International journal of surgery最新文献

{"title":"Letter to the editor: methodological considerations for oropharyngeal cancer surgical approach comparison: enhancing patient-centered evidence.","authors":"Han-Jie Long, Gui Yang, Qi-Wei Liang","doi":"10.1097/JS9.0000000000003589","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003589","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on \"Correlation analysis of postoperative cognitive function and event-related potentials in patients undergoing general anesthesia\".","authors":"Na Liu, Xianglong Yang, Yufei Wang","doi":"10.1097/JS9.0000000000003543","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003543","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celecoxib pretreatment and nab-paclitaxel-associated acute pain syndrome in patients with breast cancer: a prospective, non-randomized controlled clinical study.","authors":"Fenmei Liang, Guanhua Lu, Dexun Sun, Pangzhou Chen, Yichuan Shi, Haojie Peng, Tao Zeng, Meilin Hu, Kaili Zhu, Kai Qiu, Xinxin Chen","doi":"10.1097/JS9.0000000000003565","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003565","url":null,"abstract":"<p><strong>Background: </strong>Taxane-associated acute pain syndrome (T-APS) is a frequent adverse effect in breast cancer patients undergoing nab-paclitaxel, affecting treatment adherence and quality of life (QoL). We analyzed the effectiveness of preventative celecoxib on T-APS among these patients.</p><p><strong>Methods: </strong>This non-randomized controlled trial included 270 breast cancer patients receiving nab-paclitaxel who experienced musculoskeletal pain during the first cycle. Subjects were assigned to receive celecoxib (200 mg, administered on Days 1-7) or a placebo. The main outcome measured was the overall incidence of severe T-APS (> 5 on a 0-10 scale) during cycles 2-4. Secondary endpoints included the incidence, severity, and duration of T-APS (assessed by the Brief Pain Inventory scale); QoL; peripheral nerve function; and adverse events.</p><p><strong>Results: </strong>The overall incidence of severe T-APS was 10.2% in the celecoxib group and 50.0% in the placebo group during cycles 2-4 (p < 0.001). Mean FACT-B subscale scores were significantly higher in the celecoxib group (101.62, 95% CI: 99.70-103.53; 105.59, 95% CI: 103.57-107.61; and 108.02, 95%CI: 106.18-109.85) than the placebo group (99.02, 95% CI: 97.29-100.76; 99.80, 95% CI: 98.03-101.57; and 99.10, 95% CI: 97.39-100.81) (p < 0.05). QoL on EORTC QLQ-C30 was also better in the celecoxib group, except for appetite loss, fatigue, and insomnia (p < 0.05). Following four cycles, the mean scores on the FACT-Ntx subscale in the celecoxib group remained higher (34.10, 95% CI: 33.29-34.91 vs 32.25, 95% CI: 31.63-32.88) (p < 0.01). Additionally, the incidence of peripheral neuropathy at grade 1 or higher in CTCAE 5.0 was reduced in the celecoxib group (36.7% vs 63.8%, p < 0.001).</p><p><strong>Conclusion: </strong>Preventative celecoxib significantly reduced the incidence of severe T-APS and improved QoL in breast cancer patients.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"Impact of Child-Pugh score on surgical outcomes after distal gastrectomy and right hemicolectomy: a retrospective study from the Japanese National Clinical Database\".","authors":"Dianzhe Tian, Xin Lu, Hu Tian","doi":"10.1097/JS9.0000000000003572","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003572","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence for predicting post-excision recurrence and malignant progression in oral potentially malignant disorders a retrospective cohort study.","authors":"John Adeoye, Yu-Xiong Su","doi":"10.1097/JS9.0000000000003592","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003592","url":null,"abstract":"<p><strong>Background: </strong>Oral cancer may develop from precursor lesions and conditions termed oral potentially malignant disorders (OPMD), although not all patients progress to cancer in their lifetime. Managing patients with OPMD is challenging due to lesion recurrence and uncertain malignant progression risk following surgical excision. This study developed a multitask AI-based model to predict the risk of treatment failure, malignant progression, and recurrence among patients with OPMD treated by surgery.</p><p><strong>Methods: </strong>This study utilized multidimensional data from 366 retrospective patients with OPMD treated in two tertiary centers to construct an AI model to predict three treatment outcomes among patients with OPMD. Multifaceted prognostic variables were collected for the cohort and used to train four AI supervised learning models, followed by optimal model selection. AUC and Brier scores were used to assess model performance. External testing of the model was also performed, and metrics were compared to the WHO and binary dysplasia grading systems (current standards). We further assessed the net benefit and explainability of the final multitask model.</p><p><strong>Results: </strong>The outperforming model (TabPFN) had good AUC values of 0.829 (0.729-0.929), 0.912 (0.836-0.988), and 0.791 (0.683-0.899) for predicting treatment failure, malignant progression, and lesion recurrence at external testing. The Brier scores of the model for all three treatment outcome predictive tasks were also optimal (0.085-0.147). Furthermore, the AI model had a superior net benefit than the WHO and binary epithelial dysplasia grading systems in assessing the need for close monitoring among patients with OPMD treated by surgery. The explainability of the model was also successfully implemented.</p><p><strong>Conclusions: </strong>The multitask AI-based model developed with multidimensional data has good discriminatory performance, calibration, and net benefit, showing potential for comprehensive risk assessment and clinical decision support in the surgical management of patients with OPMD to promote early detection of oral cancer.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on DeepSeek-assisted LI-RADS classification: AI-driven precision in hepatocellular carcinoma diagnosis.","authors":"Minghao Shen, Huafeng Gu, Jianhua Xu","doi":"10.1097/JS9.0000000000003579","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003579","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the necessity of prophylactic lateral neck dissection in medullary thyroid carcinoma based on preoperative calcitonin levels: a multicenter retrospective cohort study.","authors":"Shin Jeong Pak, Douk Kwon, Byung-Chang Kim, Won Woong Kim, Tae Yon Sung, Ki-Wook Chung, Yu-Mi Lee, Jong Ju Jeong","doi":"10.1097/JS9.0000000000003557","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003557","url":null,"abstract":"<p><strong>Background: </strong>The need for prophylactic lateral neck dissection (LND) in medullary thyroid carcinoma (MTC) patients without clinically evident lateral lymph node (LN) metastasis remains controversial, particularly in those with elevated preoperative calcitonin levels. This study investigated the prognostic impact of prophylactic LND in MTC patients with preoperative calcitonin levels >200 pg/mL, but without clinically suspicious lateral LNs.</p><p><strong>Materials and methods: </strong>This multicenter retrospective cohort study included 103 patients with MTC treated between January 1980 and December 2022 at two tertiary hospitals in Seoul, South Korea. Patients had preoperative calcitonin levels above 200 pg/mL and no clinical evidence of lateral LN metastasis. They were divided into two groups based on whether LND was performed, and their long-term oncological outcomes were compared.</p><p><strong>Results: </strong>The median follow-up duration was 90 months. The LND group had significantly larger tumors and higher preoperative calcitonin levels. Although the biochemical cure rate was higher in the LND group than in the No LND group (95.2% vs. 82.5%), this difference was not statistically significant (P = 0.074). No significant differences were observed between the groups in biochemical recurrence, structural recurrence, overall survival, or disease-specific survival. Subgroup analyses based on preoperative calcitonin levels showed comparable results.</p><p><strong>Conclusion: </strong>Prophylactic LND did not significantly impact long-term oncologic outcomes in MTC patients without clinically evident lateral LN metastasis, even among those with elevated preoperative calcitonin levels above 200 pg/mL. Although prophylactic LND was associated with higher biochemical cure rates, this did not translate into reduced recurrence rates or improved survival. Routine prophylactic LND may not be necessary, and the decision to perform it should be carefully individualized based on patient-specific factors.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding the triglyceride-glucose index in metabolic dysfunction-associated steatotic liver disease: integrative insights from mendelian randomization, cross-tissue transcriptomics, and spatial multi-omics.","authors":"Shuxu Wei, Lingbin He, Youti Zhang, Xinyi Li, Suiqin Zhong, Ling Xiao, Ronghuai Shen, Xiaojia Lu, Zhouwu Shu, Yan Quan, Xianxi Huang","doi":"10.1097/JS9.0000000000003576","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003576","url":null,"abstract":"<p><strong>Background: </strong>The triglyceride-glucose (TyG) index, an insulin resistance marker linked to the progression of metabolic dysfunction-associated steatotic liver disease (MASLD), underscores the redox imbalance-mediated crosstalk between MASLD and cardiovascular-liver-metabolic health (CLMH), although its causal mechanisms and molecular drivers remain unresolved.</p><p><strong>Methods: </strong>We employed a multi-omics framework to integrate Mendelian randomization (MR) and transcriptome-wide association studies (TWAS). MR leveraged 192 genome-wide significant SNPs for TyG from the UK Biobank, employing inverse-variance weighted (IVW) and generalized summary-data MR (GSMR). Transcriptomic integration utilized four approaches: Multi-marker Analysis of GenoMic Annotation (MAGMA) for gene-set enrichment; Joint-Tissue Imputation PrediXcan (JTI-PrediXcan) for tissue-specific expression; Sparse Multi-Tissue Imputation Xcan (SMulTiXcan) for cross-tissue meta-analysis; and Fine-mapping of Causal Gene Sets (FOCUS) for Bayesian fine-mapping. Co-morbid genes were validated using Functional Summary-based Imputation (FUSION) and prioritized based on the Polygenic Priority Score (PoPS). Single-cell spatial transcriptomics (sc-ST) in embryonic mice (E16.5) mapped tissue-specific expression via genetically informed spatial mapping (gsMap).</p><p><strong>Results: </strong>MR analysis demonstrated a causal effect of TyG on MASLD risk (IVW: odds ratio [OR] = 1.58, 95%CI = 1.04-2.38, P = 0.030; GSMR: OR = 1.43, 95% CI = 1.27-1.61, P = 5.20 × 10-9). TWAS identified 12 co-morbid genes (C2orf16/SPATA31H1, FNDC4, GCKR, GMIP, HAPLN4, LPAR2, MAU2, MEF2B, NDUFA13, NRBP1, TM6SF2, ZNF513). Independent validation using the FUSION framework confirmed nine TyG-MASLD comorbid genes with genome-wide significant false discovery rate-adjusted associations. Notably, TM6SF2 (TyG-PoPS = 7.2491) and GCKR (TyG-PoPS = 6.7102) showed strong positive associations in TyG, while NDUFA13 exhibited negative scores in MASLD (PoPS = - 0.5028). Spatial mapping revealed conserved enrichment of APOA1, APOB, and APOC4 (sc-ST P<0.001) in murine liver and vascular tissues. Organ-specific analysis showed significant MASLD signals included the liver (sc-ST P = 6.43 × 10-5), adrenal gland (Cauchy P = 0.0064), and connective tissue (sc-ST P = 3.29 × 10-5).</p><p><strong>Conclusion: </strong>This study establishes TyG as a causal MASLD driver mediated by redox-sensitive hubs and evolutionarily conserved apolipoproteins, linking hepatic lipid peroxidation to systemic metabolic dysregulation. Targeting these pathways may mitigate dual hepatic-cardiovascular risks, advancing precision therapies for CLMH.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights into neoadjuvant immunotherapy and chemotherapy combination for resectable N1/N2 NSCLC: correspondence.","authors":"Weiyi Jiang, Feifei Mao, Tingsu Zhang","doi":"10.1097/JS9.0000000000003577","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003577","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor \"The NPAR index in breast cancer: diagnostic promise versus validation reality\".","authors":"Kangkang Ji, Yuwen Shangguan, Minli Sun","doi":"10.1097/JS9.0000000000003590","DOIUrl":"https://doi.org/10.1097/JS9.0000000000003590","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}