International journal of surgery最新文献

{"title":"The effects of ChatGPT on patient education of knee osteoarthritis: a preliminary study of 60 cases.","authors":"Yuanmeng Yang, Junqing Lin, Jinshan Zhang","doi":"10.1097/JS9.0000000000002494","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002494","url":null,"abstract":"<p><strong>Background: </strong>ChatGPT powered by OpenAI is a large language model that offers a potential method for patient education. Whether patients with knee osteoarthritis (KOA) can benefit from patient education via ChatGTP has not been sufficiently investigated.</p><p><strong>Methods: </strong>We enrolled 60 participants enrolled from 1 January 2024 to 1 September 2024 who had clinically diagnosed KOA for the first time. Participants were excluded from analyses if they post-traumatic osteoarthritis and history of knee surgery. Participants received physician education (n = 18), free education with ChatGPT (n = 21), or supervised education (n = 21) with ChatGPT with a pre-defined outline (5 questions for reference). The primary outcome was the physician-rated patient knowledge level on KOA measured by a visual analogue scale (VAS, 0-100 mm). We also evaluated all answers from ChatGPT via VAS rating.</p><p><strong>Results: </strong>Patients receiving free education with ChatGPT asked substantially more questions compared with those patients who were given a pre-defined outline (17.0 ± 9.3 versus 10.3 ± 7.6, P < 0.001). With the outline given to patients, ChatGPT gave higher-quality answers compared with the answers from the group with free education (92.1 ± 4.3 versus 81.4 ± 10.4, P = 0.001). Finally, the supervised education group achieved similar education effect (knowledge level, 95.3 ± 4.7) compared with physician education group (95.6 ± 5.3) while the free education group had a substantially lower knowledge level (82.1 ± 12.3, P < 0.001).</p><p><strong>Conclusion: </strong>Patient education by ChatGPT with pre-structured questions could achieve good patient education on KOA compared with patient education by physicians. Free patient education in the current stage should be cautious, considering the relative lower knowledge level and potential lower quality of answers.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Trial Landscape of Stem Cell Therapy for Female Infertility: Global Current Status and Future Perspectives.","authors":"Jin Yiru, Chen Yiru, Yiyue Jiang, Pingping Lv, Min Jin, Chun Feng","doi":"10.1097/JS9.0000000000002572","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002572","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating machine learning and molecular docking to decipher the molecular network of aflatoxin b1-induced hepatocellular carcinoma.","authors":"Junjie Gao, Meijun Zhang, Qun Chen, Kai Ye, Jing Wu, Tao Wang, Puhong Zhang, Gang Feng","doi":"10.1097/JS9.0000000000002455","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002455","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the molecular mechanisms underlying hepatocellular carcinoma (HCC) induced by Aflatoxin B1 (AFB1).</p><p><strong>Methods: </strong>Differential expression analysis of multiple datasets was performed to identify HCC-related target genes. Machine learning algorithms, network toxicology, and molecular docking techniques were integrated to explore the binding interactions between AFB1 and target proteins.</p><p><strong>Results: </strong>A total of 48 genes were identified as potential targets for AFB1-induced hepatocarcinogenesis. Subsequent machine learning analysis prioritized six core genes (RND3, PCK1, AURKA, BCAT2, UCK2, and CCNB1) as key regulators. Among these, RND3 and PCK1 exhibited significant downregulation, while AURKA, BCAT2, UCK2 and CCNB1 showed marked upregulation (P<0.05). Molecular docking simulations revealed strong binding specificity between AFB1 and target proteins.</p><p><strong>Conclusion: </strong>This study demonstrates that AFB1 may promote HCC pathogenesis by targeting specific genes and signaling pathways. Machine learning identified six core regulatory genes, and molecular docking confirmed AFB1's high binding affinity with key targets. These findings provide critical insights for further mechanistic exploration of AFB1-induced hepatocarcinogenesis.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported outcome based symptom management is a better option for early postoperative recovery after breast cancer surgery: a parallel controlled randomized clinical trial.","authors":"Zhitang Wang, Debo Chen","doi":"10.1097/JS9.0000000000002555","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002555","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: comment on \"Intra- and early postoperative predictors of delirium risk in cardiac surgery: results from the prospective observational FINDERI study\".","authors":"Yunyi Yang, Xiaoli He, Xiaoxiao Qu, Yanming He, Hongjie Yang","doi":"10.1097/JS9.0000000000002540","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002540","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twenty-year panoramic review of stem cells research in kidney diseases (2005-2025): a bibliometric and clinical trial-based exploration.","authors":"Jiayou Liu, Jiyuan Hu, Xue Gao, Hongfang Liu","doi":"10.1097/JS9.0000000000002479","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002479","url":null,"abstract":"<p><p>Over the past two decades, a systematic elucidation of the overall trajectory and clinical translation of stem cell research in kidney diseases has been lacking. To address this gap, we conducted a bibliometric analysis and clinical trial search focusing on the period from 2005 to 2025, thereby mapping the global landscape of stem cell research in kidney diseases. Our results indicate a growing body of literature, accompanied by extensive international collaborations, with the United States and China leading in research output. In terms of research themes, mesenchymal stem cells continue to garner sustained attention for their reparative applications. Over the past decade, there has been a marked increase in studies on exosomes, extracellular vesicles, and kidney organoids. Nevertheless, clinical translation remains relatively delayed, suggesting that laboratory discoveries require additional time to reach bedside applications. This study provides a global perspective grounded in empirical data, helping to clarify critical frontiers and challenges.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating through the QUAPAS framework: potential challenges in the quality appraisal of prognostic accuracy studies.","authors":"Shayan Roshdi Dizaji, Koohyar Ahmadzadeh, Mahmoud Yousefifard","doi":"10.1097/JS9.0000000000002519","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002519","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical landscape and future perspectives of targeted protein degradation therapies in lung cancer.","authors":"Man Sun, Dan Zang, Jun Chen","doi":"10.1097/JS9.0000000000002469","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002469","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Routine abdominal drainage after pancreatectomy: A Byesian meta-analysis.","authors":"Shengxiang Hou, Zonghao Hou, Li Ren, Zhixin Wang, Haijiu Wang, Chengwei Tie, Manjun Deng, Haining Fan","doi":"10.1097/JS9.0000000000002483","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002483","url":null,"abstract":"<p><strong>Objective: </strong>This meta-analysis aims to evaluate the effect of prophylactic abdominal drainage on post-pancreatectomy complications, a topic that is still debated in the medical community.</p><p><strong>Materials and methods: </strong>Following PRISMA guidelines, the authors conducted a systematic search across databases such as PubMed, EMBASE, Scopus, Cochrane Library, Ovid, clinicaltrials.gov, Web of Science, CNKI, and WanFang Data, focusing on studies comparing intraperitoneal drainage with no drainage after pancreatic surgery. Key outcomes included postoperative pancreatic fistula, clinically relevant postoperative pancreatic fistula, mortality, complications, delayed gastric emptying, bile leakage,intestinal fistula, abdominal abscess,postoperative bleeding, interventional radiology drainage, reoperation, and unplanned readmissions. Statistical analyses were conducted using either a Beta Normal Hierarchical Model or a random-effects model, providing combined odds ratios (ORs) with 95% confidence intervals (CIs). Subgroup analyses were also performed based on surgical procedures, specifically Distal Pancreatectomy (DP) and Pancreatoduodenectomy (PD).</p><p><strong>Results: </strong>This meta-analysis, incorporating 5 RCTs and 10 non-RCTs, identified a significant link between routine abdominal drainage and higher rates of postoperative pancreatic fistula, clinically relevant postoperative pancreatic fistula, and unplanned readmissions.The overall ORs were 2.46 (95% CI: 1.90-3.63), 1.92 (95% CI: 1.38-2.64), and 1.32 (95% CI: 1.04-1.65) . In the DP subgroup, the ORs were 2.48 (95% CI: 1.49-5.00), 2.75 (95% CI: 1.65-5.21), and 1.46 (95% CI: 1.06-2.18). In the PD subgroup, the ORs were 2.34 (95% CI: 1.70-3.36), 1.95 (95% CI: 1.17-3.19), and 1.25 (95% CI: 1.00-1.60). The use of drainage was associated with a decreased mortality following PD, with an OR of 0.49 (95% CI: 0.23-0.96),however, this association was not observed in relation to other surgical methods. No significant differences were found among the groups for the other outcomes.</p><p><strong>Conclusion: </strong>For surgeries other than PD, omitting drainage tubes may benefit patients postoperatively. However, unselected cessation of intraperitoneal drainage after PD correlates with reduced pancreatic fistulas but higher mortality. Future randomized trials should compare routine versus selective drainage.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of parecoxib on postoperative delirium in patients with hyperlipidemia: a randomized, double-blind, single-center, superiority trial.","authors":"Wei Shang, Chao Wu, Yanfei Yang, Wei Liu","doi":"10.1097/JS9.0000000000002549","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002549","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}