International journal of surgery最新文献

{"title":"Inositol metabolism shapes tumor aggressiveness and immune evasion in lower-grade glioma: an integrative analysis of bulk, single-cell, and spatial transcriptomics.","authors":"Qian Chen, Dongfeng Deng, Liangfang Shen, Shan Li","doi":"10.1097/JS9.0000000000003604","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003604","url":null,"abstract":"<p><strong>Background: </strong>Emerging clinical evidence has linked inositol levels to clinical features in lower-grade glioma (LGG). However, the architecture and functional significance of inositol metabolism remain poorly defined.</p><p><strong>Materials and methods: </strong>We developed a transcriptome-based inositol-related gene score (INScore) to quantify inositol metabolic status in LGG, leveraging patient subtypes identified through non-negative matrix factorization (NMF) of inositol-related gene expression profiles. A cohort of 1,659 LGG patients from six independent datasets was analyzed to evaluate the prognostic value of INScore. A comprehensive multi-omics framework-encompassing bulk transcriptomics, single-cell RNA sequencing, spatial transcriptomics, genomic profiling, and clinical data-was employed to elucidate the biological implications of INScore. The hub gene was identified via LASSO regression and validated through functional assays and clinical sample analysis.</p><p><strong>Results: </strong>The INScore model demonstrated significant prognostic power across all cohorts, with higher INScore correlating with poorer survival outcomes. Bulk transcriptomic and genomic analyses revealed that elevated INScore correlated with oncogenic signaling activation, increased genomic instability, and a macrophage-driven immunosuppressive tumor microenvironment. Single-cell and spatial transcriptomic profiling further delineated two high-INScore glioma subtypes: Glioma_C5, characterized by reduced apoptosis, impaired differentiation, and increased copy number variation burden; and Glioma_C8, marked by extensive macrophage interactions promoting immune suppression. IMPA2 was identified as the hub gene within the inositol metabolic network, with its knockdown significantly impairing LGG cell proliferation and invasion, and its overexpression enhancing malignant phenotypes. Immunohistochemical analysis confirmed that IMPA2 expression was positively associated with both M2 macrophage polarization and poor clinical outcomes.</p><p><strong>Conclusion: </strong>Inositol metabolism status serves as a potent prognostic biomarker in LGG, intricately linked to tumor aggressiveness and immune evasion, highlighting its potential as a therapeutic target.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to editor regarding article \"Long-term outcomes of endovascular embolization and stereotactic radiosurgery as the first-line treatment for ruptured arteriovenous malformations: a propensity score-matched analysis using nationwide multicenter prospective registry data\".","authors":"Li Yaotao, Zhan Yizhou, Xie Renxian","doi":"10.1097/JS9.0000000000003619","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003619","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Commentary on \"Associations of the NPAR index with breast cancer incidence and mortality (NHANES 2001-2018)\".","authors":"Guo-Ming Zhang","doi":"10.1097/JS9.0000000000003563","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003563","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transanal opening of intersphincteric space (TROPIS) for high complex fistulas: update from the innovator after a decade's experience.","authors":"Pankaj Garg","doi":"10.1097/JS9.0000000000003545","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003545","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of MASLD-IBD comorbidity from 1990 to 2021 and trend prediction to 2050.","authors":"Yuanshan Xu, Youting Yi, Xiankang Zhang, Boyi Jia, Yanrong Huang, Renyun Cui, Haowen Sun, Meng Wang, Jin-Yi Wan, Haiqiang Yao, Chun-Su Yuan","doi":"10.1097/JS9.0000000000003383","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003383","url":null,"abstract":"<p><strong>Background: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD), a prevalent chronic liver disorder, imposes a substantial global clinical and economic burden. Emerging evidence underscores inflammatory bowel disease (IBD) as a significant independent risk factor for MASLD. However, the global burden and trends of MASLD-IBD comorbidity remain largely obscured. To evaluate the global MASLD-IBD burden from 1990 to 2021, and project trajectories to 2050, informing proactive public health strategies.</p><p><strong>Methods: </strong>Leveraging the GBD 2021 database, we quantified IBD's contribution to MASLD via population-attributable fractions (PAF). We analysed the global prevalence, mortality, and disability-adjusted life years (DALYs), stratifying by socio-demographic index (SDI), sex, and age. Estimated annual percentage change (EAPC) assessed 1990-2021 trends; Bayesian age-period-cohort modelling projected 2050 trajectories.</p><p><strong>Results: </strong>In 2021, the global age-standardized prevalence of MASLD-IBD comorbidity reached 171.7 cases (95% UI: 157.3-187.1), with a corresponding DALY rate of 0.5 cases (95% UI: 0.4-0.6) per 10 million population. High-income regions, including North America, Australia, and Western Europe, bore the highest burden. From 1990 to 2021, 20 out of 21 GBD regions exhibited escalating age-standardized prevalence and DALY rates, most markedly in East Asia (prevalence EAPC = 3.18; 95% CI: 2.59-3.77) and East Europe (DALY EAPC = 4.05; 95% CI: 3.32-4.79). Middle SDI regions saw the largest absolute increases, with mortality mirroring DALY trends. Adults ≥ 60 years bore disproportionately higher burdens. By 2050, projections suggest divergent gender trends of rising female burden versus declining male rates.</p><p><strong>Conclusions: </strong>MASLD-IBD comorbidity burdens have risen globally over three decades, necessitating targeted interventions, particularly for ageing populations and high-risk regions. Gender-specific strategies will be critical for mitigating future impacts.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"The role of early cerebral edema and hematoma assessment in aneurysmal subarachnoid hemorrhage (a-SAH) in predicting early brain injury (EBI) and cognitive impairment: a case controlled study\".","authors":"Lin Zhao, Tao Zhou, Peng Zhou","doi":"10.1097/JS9.0000000000003632","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003632","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From pixels to practice: extending deep learning frameworks toward clinical translation in surgery (Correspondence).","authors":"Zhe Cheng, Haitao Yang, Ruixi Luo","doi":"10.1097/JS9.0000000000003642","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003642","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: A comparative analysis of tip-bendable suction ureteral access sheath versus traditional sheath in retrograde intrarenal stone surgery: a systematic review and meta-analysis of comparative studies.","authors":"Yanan Duan, Mingzhen Guo, Xuedi Cheng","doi":"10.1097/JS9.0000000000003622","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003622","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A commentary on \"Stapler choice, surgeon experience, and meaningful endpoints in intracorporeal versus extracorporeal esophagojejunostomy after laparoscopic total gastrectomy\".","authors":"Shi-Ping Wang, Guo-Ming Zhang","doi":"10.1097/JS9.0000000000003610","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003610","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on: risk factors for osteomyelitis: a systematic review and meta-analysis.","authors":"Jun Tao, Hongjian Li, Wenqi Feng","doi":"10.1097/JS9.0000000000003613","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003613","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}