International journal of surgery最新文献

{"title":"Letter to Editor: \"Glioma-induced neural functional remodeling in the hand motor cortex: precise mapping with ECoG grids during awake craniotomy\".","authors":"Shimeng Cui, Chao Wu, Xiu Shan","doi":"10.1097/JS9.0000000000002565","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002565","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A commentary: \"Global trends in surgically based treatment of anal fistula in Crohn's disease: a bibliometric and visualization analysis\".","authors":"Xiangcheng Hu, Lingling Ren, Shuyuan Zhu, Fangling Chen, Haiping Shen, Chengyong Qian, Guanglan Chen","doi":"10.1097/JS9.0000000000002564","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002564","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic functional luminal imaging probe for intraprocedural guidance of achalasia treatment: a systematic review and meta-analysis.","authors":"Matyas Fehervari, Isla Middleton, Emma Rose McGlone, Michael G Fadel, James Brewer, Pranav Patel, Majid Hashemi, Naim Fakih-Gomez, Sacheen Kumar","doi":"10.1097/JS9.0000000000002397","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002397","url":null,"abstract":"<p><strong>Background: </strong>Functional luminal imaging probes (EndoFLIP) have shown potential as both diagnostic tools and intraoperative guides during achalasia interventions. This systematic review and meta-analysis aim to evaluate the intraoperative use of EndoFLIP during surgical procedures for achalasia, with a focus on its impact on the distensibility index (DI) and treatment outcomes.</p><p><strong>Materials and methods: </strong>A literature search of Medline, Embase, and the Cochrane Library was conducted for studies reporting the use of EndoFLIP and DI in achalasia treatment from January 2000 to January 2024. Meta-analysis was performed using random-effect models to assess treatment effects, with heterogeneity between studies evaluated.</p><p><strong>Results: </strong>A total of 32 studies with 2,681 patients were included in the qualitative synthesis, and 17 studies with 1,734 patients were included in the quantitative synthesis. A pooled random-effects analysis demonstrated a significant reduction in DI following myotomy, with a weighted mean difference (WMD) of -3.72 (95% CI -4.16 to -3.28; I2 = 90%). The Eckardt score analysis, including data from 1,009 patients, showed a significant reduction by -5.21 (95% CI -5.8 to -4.6; p < 0.001, I2 = 89.4%). The random-effects analysis of DI pre- and post-myotomy without an endoscope demonstrated a significant increase with a WMD of -2.402 (95% CI -3.175 to -1.6; p < 0.001, I2 = 85.6%). A larger WMD was observed with endoscope placement above the FLIP device, measuring -4.14 (95% CI -5.4 to -2.8; p < 0.001, I2 = 91.2%). For the 30 mL balloon fill, the weighted mean difference (WMD) in the distensibility index (DI) post-myotomy was -2.89 (95% CI -3.2 to -2.4; p < 0.001). For the 40 mL balloon fill, the WMD was -4.02 (95% CI -4.8 to -3.1; p < 0.001).</p><p><strong>Conclusions: </strong>EndoFLIP enhances achalasia treatment by offering real-time feedback on the distensibility index, allowing for more tailored interventions and improved outcomes. A standardized protocol for EndoFLIP usage is necessary to further validate its role in clinical practice and ensure consistent, comparable measurements.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Peripheral nerve blocks for hip fracture surgeries: a bibliometric and visual analysis\".","authors":"Xinxing Fei, Jiayi Song, Yue Hu","doi":"10.1097/JS9.0000000000002542","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002542","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ferroptosis is involved in the IL-9-induced intestinal barrier injury in sepsis: an experimental animal and translational study.","authors":"Jia-Kui Sun, Xiao-Tian Huangfu, Xiang Yin, Shuai Nie, Yi-Hang Deng, Zi-Yu Ye, Xue-Hui Zhou, Xiang Wang, Yan-Na Si","doi":"10.1097/JS9.0000000000002541","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002541","url":null,"abstract":"<p><strong>Background: </strong>Interleukin-9 (IL-9) is an emerging pro-inflammatory cytokine that promotes intestinal barrier injury (IBI) in sepsis. The specific mechanisms of IL-9-induced IBI still need to be clarified. As a newly discovered form of programmed cell death, ferroptosis was demonstrated to be involved in sepsis-related organ dysfunction, yet its role in IL-9-induced IBI in sepsis remains unexplored.</p><p><strong>Methods: </strong>Serum levels of IL-9, D-lactate, intestinal fatty acid binding protein (iFABP), glutathione (GSH), and glutathione peroxidase 4 (GPX4) were tested in septic patients and control subjects. Biomarkers reflecting barrier function in serum and intestinal tissue were tested in treated rats. Rats underwent sepsis induction, IL-9, IL-9 inhibition (IL-9i), and ferroptosis inhibition (Fei) treatment were selected to examine the severity of IBI and survival rates.</p><p><strong>Results: </strong>Significantly elevated levels of IL-9, D-lactate, iFABP, GSH, and GPX4 were observed in septic patients and rats. IL-9 levels showed a negative correlation with GSH and GPX4 levels, while GSH or GPX4 levels showed an inverse correlation with D-lactate and iFABP levels. Serum GSH and GPX4 levels demonstrated strong predictive value for acute gastrointestinal injury of grade II and above in septic patients. IL-9 administration increased levels of transferrin receptor, Fe2+, and iFABP in serum and intestinal tissue of septic rats, while decreasing GSH, GPX4, and zonula occludens 1 levels. Inhibition of ferroptosis reversed these biomarkers alterations. Intestinal permeability, transmission electron microscopy, histopathology, and apoptosis assays confirmed exacerbated IBI following IL-9 upregulation and its attenuation upon ferroptosis inhibition.</p><p><strong>Conclusion: </strong>Ferroptosis was implicated in the IL-9-induced intestinal barrier injury in sepsis.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing lymph node evaluation in colorectal mucinous adenocarcinoma: a multicenter and population-based study.","authors":"Qiying Yin, Yanlai Sun, Changqing Jing, Benjia Liang, Xu Guan, Peng Zhang, Kaixiong Tao, Yueming Sun, Yifei Zhang, Shanglei Ning, Minhao Yu, Yanfeng Lv, Lei Wang, Qi Sun, Jiangang Liu, Meng Jiao, Zhao Zhang, Congqing Jiang, Xianghai Ren, Guodong Yu, Bin Ma, Zhibin Ye, Jun Li, Dongning Liu, Xiangheng Kong, Jingbo Chen, Guangyong Zhang, Hui Yang","doi":"10.1097/JS9.0000000000002545","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002545","url":null,"abstract":"<p><strong>Background: </strong>While the currently recommended minimum number of examined lymph nodes (ELNs) for colorectal cancer is 12, the applicability of this standard to colorectal mucinous adenocarcinoma (MAC), a distinct tumor entity with high metastatic potential, remains controversial. This study aimed to establish and validate the optimal ELN threshold during surgery to achieve superior survival outcomes of MAC patients.</p><p><strong>Methods: </strong>Data from 21 Chinese medical institutions and the Surveillance, Epidemiology, and End Results (SEER) database were analyzed using Cox proportional hazards models to identify prognostic factors affecting MAC patient outcomes. Restricted cubic spline (RCS) analysis was subsequently applied to determine the optimal ELN threshold.</p><p><strong>Results: </strong>The ELN distribution pattern demonstrated significant concordance between the Chinese cohort (n = 1086) and the SEER cohort (n = 12 343), with identical median values (17) and overlapping interquartile ranges (SEER: 12-23 vs. China: 13-22). Multivariate analyses adjusted for potential confounders established ELN quantity as an independent prognostic factor (SEER cohort: hazard ratio [HR] = 0.987, 95% confidence interval [CI]: 0.985-0.990, P < 0.001; Chinese cohort: HR = 0.975, 95% CI: 0.957-0.994, P = 0.011). The RCS models in both databases revealed a nonlinear L-shaped association between the ELN count and all-cause mortality risk, with 17 ELNs identified as the optimal threshold. Notably, patients with ≥17 ELNs exhibited significantly reduced mortality risks in both the SEER cohort (P < 0.001) and the Chinese cohort (P = 0.45), particularly in node-negative patients and those without adjuvant chemotherapy.</p><p><strong>Conclusion: </strong>Elevated ELN counts are correlated with improved survival. Our findings strongly suggest that 17 ELNs is the optimal cutoff for evaluating surgical quality and prognostic stratification in MAC patients, challenging the conventional 12-ELN standard.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-operative evaluation of different thyroid operations - differences and unmeasured factors.","authors":"Saisai Jing, Jianke Ma, Jiazhao Song","doi":"10.1097/JS9.0000000000002529","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002529","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of phenotypic age acceleration in aneurysmal subarachnoid hemorrhage: analysis of retrospective data from two hospital-based cohorts and prospective UK Biobank cohort.","authors":"Jiarong He, Yuquan Chen, Sidi Xu, Pengwei Hou, Yan Cui, Kai Su, Xieli Guo, Ming Wang, Mingming Zhang","doi":"10.1097/JS9.0000000000002544","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002544","url":null,"abstract":"<p><strong>Background: </strong>Phenotypic age acceleration (PhenoAgeAccel) is considered a major risk factor for various age-related diseases, but its specific role in aneurysmal subarachnoid hemorrhage (aSAH) remains unclear. This study aims to examine the relationship between PhenoAgeAccel and the risk of aSAH, and further explores whether genetic susceptibility modifies this association.</p><p><strong>Methods: </strong>Using data from the UK Biobank, we performed cross-sectional and prospective analyses to investigate the association between PhenoAgeAccel and aSAH. Polygenic risk scores were calculated to evaluate genetic susceptibility, and interactions between genetic risk and PhenoAgeAccel were explored. Additionally, using hospital cohort data, we applied an XGBoost model interpreted via SHapley Additive exPlanations (SHAP) analysis to identify key clinical predictors, including PhenoAgeAccel, which were subsequently incorporated into a nomogram for clinical risk prediction.</p><p><strong>Results: </strong>Cross-sectional analyses revealed that each 1-year increment in PhenoAgeAccel was associated with a 1%-7% elevated risk of aSAH. In the UK Biobank, biologically older individuals had a higher risk of aSAH compared to biologically younger individuals (odds ratio [OR] = 1.48; 95% confidence interval [CI], 1.10-1.97; P = 0.009) for PhenoAgeAccel. Similarly, in the hospital datasets, biologically older individuals also showed increased odds of aSAH (Second Xiangya Hospital: OR = 16.45; 95% CI, 4.72-57.34; Fujian Hospital: OR = 12.41; 95% CI, 3.33-46.26). In the prospective analyses of the UK Biobank, PhenoAgeAccel was associated with an increased risk of incident aSAH (hazard ratio [HR] = 1.04; 95% CI, 1.02-1.07). Moreover, additive interactions between PhenoAgeAccel and genetic susceptibility were observed. Further validation using the XGBoost machine learning model and SHAP analysis confirmed PhenoAgeAccel as a key predictive factor for aSAH. Based on these findings, a nomogram integrating PhenoAgeAccel and relevant clinical parameters was developed to facilitate individualized risk prediction in clinical practice.</p><p><strong>Conclusion: </strong>PhenoAgeAccel is a significant predictor of aSAH risk, particularly among genetically susceptible populations. Identifying individuals with PhenoAgeAccel could serve as a novel clinical biomarker for assessing aSAH.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of dexmedetomidine for epidural supplementation on postpartum sleep disturbance after cesarean delivery: a double-blind, randomized clinical trial.","authors":"Juan Li, Yan-Hong Zhou, Ying-Jie Yang, Qian Wang, Wan Lei, Shu-Xi Li, Jian-Jun Shen, Dong-Xin Wang, Xin-Zhong Chen, Li-Li Xu","doi":"10.1097/JS9.0000000000002489","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002489","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Dexmedetomidine has been proved to be a supplemental narcotic or/and sedative for neuraxial anesthesia during various obstetrics treatment and operation procedures. Our study aimed to investigate the effect of intraoperative low-dose dexmedetomidine epidural supplementation on postpartum sleep quality and the incidence of postpartum sleep disturbance in patients undergoing cesarean delivery.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;One hundred and twenty parturients scheduled for elective cesarean delivery with epidural anesthesia were randomized to receive either 1 μg · mL-1 dexmedetomidine or placebo, followed with patient-controlled epidural analgesia with either 0.5 μg · mL-1 dexmedetomidine or placebo, combined with ropivacaine, for up to 2 days. The primary outcome was the incidence of postpartum sleep disturbance on postoperative days 3 defined as numeric rating scale (NRS) score of subjective sleep quality of 6 or higher or Pittsburgh Sleep Quality Index (PSQI) score higher than 5 during the first 3 postoperative nights. Postoperative maternal pain intensity, ropivacaine consumption, and patient-controlled epidural analgesia boluses in 48 h were also recorded.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 120 parturients were randomized to the dexmedetomidine group and the control group. The incidence of postpartum sleep disturbance in the dexmedetomidine group was significantly lower than in the control group on postoperative days 3 (30.0% vs 61.7%; odds ratio [OR], 0.49 [95% CI, 0.32-0.75]; P&lt;0.001), and days 7 (25.9% vs 52.5%; OR, 0.49 [95% CI, 0.30-0.81]; P = 0.003). The NRS score of subjective sleep quality was lower in the dexmedetomidine group than in the control group on postoperative days 3 (P&lt;0.001) and days 7 (P = 0.001). The NRS score of subjective sleep quality and the incidence of postpartum sleep disturbance on postoperative days 14 did not differ between the two groups. The Pittsburgh Sleep Quality Index (PSQI) score, the insomnia severity index score, the self-rating anxiety scale, and the Edinburgh Postnatal Depression Scale (EPDS) on postoperative days 42 did not differ between the two groups. The NRS score of pain was lower in the dexmedetomidine group than those in the control group at the time of end of surgery, 1 h after surgery, 1 d after surgery, 2 d after surgery, and 3 d after surgery (P&lt;0.001); postoperative ropivacaine consumption (mg) and patient-controlled epidural analgesia boluses (n) in 48 h were lower in the dexmedetomidine group than that in the control group (P&lt;0.001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;Intraoperative and postoperative continuous epidural infusion of low-dose dexmedetomidine significantly improved postpartum sleep quality, reduced the incidence of postpartum sleep disturbance, which may be associated with optimized analgesia effect and decreased postoperative ropivacaine consumption in parturients undergoing elective cesarean delivery. Further studies are needed to","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Commentary on \"a comparative analysis of perioperative complications and biochemical recurrence between standard and extended pelvic lymph node dissection in prostate cancer patients undergoing radical prostatectomy: a systematic review and meta-analysis\".","authors":"Li Li, Ying Mao","doi":"10.1097/JS9.0000000000002431","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002431","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}