International journal of surgery最新文献

{"title":"Global landscape of oncolytic virus clinical trials for pancreatic cancer: challenges and opportunities.","authors":"Yubo Yang, Yuning Ma, Jingan Tan, Zhiwei Huang","doi":"10.1097/JS9.0000000000002721","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002721","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Function and mechanism of lactylation in health and diseases: a comprehensive review.","authors":"Yiren Yang, Longxin Deng, Hanzhong Zhang, Jiatao Hu, Jinxin Li, Linhui Wang, Xinxin Gan","doi":"10.1097/JS9.0000000000002623","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002623","url":null,"abstract":"<p><p>Lactylation, the post-translational modification of proteins by lactate, has emerged as a novel and dynamic regulatory mechanism in cellular metabolism and signaling. The lactylation proteome represents a frontier in the study of cellular regulation, offering new insights into the complex interplay between metabolism and signaling pathways. It not only plays a pivotal role in regulating cell fate, cell signaling, gene expression, and cellular metabolism, but also exhibits unique and profound biological implications in inflammation, immune regulation, construction of the tumor microenvironment, and maintenance of cardiovascular and cerebrovascular functions. Therefore, researchers have shown interest in this novel post-translational modification of proteins and anticipate that in-depth studies will lead to breakthroughs in understanding the progression of various diseases and the development of therapeutic approaches. In this review, we aimed to summarize the discovery of lactylation, elucidate their functional roles and molecular mechanisms in diseases such as cancer, cardiovascular diseases, and neurological disorders, and discuss their translational and future research prospects. By integrating these insights, we aim to provide researchers with a holistic perspective, ultimately advancing our understanding of lactylation.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential prognostic impact of liver resection by the site of concurrent extrahepatic diseases in patients with colorectal cancer liver metastases: a nationwide multicenter study.","authors":"Hirochika Kato, Ryo Seishima, Jun Okui, Kohei Shigeta, Yasunori Sato, Shin Kobayashi, Katsunori Sakamoto, Hirotoshi Kobayashi, Kazushige Kawai, Kimitaka Tani, Yoichi Ajioka, Itaru Endo, Keiichi Takahashi, Koji Okabayashi, Yuko Kitagawa","doi":"10.1097/JS9.0000000000002727","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002727","url":null,"abstract":"<p><strong>Background: </strong>Liver resection for colorectal liver metastases (CRLM) with concurrent extrahepatic disease (EHD) has demonstrated potential benefits for long-term prognosis; however, its effectiveness remains controversial. Additionally, the prognostic impact of different EHD sites is not well elucidated. This study aimed to assess the significance of liver resection in patients with CRLM with concurrent EHD and evaluate how different EHD sites influence prognosis.</p><p><strong>Methods: </strong>A nationwide multicenter database was used for a retrospective analysis of patients diagnosed during two periods: 2005-2007 and 2013-2015. EHD was classified into the following five subgroups: lung, peritoneum, lymph nodes, local, and others. The inverse probability of treatment weighting (IPTW) method was applied to minimize selection bias. Kaplan-Meier survival curves and Cox proportional hazards models were used to compare the overall survival (OS) between the different treatment groups and EHD subgroups.</p><p><strong>Results: </strong>Among 3,787 patients, 874 (23.1%) underwent liver resection. Following IPTW adjustment, the hepatectomy (HT) group demonstrated significantly better OS than the non-hepatectomy (non-HT) group (5-year hazard ratio, 0.322; 95% confidence interval, 0.273-0.379; p < 0.001). Analysis by the EHD site subgroup demonstrated that liver resection was associated with a better prognosis across all sites. However, the prognostic impact differed by EHD site, with peritoneal metastasis associated with poorer outcomes in both the HT (5-year OS rates, 30.1% vs. 45.0%) and non-HT (5-year OS rates, 4.4% vs. 8.6%) groups.</p><p><strong>Conclusions: </strong>Regardless of the EHD site, liver resection was associated with a significantly better OS in patients with CRLM with concurrent EHD. The prognostic impact varies across EHD sites, underscoring the significance of considering differential prognostic risks when selecting treatment strategies.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Dyclonine Mucilage and Compound Lidocaine Cream as Tracheal Catheter Lubricant on Postoperative Pharyngeal Complications After General Anesthesia.","authors":"Xuechao Li, Xu Wen, Yuantong Liu, Sisi Zeng, Fangjun Wang","doi":"10.1097/JS9.0000000000002736","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002736","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to observe the effects of dyclonine mucilage and compound lidocaine cream on postoperative pharyngeal complications after general anaesthesia.</p><p><strong>Methods: </strong>Ninety patients were randomly divided into a dyclonine mucilage group (D group), a compound lidocaine cream group (L group) and a normal saline group (NS group). The primary outcomes were the incidence and severity of postoperative sore throat (POST). The secondary outcomes were postoperative cough (POC), hoarseness of voice (HOV), and the incidence of foreign body sensation (FBS) in the pharynx at 1, 6 and 24 h after surgery.</p><p><strong>Results: </strong>The incidence of POST at 1 and 6 h after surgery in the L group was significantly lower than that in the D group (P = 0.015 and 0.012, respectively). There was no difference in the incidence of POC and HOV at 1, 6 and 24 h after surgery between the D and L groups (PPOC = 0.267, 0.236, 0.335, and PHOV = 0.500, 0.353, and 0.306, respectively). The severity scores of POST, POC and HOV were significantly lower in the L groups than in the NS group at 1and 6 h after surgery (P < 0.001, < 0.001, < 0.001, = 0.001, 0.011, and 0.005, respectively). The incidence of pharyngeal foreign body sensation in the D group was significantly greater than that in the NS group at 1 h after surgery (P = 0.012). The postoperative satisfaction scores in the L group were significantly greater than those in the D group (P = 0.007 and = 0.009).</p><p><strong>Conclusion: </strong>Compared with dyclonine mucilage, compound lidocaine cream was associated with a lower incidence of early POST and higher postoperative satisfaction, with no increase in the incidence of pharyngeal foreign body sensation.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on 'Effect of Dexmedetomidine for Epidural Supplementation on Postpartum Sleep Disturbance After Cesarean Delivery: a Double-blind, Randomized Clinical Trial'.","authors":"Xiaoyu Qin, Bingxu Ren","doi":"10.1097/JS9.0000000000002692","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002692","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor: Preoperative membranous urethra length and urinary continence following radical prostatectomy: a systematic review and meta-analysis.","authors":"Xiniming Zhao, Xiunan Li, Guangzhen Wu","doi":"10.1097/JS9.0000000000002757","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002757","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144284355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Commentary on Comparison of Percutaneous Versus Cutdown Access in Patients After Endovascular Abdominal Aortic Repair: a Randomized Controlled Trial SWEET-EVAR trial.","authors":"Liu Longbi, Zhen Wang, Yuemeng Li","doi":"10.1097/JS9.0000000000002696","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002696","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-time automatic detection of gynecological laparoscopic surgical instruments and exploration in surgical skills assessment application: a cross-sectional study.","authors":"Huanyu Wei, Li Deng, Xueju Wu, Wenwei Tan, Yi Wu, Bin Yi, Yudi Li, Ruiwei Wang, Xiaolong Liang, Yin Chen, Hui Wang, Shuai Tang, Yanzhou Wang","doi":"10.1097/JS9.0000000000002699","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002699","url":null,"abstract":"<p><strong>Background: </strong>Automatic detection of surgical instruments is essential for Artificial Intelligence Surgery. This study aimed to construct a large-scale dataset of gynecological laparoscopic surgical instruments based on real surgical scenarios, achieve high-precision real-time detection of surgical instruments, and explore their potential application in surgical skill evaluation.</p><p><strong>Materials and methods: </strong>This cross-sectional study collected 265 gynecological laparoscopic surgical videos from two medical centers for instrument detection. Videos were divided into training and testing sets in a 4:1 ratio, with 161,348 instrument instances extracted. The instruments were detected using Real-Time Models for Object Detection (RTMDet). The mean average precision, sensitivity, and F1 score served as evaluation metrics. External validation was conducted on an independent dataset from a third medical center. Additionally, we further compared the RTMDet with the state-of-the-art PP-YOLOE model on the same dataset. Furthermore, this study performed real-time tracking of instruments during the vaginal cuff suturing step of laparoscopic hysterectomy and compared the differences in kinematic data between proficient and non-proficient videos.</p><p><strong>Results: </strong>The mean average precision, sensitivity, and F1 score for 9 types of surgical instruments were 91.75%, 94.29%, and 93.00%, respectively. External validation on the independent dataset demonstrated robust performance. In the comparison with PP-YOLOE, RTMDet demonstrated superior performance in all metrics. In the comparative analysis of kinematic data, the proficient group demonstrated significantly lesser path lengths and inter-quartile range, shorter moving times, and higher movement velocities for instruments used by both hands compared to the non-proficient group.</p><p><strong>Conclusions: </strong>This study established a large-scale, real scenario-based database of gynecological laparoscopic instruments. Using the RTMDet model, high-precision real-time detection and tracking of multiple instruments were achieved. Furthermore, this study identified several instrument kinematic metrics that can be used for surgical skill assessment, providing a reference for the objective quantification of the subjective Global Operative Assessment of Laparoscopic Skills (GOALS).</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of combining regional nerve block with general anesthesia on cognitive function in patients undergoing elbow joint release surgery: a randomized controlled trial.","authors":"Fang Xie, Ai-Hua Qi, Fan Pan, Ying Zhang, Ning Gan, Xiao-Tao Xu, Ai-Zhong Wang, Nan-Nan Zhang","doi":"10.1097/JS9.0000000000002717","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002717","url":null,"abstract":"<p><strong>Background and aim: </strong>Regional nerve block, as an anesthetic technique, can enhance postoperative recovery for patients. Postoperative cognitive dysfunction (POCD) remains a critical concern for patients undergoing elbow joint release surgery. This randomized controlled trial evaluated whether combining regional nerve block (RNB) with general anesthesia (GA) improves cognitive outcomes compared to GA alone.</p><p><strong>Methods: </strong>A single-center and single-blind (outcome assessors and analysts blinded) observation study. Seventy-four patients (ASA I-II, aged 18-65 years, BMI < 26 kg/m2) undergoing elbow joint release surgery were randomly assigned to either a control group (GA alone) or an observation group (Ultrasound-guided brachial plexus block: 20 mL 0.375% ropivacaine + GA). Primary outcome was MMSE scores on Pre-op D 1 (preoperative day 1), POD 1 (postoperative day 1), and POD 3 (postoperative day 3). Secondary outcomes included awakening time, extubation time, VAS scores at 1, 6, 12 hours after extubation and hemodynamic parameters at different time points.</p><p><strong>Results: </strong>The MMSE scores in the observation group were significantly higher than those in the control group both on the POD 1 (23.06 ± 1.01 vs 20.50 ± 0.51, mean difference 2.56 [95% CI 2.18 to 2.93]; P < 0.001) and POD 3 (25.56 ± 0.51 vs 23.36 ± 0.49, mean difference 2.19 [95% CI 1.96 to 2.43]; P < 0.001). The postoperative awakening time (3.50 ± 0.56 vs 11.83 ± 1.00 min, mean difference -8.33 [95% CI -8.71 to -7.95]; p < 0.001) and extubation time (3.50 ± 0.56 vs 13.08 ± 0.84 min, mean difference -9.58 [95% CI -9.92 to -9.25]; p < 0.001) in the observation group were significantly shorter than those in the control group. Furthermore, Visual analogue scale (VAS) scores in the observation group were lower than those in the control group at 1 hour (1.28 ± 0.61 vs 4.92 ± 0.77, mean difference -3.64 [95% CI -3.97 to -3.31]; p < 0.001), 6 hours (1.36 ± 0.54 vs 5.67 ± 0.68, mean difference -4.31 [95% CI -4.59 to -4.02]; p < 0.001), and 12 hours post-extubation(3.44 ± 0.50 vs 7.67 ± 0.48, mean difference -4.22 [95% CI -4.45 to -3.99]; p < 0.001). Hemodynamic stability was superior in the observation group across perioperative phases.</p><p><strong>Conclusions: </strong>Combining RNB with GA preserves postoperative cognitive function, accelerates recovery, and enhances analgesia in elbow joint release surgery. These findings support RNB as an adjunct to GA to mitigate POCD.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The panorama of clinical trials for pediatric or adolescent sepsis: current status and future directions.","authors":"De-Peng Lu, Lang-Lang Yang, Yu-Ting Huang, Xi Chen","doi":"10.1097/JS9.0000000000002745","DOIUrl":"https://doi.org/10.1097/JS9.0000000000002745","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":12.5,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}