitive conclusions?","authors":"Huiwen Luo, Lefeng Tian, Xirui Lu, Jing Yang","doi":"10.1097/JS9.0000000000005077","DOIUrl":"10.1097/JS9.0000000000005077","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 6","pages":"12996-12997"},"PeriodicalIF":9.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perioperative cardiac safety of neoadjuvant chemo-immunotherapy: how neutral is neutral?","authors":"Man Sun, Huan Zhou, Jun Chen","doi":"10.1097/JS9.0000000000005118","DOIUrl":"10.1097/JS9.0000000000005118","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 7","pages":"13277-13278"},"PeriodicalIF":9.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336578/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Clinical translation considerations regarding deep learning-derived CT body composition as a prognostic biomarker for locally advanced gastric cancer.","authors":"Hongwei Liang, Zhigang Niu, Xiaoying Xu","doi":"10.1097/JS9.0000000000005122","DOIUrl":"10.1097/JS9.0000000000005122","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 7","pages":"13281-13282"},"PeriodicalIF":9.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"Single-cell transcriptomic analysis reveals therapeutic mechanisms of adipose-derived stem cell exosomes in sepsis-induced lung injury\".","authors":"Yue Liu, Yuchao Zhou, Wendi Liu, Tao Sun","doi":"10.1097/JS9.0000000000005151","DOIUrl":"10.1097/JS9.0000000000005151","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 7","pages":"13318-13319"},"PeriodicalIF":9.0,"publicationDate":"2026-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance evaluation of electrosurgical pencils: insights into surgical smoke mitigation and thermal damage reduction.","authors":"Kihyun Sang, Yoon Kong, Ja Kyung Lee, Hee Young Na, Hyeong Won Yu, June Young Choi","doi":"10.1097/JS9.0000000000005093","DOIUrl":"10.1097/JS9.0000000000005093","url":null,"abstract":"<p><strong>Background: </strong>Electrosurgical pencils (ESPs) are essential in modern surgery; however, concerns remain regarding their exposure to surgical smoke and thermal tissue damage. This study quantitatively evaluated four ESPs with a particular focus on two critical aspects: surgical smoke generation and minimization of thermal damage to the surrounding tissues.</p><p><strong>Methods: </strong>Full-thickness incisions were made on the porcine dorsal skin using six instruments: scalpel, uncoated Bovie, coated Bovie, PlasmaBlade, and Duoblade (with and without suction). Surgical smoke was measured by particle counting, blood loss was quantified, and histological analyses (hematoxylin and eosin, Masson's trichrome, CD3, and α-smooth muscle actin staining) were performed to assess the wound scar width and densities of CD3-positive lymphocytes and myofibroblasts.</p><p><strong>Results: </strong>Duoblades, especially those with suction, consistently produced the lowest level of surgical smoke, reducing particle counts by up to 96.1% compared to the uncoated Bovie. It also achieved the greatest reduction in blood loss (93.3% less than that of the scalpel) and resulted in the narrowest scar width among the ESPs. The wound scar width and densities of CD3-positive lymphocytes and myofibroblasts were reduced more rapidly in Duoblade-incised wounds than in those with other ESPs.</p><p><strong>Discussion: </strong>Device design and energy delivery significantly affect the surgical smoke and tissue outcomes. Duoblade dielectric heating and integrated suction provide superior environmental safety and wound healing, while maintaining excellent hemostasis. The Duoblade has a suction function that reduces the surgical smoke.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 6","pages":"12702-12710"},"PeriodicalIF":9.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148873811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Global burden, trends and forecast analysis of early-onset type 2 diabetes and diabetes-related chronic kidney disease: a global burden of disease 2021 analysis\" [Letter].","authors":"Yujun He, Zhaoyang Liu","doi":"10.1097/JS9.0000000000005146","DOIUrl":"10.1097/JS9.0000000000005146","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 7","pages":"13303-13304"},"PeriodicalIF":9.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neoadjuvant immunochemotherapy with or without radiotherapy for locally advanced esophageal squamous cell carcinoma: a pooled analysis of two prospective single-arm clinical trials.","authors":"Yixin Li, Ming Jiang, Zihao Zhu, Youtao Xu, Feng Jiang, Dongjie Feng, Guochun Cao, Xue Song, Lijun Zhao, Cheng Kong, Yinan Wu, Lingling Gu, Xiaochen Huang, Zhen Guo, Jingyuan Zhang, Bo Yang, Gang Xiao, Yang Zhao, Jinjun Ye, Ning Jiang, Xiangzhi Zhu","doi":"10.1097/JS9.0000000000005088","DOIUrl":"10.1097/JS9.0000000000005088","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 6","pages":"12922-12925"},"PeriodicalIF":9.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13249237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Objective coagulation assays for thrombotic risk stratification in peripheral artery disease: are we ready for clinical translation?","authors":"Aime Ishimwe Mugisha","doi":"10.1097/JS9.0000000000005117","DOIUrl":"10.1097/JS9.0000000000005117","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":"112 7","pages":"13259-13260"},"PeriodicalIF":9.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}