International journal of surgery最新文献

{"title":"A commentary on \"Acupuncture for rehabilitation after total knee arthroplasty: a systematic review and network meta-analysis\".","authors":"Xingping Li, Wenqing Wang, Zhixiang Wei, Huanyu Liu","doi":"10.1097/JS9.0000000000004801","DOIUrl":"10.1097/JS9.0000000000004801","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145966077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the scientific landscape of mitochondria-associated membranes: a bibliometric insight into emerging frontiers in aging and diseases.","authors":"Jiao Pang, Yunxiang Zhang, Yuan Tian, Xingrui Cao, Xueshu Tao, Cheng Sun, Zhipeng Cao","doi":"10.1097/JS9.0000000000004989","DOIUrl":"https://doi.org/10.1097/JS9.0000000000004989","url":null,"abstract":"<p><strong>Background: </strong>Mitochondria-associated membranes (MAMs) are critical hubs coordinating energy metabolism, lipid homeostasis, and Ca2⁺ signaling, thereby regulating cell survival, stress responses, and apoptosis. Increasing evidence links MAMs dysfunction to aging, neurodegenerative diseases, metabolic disorders, and cancer. Although numerous mechanistic studies and narrative reviews have been published, a systematic, mechanism-oriented bibliometric evaluation of the global MAMs research landscape is still lacking.</p><p><strong>Methods: </strong>We performed a comprehensive bibliometric analysis of MAMs-related literature indexed in the Web of Science Core Collection from 2009 to 2024, using Bibliometrix, VOSviewer, and CiteSpace to integrate publication trends, collaboration networks, keyword co-occurrence, thematic evolution, and citation impact.</p><p><strong>Results: </strong>A total of 1199 publications were identified, showing a rapid annual growth rate of 21.57%. Beyond general trend analysis, our study reveals that research hotspots converge on Ca2⁺ homeostasis, ER stress, apoptosis, and mitochondrial dynamics, and progressively shift toward aging-related biological processes. By mapping high-frequency keywords to known MAMs-associated pathways, we identify aging, ER stress, and apoptosis as interconnected emerging themes. Importantly, this analysis highlights specific MAMs-related proteins, including HSP90α, as potential regulatory hubs linking stress responses and aging.</p><p><strong>Conclusions: </strong>This study provides the first integrative, mechanism-oriented bibliometric framework of MAMs research, bridging quantitative publication patterns with underlying biological pathways. Our findings not only delineate the intellectual structure and evolving themes of the field but also generate testable hypotheses implicating MAMs and key regulatory proteins in aging-related processes, thereby offering guidance for future mechanistic and translational studies.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of SEEKflex and Stylet for double-lumen tube intubation: a multicenter randomized controlled trial.","authors":"Chenglong Zhu, Li Tan, Miao Zhou, Qinghua Wu, Yongchu Hu, Shengyu Jin, Chenyu Wang, Yang Liu, Dengyun Xia, Yaohua Yu, Wenyun Xu, Zui Zou","doi":"10.1097/JS9.0000000000004956","DOIUrl":"https://doi.org/10.1097/JS9.0000000000004956","url":null,"abstract":"<p><strong>Background: </strong>Tracheal injury, vocal cord injury, sore throat, and hoarseness are common complications of double-lumen tube (DLT) intubation. We try to make efforts to minimize these complications. Our objective is to test whether the use of Safe Easy Endotracheal kit-flexible (SEEKflex)-assisted DLT intubation reduces complications.</p><p><strong>Methods: </strong>We conducted a multicenter, non-blinded, randomized, parallel-group clinical trial with the aim of comparing the use of SEEKflex versus Stylet in DLT intubation under videolaryngoscopy. Between January 2023 and May 2024, patients aged 18-75 years who required a left-sided DLT to maintain pulmonary isolation during thoracic surgery. We randomly assigned 140 patients to two groups in a 1:1 ratio: SEEKflex combined with videolaryngoscopy group (SEEKflex group) and Stylet combined with videolaryngoscopy group (Stylet group).</p><p><strong>Results: </strong>The incidence of sore throat and hoarseness at 24 h postoperatively was significantly higher in the Stylet group than in the SEEKflex group (sore throat, 33% vs 17%, P = 0.032, hoarseness, 41% vs 26%, P = 0.049); however, there was no significant difference in severity between the two groups. No patients developed new sore throat or hoarseness on postoperative day 2, and the incidence and severity of sore throat and hoarseness were similar between the two groups. The incidence of tracheal injury was higher in the Stylet group than in the SEEKflex group (24% vs 10%, P = 0.025). After examining all participants, 12 patients in the Stylet group and 4 patients in the SEEKflex group experienced vocal cord congestion or edema. The incidence of vocal cord injury was higher in the Stylet group compared to SEEKflex group (17% vs 6%, P = 0.034).</p><p><strong>Conclusions: </strong>SEEKflex-assisted DLT intubation reduces complications.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic risk and biomarker-derived cluster for urolithiasis risk prediction: a prospective cross-cohort study in the United Kingdom and Hong Kong.","authors":"Yongle Zhan, Ruochen Ma, Ruofan Shi, Xiaohao Ruan, Chi Yao, Salida Ali, Tsun Tsun Stacia Chun, Zhenquan Lu, Yuan Yuan, Genggeng Wei, Xiang Xu, Lin Xiong, Ada Tsui-Lin Ng, Richard Ky Lo, Rong Na","doi":"10.1097/JS9.0000000000004981","DOIUrl":"https://doi.org/10.1097/JS9.0000000000004981","url":null,"abstract":"<p><strong>Background: </strong>Urolithiasis, a multifactorial disease with high recurrence, lacks robust tools for personalized risk prediction. While genetic susceptibility and biochemical signatures are implicated in pathogenesis, their combined utility remains unexplored. This study aims to evaluate the integration of polygenic risk scores (PRS) and biomarker-derived clusters in personalized urolithiasis risk stratification across ethnically diverse populations.</p><p><strong>Materials and methods: </strong>A population-based cohort study was performed using UK Biobank (UKB) data (N = 480 098). Sixteen out of 62 hematology and biochemistry markers related to urolithiasis were identified by LASSO regression. K-means clustering categorized participants into distinct biomarker profiles. Findings were validated in a Hong Kong cohort (N = 6177) from the electronic health record database of Hospital Authority (EHR-HK).</p><p><strong>Results: </strong>In the UKB, individuals with the top PRS quartile had a 41% higher urolithiasis risk (HR = 1.41, 95% CI: 1.34-1.48). Three biomarker-derived clusters were identified, namely cardiovascular-skeletal (C-S), hematal-endocrine (H-E), and inflammatory-metabolic (I-M) clusters. Compared to the C-S cluster, H-E and I-M clusters were associated with 78 and 80% increased risks of urolithiasis. The highest cumulative recurrence rate was observed in patients with I-M cluster, with 19.7, 25.4, and 28.7% at 5, 10, and 15 years after the first episode. Synergistic effects were significant: those with the top PRS quartile combined with the I-M profile faced 2.66-, 3.56-, and 2.94-fold higher incidence, recurrent, and multifocal risk of urolithiasis. Site-specific analyses revealed ureter calculi attributable to the strongest genetic-biomarker interaction (HR = 3.73, 95% CI: 3.24-4.30). Validation in EHR-HK confirmed the utility of biomarker-derived clusters in predicting recurrent urolithiasis [OR = 1.58 (1.35-1.85) for I-M cluster; OR = 1.31 (1.13-1.52) for H-E cluster].</p><p><strong>Conclusions: </strong>This cross-cohort study demonstrates that integration of genetic and biomarker profiles identifies high-risk phenotypes related to stone formation. Our framework informs clinicians to prioritize high-risk patients for targeted monitoring and prophylactic therapies. The replication across European and East Asian highlights its utility in diverse settings.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From outcome-based validation to data-driven evaluation in robotic surgery.","authors":"Fei Gao, Chen Yu","doi":"10.1097/JS9.0000000000004961","DOIUrl":"https://doi.org/10.1097/JS9.0000000000004961","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"A multi-omics pipeline integrating machine learning and spatial-cellular analysis identifies SASH1 as a prognostic biomarker and therapeutic target in head and neck squamous cell carcinoma\".","authors":"Long Xu, Yan Wang, Guiqiang Wang","doi":"10.1097/JS9.0000000000004222","DOIUrl":"https://doi.org/10.1097/JS9.0000000000004222","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Early health economic analysis of virtual reality therapy for pain management after surgery\".","authors":"Ali Pezeshkian","doi":"10.1097/JS9.0000000000004735","DOIUrl":"10.1097/JS9.0000000000004735","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147270941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative multi-omics refines the molecular subtypes of thyroid cancers and enhances cancer-progression prediction: a retrospective cohort study.","authors":"Yoo Hyung Kim, Joseph Wang, Jae-Kyung Won, Youngsoo Kim, Sun Wook Cho, Dohyun Han, Young Joo Park","doi":"10.1097/JS9.0000000000004979","DOIUrl":"https://doi.org/10.1097/JS9.0000000000004979","url":null,"abstract":"<p><strong>Background: </strong>Current molecular classification model for thyroid cancer (TC), which relies on BRAF-RAS score genes has limited efficacy in differentiating follicular-patterned tumors from normal thyroid (NT) tissues and lack predictive power for disease progression. This study aimed to refine TC classification and develop predictive systems for tumor progression.</p><p><strong>Methods: </strong>A multi-omics analysis integrating transcriptomics (SNUH-mRNASeq) and proteomics (SNUH-TMT-Pro) from retrospectively collected human tissues representing NT and tumors with mutation profiles was conducted in a single center. A novel gene set, termed NPF genes, was identified and used to construct a decision-tree based classification system and a risk stratification model for tumor progression. The discriminatory potential of protein markers was validated through immunohistochemistry (SNUH-IHC) using tissue microarrays. External datasets (TCGA-THCA, SNUH-DIA-Pro, and CellDis-Pro) were employed to validate both the classification and risk stratification systems.</p><p><strong>Results: </strong>Clustering based on NPF genes separated papillary thyroid cancer (PTC) with BRAFV600E mutation (PTC-B), follicular thyroid cancer (FTC) regardless of mutation status and NT, classifying them into BRAFV600E-like, RAS-like, and NT-like subtypes. The decision-tree based classification model with NPF genes demonstrated high accuracy (0.92, 95% CI 0.88-0.95) and Kappa statistics (0.88). IHC of three protein biomarkers (MATN2, FN1, and PLSCR4) confirmed the molecular subtypes in SNUH-IHC, with findings consistent across external datasets. Additionally, higher NP-score and NF-score predicted poorer prognosis in BRAFV600E-like and RAS-like TCs.</p><p><strong>Conclusion: </strong>The NPF gene set and classification model refine TC classification, improve diagnostic accuracy, and enable better risk stratification. These advancements offer a foundation for personalized therapeutic strategies in TC management.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147270954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative urologic safety in radical hysterectomy: surgical approach and the role of the perioperative team.","authors":"Yajun Zhao","doi":"10.1097/JS9.0000000000004983","DOIUrl":"10.1097/JS9.0000000000004983","url":null,"abstract":"","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146226915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra-microskin as cytokine reservoirs promote diabetic wound healing: experimental research.","authors":"Jingzhu Li, Yixin Wu, Yicheng Ma, Hao Chen, Zixuan Zhou, Chao Ji, Zhi Liu, Yuxiang Wang, Shunxin Jin, Xiaowan Fang, Zhenzhen Yan, Xiaoru Weng, Yuanshu Wu, Jingnan Xun, Shichu Xiao, Yongjun Zheng","doi":"10.1097/JS9.0000000000004938","DOIUrl":"https://doi.org/10.1097/JS9.0000000000004938","url":null,"abstract":"<p><strong>Background: </strong>Chronic wounds, such as diabetic foot ulcers, are challenging to heal due to persistent inflammatory responses and imbalanced growth factors. Conventional microskin grafting techniques face limitations, including insufficient viability, orientation-dependent survival, and restricted paracrine functions. This study investigates the feasibility of using ultra-microskin grafts (approximately 0.3 mm thick, 0.4 × 0.4 mm in surface dimensions) at expansion ratios of 1:10 to enhance diabetic wound repair.</p><p><strong>Materials and methods: </strong>Ultra-microskins were prepared using an automated skin-cutting device. Viability assessment of ultra-microskin and conventional microskins was performed using CCK-8 assay, LIVE/DEAD staining, transmission electron microscopy, and explant culture. Ultra-microskin was transplanted onto full-thickness defects at 1:10 and 1:20 expansion ratios; the optimal size was determined based on viability results and the \"Inter-Graft Spacing Theory.\" Cytokine release from ultra-microskin was quantified by ELISA. The effects of cytokines in ultra-microskin extracts on the migration, proliferation, and tube formation capabilities of human foreskin fibroblasts (HFB), human umbilical vein endothelial cells (HUVECs), and HaCaT cells were assessed. Ultra-microskin (0.4 mm) was transplanted onto diabetic rat wounds at a 1:10 ratio. Wound healing was evaluated via gross photography, H&E staining, Masson's trichrome staining, and CD31/Ki-67 immunohistochemistry. Proteomic analysis of wound tissues was conducted on posttransplant days 7 and 14.</p><p><strong>Results: </strong>Ultra-microskin sized ≥0.4 mm exhibited viability comparable to or exceeding that of conventional microskins. The optimal size for ultra-microskin was determined to be 0.4 mm. Ultra-microskin significantly enhanced the release of cytokines (TGF-α, EGF, MCP-1, TNF-α, IL-6, IL-10, VEGF-A, TGF-β1, IGF-1) and promoted the functions of wound healing-associated cells (HFB, HUVEC, HaCaT). Transplantation of ultra-microskin significantly attenuated inflammation, promoted vascularization and epithelialization, and accelerated the healing rate of diabetic wounds.</p><p><strong>Conclusion: </strong>Ultra-microskin (0.4 mm) dynamically accelerates diabetic wound healing via cytokine release, offering a novel therapeutic strategy for chronic wounds, including diabetic ulcers.</p>","PeriodicalId":14401,"journal":{"name":"International journal of surgery","volume":" ","pages":""},"PeriodicalIF":10.1,"publicationDate":"2026-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146258201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}